Science 17 May 1991: Vol. 252. no. 5008, pp. 965 - 969 DOI: 10.1126/science.2035027

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Articles

The accessory subunit of mitochondrial DNA polymerase {gamma} determines the DNA content of mitochondrial nucleoids in human cultured cells.

M. Di Re, H. Sembongi, J. He, A. Reyes, T. Yasukawa, P. Martinsson, L. J. Bailey, S. Goffart, J. D. Boyd-Kirkup, T. S. Wong, et al. (2009)
Nucleic Acids Res. 37, 5701-5713
 |  Abstract »  |  Full Text »  |  PDF »

Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents.

J. Kienhofer, D. J. F. Haussler, F. Ruckelshausen, E. Muessig, K. Weber, D. Pimentel, V. Ullrich, A. Burkle, and M. M. Bachschmid (2009)
FASEB J 23, 2034-2044
 |  Abstract »  |  Full Text »  |  PDF »

The conserved translocase Tim17 prevents mitochondrial DNA loss.

M. Iacovino, C. Granycome, H. Sembongi, M. Bokori-Brown, R. A. Butow, I. J. Holt, and J. M. Bateman (2009)
Hum. Mol. Genet. 18, 65-74
 |  Abstract »  |  Full Text »  |  PDF »

Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice.

Y. Hayashi, M. Yoshida, M. Yamato, T. Ide, Z. Wu, M. Ochi-Shindou, T. Kanki, D. Kang, K. Sunagawa, H. Tsutsui, et al. (2008)
J. Neurosci. 28, 8624-8634
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Maintenance of Mitochondrial DNA: New Insights into Human Disease Pathology.

G. S. Shadel (2008)
Am. J. Pathol. 172, 1445-1456
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Transcription Factor B2 Is Essential for Metabolic Function in Drosophila melanogaster Development.

C. Adan, Y. Matsushima, R. Hernandez-Sierra, R. Marco-Ferreres, M. A. Fernandez-Moreno, E. Gonzalez-Vioque, M. Calleja, J. J. Aragon, L. S. Kaguni, and R. Garesse (2008)
J. Biol. Chem. 283, 12333-12342
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism.

C. R. Cederroth, M. Vinciguerra, A. Gjinovci, F. Kuhne, M. Klein, M. Cederroth, D. Caille, M. Suter, D. Neumann, R. W. James, et al. (2008)
Diabetes 57, 1176-1185
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Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function.

R. C. Scarpulla (2008)
Physiol Rev 88, 611-638
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X-ray crystal structure of the polymerase domain of the bacteriophage N4 virion RNA polymerase.

K. S. Murakami, E. K. Davydova, and L. B. Rothman-Denes (2008)
PNAS 105, 5046-5051
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial DNA replication during differentiation of murine embryonic stem cells.

J. M. Facucho-Oliveira, J. Alderson, E. C. Spikings, S. Egginton, and J. C. St. John (2007)
J. Cell Sci. 120, 4025-4034
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Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions.

A. Valle, R. Guevara, F. J. Garcia-Palmer, P. Roca, and J. Oliver (2007)
Am J Physiol Cell Physiol 293, C1302-C1308
 |  Abstract »  |  Full Text »  |  PDF »

The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm.

A. Amaral, J. Ramalho-Santos, and J. C. St John (2007)
Hum. Reprod. 22, 1585-1596
 |  Abstract »  |  Full Text »  |  PDF »

Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function.

L. S. Chow, L. J. Greenlund, Y. W. Asmann, K. R. Short, S. K. McCrady, J. A. Levine, and K. S. Nair (2007)
J Appl Physiol 102, 1078-1089
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial gene expression: influence of nutrients and hormones..

C. D. Berdanier (2006)
Experimental Biology and Medicine 231, 1593-1601
 |  Abstract »  |  Full Text »  |  PDF »

Human Mitochondrial DNA Nucleoids Are Linked to Protein Folding Machinery and Metabolic Enzymes at the Mitochondrial Inner Membrane.

Y. Wang and D. F. Bogenhagen (2006)
J. Biol. Chem. 281, 25791-25802
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1.

C. A. Piantadosi and H. B. Suliman (2006)
J. Biol. Chem. 281, 324-333
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Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction.

M. Ikeuchi, H. Matsusaka, D. Kang, S. Matsushima, T. Ide, T. Kubota, T. Fujiwara, N. Hamasaki, A. Takeshita, K. Sunagawa, et al. (2005)
Circulation 112, 683-690
 |  Abstract »  |  Full Text »  |  PDF »

Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis.

R. Justo, J. Boada, M. Frontera, J. Oliver, J. Bermudez, and M. Gianotti (2005)
Am J Physiol Cell Physiol 289, C372-C378
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The Conserved Mec1/Rad53 Nuclear Checkpoint Pathway Regulates Mitochondrial DNA Copy Number in Saccharomyces cerevisiae.

