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Science 5 July 1991:
Vol. 253. no. 5015, pp. 71 - 74
DOI: 10.1126/science.1905842
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Articles

Science, Vol 253, Issue 5015, 71-74
Copyright © 1991 by American Association for the Advancement of Science

articles

Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1

SS Hwang, TJ Boyle, HK Lyerly, and BR Cullen

Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.

Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.


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H. A. Mbah, S. Burda, M. K. Gorny, C. Williams, K. Revesz, S. Zolla-Pazner, and P. N. Nyambi (2001)
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K. Tokunaga, M. L. Greenberg, M. A. Morse, R. I. Cumming, H. K. Lyerly, and B. R. Cullen (2001)
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J. Virol. 75, 5721-5729
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N-Linked Glycosylation Sites Adjacent to and within the V1/V2 and the V3 Loops of Dualtropic Human Immunodeficiency Virus Type 1 Isolate DH12 gp120 Affect Coreceptor Usage and Cellular Tropism.
R. A. Ogert, M. K. Lee, W. Ross, A. Buckler-White, M. A. Martin, and M. W. Cho (2001)
J. Virol. 75, 5998-6006
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E. G. Cormier, D. N. H. Tran, L. Yukhayeva, W. C. Olson, and T. Dragic (2001)
J. Virol. 75, 5541-5549
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Differential CD4/CCR5 Utilization, gp120 Conformation, and Neutralization Sensitivity between Envelopes from a Microglia-Adapted Human Immunodeficiency Virus Type 1 and Its Parental Isolate.
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Evolution of the Human Immunodeficiency Virus Type 1 Envelope during Infection Reveals Molecular Corollaries of Specificity for Coreceptor Utilization and AIDS Pathogenesis.
Q.-x. Hu, A. P. Barry, Z.-x. Wang, S. M. Connolly, S. C. Peiper, and M. L. Greenberg (2000)
J. Virol. 74, 11858-11872
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J. Virol. 74, 10852-10859
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Multiple Blocks to Human Immunodeficiency Virus Type 1 Replication in Rodent Cells.
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J. Virol. 74, 9868-9877
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Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120.
C. A. Derdeyn, J. M. Decker, J. N. Sfakianos, X. Wu, W. A. O'Brien, L. Ratner, J. C. Kappes, G. M. Shaw, and E. Hunter (2000)
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J. Arthos, A. Rubbert, R. L. Rabin, C. Cicala, E. Machado, K. Wildt, M. Hanbach, T. D. Steenbeke, R. Swofford, J. M. Farber, et al. (2000)
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Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120.
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PNAS 97, 5762-5767
   Abstract »    Full Text »    PDF »
Unusual Polymorphisms in Human Immunodeficiency Virus Type 1 Associated with Nonprogressive Infection.
L. Alexander, E. Weiskopf, T. C. Greenough, N. C. Gaddis, M. R. Auerbach, M. H. Malim, S. J. O'Brien, B. D. Walker, J. L. Sullivan, and R. C. Desrosiers (2000)
J. Virol. 74, 4361-4376
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Y. Maeda, M. Foda, S. Matsushita, and S. Harada (2000)
J. Virol. 74, 1787-1793
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J. T. C. Shieh, J. Martín, G. Baltuch, M. H. Malim, and F. González-Scarano (2000)
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S. Li, J. Juarez, M. Alali, D. Dwyer, R. Collman, A. Cunningham, and H. M. Naif (1999)
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C. C. LaBranche, T. L. Hoffman, J. Romano, B. S. Haggarty, T. G. Edwards, T. J. Matthews, R. W. Doms, and J. A. Hoxie (1999)
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D. J. Chabot, P.-F. Zhang, G. V. Quinnan, and C. C. Broder (1999)
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K. Kato, H. Sato, and Y. Takebe (1999)
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J. A. Esté, C. Cabrera, J. Blanco, A. Gutierrez, G. Bridger, G. Henson, B. Clotet, D. Schols, and E. De Clercq (1999)
