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Science 28 June 1991:
Vol. 252. no. 5014, pp. 1857 - 1860
DOI: 10.1126/science.1843843
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Articles

Science, Vol 252, Issue 5014, 1857-1860
Copyright © 1991 by American Association for the Advancement of Science

articles

Massive cortical reorganization after sensory deafferentation in adult macaques

TP Pons, PE Garraghty, AK Ommaya, JH Kaas, E Taub, and M Mishkin

Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892.

After limited sensory deafferentations in adult primates, somatosensory cortical maps reorganize over a distance of 1 to 2 millimeters mediolaterally, that is, in the dimension along which different body parts are represented. This amount of reorganization was considered to be an upper limit imposed by the size of the projection zones of individual thalamocortical axons, which typically also extend a mediolateral distance of 1 to 2 millimeters. However, after extensive long-term deafferentations in adult primates, changes in cortical maps were found to be an order of magnitude greater than those previously described. These results show the need for a reevaluation of both the upper limit of cortical reorganization in adult primates and the mechanisms responsible for it.


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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   PDF »
Response.
T. P. Pons (1994)
Science 265, 548
   PDF »
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A Pascual-Leone, J Grafman, and M Hallett (1994)
Science 263, 1287-1289
   Abstract »    PDF »
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E Zohary, S Celebrini, K. Britten, and W. Newsome (1994)
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   Abstract »    PDF »
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D. C. Good (1994)
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   Abstract »    PDF »
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V. Ramachandran, D Rogers-Ramachandran, and M Stewart (1992)
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R Desimone (1992)
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   PDF »
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M. W. Mahowald, C. H. Schenck, G. M. Rosen, and T. D. Hurwitz (1992)
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   Abstract »    PDF »
Famous monkeys provide surprising results.
J Palca (1991)
Science 252, 1789
   PDF »
Growth of new brainstem connections in adult monkeys with massive sensory loss.
N. Jain, S. L. Florence, H.-X. Qi, and J. H. Kaas (2000)
PNAS 97, 5546-5550
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »


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