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Science 17 May 1991: Vol. 252. no. 5008, pp. 958 - 961 DOI: 10.1126/science.2035025
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Articles
Science, Vol 252, Issue 5008, 958-961
Copyright © 1991 by American Association for the Advancement of Science
Site-specific recombination between homologous chromosomes in Drosophila
KG Golic
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, IL 60637.
The ability to mark a cell and its descendants genetically so that the resulting cell clone can be distinguished from neighboring cells facilitates studies in animal biology and development. A method of generating clones by inducing homologous mitotic recombination in Drosophila with a site-specific yeast recombinase is described. This method allows for frequent mosaicism after mitotic exchange is induced at predefined sites in the genome.
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