S. D. Taylor, H. Zhang, J. S. Eaton, M. S. Rodeheffer, M. A. Lebedeva, T. W. O'Rourke, W. Siede, and G. S. Shadel (2005)
Mol. Biol. Cell 16, 3010-3018
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila Mitochondrial Transcription Factor B1 Modulates Mitochondrial Translation but Not Transcription or DNA Copy Number in Schneider Cells.

Y. Matsushima, C. Adan, R. Garesse, and L. S. Kaguni (2005)
J. Biol. Chem. 280, 16815-16820
 |  Abstract »  |  Full Text »  |  PDF »

Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells.

K. Maniura-Weber, S. Goffart, H. L. Garstka, J. Montoya, and R. J. Wiesner (2004)
Nucleic Acids Res. 32, 6015-6027
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila Mitochondrial Transcription Factor B2 Regulates Mitochondrial DNA Copy Number and Transcription in Schneider Cells.

Y. Matsushima, R. Garesse, and L. S. Kaguni (2004)
J. Biol. Chem. 279, 26900-26905
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial transcription factor A regulates mtDNA copy number in mammals.

M. I. Ekstrand, M. Falkenberg, A. Rantanen, C. B. Park, M. Gaspari, K. Hultenby, P. Rustin, C. M. Gustafsson, and N.-G. Larsson (2004)
Hum. Mol. Genet. 13, 935-944
 |  Abstract »  |  Full Text »  |  PDF »

The Podospora rmp1 Gene Implicated in Nucleus-Mitochondria Cross-Talk Encodes an Essential Protein Whose Subcellular Location Is Developmentally Regulated.

V. Contamine, D. Zickler, and M. Picard (2004)
Genetics 166, 135-150
 |  Abstract »  |  Full Text »  |  PDF »

Glom Is a Novel Mitochondrial DNA Packaging Protein in Physarum polycephalum and Causes Intense Chromatin Condensation without Suppressing DNA Functions.

N. Sasaki, H. Kuroiwa, C. Nishitani, H. Takano, T. Higashiyama, T. Kobayashi, Y. Shirai, A. Sakai, S. Kawano, K. Murakami-Murofushi, et al. (2003)
Mol. Biol. Cell 14, 4758-4769
 |  Abstract »  |  Full Text »  |  PDF »

Phage N4 RNA polymerase II recruitment to DNA by a single-stranded DNA-binding protein.

R. H. Carter, A. A. Demidenko, S. Hattingh-Willis, and L. B. Rothman-Denes (2003)
Genes & Dev. 17, 2334-2345
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Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA.

H. L. Garstka, W. E. Schmitt, J. Schultz, B. Sogl, B. Silakowski, A. Perez-Martos, J. Montoya, and R. J. Wiesner (2003)
Nucleic Acids Res. 31, 5039-5047
 |  Abstract »  |  Full Text »  |  PDF »

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

A Garnier, D Fortin, C Delomenie, I Momken, V Veksler, and R Ventura-Clapier (2003)
J. Physiol. 551, 491-501
 |  Abstract »  |  Full Text »  |  PDF »

Human Mitochondrial Transcription Factor B1 Interacts with the C-Terminal Activation Region of h-mtTFA and Stimulates Transcription Independently of Its RNA Methyltransferase Activity.

V. McCulloch and G. S. Shadel (2003)
Mol. Cell. Biol. 23, 5816-5824
 |  Abstract »  |  Full Text »  |  PDF »

Functional Domains of Chicken Mitochondrial Transcription Factor A for the Maintenance of Mitochondrial DNA Copy Number in Lymphoma Cell Line DT40.

Y. Matsushima, K. Matsumura, S. Ishii, H. Inagaki, T. Suzuki, Y. Matsuda, K. Beck, and Y. Kitagawa (2003)
J. Biol. Chem. 278, 31149-31158
 |  Abstract »  |  Full Text »  |  PDF »

p53 Physically Interacts with Mitochondrial Transcription Factor A and Differentially Regulates Binding to Damaged DNA.

Y. Yoshida, H. Izumi, T. Torigoe, H. Ishiguchi, H. Itoh, D. Kang, and K. Kohno (2003)
Cancer Res. 63, 3729-3734
 |  Abstract »  |  Full Text »  |  PDF »

Postlipopolysaccharide Oxidative Damage of Mitochondrial DNA.

H. B. Suliman, M. S. Carraway, and C. A. Piantadosi (2003)
Am. J. Respir. Crit. Care Med. 167, 570-579
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Transcription Factor A and Its Downstream Targets Are Up-regulated in a Rat Hepatoma.

