Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 May 1991:
Vol. 252. no. 5007, pp. 848 - 851
DOI: 10.1126/science.1709303
Prev | Table of Contents | Next

Articles

Science, Vol 252, Issue 5007, 848-851
Copyright © 1991 by American Association for the Advancement of Science

articles

FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu

G Lavorgna, H Ueda, J Clos, and C Wu

Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

The Drosophila homeobox segmentation gene fushi tarazu (ftz) is expressed in a seven-stripe pattern during early embryogenesis. This characteristic pattern is largely specified by the zebra element located immediately upstream of the ftz transcriptional start site. The FTZ-F1 protein, one of multiple DNA binding factors that interacts with the zebra element, is implicated in the activation of ftz transcription, especially in stripes 1, 2, 3, and 6. An FTZ-F1 complementary DNA has been cloned by recognition site screening of a Drosophila expression library. The identity of the FTZ-F1 complementary DNA clone was confirmed by immunological cross-reaction with antibodies to FTZ-F1 and by sequence analysis of peptides from purified FTZ-F1 protein. The predicted amino acid sequence of FTZ-F1 revealed that the protein is a member of the nuclear hormone receptor superfamily. This finding raises the possibility that a hormonal ligand affects the expression of a homeobox segmentation gene early in embryonic development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mutations in NR5A1 Associated with Ovarian Insufficiency.
D. Lourenco, R. Brauner, L. Lin, A. De Perdigo, G. Weryha, M. Muresan, R. Boudjenah, G. Guerra-Junior, A. T. Maciel-Guerra, J. C. Achermann, et al. (2009)
N. Engl. J. Med. 360, 1200-1210
   Abstract »    Full Text »    PDF »
Pituitary Homeobox 2 Regulates Adrenal4 Binding Protein/Steroidogenic Factor-1 Gene Transcription in the Pituitary Gonadotrope through Interaction with the Intronic Enhancer.
Y. Shima, M. Zubair, T. Komatsu, S. Oka, C. Yokoyama, T. Tachibana, T. A. Hjalt, J. Drouin, and K.-i. Morohashi (2008)
Mol. Endocrinol. 22, 1633-1646
   Abstract »    Full Text »    PDF »
Drosophila Blimp-1 Is a Transient Transcriptional Repressor That Controls Timing of the Ecdysone-Induced Developmental Pathway.
Y. Agawa, M. Sarhan, Y. Kageyama, K. Akagi, M. Takai, K. Hashiyama, T. Wada, H. Handa, A. Iwamatsu, S. Hirose, et al. (2007)
Mol. Cell. Biol. 27, 8739-8747
   Abstract »    Full Text »    PDF »
Sequence-Specific Deoxyribonucleic Acid (DNA) Recognition by Steroidogenic Factor 1: A Helix at the Carboxy Terminus of the DNA Binding Domain Is Necessary for Complex Stability.
T. H. Little, Y. Zhang, C. K. Matulis, J. Weck, Z. Zhang, A. Ramachandran, K. E. Mayo, and I. Radhakrishnan (2006)
Mol. Endocrinol. 20, 831-843
   Abstract »    Full Text »    PDF »
Phosphorylation of the Hinge Domain of the Nuclear Hormone Receptor LRH-1 Stimulates Transactivation.
Y.-K. Lee, Y.-H. Choi, S. Chua, Y. J. Park, and D. D. Moore (2006)
J. Biol. Chem. 281, 7850-7855
   Abstract »    Full Text »    PDF »
Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor {gamma} Coactivator-1{alpha} on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy.
R. Safi, A. Kovacic, S. Gaillard, Y. Murata, E. R. Simpson, D. P. McDonnell, and C. D. Clyne (2005)
Cancer Res. 65, 11762-11770
   Abstract »    Full Text »    PDF »
Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.
