Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 July 1991:
Vol. 253. no. 5015, pp. 49 - 53
DOI: 10.1126/science.1905840
Prev | Table of Contents | Next

Articles

Science, Vol 253, Issue 5015, 49-53
Copyright © 1991 by American Association for the Advancement of Science

articles

p53 mutations in human cancers

M Hollstein, D Sidransky, B Vogelstein, and CC Harris

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues. Analysis of these mutations can provide clues to the etiology of these diverse tumors and to the function of specific regions of p53. Transitions predominate in colon, brain, and lymphoid malignancies, whereas G:C to T:A transversions are the most frequent substitutions observed in cancers of the lung and liver. Mutations at A:T base pairs are seen more frequently in esophageal carcinomas than in other solid tumors. Most transitions in colorectal carcinomas, brain tumors, leukemias, and lymphomas are at CpG dinucleotide mutational hot spots. G to T transversions in lung, breast, and esophageal carcinomas are dispersed among numerous codons. In liver tumors in persons from geographic areas in which both aflatoxin B1 and hepatitis B virus are cancer risk factors, most mutations are at one nucleotide pair of codon 249. These differences may reflect the etiological contributions of both exogenous and endogenous factors to human carcinogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Cytomegalovirus IE1-72 Protein Interacts with p53 and Inhibits p53-Dependent Transactivation by a Mechanism Different from That of IE2-86 Protein.
E.-S. Hwang, Z. Zhang, H. Cai, D. Y. Huang, S.-M. Huong, C.-Y. Cha, and E.-S. Huang (2009)
J. Virol. 83, 12388-12398
   Abstract »    Full Text »    PDF »
In vitro and Clinical Studies of Gene Therapy with Recombinant Human Adenovirus-p53 Injection for Oral Leukoplakia.
Y. Li, L.-J. Li, S.-T. Zhang, L.-J. Wang, Z. Zhang, N. Gao, Y.-Y. Zhang, and Q.-M. Chen (2009)
Clin. Cancer Res. 15, 6724-6731
   Abstract »    Full Text »    PDF »
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair.
E. Bolderson, D. J. Richard, B.-B. S. Zhou, and K. K. Khanna (2009)
Clin. Cancer Res. 15, 6314-6320
   Abstract »    Full Text »    PDF »
Cancer-Selective Targeting and Cytotoxicity by Liposomal-Coupled Lysosomal Saposin C Protein.
X. Qi, Z. Chu, Y. Y. Mahller, K. F. Stringer, D. P. Witte, and T. P. Cripe (2009)
Clin. Cancer Res. 15, 5840-5851
   Abstract »    Full Text »    PDF »
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response.
H. Nishida, N. Tatewaki, Y. Nakajima, T. Magara, K. M. Ko, Y. Hamamori, and T. Konishi (2009)
Nucleic Acids Res. 37, 5678-5689
   Abstract »    Full Text »    PDF »
Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin.
J. Zhang, Y.-H. Song, B. W. Brannigan, D. C.R. Wahrer, T. A. Schiripo, P. L. Harris, S. M. Haserlat, L. E. Ulkus, K. M. Shannon, J. E. Garber, et al. (2009)
Mol. Cancer Res. 7, 1510-1516
   Abstract »    Full Text »    PDF »
Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1.
L. I. Huschtscha, J. D. Moore, J. R. Noble, H. G. Campbell, J. A. Royds, A. W. Braithwaite, and R. R. Reddel (2009)
J. Cell Sci. 122, 2989-2995
   Abstract »    Full Text »    PDF »
p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.
S. P. Tu, A. L. Chi, W. Ai, S. Takaishi, Z. Dubeykovskaya, M. Quante, J. G. Fox, and T. C. Wang (2009)
Am J Physiol Gastrointest Liver Physiol 297, G385-G396
   Abstract »    Full Text »    PDF »
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
M. Seike, A. Goto, T. Okano, E. D. Bowman, A. J. Schetter, I. Horikawa, E. A. Mathe, J. Jen, P. Yang, H. Sugimura, et al. (2009)
PNAS 106, 12085-12090
   Abstract »    Full Text »    PDF »
Activating Transcription Factor 2 and c-Jun-Mediated Induction of FoxP3 for Experimental Therapy of Mammary Tumor in the Mouse.
