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Science 14 June 1991:
Vol. 252. no. 5012, pp. 1546 - 1548
DOI: 10.1126/science.2047861
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Articles

Science, Vol 252, Issue 5012, 1546-1548
Copyright © 1991 by American Association for the Advancement of Science

articles

Dopamine activation of an orphan of the steroid receptor superfamily

RF Power, JP Lydon, OM Conneely, and BW O'Malley

Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.

The chicken ovalbumin upstream promoter transcription factor (COUP-TF) is a member of the steroid receptor superfamily and participates in the regulation of several genes. While a number of functions have been ascribed to COUP-TF, no ligand or activator molecule has been identified, and thus it is classified as one of a group of orphan receptors. Activation of COUP-TF by physiological concentrations of the neurotransmitter dopamine was observed in transient transfection assays. Treatment of transfected cells with the dopamine receptor agonist alpha-ergocryptine also activated COUP-dependent expression of a reporter gene. COUP-TF that contained a deletion in the COOH-terminal domain was not activated by these compounds. These observations suggest that dopamine may be a physiological activator of COUP-TF.


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