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Science 28 June 1991: Vol. 252. no. 5014, pp. 1813 - 1816 DOI: 10.1126/science.2063193
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Articles
Science, Vol 252, Issue 5014, 1813-1816
Copyright © 1991 by American Association for the Advancement of Science
Blood pressure control--special role of the kidneys and body fluids
AC Guyton
Department of Physiology and Biophysics, University of Mississippi School of Medicine, Jackson 39216.
The arterial pressure of the adult human rarely deviates from normal by more than 10 to 15 percent during each day. To achieve such constancy, the body has a network of pressure control systems. Several are based on neural receptors that respond within seconds to help correct any abnormal pressure. The activities of these systems are followed within minutes by activation of hormonal controllers. Within hours or days, a kidney pressure control system is induced that increases body fluid volume when the pressure falls (or decreases the volume when the pressure rises). This kidney-fluid system is the dominant method of establishing long-term pressure control.
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Hypertension
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Hypertension
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Seminars in Cardiothoracic and Vascular Anesthesia
2, 222-230
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Physiology
13, 170-176
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- Inhibition of renal arachidonic acid omega -hydroxylase activity with ABT reduces blood pressure in the SHR.
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Am J Physiol Regulatory Integrative Comp Physiol
275, R426-R438
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Am J Physiol Renal Physiol
274, F680-F686
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- Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension.
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Circulation
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