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Variable Constraints on the Principal Immunodominant Domain of the Transmembrane Glycoprotein of Human Immunodeficiency Virus Type 1.
R. Merat, H. Raoul, T. Leste-Lasserre, P. Sonigo, and G. Pancino (1999)
J. Virol. 73, 5698-5706
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Definition of the Stage of Host Cell Genetic Restriction of Replication of Human Immunodeficiency Virus Type 1 in Monocytes and Monocyte-Derived Macrophages by Using Twins.
H. M. Naif, S. Li, M. Alali, J. Chang, C. Mayne, J. Sullivan, and A. L. Cunningham (1999)
J. Virol. 73, 4866-4881
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Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.
T. L. Hoffman, C. C. LaBranche, W. Zhang, G. Canziani, J. Robinson, I. Chaiken, J. A. Hoxie, and R. W. Doms (1999)
PNAS 96, 6359-6364
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Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated with the Development of Thrombocytopenia.
F. Voulgaropoulou, B. Tan, M. Soares, B. Hahn, and L. Ratner (1999)
J. Virol. 73, 3497-3504
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Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates, Like HIV-1 Isolates, Frequently Use CCR5 but Show Promiscuity in Coreceptor Usage.
A. Mörner, A. Björndal, J. Albert, V. N. KewalRamani, D. R. Littman, R. Inoue, R. Thorstensson, E. M. Fenyö, and E. Björling (1999)
J. Virol. 73, 2343-2349
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Apoptosis Induced by Infection of Primary Brain Cultures with Diverse Human Immunodeficiency Virus Type 1 Isolates: Evidence for a Role of the Envelope.
A. Ohagen, S. Ghosh, J. He, K. Huang, Y. Chen, M. Yuan, R. Osathanondh, S. Gartner, B. Shi, G. Shaw, et al. (1999)
J. Virol. 73, 897-906
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H. M. Vu, D. Myers, R. de Lorimier, T. J. Matthews, M. A. Moody, C. Heinly, J. V. Torres, B. F. Haynes, and L. Spicer (1999)
J. Virol. 73, 746-750
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Study of the V3 Loop as a Target Epitope for Antibodies Involved in the Neutralization of Primary Isolates versus T-Cell-Line-Adapted Strains of Human Immunodeficiency Virus Type 1.
C. Spenlehauer, S. Saragosti, H. J. A. Fleury, A. Kirn, A.-M. Aubertin, and C. Moog (1998)
J. Virol. 72, 9855-9864
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Mapping of Epitopes Exposed on Intact Human Immunodeficiency Virus Type 1 (HIV-1) Virions: a New Strategy for Studying the Immunologic Relatedness of HIV-1.
P. N. Nyambi, M. K. Gorny, L. Bastiani, G. van der Groen, C. Williams, and S. Zolla-Pazner (1998)
J. Virol. 72, 9384-9391
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Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline.
R. B. Markham, W.-C. Wang, A. E. Weisstein, Z. Wang, A. Munoz, A. Templeton, J. Margolick, D. Vlahov, T. Quinn, H. Farzadegan, et al. (1998)
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Evolution of Envelope Sequences from the Genital Tract and Peripheral Blood of Women Infected with Clade A Human Immunodeficiency Virus Type 1.
M. Poss, A. G. Rodrigo, J. J. Gosink, G. H. Learn, D. de Vange Panteleeff, H. L. Martin Jr., J. Bwayo, J. K. Kreiss, and J. Overbaugh (1998)
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HIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptors.
T. L. Hoffman, E. B. Stephens, O. Narayan, and R. W. Doms (1998)
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   Abstract »    Full Text »    PDF »
Mutations in both gp120 and gp41 Are Responsible for the Broad Neutralization Resistance of Variant Human Immunodeficiency Virus Type 1 MN to Antibodies Directed at V3 and Non-V3 Epitopes.
E. J. Park, L. K. Vujcic, R. Anand, T. S. Theodore, and G. V. Quinnan Jr. (1998)
J. Virol. 72, 7099-7107
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Dissociation of the CD4 and CXCR4 Binding Properties of Human Immunodeficiency Virus Type 1 gp120 by Deletion of the First Putative Alpha-Helical Conserved Structure.
D. Misse, M. Cerutti, I. Schmidt, A. Jansen, G. Devauchelle, F. Jansen, and F. Veas (1998)
