Science 5 July 1991: Vol. 253. no. 5015, pp. 59 - 63 DOI: 10.1126/science.1648265

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Articles

Co-administration of Ciliary Neurotrophic Factor with Its Soluble Receptor Protects against Neuronal Death and Enhances Neurite Outgrowth.

M. A. Ozog, G. Modha, J. Church, R. Reilly, and C. C. Naus (2008)
J. Biol. Chem. 283, 6546-6560
 |  Abstract »  |  Full Text »  |  PDF »

Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women.

G. De Mars, A. Windelinckx, G. Beunen, C. Delecluse, J. Lefevre, and M. A. I. Thomis (2007)
J Appl Physiol 102, 1824-1831
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Prevents Acute Lipid-Induced Insulin Resistance by Attenuating Ceramide Accumulation and Phosphorylation of c-Jun N-Terminal Kinase in Peripheral Tissues.

M. J. Watt, A. Hevener, G. I. Lancaster, and M. A. Febbraio (2006)
Endocrinology 147, 2077-2085
 |  Abstract »  |  Full Text »  |  PDF »

Parvovirus Nonstructural Proteins Induce an Epigenetic Modification through Histone Acetylation in Host Genes and Revert Tumor Malignancy to Benignancy.

H. Iseki, R. Shimizukawa, F. Sugiyama, S. Kunita, A. Iwama, M. Onodera, H. Nakauchi, and K.-i. Yagami (2005)
J. Virol. 79, 8886-8893
 |  Abstract »  |  Full Text »  |  PDF »

Rapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factor.

S Talon, M.-A Giroux-Metges, J.-P Pennec, C Guillet, H Gascan, and M Gioux (2005)
J. Physiol. 565, 827-841
 |  Abstract »  |  Full Text »  |  PDF »

Human Tumorous Imaginal Disc 1 (TID1) Associates with Trk Receptor Tyrosine Kinases and Regulates Neurite Outgrowth in nnr5-TrkA Cells.

H.-Y. Liu, J. I. S. MacDonald, T. Hryciw, C. Li, and S. O. Meakin (2005)
J. Biol. Chem. 280, 19461-19471
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Soluble Cytokine Receptor Generation.

S. J. Levine (2004)
J. Immunol. 173, 5343-5348
 |  Abstract »  |  Full Text »  |  PDF »

Two Different Contact Sites Are Recruited by Cardiotrophin-like Cytokine (CLC) to Generate the CLC/CLF and CLC/sCNTFR{alpha} Composite Cytokines.

D. Perret, C. Guillet, G. Elson, J. Froger, H. Plun-Favreau, F. Rousseau, M. Chabbert, J.-F. Gauchat, and H. Gascan (2004)
J. Biol. Chem. 279, 43961-43970
 |  Abstract »  |  Full Text »  |  PDF »

Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells.

D. M. Buk, M. Waibel, C. Braig, A. S. Martens, P. C. Heinrich, and L. Graeve (2004)
J. Cell Sci. 117, 2063-2075
 |  Abstract »  |  Full Text »  |  PDF »

GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor.

C. Diveu, E. Lelievre, D. Perret, A.-H. L. Lak-Hal, J. Froger, C. Guillet, S. Chevalier, F. Rousseau, A. Wesa, L. Preisser, et al. (2003)
J. Biol. Chem. 278, 49850-49859
 |  Abstract »  |  Full Text »  |  PDF »

Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei.

J.-P. K. Hyatt, R. R. Roy, K. M. Baldwin, and V. R. Edgerton (2003)
Am J Physiol Cell Physiol 285, C1161-C1173
 |  Abstract »  |  Full Text »  |  PDF »

C174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women.

S. M. Roth, E. J. Metter, M. R. Lee, B. F. Hurley, and R. E. Ferrell (2003)
J Appl Physiol 95, 1425-1430
 |  Abstract »  |  Full Text »  |  PDF »

Cloning, Mapping, and Retinal Expression of the Canine Ciliary Neurotrophic Factor Receptor {alpha} (CNTFR{alpha}).

W. A. Beltran, Q. Zhang, J. W. Kijas, D. Gu, H. Rohrer, J. A. Jordan, and G. D. Aguirre (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3642-3649
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor.

