Science 31 May 1991: Vol. 252. no. 5010, pp. 1308 - 1310 DOI: 10.1126/science.1833816

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Articles

Activation and control of pathogenic T cells in OSP/claudin-11-induced EAE in SJL/J mice are dominated by their focused recognition of a single epitopic residue (OSP58M).

N. Kaushansky, M. Eisenstein, J. H. Oved, and A. Ben-Nun (2008)
Int. Immunol. 20, 1439-1449
 |  Abstract »  |  Full Text »  |  PDF »

TCR Antagonism by Peptide Requires High TCR Expression.

D. S. Jones, P. Reichardt, M. L. Ford, L. J. Edwards, and B. D. Evavold (2008)
J. Immunol. 181, 1760-1766
 |  Abstract »  |  Full Text »  |  PDF »

Th17 Cells Exhibit a Distinct Calcium Profile from Th1 and Th2 Cells and Have Th1-Like Motility and NF-AT Nuclear Localization.

K. S. Weber, M. J. Miller, and P. M. Allen (2008)
J. Immunol. 180, 1442-1450
 |  Abstract »  |  Full Text »  |  PDF »

Differential Functional Avidity of Dengue Virus-Specific T-Cell Clones for Variant Peptides Representing Heterologous and Previously Encountered Serotypes.

A. Imrie, J. Meeks, A. Gurary, M. Sukhbataar, P. Kitsutani, P. Effler, and Z. Zhao (2007)
J. Virol. 81, 10081-10091
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Levels of Costimulation Lead to Reduced Effector/Memory CD8+ T Cell Functionality.

S. Mostbock, S. Vidal, J. Schlom, and H. Sabzevari (2007)
J. Immunol. 179, 3524-3534
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The role of cytokines in hepatocellular carcinoma.

A. Budhu and X. W. Wang (2006)
J. Leukoc. Biol. 80, 1197-1213
 |  Abstract »  |  Full Text »  |  PDF »

The Study of High-Affinity TCRs Reveals Duality in T Cell Recognition of Antigen: Specificity and Degeneracy.

D. L. Donermeyer, K. S. Weber, D. M. Kranz, and P. M. Allen (2006)
J. Immunol. 177, 6911-6919
 |  Abstract »  |  Full Text »  |  PDF »

T-cell responses to peptide fragments of the BK virus T antigen: implications for cross-reactivity of immune response to JC virus..

J. Li, J. Melenhorst, N. Hensel, K. Rezvani, G. Sconocchia, Y. Kilical, J. Hou, B. Curfman, E. Major, and A. J. Barrett (2006)
J. Gen. Virol. 87, 2951-2960
 |  Abstract »  |  Full Text »  |  PDF »

Defining Yourself: Tolerance Development in the Immune System.

P. M. Allen (2006)
J. Immunol. 177, 1369-1372
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I-Ep-Bound Self-Peptides: Identification, Characterization, and Role in Alloreactivity.

N. J. Felix, A. Suri, J. J. Walters, S. Horvath, M. L. Gross, and P. M. Allen (2006)
J. Immunol. 176, 1062-1071
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Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.

K. S. Weber, D. L. Donermeyer, P. M. Allen, and D. M. Kranz (2005)
PNAS 102, 19033-19038
 |  Abstract »  |  Full Text »  |  PDF »

Human CD4+ T Cells Induced by Synthetic Peptide Malaria Vaccine Are Comparable to Cells Elicited by Attenuated Plasmodium falciparum Sporozoites.

J. M. Calvo-Calle, G. A. Oliveira, and E. H. Nardin (2005)
J. Immunol. 175, 7575-7585
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Tolerance Induced by Cross-Reactive TCR Ligands Can Be Broken by Superagonist Resulting in Anti-Inflammatory T Cell Cytokine Production.

Z. Illes, H. Waldner, J. Reddy, E. Bettelli, L. B. Nicholson, and V. K. Kuchroo (2005)
J. Immunol. 175, 1491-1497
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Memory CD4 T Cell Function and Survival Potential by Altering the Strength of the Recall Stimulus.

D. S. Patke and D. L. Farber (2005)
J. Immunol. 174, 5433-5443
 |  Abstract »  |  Full Text »  |  PDF »

Amelioration of Established Experimental Autoimmune Encephalomyelitis by an MHC Anchor-Substituted Variant of Proteolipid Protein 139-151.