P. Gut, K. Huber, J. Lohr, B. Bruhl, S. Oberle, M. Treier, U. Ernsberger, C. Kalcheim, and K. Unsicker (2005)
Development 132, 4611-4619
   Abstract »    Full Text »    PDF »
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
W. Wang, C. Zhang, A. Marimuthu, H. I. Krupka, M. Tabrizizad, R. Shelloe, U. Mehra, K. Eng, H. Nguyen, C. Settachatgul, et al. (2005)
PNAS 102, 7505-7510
   Abstract »    Full Text »    PDF »
The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification.
M. B. Lee, L. A. Lebedeva, M. Suzawa, S. A. Wadekar, M. Desclozeaux, and H. A. Ingraham (2005)
Mol. Cell. Biol. 25, 1879-1890
   Abstract »    Full Text »    PDF »
A Screen for Genes That Interact With the Drosophila Pair-Rule Segmentation Gene fushi tarazu.
M. W. Kankel, D. M. Duncan, and I. Duncan (2004)
Genetics 168, 161-180
   Abstract »    Full Text »    PDF »
Differential Expression of Steroidogenic Factor-1/Adrenal 4 Binding Protein and Liver Receptor Homolog-1 (LRH-1)/Fetoprotein Transcription Factor in the Rat Testis: LRH-1 as a Potential Regulator of Testicular Aromatase Expression.
V. Pezzi, R. Sirianni, A. Chimento, M. Maggiolini, S. Bourguiba, C. Delalande, S. Carreau, S. Ando, E. R. Simpson, and C. D. Clyne (2004)
Endocrinology 145, 2186-2196
   Abstract »    Full Text »    PDF »
A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development.
B. J. Hwang and P. W. Sternberg (2004)
Development 131, 143-151
   Abstract »    Full Text »    PDF »
Temporal Profiles of Nuclear Receptor Gene Expression Reveal Coordinate Transcriptional Responses during Drosophila Development.
A. A. Sullivan and C. S. Thummel (2003)
Mol. Endocrinol. 17, 2125-2137
   Abstract »    Full Text »    PDF »
Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development.
J.-S. Annicotte, E. Fayard, G. H. Swift, L. Selander, H. Edlund, T. Tanaka, T. Kodama, K. Schoonjans, and J. Auwerx (2003)
Mol. Cell. Biol. 23, 6713-6724
   Abstract »    Full Text »    PDF »
piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila.
U. Hacker, S. Nystedt, M. P. Barmchi, C. Horn, and E. A. Wimmer (2003)
PNAS 100, 7720-7725
   Abstract »    Full Text »    PDF »
Expression and Regulation of Fushi Tarazu Factor-1 and Steroidogenic Genes During Reproduction in Arctic Char (Salvelinus alpinus).
J. von Hofsten, J. Karlsson, I. Jones, and P.-E. Olsson (2002)
Biol Reprod 67, 1297-1304
   Abstract »    Full Text »    PDF »
Bile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors.
J. Y. L. Chiang (2002)
Endocr. Rev. 23, 443-463
   Abstract »    Full Text »    PDF »
Liver Receptor Homologue-1 (LRH-1) Regulates Expression of Aromatase in Preadipocytes.
C. D. Clyne, C. J. Speed, J. Zhou, and E. R. Simpson (2002)
J. Biol. Chem. 277, 20591-20597
   Abstract »    Full Text »    PDF »
Cloning and Expression of Zebra Finch (Taeniopygia guttata) Steroidogenic Factor 1: Overlap with Hypothalamic but Not with Telencephalic Aromatase.
R. J. Agate, W. R. Perlman, and A. P. Arnold (2002)
Biol Reprod 66, 1127-1133
   Abstract »    Full Text »    PDF »
Quantitative Analysis of fushi tarazu Factor 1 Homolog Messenger Ribonucleic Acids in the Pituitary of Salmon at Different Prespawning Stages.
M. Higa, H. Kanda, T. Kitahashi, M. Ito, T. Shiba, and H. Ando (2000)
Biol Reprod 63, 1756-1763
   Abstract »    Full Text »
Encroaching genomics: adapting large-scale science to small academic laboratories.
M. B. EINARSON and E. A. GOLEMIS (2000)
