Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 June 1991:
Vol. 252. no. 5013, pp. 1718 - 1720
DOI: 10.1126/science.1675489
Prev | Table of Contents | Next

Articles

Science, Vol 252, Issue 5013, 1718-1720
Copyright © 1991 by American Association for the Advancement of Science

articles

Facilitation of the induction of long-term potentiation by GABAB receptors

DD Mott and DV Lewis

Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.

Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Noradrenergic and GABAB Receptor Activation Differentially Modulate Inputs to the Premotor Nucleus RA in Zebra Finches.
M. Sizemore and D. J. Perkel (2008)
J Neurophysiol 100, 8-18
   Abstract »    Full Text »    PDF »
Inhibition facilitates depression.
R. H. Cudmore, J.-M. Goaillard, and D. Debanne (2007)
J. Physiol. 585, 323
   Full Text »    PDF »
Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome.
J. C. Lauterborn, C. S. Rex, E. Kramar, L. Y. Chen, V. Pandyarajan, G. Lynch, and C. M. Gall (2007)
J. Neurosci. 27, 10685-10694
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease.
G. Lynch, E. A. Kramar, C. S. Rex, Y. Jia, D. Chappas, C. M. Gall, and D. A. Simmons (2007)
J. Neurosci. 27, 4424-4434
   Abstract »    Full Text »    PDF »
Simultaneous NMDA-Dependent Long-Term Potentiation of EPSCs and Long-Term Depression of IPSCs in Cultured Rat Hippocampal Neurons.
M. Ivenshitz and M. Segal (2006)
J. Neurosci. 26, 1199-1210
   Abstract »    Full Text »    PDF »
cAMP Response Element-Binding Protein, Activating Transcription Factor-4, and Upstream Stimulatory Factor Differentially Control Hippocampal GABABR1a and GABABR1b Subunit Gene Expression through Alternative Promoters.
J. L. Steiger, S. Bandyopadhyay, D. H. Farb, and S. J. Russek (2004)
J. Neurosci. 24, 6115-6126
   Abstract »    Full Text »    PDF »
Molecular Structure and Physiological Functions of GABAB Receptors.
B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann (2004)
Physiol Rev 84, 835-867
   Abstract »    Full Text »    PDF »
Subcellular Localization of Metabotropic GABAB Receptor Subunits GABAB1a/b and GABAB2 in the Rat Hippocampus.
A. Kulik, I. Vida, R. Lujan, C. A. Haas, G. Lopez-Bendito, R. Shigemoto, and M. Frotscher (2003)
J. Neurosci. 23, 11026-11035
   Abstract »    Full Text »    PDF »
GABAB receptor modulation of excitatory and inhibitory synaptic transmission onto rat CA3 hippocampal interneurons.
S. Lei and C. J McBain (2003)
J. Physiol. 546, 439-453
   Abstract »    Full Text »    PDF »
Control of Feedforward Dendritic Inhibition by NMDA Receptor-Dependent Spike Timing in Hippocampal Interneurons.
G. Maccaferri and R. Dingledine (2002)
J. Neurosci. 22, 5462-5472
   Abstract »    Full Text »    PDF »
Long-Term Potentiation in the Rat Hippocampus Is Reversibly Depressed by Chronic Intermittent Ethanol Exposure.
M. Roberto, T. E. Nelson, C. L. Ur, and D. L. Gruol (2002)
J Neurophysiol 87, 2385-2397
   Abstract »    Full Text »    PDF »
GABAB Presynaptic Inhibition Has an In Vivo Time Constant Sufficiently Rapid to Allow Modulation at Theta Frequency.
B. J. Molyneaux and M. E. Hasselmo (2002)
J Neurophysiol 87, 1196-1205
   Abstract »    Full Text »    PDF »
Random Response Fluctuations Lead to Spurious Paired-Pulse Facilitation.
J. Kim and B. E. Alger (2001)
J. Neurosci. 21, 9608-9618
   Abstract »    Full Text »    PDF »
Differences in Time Course of ACh and GABA Modulation of Excitatory Synaptic Potentials in Slices of Rat Hippocampus.
M. E. Hasselmo and B. P. Fehlau (2001)
J Neurophysiol 86, 1792-1802
   Abstract »    Full Text »    PDF »
Origins and Distribution of Cholinergically Induced beta Rhythms in Hippocampal Slices.