Y. Liu, Y. Wang, W. Li, P. Zheng, and Y. Liu (2009)
Cancer Res. 69, 5954-5960
   Abstract »    Full Text »    PDF »
Restoration of p53 Pathway by Nutlin-3 Induces Cell Cycle Arrest and Apoptosis in Human Rhabdomyosarcoma Cells.
M. Miyachi, N. Kakazu, S. Yagyu, Y. Katsumi, S. Tsubai-Shimizu, K. Kikuchi, K. Tsuchiya, T. Iehara, and H. Hosoi (2009)
Clin. Cancer Res. 15, 4077-4084
   Abstract »    Full Text »    PDF »
p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon.
U. K. Mukhopadhyay, R. Eves, L. Jia, P. Mooney, and A. S. Mak (2009)
Mol. Cell. Biol. 29, 3088-3098
   Abstract »    Full Text »    PDF »
A Single Recombinant Adenovirus Expressing p53 and p21-targeting Artificial microRNAs Efficiently Induces Apoptosis in Human Cancer Cells.
M. Idogawa, Y. Sasaki, H. Suzuki, H. Mita, K. Imai, Y. Shinomura, and T. Tokino (2009)
Clin. Cancer Res. 15, 3725-3732
   Abstract »    Full Text »    PDF »
Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.
I. R. Logan, H. V. McNeill, S. Cook, X. Lu, D. W. Meek, F. V. Fuller-Pace, J. Lunec, and C. N. Robson (2009)
Nucleic Acids Res. 37, 2962-2973
   Abstract »    Full Text »    PDF »
Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1.
H. Hu, J. Zhang, H. J. Lee, S.-H. Kim, and J. Lu (2009)
Carcinogenesis 30, 818-823
   Abstract »    Full Text »    PDF »
Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation.
S. Nemoto, M. Nakamura, Y. Osawa, S. Kono, Y. Itoh, Y. Okano, T. Murate, A. Hara, H. Ueda, Y. Nozawa, et al. (2009)
J. Biol. Chem. 284, 10422-10432
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Estrogen Receptor-{alpha} by p53 in Human Breast Cancer Cells.
S. H. Shirley, J. E. Rundhaug, J. Tian, N. Cullinan-Ammann, I. Lambertz, C. J. Conti, and R. Fuchs-Young (2009)
Cancer Res. 69, 3405-3414
   Abstract »    Full Text »    PDF »
Differential Diagnosis of Pulmonary Carcinoma Following Head and Neck Cancer by Genetic Analysis.
T.W. Geurts, M.L.F van Velthuysen, F. Broekman, T. Hooft van Huysduynen, M.W.M. van den Brekel, N. van Zandwijk, H. van Tinteren, P. Nederlof, A.J.M. Balm, and R.H. Brakenhoff (2009)
Clin. Cancer Res. 15, 980-985
   Abstract »    Full Text »    PDF »
Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer.
F. M. Speetjens, P. J.K. Kuppen, M. J.P. Welters, F. Essahsah, A. M. E.G. Voet van den Brink, M. G. K. Lantrua, A. R. P.M. Valentijn, J. Oostendorp, L. M. Fathers, H. W. Nijman, et al. (2009)
Clin. Cancer Res. 15, 1086-1095
   Abstract »    Full Text »    PDF »
High Frequency of TP53 Mutation in BRCA1 and Sporadic Basal-like Carcinomas but not in BRCA1 Luminal Breast Tumors.