H. Plun-Favreau, D. Perret, C. Diveu, J. Froger, S. Chevalier, E. Lelievre, H. Gascan, and M. Chabbert (2003)
J. Biol. Chem. 278, 27169-27179
 |  Abstract »  |  Full Text »  |  PDF »

The Regulation and Activation of Ciliary Neurotrophic Factor Signaling Proteins in Adipocytes.

S. Zvonic, P. Cornelius, W. C. Stewart, R. L. Mynatt, and J. M. Stephens (2003)
J. Biol. Chem. 278, 2228-2235
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Released by Corneal Endothelium Surviving Oxidative Stress Ex Vivo.

S.-W. M. Koh (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2887-2896
 |  Abstract »  |  Full Text »  |  PDF »

Erythropoietin in Human Milk: Physiology and Role in Infant Health.

R. D. Semba and S. E. Juul (2002)
J Hum Lact 18, 252-261
 |  Abstract »  |  PDF »

Ciliary Neurotrophic Factor (CNTF) in Combination with Its Soluble Receptor (CNTFR{alpha}) Increases Connexin43 Expression and Suppresses Growth of C6 Glioma Cells.

M. A. Ozog, J. F. Bechberger, and C. C. G. Naus (2002)
Cancer Res. 62, 3544-3548
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory Effects of Novel Neurotrophin-1/B Cell-Stimulating Factor-3 (Cardiotrophin-Like Cytokine) on B Cell Function.

G. Senaldi, M. Stolina, J. Guo, R. Faggioni, S. McCabe, S. A. Kaufman, G. Van, W. Xu, F. A. Fletcher, T. Boone, et al. (2002)
J. Immunol. 168, 5690-5698
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of Ciliary Neurotrophic Factor (CNTF) and CNTF Receptor {{alpha}} in Rat Kidney with Ischemia-Reperfusion Injury.

C. W. YANG, S. W. LIM, K. W. HAN, H. J. AHN, J. H. PARK, Y. H. KIM, M. KIRSH, J. H. CHA, J. H. PARK, Y. S. KIM, et al. (2001)
J. Am. Soc. Nephrol. 12, 749-757
 |  Abstract »  |  Full Text »  |  PDF »

Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins.

T. Nakashiba, T. Ikeda, S. Nishimura, K. Tashiro, T. Honjo, J. G. Culotti, and S. Itohara (2000)
J. Neurosci. 20, 6540-6550
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor Requires Concurrent p75LNTR Signaling to Induce Apoptosis of Cultured Sympathetic Neurons.

S. I. Savitz and J. A. Kessler (2000)
J. Neurosci. 20, 4198-4205
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle.

B. Fraysse, C. Guillet, C. Huchet-Cadiou, D. C. Camerino, H. Gascan, and C. Leoty (2000)
J Appl Physiol 88, 1623-1630
 |  Abstract »  |  Full Text »  |  PDF »

The gp130 Cytokines Interleukin-11 and Ciliary Neurotropic Factor Regulate through Specific Receptors the Function and Growth of Lactosomatotropic and Folliculostellate Pituitary Cell Lines.

C. P. Castro, A. C. Nagashima, M. P. Pereda, V. Goldberg, A. Chervin, P. Largen, U. Renner, G. K. Stalla, and E. Arzt (2000)
Endocrinology 141, 1746-1753
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response.

C. Olivier, P. Auguste, M. Chabbert, E. Lelievre, S. Chevalier, and H. Gascan (2000)
J. Biol. Chem. 275, 5648-5656
 |  Abstract »  |  Full Text »  |  PDF »

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies.

G. Muller-Newen, A. Kuster, J. Wijdenes, F. Schaper, and P. C. Heinrich (2000)
J. Biol. Chem. 275, 4579-4586
 |  Abstract »  |  Full Text »  |  PDF »

Subcellular Localization of Full-Length and Truncated Trk Receptor Isoforms in Polarized Neurons and Epithelial Cells.

