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Science 14 June 1991:
Vol. 252. no. 5012, pp. 1562 - 1564
DOI: 10.1126/science.2047864
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Articles

Science, Vol 252, Issue 5012, 1562-1564
Copyright © 1991 by American Association for the Advancement of Science

articles

Alteration of four identified K+ currents in Drosophila muscle by mutations in eag

Y Zhong and CF Wu

Department of Biology, University of Iowa, Iowa City 52242.

Voltage-clamp analysis of Drosophila larval muscle revealed that ether a go-go (eag) mutations affected all identified potassium currents, including those specifically eliminated by mutations in the Shaker or slowpoke gene. Together with DNA sequence analysis, the results suggest that the eag locus encodes a subunit common to different potassium channels. Thus, combinatorial assembly of polypeptides from different genes may contribute to potassium channel diversity.


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Presynaptic Recordings from Drosophila: Correlatin of Macroscopic and Single-Channel K+ Currents.
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Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in Xenopus oocytes.
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Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels.
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Science 254, 730
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A component of calcium-activated potassium channels encoded by the Drosophila slo locus.
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A distinct potassium channel polypeptide encoded by the Drosophila eag locus.
J Warmke, R Drysdale, and B Ganetzky (1991)
Science 252, 1560-1562
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Science. ISSN 0036-8075 (print), 1095-9203 (online)