C. D. Margot, M. L. Ford, and B. D. Evavold (2005)
J. Immunol. 174, 3352-3358
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules.

M. P. Mycko, H. Waldner, D. E. Anderson, K. D. Bourcier, K. W. Wucherpfennig, V. K. Kuchroo, and D. A. Hafler (2004)
J. Immunol. 173, 1689-1698
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a dual pathway of activation in CD43-stimulated Th2 cells: differential requirement for the Lck tyrosine kinase.

M. J. Fernandez-Cabezudo, C. Vijayasarathy, D. L. Pflugh, A. L. M. Bothwell, and B. K. al-Ramadi (2004)
Int. Immunol. 16, 1215-1223
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Polyclonal T Cell Responses by an MHC Anchor-Substituted Variant of Myelin Oligodendrocyte Glycoprotein 35-55.

M. L. Ford and B. D. Evavold (2003)
J. Immunol. 171, 1247-1254
 |  Abstract »  |  Full Text »  |  PDF »

Innate Immunity Together with Duration of Antigen Persistence Regulate Effector T Cell Induction.

T. Storni, C. Ruedl, W. A. Renner, and M. F. Bachmann (2003)
J. Immunol. 171, 795-801
 |  Abstract »  |  Full Text »  |  PDF »

Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function.

D.-G. Lim, J. M. Slavik, K. Bourcier, K. J. Smith, and D. A. Hafler (2003)
J. Exp. Med. 198, 99-109
 |  Abstract »  |  Full Text »  |  PDF »

Restricted Clonal Expression of IL-2 By Naive T Cells Reflects Differential Dynamic Interactions with Dendritic Cells.

V. Hurez, A. Saparov, A. Tousson, M. J. Fuller, T. Kubo, J. Oliver, B. T. Weaver, and C. T. Weaver (2003)
J. Exp. Med. 198, 123-132
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Dependence of TCR Antagonism on Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Activity.

N. E. Kilgore, J. D. Carter, U. Lorenz, and B. D. Evavold (2003)
J. Immunol. 170, 4891-4895
 |  Abstract »  |  Full Text »  |  PDF »

Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells.

W. Yang and H. M. Grey (2003)
J. Immunol. 170, 4532-4538
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor.

D. Davidson, M. Bakinowski, M. L. Thomas, V. Horejsi, and A. Veillette (2003)
Mol. Cell. Biol. 23, 2017-2028
 |  Abstract »  |  Full Text »  |  PDF »

Induction of the Early Growth Response Gene 1 Promoter by TCR Agonists and Partial Agonists: Ligand Potency Is Related to Sustained Phosphorylation of Extracellular Signal-Related Kinase Substrates.

H. Xi and G. J. Kersh (2003)
J. Immunol. 170, 315-324
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Antagonistic Variant Virus Prevents Wild-type Virus-induced Lethal Immunopathology.

L. Hunziker, M. Recher, A. Ciurea, M. M.A. Martinic, B. Odermatt, H. Hengartner, and R. M. Zinkernagel (2002)
J. Exp. Med. 196, 1039-1046
 |  Abstract »  |  Full Text »  |  PDF »

Preferential Induction of IL-10 in APC Correlates with a Switch from Th1 to Th2 Response Following Infection with a Low Pathogenic Variant of Theiler's Virus.

J. P. Palma, R. L. Yauch, H.-K. Kang, H.-G. Lee, and B. S. Kim (2002)
J. Immunol. 168, 4221-4230
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Naive CD4+ T Cells Exhibit Distinct Expression Patterns of Cytokines and Cell Surface Molecules on Their Primary Responses to Varying Doses of Antigen.

W. Ise, M. Totsuka, Y. Sogawa, A. Ametani, S. Hachimura, T. Sato, Y. Kumagai, S. Habu, and S. Kaminogawa (2002)
J. Immunol. 168, 3242-3250
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Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy.

C. Rossig, C. M. Bollard, J. G. Nuchtern, C. M. Rooney, and M. K. Brenner (2002)
Blood 99, 2009-2016
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Chronic Soluble Antigen Sensitization Primes a Unique Memory/Effector T Cell Repertoire Associated with Th2 Phenotype Acquisition In Vivo.