D. Kryl, T. Yacoubian, A. Haapasalo, E. Castren, D. Lo, and P. A. Barker (1999)
J. Neurosci. 19, 5823-5833
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Leukemia Inhibitory Factor (LIF) to Mutants of Its Low Affinity Receptor, gp190, Reveals a LIF Binding Site Outside and Interactions between the Two Cytokine Binding Domains.

J.-L. Taupin, V. Miossec, V. Pitard, F. Blanchard, S. Daburon, S. Raher, Y. Jacques, A. Godard, and J.-F. Moreau (1999)
J. Biol. Chem. 274, 14482-14489
 |  Abstract »  |  Full Text »  |  PDF »

Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.

C. Bjørbæk, J. K. Elmquist, K. El-Haschimi, J. Kelly, R. S. Ahima, S. Hileman, and J. S. Flier (1999)
Endocrinology 140, 2035-2043
 |  Abstract »  |  Full Text »

Receptor Recognition Sites of Cytokines Are Organized as Exchangeable Modules. TRANSFER OF THE LEUKEMIA INHIBITORY FACTOR RECEPTOR-BINDING SITE FROM CILIARY NEUROTROPHIC FACTOR TO INTERLEUKIN-6.

K.-J. Kallen, J. Grotzinger, E. Lelievre, P. Vollmer, D. Aasland, C. Renne, J. Mullberg, K.-H. M. zum Buschenfelde, H. Gascan, and S. Rose-John (1999)
J. Biol. Chem. 274, 11859-11867
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor is a Regulator of Muscular Strength in Aging.

C. Guillet, P. Auguste, W. Mayo, P. Kreher, and H. Gascan (1999)
J. Neurosci. 19, 1257-1262
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophins regulate agrin-induced postsynaptic differentiation.

D. G. Wells, B. A. McKechnie, S. Kelkar, and J. R. Fallon (1999)
PNAS 96, 1112-1117
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes.

I. Kurth, U. Horsten, S. Pflanz, H. Dahmen, A. Kuster, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (1999)
J. Immunol. 162, 1480-1487
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Receptor alpha  in Spinal Motoneurons is Regulated by Gonadal Hormones.

N. G. Forger, C. K. Wagner, M. Contois, L. Bengston, and A. J. MacLennan (1998)
J. Neurosci. 18, 8720-8729
 |  Abstract »  |  Full Text »  |  PDF »

Functional Map of a Placenta-specific Enhancer of the Human Leukemia Inhibitory Factor Receptor Gene.

Z. Wang and S. Melmed (1998)
J. Biol. Chem. 273, 26069-26077
 |  Abstract »  |  Full Text »  |  PDF »

Expression Cloning and Characterization of NSIST, a Novel Sulfotransferase Expressed by a Subset of Neurons and Postsynaptic Targets.

M. A. Nastuk, S. Davis, G. D. Yancopoulos, and J. R. Fallon (1998)
J. Neurosci. 18, 7167-7177
 |  Abstract »  |  Full Text »  |  PDF »

A Bidirectional Regulation between the TR2/TR4 Orphan Receptors (TR2/TR4) and the Ciliary Neurotrophic Factor (CNTF) Signaling Pathway.

W.-J. Young, Y.-F. Lee, S. M. Smith, and C. Chang (1998)
J. Biol. Chem. 273, 20877-20885
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-Like Factor-1, a Novel Soluble Protein, Shares Homology with Members of the Cytokine Type I Receptor Family.

G. C. A. Elson, P. Graber, C. Losberger, S. Herren, D. Gretener, L. N. Menoud, T. N. C. Wells, M. H. Kosco-Vilbois, and J.-F. Gauchat (1998)
J. Immunol. 161, 1371-1379
 |  Abstract »  |  Full Text »  |  PDF »

rMAL Is a Glycosphingolipid-Associated Protein of Myelin and Apical Membranes of Epithelial Cells in Kidney and Stomach.

M. Frank, M. E. van der Haar, N. Schaeren-Wiemers, and M. E. Schwab (1998)
J. Neurosci. 18, 4901-4913
 |  Abstract »  |  Full Text »  |  PDF »

The Neurotrophins and Neuropoietic Cytokines: Two Families of Growth Factors Acting on Neural and Hematopoietic Cells.

