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Science 28 June 1991: Vol. 252. no. 5014, pp. 1857 - 1860 DOI: 10.1126/science.1843843
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Articles
Science, Vol 252, Issue 5014, 1857-1860
Copyright © 1991 by American Association for the Advancement of Science
Massive cortical reorganization after sensory deafferentation in adult macaques
TP Pons,
PE Garraghty,
AK Ommaya,
JH Kaas,
E Taub,
and
M Mishkin
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892.
After limited sensory deafferentations in adult primates, somatosensory cortical maps reorganize over a distance of 1 to 2 millimeters mediolaterally, that is, in the dimension along which different body parts are represented. This amount of reorganization was considered to be an upper limit imposed by the size of the projection zones of individual thalamocortical axons, which typically also extend a mediolateral distance of 1 to 2 millimeters. However, after extensive long-term deafferentations in adult primates, changes in cortical maps were found to be an order of magnitude greater than those previously described. These results show the need for a reevaluation of both the upper limit of cortical reorganization in adult primates and the mechanisms responsible for it.
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