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Science 10 May 1991: Vol. 252. no. 5007, pp. 851 - 853 DOI: 10.1126/science.1709304
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Articles
Science, Vol 252, Issue 5007, 851-853
Copyright © 1991 by American Association for the Advancement of Science
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
M Hollmann,
M Hartley,
and
S Heinemann
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
NMDA (N-methyl-D-aspartate) receptors and non-NMDA receptors represent the two major classes of ion channel-linked glutamate receptors. Unlike the NMDA receptor channels, non-NMDA receptor channels have usually been thought to conduct monovalent cations only. Non-NMDA receptor ion channels that can be gated by kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) are formed by the glutamate receptor subunits GluR1, GluR2, and GluR3. These subunits were expressed in various combinations in Xenopus oocytes so that their permeability to divalent cations could be studied. At physiological resting potentials, KA and AMPA elicited inward calcium currents in oocytes expressing GluR1, GluR3, and GluR1 plus GluR3. In contrast, oocytes expressing GluR1 plus GluR2 or GluR3 plus GluR2 showed no such permeability. Thus, in neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.
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- S. D. Grossman, B. B. Wolfe, R. P. Yasuda, and J. R. Wrathall (1999)
J. Neurosci.
19, 5711-5720
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- Subtype-specific Assembly of alpha -Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits Is Mediated by Their N-terminal Domains.
- W. D. Leuschner and W. Hoch (1999)
J. Biol. Chem.
274, 16907-16916
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- Differential Roles of NMDA and Non-NMDA Receptors in Synaptic Responses of Neurons in Nucleus Tractus Solitarii of the Rat.
- J. C. Yen, J. Y. H. Chan, and S. H. H. Chan (1999)
J Neurophysiol
81, 3034-3043
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- RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity.
- C. M. Niswender, S. C. Copeland, K. Herrick-Davis, R. B. Emeson, and E. Sanders-Bush (1999)
J. Biol. Chem.
274, 9472-9478
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- Subtype-Specific Effects of Lithium on Glutamate Receptor Function.
- N. B. Karkanias and R. L. Papke (1999)
J Neurophysiol
81, 1506-1512
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- The Distribution of Neurons Expressing Calcium-Permeable AMPA Receptors in the Superficial Laminae of the Spinal Cord Dorsal Horn.
- H. S. Engelman, T. B. Allen, and A. B. MacDermott (1999)
J. Neurosci.
19, 2081-2089
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- The Glutamate Receptor Ion Channels.
- R. Dingledine, K. Borges, D. Bowie, and S. F. Traynelis (1999)
Pharmacol. Rev.
51, 7-62
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- Editing of Glutamate Receptor Subunit B Pre-mRNA by Splice-site Variants of Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase ADAR1.
- Y. Liu and C. E. Samuel (1999)
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274, 5070-5077
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- Distinct Populations of NMDA Receptors at Subcortical and Cortical Inputs to Principal Cells of the Lateral Amygdala.
- M. G. Weisskopf and J. E. LeDoux (1999)
J Neurophysiol
81, 930-934
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- The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.
- K. Kask, D. Zamanillo, A. Rozov, N. Burnashev, R. Sprengel, and P. H. Seeburg (1998)
PNAS
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- Neuroprotective Efficacy of YM872, an alpha -Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptor Antagonist, after Permanent Middle Cerebral Artery Occlusion in Rats.
- M. Takahashi, J. W. Ni, S. Kawasaki-Yatsugi, T. Toya, C. Ichiki, S.-I. Yatsugi, K. Koshiya, M. Shimizu-Sasamata, and T. Yamaguchi (1998)
J. Pharmacol. Exp. Ther.
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- Brain Injury With Prolonged Seizures in Children and Adults.
- S. L. Moshe (1998)
J Child Neurol
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- Transcriptional Regulation of the GluR2 Gene: Neural-Specific Expression, Multiple Promoters, and Regulatory Elements.
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J. Neurosci.
18, 6723-6739
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- Extracellular Acidity Potentiates AMPA Receptor-Mediated Cortical Neuronal Death.
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J. Neurosci.
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- Effects of the Abused Solvent Toluene on Recombinant N-Methyl-D-Aspartate and non-N-Methyl-D-Aspartate Receptors Expressed in Xenopus Oocytes.
- S. L. Cruz, T. Mirshahi, B. Thomas, R. L. Balster, and J. J. Woodward (1998)
J. Pharmacol. Exp. Ther.
286, 334-340
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- AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons.
- E. L. Gleason and N. C. Spitzer (1998)
J Neurophysiol
79, 2986-2998
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- AMPA Receptors: Players in Calcium-Mediated Neuronal Injury?.
- H. L. Gaspary (1998)
Neuroscientist
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- Modulation of Pre- and Postsynaptic Calcium Dynamics by Ionotropic Glutamate Receptors at a Plastic Synapse.
- N. E. Schwartz and S. Alford (1998)
J Neurophysiol
79, 2191-2203
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- Pharmacological Characterization of the Human Ionotropic Glutamate Receptor Subtype GluR3 Stably Expressed in Mammalian Cells.
- M. A. Varney, S. P. Rao, C. Jachec, C. Deal, S. D. Hess, L. P. Daggett, F.-F. Lin, E. C. Johnson, and G. Veliçelebi (1998)
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285, 358-370
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- Corticosteroid Regulation of Ion Channel Conductances and mRNA Levels in Individual Hippocampal CA1 Neurons.
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