N. Y. IP (1998)
Ann. N.Y. Acad. Sci. 840, 97-106
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia Inhibitory Factor Regulates Proopiomelanocortin Transcription.

D. W. RAY, S.-G. REN, and S. MELMED (1998)
Ann. N.Y. Acad. Sci. 840, 162-173
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Effects of Schwann- and Muscle-Derived Factors on Motoneuron Survival Involve GDNF and Cardiotrophin-1 (CT-1).

V. Arce, R. A. Pollock, J.-M. Philippe, D. Pennica, C. E. Henderson, and O. deLapeyriere (1998)
J. Neurosci. 18, 1440-1448
 |  Abstract »  |  Full Text »  |  PDF »

The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling.

M Geissen, S Heller, D Pennica, U Ernsberger, and H Rohrer (1998)
Development 125, 4791-4801
 |  Abstract »  |  PDF »

Identification of an Upstream Enhancer within a Functional Promoter of the Human Leukemia Inhibitory Factor Receptor Gene and Its Alternative Promoter Usage.

Z. Wang and S. Melmed (1997)
J. Biol. Chem. 272, 27957-27965
 |  Abstract »  |  Full Text »  |  PDF »

Agonistic and Antagonistic Variants of Ciliary Neurotrophic Factor (CNTF) Reveal Functional Differences between Membrane-bound and Soluble CNTF alpha -Receptor.

A. Di Marco, I. Gloaguen, A. Demartis, I. Saggio, R. Graziani, G. Paonessa, and R. Laufer (1997)
J. Biol. Chem. 272, 23069-23075
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor.

C. R. Gutman, W. J. Strittmatter, K. H. Weisgraber, and W. D. Matthew (1997)
J. Neurosci. 17, 6114-6121
 |  Abstract »  |  Full Text »  |  PDF »

Signaling of the Cardiotrophin-1 Receptor. EVIDENCE FOR A THIRD RECEPTOR COMPONENT.

O. Robledo, M. Fourcin, S. Chevalier, C. Guillet, P. Auguste, A. Pouplard-Barthelaix, D. Pennica, and H. Gascan (1997)
J. Biol. Chem. 272, 4855-4863
 |  Abstract »  |  Full Text »  |  PDF »

Induction of the Intronic Enhancer of the Human Ciliary Neurotrophic Factor Receptor (CNTFRalpha ) Gene by the TR4 Orphan Receptor. A MEMBER OF STEROID RECEPTOR SUPERFAMILY.

W.-J. Young, S. M. Smith, and C. Chang (1997)
J. Biol. Chem. 272, 3109-3116
 |  Abstract »  |  Full Text »  |  PDF »

Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor alpha and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130.

P. Neddermann, R. Graziani, G. Ciliberto, and G. Paonessa (1996)
J. Biol. Chem. 271, 30986-30991
 |  Abstract »  |  Full Text »  |  PDF »

Alanine Substitution for Thr268 and Asp269 of Soluble Ciliary Neurotrophic Factor (CNTF) Receptor alpha Component Defines a Specific Antagonist for the CNTF Response.

P. Auguste, O. Robledo, C. Olivier, J. Froger, V. Praloran, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 26049-26056
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Erythropoietin (EPO) Receptor by Bivalent Anti-EPO Receptor Antibodies.

S. Elliott, T. Lorenzini, D. Yanagihara, D. Chang, and G. Elliott (1996)
J. Biol. Chem. 271, 24691-24697
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Endothelial Cell Growth by Macrophage-like U-937 Cell-derived Oncostatin M, Leukemia Inhibitory Factor, and Transforming Growth Factor beta 1.

S. Takashima and M. Klagsbrun (1996)
J. Biol. Chem. 271, 24901-24906
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the JAK/STAT Pathway Leads to Proliferation of ST14A Central Nervous System Progenitor Cells.

E. Cattaneo, C. De Fraja, L. Conti, B. Reinach, L. Bolis, S. Govoni, and E. Liboi (1996)
J. Biol. Chem. 271, 23374-23379
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor Induces Down-regulation of Its Receptor and Desensitization of Signal Transduction Pathways in Vivo:. NON-EQUIVALENCE WITH PHARMACOLOGICAL ACTIVITY.