J. Virol. 72, 7280-7288
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The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop.
T. M. Ross and B. R. Cullen (1998)
PNAS 95, 7682-7686
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CXCR4 Sequences Involved in Coreceptor Determination of Human Immunodeficiency Virus Type-1 Tropism. UNMASKING OF ACTIVITY WITH M-TROPIC Env GLYCOPROTEINS.
Z.-x. Wang, J. F. Berson, T.-y. Zhang, Y.-H. Cen, Y. Sun, M. Sharron, Z.-h. Lu, and S. C. Peiper (1998)
J. Biol. Chem. 273, 15007-15015
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Human Immunodeficiency Virus Type 1 T-Lymphotropic Strains Enter Macrophages via a CD4- and CXCR4-Mediated Pathway: Replication Is Restricted at a Postentry Level.
H. Schmidtmayerova, M. Alfano, G. Nuovo, and M. Bukrinsky (1998)
J. Virol. 72, 4633-4642
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Evolution of Syncytium-Inducing and Non-Syncytium-Inducing Biological Virus Clones in Relation to Replication Kinetics during the Course of Human Immunodeficiency Virus Type 1 Infection.
A. B. van 't Wout, H. Blaak, L. J. Ran, M. Brouwer, C. Kuiken, and H. Schuitemaker (1998)
J. Virol. 72, 5099-5107
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The Effect of Deletion of the V3 Loop of gp120 on Cytotoxic T Cell Responses and HIV gp120-Mediated Pathogenesis.
D. Kmieciak, T. J. Wasik, H. Teppler, J. Pientka, S. H. Hsu, H. Takahashi, K. Okumura, Y. Kaneko, and D. Kozbor (1998)
J. Immunol. 160, 5676-5683
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Determinants of Entry Cofactor Utilization and Tropism in a Dualtropic Human Immunodeficiency Virus Type 1 Primary Isolate.
R. J. Smyth, Y. Yi, A. Singh, and R. G. Collman (1998)
J. Virol. 72, 4478-4484
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Differentiation of Promonocytic U937 Subclones into Macrophagelike Phenotypes Regulates a Cellular Factor(s) Which Modulates Fusion/Entry of Macrophagetropic Human Immunodeficiency Virus Type 1.
H. Moriuchi, M. Moriuchi, and A. S. Fauci (1998)
J. Virol. 72, 3394-3400
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Multiple Residues Contribute to the Inability of Murine CCR-5 To Function as a Coreceptor for Macrophage-Tropic Human Immunodeficiency Virus Type 1 Isolates.
T. M. Ross, P. D. Bieniasz, and B. R. Cullen (1998)
J. Virol. 72, 1918-1924
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Identification of a Domain within the Human T-Cell Leukemia Virus Type 2 Envelope Required for Syncytium Induction and Replication.
B. Poon and I. S. Y. Chen (1998)
J. Virol. 72, 1959-1966
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The Cell Tropism of Human Immunodeficiency Virus Type 1 Determines the Kinetics of Plasma Viremia in SCID Mice Reconstituted with Human Peripheral Blood Leukocytes.
G. R. Picchio, R. J. Gulizia, K. Wehrly, B. Chesebro, and D. E. Mosier (1998)
J. Virol. 72, 2002-2009
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Delayed Infection after Immunization with a Peptide from the Transmembrane Glycoprotein of the Feline Immunodeficiency Virus.
J. Richardson, A. Moraillon, F. Crespeau, S. Baud, P. Sonigo, and G. Pancino (1998)
J. Virol. 72, 2406-2415
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Identification of Determinants on a Dualtropic Human Immunodeficiency Virus Type 1 Envelope Glycoprotein That Confer Usage of CXCR4.
M. W. Cho, M. K. Lee, M. C. Carney, J. F. Berson, R. W. Doms, and M. A. Martin (1998)
J. Virol. 72, 2509-2515
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An Intricate Web: Chemokine Receptors, HIV-1 and Hematopoiesis.
B. Lee, B. J. Doranz, M. Z. Ratajczak, and R. W. Doms (1998)
Stem Cells 16, 79-88
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Conservation of an Intact vif Gene of Human Immunodeficiency Virus Type 1 during Maternal-Fetal Transmission.
V. R. K. Yedavalli, C. Chappey, E. Matala, and N. Ahmad (1998)
J. Virol. 72, 1092-1102
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Differential Tropism and Chemokine Receptor Expression of Human Immunodeficiency Virus Type 1 in Neonatal Monocytes, Monocyte-Derived Macrophages, and Placental Macrophages.