G. Foucras, A. Gallard, C. Coureau, J.-M. Kanellopoulos, and J.-C. Guery (2002)
J. Immunol. 168, 179-187
 |  Abstract »  |  Full Text »  |  PDF »

Diversity of the Human Allergen-Specific T Cell Repertoire Associated with Distinct Skin Test Reactions: Delayed-Type Hypersensitivity-Associated Major Epitopes Induce Th1- and Th2-Dominated Responses.

J. A. Woodfolk and T. A. E. Platts-Mills (2001)
J. Immunol. 167, 5412-5419
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Selection and Differential Activation on Structurally Related HLA-DR4 Ligands.

J. A. Gebe, E. J. Novak, W. W. Kwok, A. G. Farr, G. T. Nepom, and J. H. Buckner (2001)
J. Immunol. 167, 3250-3256
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Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection.

J. Lieberman, P. Shankar, N. Manjunath, and J. Andersson (2001)
Blood 98, 1667-1677
 |  Abstract »  |  Full Text »  |  PDF »

Different Levels of T-Cell Receptor Triggering Induce Distinct Functions in Hepatitis B and Hepatitis C Virus-Specific Human CD4+ T-Cell Clones.

H. M. Diepolder, N. H. Gruener, J. T. Gerlach, M.-C. Jung, E. A. Wierenga, and G. R. Pape (2001)
J. Virol. 75, 7803-7810
 |  Abstract »  |  Full Text »  |  PDF »

Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs.

P. J. Ruiz, J. J. DeVoss, L.-V. T. Nguyen, P. P. Fontoura, D. L. Hirschberg, D. J. Mitchell, K. C. Garcia, and L. Steinman (2001)
J. Immunol. 167, 2688-2693
 |  Abstract »  |  Full Text »  |  PDF »

V{beta}6+ T Cells Are Obligatory for Vaccine-Induced Immunity to Histoplasma capsulatum.

G. S. Deepe Jr. and R. Gibbons (2001)
J. Immunol. 167, 2219-2226
 |  Abstract »  |  Full Text »  |  PDF »

Degeneracy and additional alloreactivity of drug-specific human {{alpha}}{beta}+ T cell clones.

S. von Greyerz, G. Bultemann, K. Schnyder, C. Burkhart, B. Lotti, Y. Hari, and W. J. Pichler (2001)
Int. Immunol. 13, 877-885
 |  Abstract »  |  Full Text »  |  PDF »

Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue.

G. J. Kersh, M. J. Miley, C. A. Nelson, A. Grakoui, S. Horvath, D. L. Donermeyer, J. Kappler, P. M. Allen, and D. H. Fremont (2001)
J. Immunol. 166, 3345-3354
 |  Abstract »  |  Full Text »  |  PDF »

Human and Murine CD4 T Cell Reactivity to a Complex Antigen: Recognition of the Synthetic Random Polypeptide Glatiramer Acetate.

P. W. Duda, J. I. Krieger, M. C. Schmied, C. Balentine, and D. A. Hafler (2000)
J. Immunol. 165, 7300-7307
 |  Abstract »  |  Full Text »  |  PDF »

Differential Sensitivity to Mutations in a Single Peptide by Two TCRs Having Identical {beta}-Chains and Closely Related {alpha}-Chains.

B. N. Dittel and C. A. Janeway Jr. (2000)
J. Immunol. 165, 6334-6340
 |  Abstract »  |  Full Text »  |  PDF »

Antagonism of Direct Alloreactivity of an HLA-B27-Specific CTL Clone by Altered Peptide Ligands of Its Natural Epitope.

M. Garcia-Peydro, A. Paradela, J. P. Albar, and J. A. L. d. Castro (2000)
J. Immunol. 165, 5680-5685
 |  Abstract »  |  Full Text »  |  PDF »

C8/119S Mutation of Major Mite Allergen Derf-2 Leads to Degenerate Secondary Structure and Molecular Polymerization and Induces Potent and Exclusive Th1 Cell Differentiation.