P. S. DiStefano, T. G. Boulton, J. L. Stark, Y. Zhu, K. M. Adryan, T. E. Ryan, and R. M. Lindsay (1996)
J. Biol. Chem. 271, 22839-22846
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-independent Cell Surface Expression of the Human Soluble Granulocyte-Macrophage Colony-stimulating Factor Receptor alpha Subunit Depends on Co-expression of the Membrane-associated Receptor beta Subunit.

E. W. Murray, C. Pihl, A. Morcos, and C. B. Brown (1996)
J. Biol. Chem. 271, 15330-15335
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein.

S. Chevalier, M. Fourcin, O. Robledo, J. Wijdenes, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 14764-14772
 |  Abstract »  |  Full Text »  |  PDF »

gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses.

M. Fourcin, S. Chevalier, C. Guillet, O. Robledo, J. Froger, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 11756-11760
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Receptor Binding Sites of Human Leukemia Inhibitory Factor and Creation of Antagonists.

K. R. Hudson, A. B. Vernallis, and J. K. Heath (1996)
J. Biol. Chem. 271, 11971-11978
 |  Abstract »  |  Full Text »  |  PDF »

Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy.

K. C. Wollert, T. Taga, M. Saito, M. Narazaki, T. Kishimoto, C. C. Glembotski, A. B. Vernallis, J. K. Heath, D. Pennica, W. I. Wood, et al. (1996)
J. Biol. Chem. 271, 9535-9545
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of an Interleukin 6 Cytokine Family Antagonist Protein from a Marine Sponge, Callyspongia sp..

J. V. Peppard, P. Loo, M. A. Sills, D. Munster, S. A. Pomponi, and A. E. Wright (1996)
J. Biol. Chem. 271, 7281-7284
 |  Abstract »  |  Full Text »  |  PDF »

Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor.

D. J. Hilton, S. S. Watowich, L. Katz, and H. F. Lodish (1996)
J. Biol. Chem. 271, 4699-4708
 |  Abstract »  |  Full Text »  |  PDF »

Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells.

U Koshimizu, T Taga, M Watanabe, M Saito, Y Shirayoshi, T Kishimoto, and N Nakatsuji (1996)
Development 122, 1235-1242
 |  Abstract »  |  PDF »

Designer Cytokines: Targeting Actions to Cells of Choice.

A. N. Economides, J. V. Ravetch, G. D. Yancopoulos, and N. Stahl (1995)
Science 270, 1351-1353
 |  Abstract »  |  PDF »

Requirement for the Immunoglobulin-like Domain of Granulocyte Colony-stimulating Factor Receptor in Formation of a 2:1 Receptor-Ligand Complex.

O. Hiraoka, H. Anaguchi, A. Asakura, and Y. Ota (1995)
J. Biol. Chem. 270, 25928-25934
 |  Abstract »  |  Full Text »  |  PDF »

Naturally Occurring Tyrosine Kinase Inserts Block High Affinity Binding of Phospholipase C[IMAGE] and Shc to TrkC and Neurotrophin-3 Signaling.

M. Guiton, F. J. Gunn-Moore, D. J. Glass, D. R. Geis, G. D. Yancopoulos, and J. M. Tavaré (1995)
J. Biol. Chem. 270, 20384-20390
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Functional Receptor Epitopes on the Structure of Ciliary Neurotrophic Factor Indicates a Conserved, Function-related Epitope Topography among Helical Cytokines.

N. Panayotatos, E. Radziejewska, A. Acheson, R. Somogyi, A. Thadani, W. A. Hendrickson, and N. Q. McDonald (1995)
J. Biol. Chem. 270, 14007-14014
 |  Abstract »  |  Full Text »  |  PDF »

Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling.

R Stoop and M. Poo (1995)
Science 267, 695-699
 |  Abstract »  |  PDF »

Analysis of function and expression of the chick GPA receptor (GPAR alpha) suggests multiple roles in neuronal development.

S Heller, T. Finn, J Huber, R Nishi, M Geissen, A. Puschel, and H Rohrer (1995)
Development 121, 2681-2693
 |  Abstract »  |  PDF »

Binding Characteristics of Ciliary Neurotrophic Factor to Sympathetic Neurons and Neuronal Cell Lines.