X. Dong, K. Ghoshal, S. Majumder, S. P. Yadav, and S. T. Jacob (2002)
J. Biol. Chem. 277, 43309-43318
 |  Abstract »  |  Full Text »  |  PDF »

N4 RNA Polymerase II, a Heterodimeric RNA Polymerase with Homology to the Single-Subunit Family of RNA Polymerases.

S. H. Willis, K. M. Kazmierczak, R. H. Carter, and L. B. Rothman-Denes (2002)
J. Bacteriol. 184, 4952-4961
 |  Abstract »  |  Full Text »  |  PDF »

Two Copies of mthmg1, Encoding a Novel Mitochondrial HMG-Like Protein, Delay Accumulation of Mitochondrial DNA Deletions in Podospora anserina.

M. Dequard-Chablat and C. Alland (2002)
Eukaryot. Cell 1, 503-513
 |  Abstract »  |  Full Text »  |  PDF »

The C-terminal Region of Mitochondrial Single-subunit RNA Polymerases Contains Species-specific Determinants for Maintenance of Intact Mitochondrial Genomes.

T. Lisowsky, D. Wilkens, T. Stein, B. Hedtke, T. Borner, and A. Weihe (2002)
Mol. Biol. Cell 13, 2245-2255
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells.

B. L. Seidel-Rogol and G. S. Shadel (2002)
Nucleic Acids Res. 30, 1929-1934
 |  Abstract »  |  Full Text »  |  PDF »

Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.

M. Rojo, F. Legros, D. Chateau, and A. Lombes (2002)
J. Cell Sci. 115, 1663-1674
 |  Abstract »  |  Full Text »  |  PDF »

The Histone-Like Protein HU Does Not Obstruct Movement of T7 RNA Polymerase in Escherichia coli Cells but Stimulates Its Activity.

P. Morales, J. Rouviere-Yaniv, and M. Dreyfus (2002)
J. Bacteriol. 184, 1565-1570
 |  Abstract »  |  Full Text »  |  PDF »

A Human Mitochondrial Transcription Factor Is Related to RNA Adenine Methyltransferases and Binds S-Adenosylmethionine.

V. McCulloch, B. L. Seidel-Rogol, and G. S. Shadel (2002)
Mol. Cell. Biol. 22, 1116-1125
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of mammalian mitochondrial DNA replication: import of mitochondrial transcription factor A into isolated mitochondria stimulates 7S DNA synthesis.

S. Gensler, K. Weber, W. E. Schmitt, A. Perez-Martos, J. A. Enriquez, J. Montoya, and R. J. Wiesner (2001)
Nucleic Acids Res. 29, 3657-3663
 |  Abstract »  |  Full Text »  |  PDF »

Plasticity in Skeletal, Cardiac, and Smooth Muscle: Selected Contribution: Effects of contractile activity on mitochondrial transcription factor A expression in skeletal muscle.

J. W. Gordon, A. A. Rungi, H. Inagaki, and D. A. Hood (2001)
J Appl Physiol 90, 389-396
 |  Abstract »  |  Full Text »  |  PDF »

A Variant Form of the Nuclear Triiodothyronine Receptor c-ErbAalpha 1 Plays a Direct Role in Regulation of Mitochondrial RNA Synthesis.

F. Casas, P. Rochard, A. Rodier, I. Cassar-Malek, S. Marchal-Victorion, R. J. Wiesner, G. Cabello, and C. Wrutniak (1999)
Mol. Cell. Biol. 19, 7913-7924
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a DNA-Binding Protein Implicated in Transcription in Wheat Mitochondria.

T. M. Ikeda and M. W. Gray (1999)
Mol. Cell. Biol. 19, 8113-8122
 |  Abstract »  |  Full Text »  |  PDF »

The tamas Gene, Identified as a Mutation That Disrupts Larval Behavior in Drosophila melanogaster, Codes for the Mitochondrial DNA Polymerase Catalytic Subunit (DNApol-{gamma}125).

B. Iyengar, J. Roote, and A. R. Campos (1999)
Genetics 153, 1809-1824
 |  Abstract »  |  Full Text »

The Accessory Subunit of Xenopus laevis Mitochondrial DNA Polymerase gamma  Increases Processivity of the Catalytic Subunit of Human DNA Polymerase gamma  and Is Related to Class II Aminoacyl-tRNA Synthetases.

J. A. Carrodeguas, R. Kobayashi, S. E. Lim, W. C. Copeland, and D. F. Bogenhagen (1999)
Mol. Cell. Biol. 19, 4039-4046
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator.

H. Yamamoto, K. Tsukahara, Y. Kanaoka, S. Jinno, and H. Okayama (1999)
Mol. Cell. Biol. 19, 3829-3841
 |  Abstract »  |  Full Text »  |  PDF »

FILAMENTOUS FLOWER, a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains.