Physiol Genomics 2, 85-92
   Abstract »    Full Text »    PDF »
Expression of Steroidogenic Factor 1 in the Testis Requires an E Box and CCAAT Box in its Promoter Proximal Region.
M. A.F. Daggett, D. A. Rice, and L. L. Heckert (2000)
Biol Reprod 62, 670-679
   Abstract »    Full Text »
Microarray Analysis of Drosophila Development During Metamorphosis.
K. P. White, S. A. Rifkin, P. Hurban, and D. S. Hogness (1999)
Science 286, 2179-2184
   Abstract »    Full Text »
Orphan Nuclear Receptors: From Gene to Function.
V. Giguère (1999)
Endocr. Rev. 20, 689-725
   Abstract »    Full Text »
Selective Binding of Steroid Hormone Receptors to Octamer Transcription Factors Determines Transcriptional Synergism at the Mouse Mammary Tumor Virus Promoter.
G. G. Prefontaine, R. Walther, W. Giffin, M. E. Lemieux, L. Pope, and R. J. G. Hache (1999)
J. Biol. Chem. 274, 26713-26719
   Abstract »    Full Text »    PDF »
CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha -hydroxylase gene.
M. Nitta, S. Ku, C. Brown, A. Y. Okamoto, and B. Shan (1999)
PNAS 96, 6660-6665
   Abstract »    Full Text »    PDF »
The Nuclear Receptor Superfamily Has Undergone Extensive Proliferation and Diversification in Nematodes.
A. E. Sluder, S. W. Mathews, D. Hough, V. P. Yin, and C. V. Maina (1999)
Genome Res. 9, 103-120
   Abstract »    Full Text »
Cloning and Characterization of a Novel Human Hepatocyte Transcription Factor, hB1F, Which Binds and Activates Enhancer II of Hepatitis B Virus.
M. Li, Y.-H. Xie, Y.-Y. Kong, X. Wu, L. Zhu, and Y. Wang (1998)
J. Biol. Chem. 273, 29022-29031
   Abstract »    Full Text »    PDF »
A Binding Site for Multiple Transcriptional Activators in the fushi tarazu Proximal Enhancer Is Essential for Gene Expression In Vivo.
W. Han, Y. Yu, K. Su, R. A. Kohanski, and L. Pick (1998)
Mol. Cell. Biol. 18, 3384-3394
   Abstract »    Full Text »
The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells.
A. N. Harris and P. L. Mellon (1998)
Mol. Endocrinol. 12, 714-726
   Abstract »    Full Text »
Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1.
M. Ito, R. N. Yu, and J. L. Jameson (1998)
Mol. Endocrinol. 12, 290-301
   Abstract »    Full Text »
NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2. THE CARBOXYL-TERMINAL EXTENSION TO THE ZINC-FINGER REGION IS UNSTRUCTURED IN THE FREE FORM OF THE PROTEIN.
D. S. Sem, D. R. Casimiro, S. A. Kliewer, J. Provencal, R. M. Evans, and P. E. Wright (1997)
J. Biol. Chem. 272, 18038-18043
   Abstract »    Full Text »    PDF »
Multiprotein bridging factor 1 (MBF1) is an evolutionarily conserved transcriptional coactivator that connects a regulatory factor and TATA element-binding protein.
K.-i. Takemaru, F.-Q. Li, H. Ueda, and S. Hirose (1997)
PNAS 94, 7251-7256
   Abstract »    Full Text »    PDF »
Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function.
K. L. Parker and B. P. Schimmer (1997)
Endocr. Rev. 18, 361-377
   Abstract »    Full Text »
Teleost FTZ-F1 Homolog and Its Splicing Variant Determine the Expression of the Salmon Gonadotropin II{beta} Subunit Gene.
D. Liu, Y. Le Drean, M. Ekker, F. Xiong, and C. L. Hew (1997)
Mol. Endocrinol. 11, 877-890
   Abstract »    Full Text »
Synergistic Activation of the Human Type II 3beta -Hydroxysteroid Dehydrogenase/Delta 5-Delta 4 Isomerase Promoter by the Transcription Factor Steroidogenic Factor-1/Adrenal 4-binding Protein and Phorbol Ester.