S. Korematsu, Y. Tanaka, S. Hosoi, S. Koyanagi, T. Yokota, B. Mikami, and N. Minato (2000)
J. Immunol. 165, 2895-2902
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A self-hsp60 peptide acts as a partial agonist inducing expression of B7-2 on mycobacterial hsp60-specific T cells: a possible mechanism for inhibitory T cell regulation of adjuvant arthritis?.

A. G. A. Paul, R. van der Zee, L. S. Taams, and W. van Eden (2000)
Int. Immunol. 12, 1041-1050
 |  Abstract »  |  Full Text »  |  PDF »

Alteration at a Single Amino Acid Residue in the T Cell Receptor {alpha} Chain Complementarity Determining Region 2 Changes the Differentiation of Naive CD4 T Cells in Response to Antigen from T Helper Cell Type 1 (Th1) to Th2.

J. M. Blander, D. B. Sant'Angelo, K. Bottomly, and C. A. Janeway , Jr. (2000)
J. Exp. Med. 191, 2065-2074
 |  Abstract »  |  Full Text »  |  PDF »

Threshold Signaling of Human Th0 Cells in Activation and Anergy: Modulation of Effector Function by Altered TCR Ligand.

A. Verhoef and J. R. Lamb (2000)
J. Immunol. 164, 6034-6040
 |  Abstract »  |  Full Text »  |  PDF »

An Altered Peptide Ligand Antagonizes Antigen-Specific T Cells of Patients with Human T Lymphotropic Virus Type I-Associated Neurological Disease.

R. Kubota, S. S. Soldan, R. Martin, and S. Jacobson (2000)
J. Immunol. 164, 5192-5198
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus.

F. Lechner, D. K.H. Wong, P. R. Dunbar, R. Chapman, R. T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, and B. D. Walker (2000)
J. Exp. Med. 191, 1499-1512
 |  Abstract »  |  Full Text »  |  PDF »

T-Cell Receptor-Mediated Anergy of a Human Immunodeficiency Virus (HIV) gp120-Specific CD4+ Cytotoxic T-Cell Clone, Induced by a Natural HIV Type 1 Variant Peptide.

L. Bouhdoud, P. Villain, A. Merzouki, M. Arella, and C. Couture (2000)
J. Virol. 74, 2121-2130
 |  Abstract »  |  Full Text »

T-Cell Epitopes and Human Leukocyte Antigen Restriction Elements of an Immunodominant Antigen of Blastomyces dermatitidis.

W. L. Chang, R. G. Audet, B. D. Aizenstein, L. H. Hogan, R. I. DeMars, and B. S. Klein (2000)
Infect. Immun. 68, 502-510
 |  Abstract »  |  Full Text »  |  PDF »

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands.

L. B. Nicholson, A. C. Anderson, and V. K. Kuchroo (2000)
Int. Immunol. 12, 205-213
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Th2 Responses by Peptide Analogues in a Murine Model of Allergic Asthma: Amelioration or Deterioration of the Disease Process Depends on the Th1 or Th2 Skewing Characteristics of the Therapeutic Peptide.

E. M. Janssen, A. J. M. van Oosterhout, A. J. M. L. van Rensen, W. van Eden, F. P. Nijkamp, and M. H. M. Wauben (2000)
J. Immunol. 164, 580-588
 |  Abstract »  |  Full Text »  |  PDF »

Th1 and Th2 Deviation of Myelin-Autoreactive T Cells by Altered Peptide Ligands Is Associated with Reciprocal Regulation of Lck, Fyn, and ZAP-70.

R. A. K. Singh, Y. C. Q. Zang, A. Shrivastava, J. Hong, G. T. Wang, S. Li, M. V. Tejada-Simon, M. Kozovska, V. M. Rivera, and J. Z. Zhang (1999)
J. Immunol. 163, 6393-6402
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirements for NF-{kappa}B and AP-1 trans-Activation in Response to Minimal TCR Engagement by a Partial Agonist in Naive CD8 T Cells.

N. Auphan, S. Ghosh, R. A. Flavell, and A.-M. Schmitt-Verhulst (1999)
J. Immunol. 163, 5219-5227
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirements for CD4 in TCR-Ligand Interactions.

K. Vidal, C. Daniel, M. Hill, D. R. Littman, and P. M. Allen (1999)
J. Immunol. 163, 4811-4818
 |  Abstract »  |  Full Text »  |  PDF »

Effector CD4 T Cells Are Biochemically Distinct from the Memory Subset: Evidence for Long-Term Persistence of Effectors In Vivo.