E. Manie, A. Vincent-Salomon, J. Lehmann-Che, G. Pierron, E. Turpin, M. Warcoin, N. Gruel, I. Lebigot, X. Sastre-Garau, R. Lidereau, et al. (2009)
Cancer Res. 69, 663-671
   Abstract »    Full Text »    PDF »
p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts.
E. B. Dinca, K. V. Lu, J. N. Sarkaria, R. O. Pieper, M. D. Prados, D. A. Haas-Kogan, S. R. VandenBerg, M. S. Berger, and C. D. James (2008)
Cancer Res. 68, 10034-10039
   Abstract »    Full Text »    PDF »
Genetic and Epigenetic Alterations of Familial Pancreatic Cancers.
K. Brune, S.-M. Hong, A. Li, S. Yachida, T. Abe, M. Griffith, D. Yang, N. Omura, J. Eshleman, M. Canto, et al. (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 3536-3542
   Abstract »    Full Text »    PDF »
Mining the Epigenome for Methylated Genes in Lung Cancer.
M. Tessema and S. A. Belinsky (2008)
Proceedings of the ATS 5, 806-810
   Abstract »    Full Text »    PDF »
Preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours.
M. J. E. M. Gosens, R. C. Dresen, H. J. T. Rutten, G. A. P. Nieuwenhuijzen, J. A. W. M. van der Laak, H. Martijn, I. Tan-Go, I. D. Nagtegaal, A. J. C. van den Brule, and J. H. J. M. van Krieken (2008)
Ann. Onc. 19, 2026-2032
   Abstract »    Full Text »    PDF »
Cell Proliferation, Cell Cycle Abnormalities, and Cancer Outcome in Patients with Barrett's Esophagus: A Long-term Prospective Study.
D. L. Chao, C. A. Sanchez, P. C. Galipeau, P. L. Blount, T. G. Paulson, D. S. Cowan, K. Ayub, R. D. Odze, P. S. Rabinovitch, and B. J. Reid (2008)
Clin. Cancer Res. 14, 6988-6995
   Abstract »    Full Text »    PDF »
P53 mutations in lymphomas: position matters.
A. J. Levine and E. Vosburgh (2008)
Blood 112, 2997-2998
   Full Text »    PDF »
Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.
K. H. Young, K. Leroy, M. B. Moller, G. W. B. Colleoni, M. Sanchez-Beato, F. R. Kerbauy, C. Haioun, J. C. Eickhoff, A. H. Young, P. Gaulard, et al. (2008)
Blood 112, 3088-3098
   Abstract »    Full Text »    PDF »
Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots.
E. Liapis, K. I.E. McLuckie, P. D. Lewis, P. B. Farmer, and K. Brown (2008)
Nucleic Acids Res. 36, 5933-5945
   Abstract »    Full Text »    PDF »
Phase I Study of Adenovirus p53 Administered by Bronchoalveolar Lavage in Patients With Bronchioloalveolar Cell Lung Carcinoma: ECOG 6597.
V. Keedy, W. Wang, J. Schiller, S. Chada, B. Slovis, K. Coffee, J. Worrell, L. A. Thet, D. H. Johnson, and D. P. Carbone (2008)
J. Clin. Oncol. 26, 4166-4171
   Abstract »    Full Text »    PDF »
Advances in Chemical Carcinogenesis: A Historical Review and Prospective.
L. A. Loeb and C. C. Harris (2008)
Cancer Res. 68, 6863-6872
   Full Text »    PDF »
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
C. Slape, L. Y. Liu, S. Beachy, and P. D. Aplan (2008)
Blood 112, 2017-2019
   Abstract »    Full Text »    PDF »
ID1, Inhibitor of Differentiation/DNA Binding, Is an Effector of the p53-dependent DNA Damage Response Pathway.
Y. Qian and X. Chen (2008)
J. Biol. Chem. 283, 22410-22416
   Abstract »    Full Text »    PDF »
Checkpoint Kinase 1 Down-Regulation by an Inducible Small Interfering RNA Expression System Sensitized In vivo Tumors to Treatment with 5-Fluorouracil.
