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Science 21 June 1991: Vol. 252. no. 5013, pp. 1705 - 1708 DOI: 10.1126/science.1646484
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Articles
Science, Vol 252, Issue 5013, 1705-1708
Copyright © 1991 by American Association for the Advancement of Science
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation
AC Rapraeger,
A Krufka,
and
BB Olwin
Department of Pathology, University of Wisconsin, Madison 53706.
Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor. These results indicate that cell surface heparan sulfate is directly involved in bFGF cell signaling.
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- T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein.
- K. Oritani, S. Hirota, T. Nakagawa, I. Takahashi, S.-i. Kawamoto, M. Yamada, N. Ishida, T. Kadoya, Y. Tomiyama, P. W. Kincade, et al. (2003)
Blood
101, 178-185
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- MuSK Glycosylation Restrains MuSK Activation and Acetylcholine Receptor Clustering.
- A. Watty and S. J. Burden (2002)
J. Biol. Chem.
277, 50457-50462
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- Identification of a Drosophila Gene Encoding Xylosylprotein beta 4-Galactosyltransferase That Is Essential for the Synthesis of Glycosaminoglycans and for Morphogenesis.
- Y. Nakamura, N. Haines, J. Chen, T. Okajima, K. Furukawa, T. Urano, P. Stanley, K. D. Irvine, and K. Furukawa (2002)
J. Biol. Chem.
277, 46280-46288
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- Dermatan Sulfate Binds and Potentiates Activity of Keratinocyte Growth Factor (FGF-7).
- J. M. Trowbridge, J. A. Rudisill, D. Ron, and R. L. Gallo (2002)
J. Biol. Chem.
277, 42815-42820
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- Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells.
- T. Standal, C. Seidel, O. Hjertner, T. Plesner, R. D. Sanderson, A. Waage, M. Borset, and A. Sundan (2002)
Blood
100, 3002-3007
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- Heparin/Heparan Sulfate Domains in Binding and Signaling of Fibroblast Growth Factor 8b.
- B.-M. Loo and M. Salmivirta (2002)
J. Biol. Chem.
277, 32616-32623
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- Fibroblast Growth Factor Receptors 1 and 2 Interact Differently with Heparin/Heparan Sulfate. IMPLICATIONS FOR DYNAMIC ASSEMBLY OF A TERNARY SIGNALING COMPLEX.
- A. K. Powell, D. G. Fernig, and J. E. Turnbull (2002)
J. Biol. Chem.
277, 28554-28563
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- FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.
- D. M. Ornitz and P. J. Marie (2002)
Genes & Dev.
16, 1446-1465
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- Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts.
- M. I. Kontaridis, X. Liu, L. Zhang, and A. M. Bennett (2002)
Mol. Cell. Biol.
22, 3875-3891
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- Heparin Amplifies Platelet-derived Growth Factor (PDGF)- BB-induced PDGF alpha -Receptor but Not PDGF beta -Receptor Tyrosine Phosphorylation in Heparan Sulfate-deficient Cells. EFFECTS ON SIGNAL TRANSDUCTION AND BIOLOGICAL RESPONSES.
- C. Rolny, D. Spillmann, U. Lindahl, and L. Claesson-Welsh (2002)
J. Biol. Chem.
277, 19315-19321
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- Fibroblast growth factor-specific modulation of cellular response by syndecan-4.
- A. Horowitz, E. Tkachenko, and M. Simons (2002)
J. Cell Biol.
157, 715-725
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- Treatment with the novel anti-angiogenic agent PI-88 is associated with immune-mediated thrombocytopenia.
- M. A. Rosenthal, D. Rischin, G. McArthur, K. Ribbons, B. Chong, J. Fareed, G. Toner, M. D. Green, and R. L. Basser (2002)
Ann. Onc.
13, 770-776
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- Alternative Splicing of the IIICS Domain in Fibronectin Governs the Role of the Heparin II Domain in Fibrillogenesis and Cell Spreading.
- A. J. Santas, J. A. Peterson, J. L. Halbleib, S. E. Craig, M. J. Humphries, and D. M. P. Peters (2002)
J. Biol. Chem.
277, 13650-13658
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- Hepatocyte Growth Factor/Scatter Factor Binds to Small Heparin-derived Oligosaccharides and Stimulates the Proliferation of Human HaCaT Keratinocytes.
- M. Delehedde, M. Lyon, R. Vidyasagar, T. J. McDonnell, and D. G. Fernig (2002)
J. Biol. Chem.
277, 12456-12462
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- Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization.
- W. B. Stallcup and K. Dahlin-Huppe (2002)
J. Cell Sci.
114, 2315-2325
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- Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
- P. W. B. Derksen, R. M. J. Keehnen, L. M. Evers, M. H. J. van Oers, M. Spaargaren, and S. T. Pals (2002)
Blood
99, 1405-1410
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- Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan.
- M. W. Barnett, C. E. Fisher, G. Perona-Wright, and J. A. Davies (2002)
J. Cell Sci.
115, 4495-4503
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- Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1{alpha}-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.
- J. Li, N. W. Shworak, and M. Simons (2002)
J. Cell Sci.
115, 1951-1959
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- Specific heparan sulfate structures involved in retinal axon targeting.
- A. Irie, E. A. Yates, J. E. Turnbull, and C. E. Holt (2002)
Development
129, 61-70
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- Heparan Sulfate Proteoglycans as Regulators of Fibroblast Growth Factor-2 Receptor Binding in Breast Carcinomas.
- C. Mundhenke, K. Meyer, S. Drew, and A. Friedl (2002)
Am. J. Pathol.
160, 185-194
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- Inhibition of vascular smooth muscle cell proliferation by a novel fibroblast growth factor receptor antagonist.
- A. Segev, D. Aviezer, M. Safran, Z. Gross, and A. Yayon (2002)
Cardiovasc Res
53, 232-241
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- Carbohydrate-modifying Sulfotransferases: Structure, Function, and Pathophysiology.
- M. Fukuda, N. Hiraoka, T. O. Akama, and M. N. Fukuda (2001)
J. Biol. Chem.
276, 47747-47750
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- Endocan Is a Novel Chondroitin Sulfate/Dermatan Sulfate Proteoglycan That Promotes Hepatocyte Growth Factor/Scatter Factor Mitogenic Activity.
- D. Bechard, T. Gentina, M. Delehedde, A. Scherpereel, M. Lyon, M. Aumercier, R. Vazeux, C. Richet, P. Degand, B. Jude, et al. (2001)
J. Biol. Chem.
276, 48341-48349
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- Foxl1 Controls the Wnt/beta -Catenin Pathway by Modulating the Expression of Proteoglycans in the Gut.
- N. Perreault, J. P. Katz, S. D. Sackett, and K. H. Kaestner (2001)
J. Biol. Chem.
276, 43328-43333
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- Membrane Heparan Sulfate Proteoglycan-supported FGF2-FGFR1 Signaling. EVIDENCE IN SUPPORT OF THE "COOPERATIVE END STRUCTURES" MODEL.
- Z. Zhang, C. Coomans, and G. David (2001)
J. Biol. Chem.
276, 41921-41929
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