M. Ahmadzadeh, S. F. Hussain, and D. L. Farber (1999)
J. Immunol. 163, 3053-3063
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: N-Hydroxy Peptides: A New Class of TCR Antagonists.

S. Hin, C. Zabel, A. Bianco, G. Jung, and P. Walden (1999)
J. Immunol. 163, 2363-2367
 |  Abstract »  |  Full Text »  |  PDF »

A Partially Agonistic Peptide Acts as a Selective Inducer of Apoptosis in CD8+ CTLs.

C.-H. Wei, C. Beeson, M. G. Masucci, and V. Levitsky (1999)
J. Immunol. 163, 2601-2609
 |  Abstract »  |  Full Text »  |  PDF »

Anergic CD8+ T Cells Can Persist and Function In Vivo.

C. A. Blish, S. R. Dillon, A. G. Farr, and P. J. Fink (1999)
J. Immunol. 163, 155-164
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Peptide Superagonists for a Self-K-ras-Reactive CD4+ T Cell Clone Using Combinatorial Peptide Libraries and Mass Spectrometry.

Y. Tanaka, H. Ohyama, M. Ogawa, Y. Nishimura, and S. Matsushita (1999)
J. Immunol. 162, 7155-7161
 |  Abstract »  |  Full Text »  |  PDF »

A Kinetic Threshold between Negative and Positive Selection Based on the Longevity of the T Cell Receptor-Ligand Complex.

C. B. Williams, D. L. Engle, G. J. Kersh, J. Michael White, and P. M. Allen (1999)
J. Exp. Med. 189, 1531-1544
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation Reverses the Defect in IL-2 But Not Effector Cytokine Production by T Cells with Impaired I{kappa}B{alpha} Degradation.

T. M. Aune, A. L. Mora, S. Kim, M. Boothby, and A. H. Lichtman (1999)
J. Immunol. 162, 5805-5812
 |  Abstract »  |  Full Text »  |  PDF »

The Surface Protein Superfamily of Trypanosoma cruzi Stimulates a Polarized Th1 Response That Becomes Anergic.

A. E. Millar, M. Wleklinski-Lee, and S. J. Kahn (1999)
J. Immunol. 162, 6092-6099
 |  Abstract »  |  Full Text »  |  PDF »

Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis.

P. J. Ruiz, H. Garren, D. L. Hirschberg, A. M. Langer-Gould, M. Levite, M. V. Karpuj, S. Southwood, A. Sette, P. Conlon, and L. Steinman (1999)
J. Exp. Med. 189, 1275-1284
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-10 and Antigen-Presenting Cells Actively Suppress Th1 Cells in BALB/c Mice Infected with the Filarial Parasite Brugia pahangi.

J. Osborne and E. Devaney (1999)
Infect. Immun. 67, 1599-1605
 |  Abstract »  |  Full Text »  |  PDF »

TCR-Independent Pathways Mediate the Effects of Antigen Dose and Altered Peptide Ligands on Th Cell Polarization.

A. Grakoui, D. L. Donermeyer, O. Kanagawa, K. M. Murphy, and P. M. Allen (1999)
J. Immunol. 162, 1923-1930
 |  Abstract »  |  Full Text »  |  PDF »

An Altered Peptide Ligand Specifically Inhibits Th2 Cytokine Synthesis by Abrogating TCR Signaling.

A. Faith, C. A. Akdis, M. Akdis, A. Joss, D. Wymann, and K. Blaser (1999)
J. Immunol. 162, 1836-1842
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Sulfonamide Derivatives with the TCR of Sulfamethoxazole-Specific Human {alpha}{beta}+ T Cell Clones.

S. von Greyerz, M. P. Zanni, K. Frutig, B. Schnyder, C. Burkhart, and W. J. Pichler (1999)
J. Immunol. 162, 595-602
 |  Abstract »  |  Full Text »  |  PDF »

Variant antigenic peptide promotes cytotoxic T lymphocyte adhesion to target cells without cytotoxicity.

D. M. Shotton and A. Attaran (1998)
PNAS 95, 15571-15576
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of CD28 Engagement and IL-12 on T Cell Activation by Altered Peptide Ligands.