M. Ganzinelli, L. Carrassa, F. Crippa, M. Tavecchio, M. Broggini, and G. Damia (2008)
Clin. Cancer Res. 14, 5131-5141
   Abstract »    Full Text »    PDF »
Oligomerization of BAK by p53 Utilizes Conserved Residues of the p53 DNA Binding Domain.
E. C. Pietsch, E. Perchiniak, A. A. Canutescu, G. Wang, R. L. Dunbrack, and M. E. Murphy (2008)
J. Biol. Chem. 283, 21294-21304
   Abstract »    Full Text »    PDF »
Gain of Oncogenic Function of p53 Mutants Induces Invasive Phenotypes in Human Breast Cancer Cells by Silencing CCN5/WISP-2.
G. Dhar, S. Banerjee, K. Dhar, O. Tawfik, M. S. Mayo, P. J. VanVeldhuizen, and S. K. Banerjee (2008)
Cancer Res. 68, 4580-4587
   Abstract »    Full Text »    PDF »
Local Recurrence in Mismatch Repair-Proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-Infiltrating Lymphocytes.
I. Zlobec, L. M. Terracciano, and A. Lugli (2008)
Clin. Cancer Res. 14, 3792-3797
   Abstract »    Full Text »    PDF »
Mitotane increases the radiotherapy inhibitory effect and induces G2-arrest in combined treatment on both H295R and SW13 adrenocortical cell lines.
L Cerquetti, B Bucci, R Marchese, S Misiti, U De Paula, R Miceli, A Muleti, D Amendola, P Piergrossi, E Brunetti, et al. (2008)
Endocr. Relat. Cancer 15, 623-634
   Abstract »    Full Text »    PDF »
Characterization of genome-wide p53-binding sites upon stress response.
L. Smeenk, S. J. van Heeringen, M. Koeppel, M. A. van Driel, S. J. J. Bartels, R. C. Akkers, S. Denissov, H. G. Stunnenberg, and M. Lohrum (2008)
Nucleic Acids Res. 36, 3639-3654
   Abstract »    Full Text »    PDF »
Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells.
N. Zhu, L. Gu, F. Li, and M. Zhou (2008)
Mol. Cancer Ther. 7, 1101-1109
   Abstract »    Full Text »    PDF »
Molecular Markers and the Pathogenesis of Adrenocortical Cancer.
P. S. H. Soon, K. L. McDonald, B. G. Robinson, and S. B. Sidhu (2008)
Oncologist 13, 548-561
   Abstract »    Full Text »    PDF »
Synthetic Lethality by Lentiviral Short Hairpin RNA Silencing of Thymidylate Kinase and Doxorubicin in Colon Cancer Cells Regardless of the p53 Status.
C.-M. Hu and Z.-F. Chang (2008)
Cancer Res. 68, 2831-2840
   Abstract »    Full Text »    PDF »
Quantitative Proteomics Analysis of the Effects of Ionizing Radiation in Wild Type and p53K317R Knock-in Mouse Thymocytes.
L. M. Miller Jenkins, S. J. Mazur, M. Rossi, O. Gaidarenko, Y. Xu, and E. Appella (2008)
Mol. Cell. Proteomics 7, 716-727
   Abstract »    Full Text »    PDF »
Modulation of drug resistance by artificial transcription factors.
P. Blancafort, M. P. Tschan, S. Bergquist, D. Guthy, A. Brachat, D. A. Sheeter, B. E. Torbett, D. Erdmann, and C. F. Barbas III (2008)
Mol. Cancer Ther. 7, 688-697
   Abstract »    Full Text »    PDF »
Self-Tolerance Does Not Restrict the CD4+ T-Helper Response against the p53 Tumor Antigen.