S. Sawa, K. Watanabe, K. Goto, E. Kanaya, E. H. Morita, and K. Okada (1999)
Genes & Dev. 13, 1079-1088
 |  Abstract »  |  Full Text »

The mechanism of sequence non-specific DNA binding of HMG1/2-box B in HMG1 with DNA.

K. Saito, T. Kikuchi, and M. Yoshida (1999)
Protein Eng. Des. Sel. 12, 235-242
 |  Abstract »  |  Full Text »  |  PDF »

The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo.

D. M. MacAlpine, P. S. Perlman, and R. A. Butow (1998)
PNAS 95, 6739-6743
 |  Abstract »  |  Full Text »  |  PDF »

Functions of the High Mobility Group Protein, Abf2p, in Mitochondrial DNA Segregation, Recombination and Copy Number in Saccharomyces cerevisiae.

O. Zelenaya-Troitskaya, S. M. Newman, K. Okamoto, P. S. Perlman, and R. A. Butow (1998)
Genetics 148, 1763-1776
 |  Abstract »  |  Full Text »  |  PDF »

Determinants of DNA Binding and Bending by the Saccharomyces cerevisiae High Mobility Group Protein NHP6A That Are Important for Its Biological Activities. ROLE OF THE UNIQUE N TERMINUS AND PUTATIVE INTERCALATING METHIONINE.

Y.-M. Yen, B. Wong, and R. C. Johnson (1998)
J. Biol. Chem. 273, 4424-4435
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of DNA-Binding Proteins from Pea Mitochondria.

F. Hatzack, S. Dombrowski, A. Brennicke, and S. Binder (1998)
Plant Physiology 116, 519-527
 |  Abstract »  |  Full Text »  |  PDF »

Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa.

A Santel, N Blumer, M Kampfer, and R Renkawitz-Pohl (1998)
J. Cell Sci. 111, 3299-3309
 |  Abstract »  |  PDF »

Neuronal Mitochondrial Morphology and Transmembrane Potential Are Severely Altered by Hypothyroidism during Rat Brain Development.

E. Vega-Nunez, A. M. Alvarez, A. Menendez-Hurtado, A. Santos, and A. Perez-Castillo (1997)
Endocrinology 138, 3771-3778
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of mtTFB and mtRNA Polymerase at Core Promoters for Transcription of Xenopus laevis mtDNA.

D. F. Bogenhagen and D. F. Bogenhagen (1996)
J. Biol. Chem. 271, 12036-12041
 |  Abstract »  |  Full Text »  |  PDF »

Ischemic Delayed Neuronal Death : A Mitochondrial Hypothesis.

K. Abe, M. Aoki, J. Kawagoe, T. Yoshida, A. Hattori, K. Kogure, and Y. Itoyama (1995)
Stroke 26, 1478-1489
 |  Abstract »  |  Full Text »

DNA Looping by Saccharomyces cerevisiae High Mobility Group Proteins NHP6A/B.

T. T. Paull and R. C. Johnson (1995)
J. Biol. Chem. 270, 8744-8754
 |  Abstract »  |  Full Text »  |  PDF »

Multiple domains of the RNA polymerase I activator hUBF interact with the TATA-binding protein complex hSL1 to mediate transcription..

H M Jantzen, A M Chow, D S King, and R Tjian (1992)
Genes & Dev. 6, 1950-1963
 |  Abstract »  |  PDF »

DNA binding activity of recombinant SRY from normal males and XY females.

V. Harley, D. Jackson, P. Hextall, Hawkins JR, G. Berkovitz, S Sockanathan, R Lovell-Badge, and P. Goodfellow (1992)
Science 255, 453-456
 |  Abstract »  |  PDF »

DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1..

K Giese, A Amsterdam, and R Grosschedl (1991)
Genes & Dev. 5, 2567-2578
 |  Abstract »  |  PDF »

xUBF contains a novel dimerization domain essential for RNA polymerase I transcription..

B McStay, M W Frazier, and R H Reeder (1991)
Genes & Dev. 5, 1957-1968
 |  Abstract »  |  PDF »

Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart.

A. Kanazawa, Y. Nishio, A. Kashiwagi, H. Inagaki, R. Kikkawa, and K. Horiike (2002)
Am J Physiol Endocrinol Metab 282, E778-E785
 |  Abstract »  |  Full Text »  |  PDF »

Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.

Y. Nagai, Y. Nishio, T. Nakamura, H. Maegawa, R. Kikkawa, and A. Kashiwagi (2002)
Am J Physiol Endocrinol Metab 282, E1180-E1190
 |  Abstract »  |  Full Text »  |  PDF »

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