L. Ding and E. M. Shevach (1998)
J. Immunol. 161, 6614-6621
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Variation Diminishes CD4 T Lymphocyte Recognition.

G. C. Harcourt, S. Garrard, M. P. Davenport, A. Edwards, and R. E. Phillips (1998)
J. Exp. Med. 188, 1785-1793
 |  Abstract »  |  Full Text »  |  PDF »

Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses.

V. Kouskoff, S. Famiglietti, G. Lacaud, P. Lang, J. E. Rider, B. K. Kay, J. C. Cambier, and D. Nemazee (1998)
J. Exp. Med. 188, 1453-1464
 |  Abstract »  |  Full Text »  |  PDF »

Fine Specificity of the Myelin-Reactive T Cell Repertoire: Implications for TCR Antagonism in Autoimmunity.

S. M. Anderton, S. P. Manickasingham, C. Burkhart, T. A. Luckcuck, S. J. Holland, A. G. Lamont, and D. C. Wraith (1998)
J. Immunol. 161, 3357-3364
 |  Abstract »  |  Full Text »  |  PDF »

Autoimmunity Without Diabetes in Transgenic Mice Expressing {beta} Cell-Specific CD86, But Not CD80: Parameters that Trigger Progression to Diabetes.

S. Guerder, E. E. Eynon, and R. A. Flavell (1998)
J. Immunol. 161, 2128-2140
 |  Abstract »  |  Full Text »  |  PDF »

Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.

Y. Ghendler, M.-k. Teng, J.-h. Liu, T. Witte, J. Liu, K. S. Kim, P. Kern, H.-C. Chang, J.-h. Wang, and E. L. Reinherz (1998)
PNAS 95, 10061-10066
 |  Abstract »  |  Full Text »  |  PDF »

CD4 Regulation of TCR Signaling and T Cell Differentiation Following Stimulation with Peptides of Different Affinities for the TCR.

D. Leitenberg, Y. Boutin, S. Constant, and K. Bottomly (1998)
J. Immunol. 161, 1194-1203
 |  Abstract »  |  Full Text »  |  PDF »

Following Antigen Challenge, T Cells Up-Regulate Cell Surface Expression of CD4 In Vitro and In Vivo.

W. Ridgway, M. Fasso, and C. G. Fathman (1998)
J. Immunol. 161, 714-720
 |  Abstract »  |  Full Text »  |  PDF »

Substitutions in a Major Histocompatibility Complex Class II-Restricted Human Immunodeficiency Virus Type 1 gp120 Epitope Can Affect CD4+ T-Helper-Cell Function.

C. Lekutis and N. L. Letvin (1998)
J. Virol. 72, 5840-5844
 |  Abstract »  |  Full Text »  |  PDF »

TCR Agonist and Antagonist Exert In Vivo Cross-Regulation When Presented on Igs.

K. L. Legge, B. Min, A. E. Cestra, C. D. Pack, and H. Zaghouani (1998)
J. Immunol. 161, 106-111
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Expression of a TCR Antagonist: T Cells Escape Central Tolerance But Are Antagonized in the Periphery.

C. B. Williams, K. Vidal, D. Donermeyer, D. A. Peterson, J. M. White, and P. M. Allen (1998)
J. Immunol. 161, 128-137
 |  Abstract »  |  Full Text »  |  PDF »

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells.

B. Hemmer, I. Stefanova, M. Vergelli, R. N. Germain, and R. Martin (1998)
J. Immunol. 160, 5807-5814
 |  Abstract »  |  Full Text »  |  PDF »

Increased Threshold for TCR-Mediated Signaling Controls Self Reactivity of Intraepithelial Lymphocytes.

S. R. Guehler, R. J. Finch, J. A. Bluestone, and T. A. Barrett (1998)
J. Immunol. 160, 5341-5346
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of T Cells by Natural Antigen Peptide Analogues: Influence on Autoimmune and Alloimmune In Vivo T Cell Responses.

L. R. B. Soares, P. L. Orr, M. R. Garovoy, and G. Benichou (1998)
J. Immunol. 160, 4768-4775
 |  Abstract »  |  Full Text »  |  PDF »

Evidence That the Autoimmune Antigen Myelin Basic Protein (MBP) Ac1-9 Binds Towards One End of the Major Histocompatibility Complex (MHC) Cleft.