M. M. Lauwen, S. Zwaveling, L. de Quartel, S. C. Ferreira Mota, J. A.C. Grashorn, C. J.M. Melief, S. H. van der Burg, and R. Offringa (2008)
Cancer Res. 68, 893-900
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus K-Cyclin Interacts with Cdk9 and Stimulates Cdk9-Mediated Phosphorylation of p53 Tumor Suppressor.
P.-C. Chang and M. Li (2008)
J. Virol. 82, 278-290
   Abstract »    Full Text »    PDF »
Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases.
A. Patocs, L. Zhang, Y. Xu, F. Weber, T. Caldes, G. L. Mutter, P. Platzer, and C. Eng (2007)
N. Engl. J. Med. 357, 2543-2551
   Abstract »    Full Text »    PDF »
Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma.
K. H. Young, D. D. Weisenburger, B. J. Dave, L. Smith, W. Sanger, J. Iqbal, E. Campo, J. Delabie, R. D. Gascoyne, G. Ott, et al. (2007)
Blood 110, 4396-4405
   Abstract »    Full Text »    PDF »
p53 Gene and Protein Status: The Role of p53 Alterations in Predicting Outcome in Patients With Bladder Cancer.
B. George, R. H. Datar, L. Wu, J. Cai, N. Patten, S. J. Beil, S. Groshen, J. Stein, D. Skinner, P. A. Jones, et al. (2007)
J. Clin. Oncol. 25, 5352-5358
   Abstract »    Full Text »    PDF »
Ubiquitination and Degradation of Mutant p53.
N. Lukashchuk and K. H. Vousden (2007)
Mol. Cell. Biol. 27, 8284-8295
   Abstract »    Full Text »    PDF »
The Guardian's Little Helper: MicroRNAs in the p53 Tumor Suppressor Network.
X. He, L. He, and G. J. Hannon (2007)
Cancer Res. 67, 11099-11101
   Abstract »    Full Text »    PDF »
Prognostic Significance of p53 and X-ray Repair Cross-complementing Group 1 Polymorphisms on Prostate-Specific Antigen Recurrence in Prostate Cancer Post Radical Prostatectomy.
S.-P. Huang, C.-Y. Huang, J.-S. Wang, C.-C. Liu, Y.-S. Pu, H.-J. Yu, C.-C. Yu, T. T. Wu, C.-H. Huang, W.-J. Wu, et al. (2007)
Clin. Cancer Res. 13, 6632-6638
   Abstract »    Full Text »    PDF »
Apoptotic Actions of p53 Require Transcriptional Activation of PUMA and Do Not Involve a Direct Mitochondrial/Cytoplasmic Site of Action in Postnatal Cortical Neurons.
T. Uo, Y. Kinoshita, and R. S. Morrison (2007)
J. Neurosci. 27, 12198-12210
   Abstract »    Full Text »    PDF »
Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
V. M. Arlt, M. Stiborova, J. vom Brocke, M. L. Simoes, G. M. Lord, J. L. Nortier, M. Hollstein, D. H. Phillips, and H. H. Schmeiser (2007)
Carcinogenesis 28, 2253-2261
   Abstract »    Full Text »    PDF »
Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium.
W.-C. L. Chang, R. A. Coudry, M. L. Clapper, X. Zhang, K.-L. Williams, C. S. Spittle, T. Li, and H. S. Cooper (2007)
Carcinogenesis 28, 2375-2381
   Abstract »    Full Text »    PDF »
Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.
K. Iida, K. Itoh, J. M. Maher, Y. Kumagai, R. Oyasu, Y. Mori, T. Shimazui, H. Akaza, and M. Yamamoto (2007)
Carcinogenesis 28, 2398-2403
   Abstract »    Full Text »    PDF »
TAp73 Is a Downstream Target of p53 in Controlling the Cellular Defense against Stress.
J. Wang, Y.-X. Liu, M. P. Hande, A. C. Wong, Y. J. Jin, and Y. Yin (2007)
J. Biol. Chem. 282, 29152-29162
   Abstract »    Full Text »    PDF »
Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage.
