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Science 10 May 1991:
Vol. 252. no. 5007, pp. 851 - 853
DOI: 10.1126/science.1709304

Articles

Science, Vol 252, Issue 5007, 851-853
Copyright © 1991 by American Association for the Advancement of Science


articles

Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition

M Hollmann, M Hartley, and S Heinemann

Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.

NMDA (N-methyl-D-aspartate) receptors and non-NMDA receptors represent the two major classes of ion channel-linked glutamate receptors. Unlike the NMDA receptor channels, non-NMDA receptor channels have usually been thought to conduct monovalent cations only. Non-NMDA receptor ion channels that can be gated by kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) are formed by the glutamate receptor subunits GluR1, GluR2, and GluR3. These subunits were expressed in various combinations in Xenopus oocytes so that their permeability to divalent cations could be studied. At physiological resting potentials, KA and AMPA elicited inward calcium currents in oocytes expressing GluR1, GluR3, and GluR1 plus GluR3. In contrast, oocytes expressing GluR1 plus GluR2 or GluR3 plus GluR2 showed no such permeability. Thus, in neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.


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Pharmacol. Rev. 51, 7-62
   Abstract »    Full Text »    PDF »
Editing of Glutamate Receptor Subunit B Pre-mRNA by Splice-site Variants of Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1.
Y. Liu and C. E. Samuel (1999)
J. Biol. Chem. 274, 5070-5077
   Abstract »    Full Text »    PDF »
Distinct Populations of NMDA Receptors at Subcortical and Cortical Inputs to Principal Cells of the Lateral Amygdala.
M. G. Weisskopf and J. E. LeDoux (1999)
J Neurophysiol 81, 930-934
   Abstract »    Full Text »    PDF »
The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.
K. Kask, D. Zamanillo, A. Rozov, N. Burnashev, R. Sprengel, and P. H. Seeburg (1998)
PNAS 95, 13777-13782
   Abstract »    Full Text »    PDF »
Neuroprotective Efficacy of YM872, an alpha -Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptor Antagonist, after Permanent Middle Cerebral Artery Occlusion in Rats.
M. Takahashi, J. W. Ni, S. Kawasaki-Yatsugi, T. Toya, C. Ichiki, S.-I. Yatsugi, K. Koshiya, M. Shimizu-Sasamata, and T. Yamaguchi (1998)
J. Pharmacol. Exp. Ther. 287, 559-566
   Abstract »    Full Text »
Brain Injury With Prolonged Seizures in Children and Adults.
S. L. Moshe (1998)
J Child Neurol 13, S3-S6
   Abstract »    PDF »
Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements.
S. J. Myers, J. Peters, Y. Huang, M. B. Comer, F. Barthel, and R. Dingledine (1998)
J. Neurosci. 18, 6723-6739
   Abstract »    Full Text »    PDF »
Extracellular Acidity Potentiates AMPA Receptor-Mediated Cortical Neuronal Death.
J. W. McDonald, T. Bhattacharyya, S. L. Sensi, D. Lobner, H. S. Ying, L. M.T. Canzoniero, and D. W. Choi (1998)
J. Neurosci. 18, 6290-6299
   Abstract »    Full Text »    PDF »
Effects of the Abused Solvent Toluene on Recombinant N-Methyl-D-Aspartate and non-N-Methyl-D-Aspartate Receptors Expressed in Xenopus Oocytes.
S. L. Cruz, T. Mirshahi, B. Thomas, R. L. Balster, and J. J. Woodward (1998)
J. Pharmacol. Exp. Ther. 286, 334-340
   Abstract »    Full Text »
AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons.
E. L. Gleason and N. C. Spitzer (1998)
J Neurophysiol 79, 2986-2998
   Abstract »    Full Text »    PDF »
AMPA Receptors: Players in Calcium-Mediated Neuronal Injury?.
H. L. Gaspary (1998)
Neuroscientist 4, 149-153
   Abstract »    PDF »
Modulation of Pre- and Postsynaptic Calcium Dynamics by Ionotropic Glutamate Receptors at a Plastic Synapse.
N. E. Schwartz and S. Alford (1998)
J Neurophysiol 79, 2191-2203
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Pharmacological Characterization of the Human Ionotropic Glutamate Receptor Subtype GluR3 Stably Expressed in Mammalian Cells.
M. A. Varney, S. P. Rao, C. Jachec, C. Deal, S. D. Hess, L. P. Daggett, F.-F. Lin, E. C. Johnson, and G. Veliçelebi (1998)
J. Pharmacol. Exp. Ther. 285, 358-370
   Abstract »    Full Text »
Corticosteroid Regulation of Ion Channel Conductances and mRNA Levels in Individual Hippocampal CA1 Neurons.
S. M. Nair, T. R. Werkman, J. Craig, R. Finnell, M. Joels, and J. H. Eberwine (1998)
J. Neurosci. 18, 2685-2696
   Abstract »    Full Text »    PDF »



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