C. Lee, M. N. Liang, K. M. Tate, J. D. Rabinowitz, C. Beeson, P. P. Jones, and H. M. McConnell (1998)
J. Exp. Med. 187, 1505-1516
 |  Abstract »  |  Full Text »  |  PDF »

T cell positive selection by a high density, low affinity ligand.

C.-P. Liu, F. Crawford, P. Marrack, and J. Kappler (1998)
PNAS 95, 4522-4526
 |  Abstract »  |  Full Text »  |  PDF »

Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.

M. A. Purbhoo, A. K. Sewell, P. Klenerman, P. J. R. Goulder, K. L. Hilyard, J. I. Bell, B. K. Jakobsen, and R. E. Phillips (1998)
PNAS 95, 4527-4532
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Signal Transduction Through the TCR-{zeta} Chain Following T Cell Stimulation with Analogue Peptides of Type II Collagen 260-267.

B. Tang, L. K. Myers, E. F. Rosloniec, K. B. Whittington, J. M. Stuart, and A. H. Kang (1998)
J. Immunol. 160, 3135-3142
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of an In Vitro CD4+ T Cell Alloresponse Using Altered Peptide Ligands.

C. Daniel, A. Grakoui, and P. M. Allen (1998)
J. Immunol. 160, 3244-3250
 |  Abstract »  |  Full Text »  |  PDF »

Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity.

L. B. Nicholson, H. Waldner, A. M. Carrizosa, A. Sette, M. Collins, and V. K. Kuchroo (1998)
PNAS 95, 264-269
 |  Abstract »  |  Full Text »  |  PDF »

Persistence of Peptide-induced CD4+ T cell Anergy In Vitro.

K. R. Ryan and B. D. Evavold (1998)
J. Exp. Med. 187, 89-96
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence.

J. D. Ahlers, T. Takeshita, C. D. Pendleton, and J. A. Berzofsky (1997)
PNAS 94, 10856-10861
 |  Abstract »  |  Full Text »  |  PDF »

Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells.

Y. Itoh and R. N. Germain (1997)
J. Exp. Med. 186, 757-766
 |  Abstract »  |  Full Text »  |  PDF »

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens.

L. B. Nicholson, A. Murtaza, B. P. Hafler, A. Sette, and V. K. Kuchroo (1997)
PNAS 94, 9279-9284
 |  Abstract »  |  Full Text »  |  PDF »

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal.

C. Wulfing, J. D. Rabinowitz, C. Beeson, M. D. Sjaastad, H. M. McConnell, and M. M. Davis (1997)
J. Exp. Med. 185, 1815-1825
 |  Abstract »  |  Full Text »  |  PDF »

Presentation of a T Cell Receptor Antagonist Peptide by Immunoglobulins Ablates Activation of  T Cells by a Synthetic Peptide or Proteins Requiring Endocytic Processing.

K. L. Legge, B. Min, N. T. Potter, and H. Zaghouani (1997)
J. Exp. Med. 185, 1043-1054
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Epitope Modification on T Cell Receptor-Ligand Binding and Antigen Recognition by Seven H-2Kd-restricted Cytotoxic T Lymphocyte Clones Specific for a Photoreactive Peptide Derivative.

B. M. Kessler, P. Bassanini, J.-C. Cerottini, and I. F. Luescher (1997)
J. Exp. Med. 185, 629-640
 |  Abstract »  |  Full Text »  |  PDF »

The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide-MHC Molecule Ligands.

J. Madrenas, L. A. Chau, J. Smith, J. A. Bluestone, and R. N. Germain (1997)
J. Exp. Med. 185, 219-230
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway.

M. I. Reinhold, F. P. Lindberg, G. J. Kersh, P. M. Allen, and E. J. Brown (1997)
J. Exp. Med. 185, 1-12
 |  Abstract »  |  Full Text »  |  PDF »

Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones.

L. J. Ausubel, C. K. Kwan, A. Sette, V. Kuchroo, and D. A. Hafler (1996)
PNAS 93, 15317-15322
 |  Abstract »  |  Full Text »  |  PDF »

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