G. S. Ivanov, T. Ivanova, J. Kurash, A. Ivanov, S. Chuikov, F. Gizatullin, E. M. Herrera-Medina, F. Rauscher III, D. Reinberg, and N. A. Barlev (2007)
Mol. Cell. Biol. 27, 6756-6769
   Abstract »    Full Text »    PDF »
Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.
M.G. Luciani, C. Campregher, and C. Gasche (2007)
Carcinogenesis 28, 2207-2217
   Abstract »    Full Text »    PDF »
Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.
S. Rubio, J. Quintana, J. L. Eiroa, J. Triana, and F. Estevez (2007)
Carcinogenesis 28, 2105-2113
   Abstract »    Full Text »    PDF »
Cell Cycle Disturbances and Mitotic Catastrophes in HeLa Hep2 Cells following 2.5 to 10 Gy of Ionizing Radiation.
D. Eriksson, P.-O. Lofroth, L. Johansson, K. A. Riklund, and T. Stigbrand (2007)
Clin. Cancer Res. 13, 5501s-5508s
   Abstract »    Full Text »    PDF »
Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.
K. Chen, Z. Hu, L.-E Wang, E. M. Sturgis, A. K. El-Naggar, W. Zhang, and Q. Wei (2007)
Carcinogenesis 28, 2008-2012
   Abstract »    Full Text »    PDF »
Polymorphic TP53BP1 and TP53 Gene Interactions Associated with Risk of Squamous Cell Carcinoma of the Head and Neck.
K. Chen, Z. Hu, L.-E Wang, W. Zhang, A. K. El-Naggar, E. M. Sturgis, and Q. Wei (2007)
Clin. Cancer Res. 13, 4300-4305
   Abstract »    Full Text »    PDF »
Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.
S. A. Danziger, J. Zeng, Y. Wang, R. K. Brachmann, and R. H. Lathrop (2007)
Bioinformatics 23, i104-i114
   Abstract »    Full Text »    PDF »
Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis.
A. Kurihara, H. Nagoshi, M. Yabuki, R. Okuyama, M. Obinata, and S. Ikawa (2007)
Genes Cells 12, 853-861
   Abstract »    Full Text »    PDF »
Inhibition of p53-Murine Double Minute 2 Interaction by Nutlin-3A Stabilizes p53 and Induces Cell Cycle Arrest and Apoptosis in Hodgkin Lymphoma.
E. Drakos, A. Thomaides, L. J. Medeiros, J. Li, V. Leventaki, M. Konopleva, M. Andreeff, and G. Z. Rassidakis (2007)
Clin. Cancer Res. 13, 3380-3387
   Abstract »    Full Text »    PDF »
Dominant-Negative but not Gain-of-Function Effects of a p53.R270H Mutation in Mouse Epithelium Tissue after DNA Damage.
S. W.P. Wijnhoven, E. N. Speksnijder, X. Liu, E. Zwart, C. Th. M. vanOostrom, R. B. Beems, E. M. Hoogervorst, M. M. Schaap, L. D. Attardi, T. Jacks, et al. (2007)
Cancer Res. 67, 4648-4656
   Abstract »    Full Text »    PDF »
MDM2 Binding Induces a Conformational Change in p53 That Is Opposed by Heat-shock Protein 90 and Precedes p53 Proteasomal Degradation.
M. Sasaki, L. Nie, and C. G. Maki (2007)
J. Biol. Chem. 282, 14626-14634
   Abstract »    Full Text »    PDF »
Regulation of p53 Nuclear Export through Sequential Changes in Conformation and Ubiquitination.
L. Nie, M. Sasaki, and C. G. Maki (2007)
J. Biol. Chem. 282, 14616-14625
   Abstract »    Full Text »    PDF »
Translating at Work: Genetically Modified Mouse Models and Molecularization in the Environmental Health Sciences.
S. Shostak (2007)
Science Technology Human Values 32, 315-338
   Abstract »    PDF »
Mitogen-Activated Protein Kinase Kinase Inhibition Enhances Nuclear Proapoptotic Function of p53 in Acute Myelogenous Leukemia Cells.