K. Shimono, F. Brucher, R. Granger, G. Lynch, and M. Taketani (2000)
J. Neurosci. 20, 8462-8473
   Abstract »    Full Text »    PDF »
GABAB-Receptor-Mediated Currents in Interneurons of the Dentate-Hilus Border.
D. D. Mott, Q. Li, M. M. Okazaki, D. A. Turner, and D. V. Lewis (1999)
J Neurophysiol 82, 1438-1450
   Abstract »    Full Text »    PDF »
GABAB Receptor Antagonism: Facilitatory Effects on Memory Parallel Those on LTP Induced by TBS but Not HFS.
U. Staubli, J. Scafidi, and D. Chun (1999)
J. Neurosci. 19, 4609-4615
   Abstract »    Full Text »    PDF »
Chronic Changes in Synaptic Responses of Entorhinal and Hippocampal Neurons After Amino-Oxyacetic Acid (AOAA)-Induced Entorhinal Cortical Neuron Loss.
H. E. Scharfman, J. H. Goodman, F. Du, and R. Schwarcz (1998)
J Neurophysiol 80, 3031-3046
   Abstract »    Full Text »    PDF »
The Synaptic Basis of GABAA,slow.
M. I. Banks, T.-B. Li, and R. A. Pearce (1998)
J. Neurosci. 18, 1305-1317
   Abstract »    Full Text »    PDF »
Partial Hippocampal Kindling Decreases Efficacy of Presynaptic GABAB Autoreceptors in CA1.
C. Wu and L. S. Leung (1997)
J. Neurosci. 17, 9261-9269
   Abstract »    Full Text »    PDF »
GABAA-Mediated IPSCs in Piriform Cortex Have Fast and Slow Components With Different Properties and Locations on Pyramidal Cells.
A. Kapur, R. A. Pearce, W. W. Lytton, and L. B. Haberly (1997)
J Neurophysiol 78, 2531-2545
   Abstract »    Full Text »    PDF »
Defective gamma -aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.
P. A. Slesinger, M. Stoffel, Y. N. Jan, and L. Y. Jan (1997)
PNAS 94, 12210-12217
   Abstract »    Full Text »    PDF »
GABAergic Modulation of Hippocampal Population Activity: Sequence Learning, Place Field Development, and the Phase Precession Effect.
G. V. Wallenstein and M. E. Hasselmo (1997)
J Neurophysiol 78, 393-408
   Abstract »    Full Text »    PDF »
Adrenoceptor-Mediated Elevation of Ambient GABA Levels Activates Presynaptic GABAB Receptors in Rat Sensorimotor Cortex.
B. D. Bennett, J. R. Huguenard, and D. A. Prince (1997)
J Neurophysiol 78, 561-566
   Abstract »    Full Text »    PDF »
REVIEW {blacksquare} : GABAergic Inhibitory Processes and Hippocampal Long-term Potentiation.
L. M. Schultz (1997)
Neuroscientist 3, 226-236
   Abstract »    PDF »
Inhibition of GABAA Synaptic Responses by Brain-Derived Neurotrophic Factor (BDNF) in Rat Hippocampus.
T. Tanaka, H. Saito, and N. Matsuki (1997)
J. Neurosci. 17, 2959-2966
   Abstract »    Full Text »    PDF »
Heterogeneity in Use-Dependent Depression of Inhibitory Postsynaptic Potentials in the Rat Neostriatum In Vitro.
G. Radnikow, J. Rohrbacher, and U. Misgeld (1997)
J Neurophysiol 77, 427-434
   Abstract »    Full Text »    PDF »
GABAB Receptors, Monoamine Receptors, and Postsynaptic Inositol Trisphosphate-Induced Ca2+ Release Are Involved in the Induction of Long-Term Potentiation at Visual Cortical Inhibitory Synapses.
Y. Komatsu (1996)
J. Neurosci. 16, 6342-6352
   Abstract »    Full Text »    PDF »
Low-frequency stimulation erases LTP through an NMDA receptor-mediated activation of protein phosphatases..
T J O'Dell and E R Kandel (1994)
Learn. Mem. 1, 129-139
   Abstract »    PDF »
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.
D. Hosford, S Clark, Z Cao, W. Wilson Jr, F. Lin, R. Morrisett, and A Huin (1992)
Science 257, 398-401
   Abstract »    PDF »
Variation in Effective Stimulus Patterns for Induction of Long-Term Potentiation Across Different Layers of Rat Entorhinal Cortex.
S. H. Yun, I. Mook-Jung, and M. W. Jung (2002)
J. Neurosci. 22, RC214
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)