S. Leers-Sucheta, K.-i. Morohashi, J. I. Mason, and M. H. Melner (1997)
J. Biol. Chem. 272, 7960-7967
   Abstract »    Full Text »    PDF »
Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development.
K. G. Woodson, P. A. Crawford, Y. Sadovsky, and J. Milbrandt (1997)
Mol. Endocrinol. 11, 117-126
   Abstract »    Full Text »
Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene.
B Florence, A Guichet, A Ephrussi, and A Laughon (1997)
Development 124, 839-847
   Abstract »    PDF »
Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio..
D K Pritchard and G Schubiger (1996)
Genes & Dev. 10, 1131-1142
   Abstract »    PDF »
Estrogen-related Receptor, hERR1, Modulates Estrogen Receptor-mediated Response of Human Lactoferrin Gene Promoter.
N. Yang, H. Shigeta, H. Shi, and C. T. Teng (1996)
J. Biol. Chem. 271, 5795-5804
   Abstract »    Full Text »    PDF »
An E Box Element Is Required for the Expression of the ad4bp Gene, a Mammalian Homologue of ftz-f1 Gene, Which Is Essential for Adrenal and Gonadal Development.
M. Nomura, S. Bärtsch, H. Nawata, T. Omura, and K.-i. Morohashi (1995)
J. Biol. Chem. 270, 7453-7461
   Abstract »    Full Text »    PDF »
Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo.
A John, S. Smith, and J. Jaynes (1995)
Development 121, 1801-1813
   Abstract »    PDF »
Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot..
N Fuse, S Hirose, and S Hayashi (1994)
Genes & Dev. 8, 2270-2281
   Abstract »    PDF »
Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors..
V Giguere, M Tini, G Flock, E Ong, R M Evans, and G Otulakowski (1994)
Genes & Dev. 8, 538-553
   Abstract »    PDF »
Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack.
J. L. Brown and C. Wu (1993)
Development 117, 45-58
   Abstract »    PDF »
Competition for overlapping sites in the regulatory region of the Drosophila gene Kruppel.
M Hoch, N Gerwin, H Taubert, and H Jackle (1992)
Science 256, 94-97
   Abstract »    PDF »
A Zebrafish Ftz-F1 (Fushi Tarazu Factor 1) Homologue Requires Multiple Subdomains in the D and E Regions for Its Transcriptional Activity.
D. Liu, M. Chandy, S.-K. Lee, Y. Le Drean, H. Ando, F. Xiong, J. Woon Lee, and C. L. Hew (2000)
J. Biol. Chem. 275, 16758-16766
   Abstract »    Full Text »    PDF »
alpha 1-Fetoprotein Transcription Factor Is Required for the Expression of Sterol 12alpha -Hydroxylase, the Specific Enzyme for Cholic Acid Synthesis. POTENTIAL ROLE IN THE BILE ACID-MEDIATED REGULATION OF GENE TRANSCRIPTION.
A. del Castillo-Olivares and G. Gil (2000)
J. Biol. Chem. 275, 17793-17799
   Abstract »    Full Text »    PDF »
The Mouse Fetoprotein Transcription Factor (FTF) Gene Promoter Is Regulated by Three GATA Elements with Tandem E Box and Nkx Motifs, and FTF in Turn Activates the Hnf3beta , Hnf4alpha , and Hnf1alpha Gene Promoters.
J.-F. Pare, S. Roy, L. Galarneau, and L. Belanger (2001)
J. Biol. Chem. 276, 13136-13144
   Abstract »    Full Text »    PDF »
Regulation of Ecdysteroid Signaling: Cloning and Characterization of Ecdysone Oxidase. A NOVEL STEROID OXIDASE FROM THE COTTON LEAFWORM, SPODOPTERA LITTORALIS.
H. Takeuchi, J.-H. Chen, D. R. O'Reilly, P. C. Turner, and H. H. Rees (2001)
J. Biol. Chem. 276, 26819-26828
   Abstract »    Full Text »    PDF »
Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1.
T. Suzuki, H. Kawasaki, R. T. Yu, H. Ueda, and K. Umesono (2001)
PNAS 98, 12403-12408
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)