K. Kojima, M. Konopleva, I. J. Samudio, V. Ruvolo, and M. Andreeff (2007)
Cancer Res. 67, 3210-3219
   Abstract »    Full Text »    PDF »
Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
Y. Tambe, A. Yoshioka-Yamashita, K.-i. Mukaisho, S. Haraguchi, T. Chano, T. Isono, T. Kawai, Y. Suzuki, R. Kushima, T. Hattori, et al. (2007)
Carcinogenesis 28, 777-784
   Abstract »    Full Text »    PDF »
Oxidative stress induces p53-dependent apoptosis in hepatoblastoma cell through its nuclear translocation.
H. Yamamoto, T. Ozaki, M. Nakanishi, H. Kikuchi, K. Yoshida, H. Horie, H. Kuwano, and A. Nakagawara (2007)
Genes Cells 12, 461-471
   Abstract »    Full Text »    PDF »
Cancer of Unknown Primary Site: Missing Primary or Missing Biology?.
G. Pentheroudakis, E. Briasoulis, and N. Pavlidis (2007)
Oncologist 12, 418-425
   Abstract »    Full Text »    PDF »
An Essential Role of Human Ada3 in p53 Acetylation.
A. Nag, A. Germaniuk-Kurowska, M. Dimri, M. A. Sassack, C. B. Gurumurthy, Q. Gao, G. Dimri, H. Band, and V. Band (2007)
J. Biol. Chem. 282, 8812-8820
   Abstract »    Full Text »    PDF »
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
C. M. Khoo, D. R. Carrasco, M. W. Bosenberg, J.-H. Paik, and R. A. DePinho (2007)
PNAS 104, 3931-3936
   Abstract »    Full Text »    PDF »
Sperm-Associated Antigen 9, a Novel Cancer Testis Antigen, Is a Potential Target for Immunotherapy in Epithelial Ovarian Cancer.
M. Garg, D. Chaurasiya, R. Rana, N. Jagadish, D. Kanojia, N. Dudha, N. Kamran, S. Salhan, A. Bhatnagar, S. Suri, et al. (2007)
Clin. Cancer Res. 13, 1421-1428
   Abstract »    Full Text »    PDF »
In vitro analysis of DNA-protein interactions by proximity ligation.
S. M. Gustafsdottir, J. Schlingemann, A. Rada-Iglesias, E. Schallmeiner, M. Kamali-Moghaddam, C. Wadelius, and U. Landegren (2007)
PNAS 104, 3067-3072
   Abstract »    Full Text »    PDF »
Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors.
L. E. Mechanic, E. D. Bowman, J. A. Welsh, M. A. Khan, N. Hagiwara, L. Enewold, P. G. Shields, L. Burdette, S. Chanock, and C. C. Harris (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 214-222
   Abstract »    Full Text »    PDF »
p53 Enhances Gefitinib-Induced Growth Inhibition and Apoptosis by Regulation of Fas in Non-Small Cell Lung Cancer.
J. K. Rho, Y. J. Choi, B.-Y. Ryoo, I. I. Na, S. H. Yang, C. H. Kim, and J. C. Lee (2007)
Cancer Res. 67, 1163-1169
   Abstract »    Full Text »    PDF »
Sensitizing Effect of Galectin-7 in Urothelial Cancer to Cisplatin through the Accumulation of Intracellular Reactive Oxygen Species.
Y. Matsui, S. Ueda, J. Watanabe, I. Kuwabara, O. Ogawa, and H. Nishiyama (2007)
Cancer Res. 67, 1212-1220
   Abstract »    Full Text »    PDF »
Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers.
L. R. Dearth, H. Qian, T. Wang, T. E. Baroni, J. Zeng, S. W. Chen, S. Y. Yi, and R. K. Brachmann (2007)
Carcinogenesis 28, 289-298
   Abstract »    Full Text »    PDF »
Protoporphyrin IX Interacts with Wild-type p53 Protein in Vitro and Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent Manner.