V. Wong, D. Pearsall, R. Arriaga, N. Y. Ip, N. Stahl, and R. M. Lindsay (1995)
J. Biol. Chem. 270, 313-318
 |  Abstract »  |  Full Text »  |  PDF »

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

S Davis, N. Gale, T. Aldrich, P. Maisonpierre, V Lhotak, T Pawson, M Goldfarb, and G. Yancopoulos (1994)
Science 266, 816-819
 |  Abstract »  |  PDF »

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF.

H Mitsumoto, K Ikeda, B Klinkosz, J. Cedarbaum, V Wong, and R. Lindsay (1994)
Science 265, 1107-1110
 |  Abstract »  |  PDF »

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

N Stahl, T. Boulton, T Farruggella, N. Ip, S Davis, B. Witthuhn, F. Quelle, O Silvennoinen, G Barbieri, S Pellegrini, et al. (1994)
Science 263, 92-95
 |  Abstract »  |  PDF »

Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.

A Bonni, D. Frank, C Schindler, and M. Greenberg (1993)
Science 262, 1575-1579
 |  Abstract »  |  PDF »

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.

S Davis, T. Aldrich, N Stahl, L Pan, T Taga, T Kishimoto, N. Ip, and G. Yancopoulos (1993)
Science 260, 1805-1808
 |  Abstract »  |  PDF »

Identification of the von Hippel-Lindau disease tumor suppressor gene.

F Latif, K Tory, J Gnarra, M Yao, F. Duh, M. Orcutt, T Stackhouse, I Kuzmin, W Modi, L Geil, et al. (1993)
Science 260, 1317-1320
 |  Abstract »  |  PDF »

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses.

S Davis, T. Aldrich, N. Ip, N Stahl, S Scherer, T Farruggella, P. DiStefano, R Curtis, N Panayotatos, H Gascan, et al. (1993)
Science 259, 1736-1739
 |  Abstract »  |  PDF »

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.

J. Conover, N. Ip, W. Poueymirou, B Bates, M. Goldfarb, T. DeChiara, and G. Yancopoulos (1993)
Development 119, 559-565
 |  Abstract »  |  PDF »

Interleukin-6 and its receptor: a paradigm for cytokines.

T Kishimoto, S Akira, and T Taga (1992)
Science 258, 593-597
 |  Abstract »  |  PDF »

Three-Dimensional Solution Structure of Human Interleukin-4 by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy.

R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn, and G. M. Clore (1992)
Science 256, 1673-1677
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The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor.

D. Gearing, M. Comeau, D. Friend, S. Gimpel, C. Thut, J McGourty, K. Brasher, J. King, S Gillis, B Mosley, et al. (1992)
Science 255, 1434-1437
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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.

A. de Vos, M Ultsch, and A. Kossiakoff (1992)
Science 255, 306-312
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The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth.

Y Sumi, M. Dent, D. Owen, P. Seeley, and R. Morris (1992)
Development 116, 625-637
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Interleukin-11 Signals through the Formation of a Hexameric Receptor Complex.

V. A. Barton, M. A. Hall, K. R. Hudson, and J. K. Heath (2000)
J. Biol. Chem. 275, 36197-36203
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Signaling Pathways Recruited by the Cardiotrophin-like Cytokine/Cytokine-like Factor-1 Composite Cytokine. SPECIFIC REQUIREMENT OF THE MEMBRANE-BOUND FORM OF CILIARY NEUROTROPHIC FACTOR RECEPTOR alpha COMPONENT.

E. Lelievre, H. Plun-Favreau, S. Chevalier, J. Froger, C. Guillet, G. C. A. Elson, J.-F. Gauchat, and H. Gascan (2001)
J. Biol. Chem. 276, 22476-22484
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From the Cover: Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.

P. D. Lambert, K. D. Anderson, M. W. Sleeman, V. Wong, J. Tan, A. Hijarunguru, T. L. Corcoran, J. D. Murray, K. E. Thabet, G. D. Yancopoulos, et al. (2001)
PNAS 98, 4652-4657
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