J. Zawacka-Pankau, N. Issaeva, S. Hossain, A. Pramanik, G. Selivanova, and A. J. Podhajska (2007)
J. Biol. Chem. 282, 2466-2472
   Abstract »    Full Text »    PDF »
Dissecting the Senescence-like Program in Tumor Cells Activated by Ras Signaling.
T. Bihani, A. Chicas, C. P.-K. Lo, and A. W. Lin (2007)
J. Biol. Chem. 282, 2666-2675
   Abstract »    Full Text »    PDF »
Abrogation of the Transactivation Activity of p53 by BCCIP Down-regulation.
X. Meng, J. Yue, Z. Liu, and Z. Shen (2007)
J. Biol. Chem. 282, 1570-1576
   Abstract »    Full Text »    PDF »
Synergistic Tumor Suppression by Coexpression of FUS1 and p53 Is Associated with Down-regulation of Murine Double Minute-2 and Activation of the Apoptotic Protease-Activating Factor 1-Dependent Apoptotic Pathway in Human Non-Small Cell Lung Cancer Cells.
W.-G. Deng, H. Kawashima, G. Wu, G. Jayachandran, K. Xu, J. D. Minna, J. A. Roth, and L. Ji (2007)
Cancer Res. 67, 709-717
   Abstract »    Full Text »    PDF »
A Novel Application for Murine Double Minute 2 Antagonists: The p53 Tumor Suppressor Network Also Controls Angiogenesis.
B. R. Binder (2007)
Circ. Res. 100, 13-14
   Full Text »    PDF »
Is there a role for PCR-SSCP among the methods for missense mutation detection of TP53 gene?.
J Peltonen, J A Welsh, and K H Vahakangas (2007)
Human and Experimental Toxicology 26, 9-18
   Abstract »    PDF »
Development of a novel site-specific mutagenesis assay using MALDI-ToF MS (SSMA-MS).
K. I. E. McLuckie, J. H. Lamb, J. K. Sandhu, H. L. Pearson, K. Brown, P. B. Farmer, and D. J. L. Jones (2006)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression..
J. P. Hamilton, F. Sato, Z. Jin, B. D. Greenwald, T. Ito, Y. Mori, B. C. Paun, T. Kan, Y. Cheng, S. Wang, et al. (2006)
Clin. Cancer Res. 12, 6637-6642
   Abstract »    Full Text »    PDF »
BM88 Is a Dual Function Molecule Inducing Cell Cycle Exit and Neuronal Differentiation of Neuroblastoma Cells via Cyclin D1 Down-regulation and Retinoblastoma Protein Hypophosphorylation.
N. Georgopoulou, C. Hurel, P. K. Politis, M. Gaitanou, R. Matsas, and D. Thomaidou (2006)
J. Biol. Chem. 281, 33606-33620
   Abstract »    Full Text »    PDF »
Retinoblastoma Pathway Defects Show Differential Ability to Activate the Constitutive DNA Damage Response in Human Tumorigenesis.
F. Tort, J. Bartkova, M. Sehested, T. Orntoft, J. Lukas, and J. Bartek (2006)
Cancer Res. 66, 10258-10263
   Abstract »    Full Text »    PDF »
Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines..
A. I. Robles, M. H. Wright, B. Gandhi, S. S. Feis, C. L. Hanigan, A. Wiestner, and L. Varticovski (2006)
Clin. Cancer Res. 12, 6547-6556
   Abstract »    Full Text »    PDF »
The Consensus Coding Sequences of Human Breast and Colorectal Cancers.
T. Sjoblom, S. Jones, L. D. Wood, D. W. Parsons, J. Lin, T. D. Barber, D. Mandelker, R. J. Leary, J. Ptak, N. Silliman, et al. (2006)
Science 314, 268-274
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)