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Science 10 May 1991:
Vol. 252. no. 5007, pp. 802 - 808
DOI: 10.1126/science.1902986

Articles

Science, Vol 252, Issue 5007, 802-808
Copyright © 1991 by American Association for the Advancement of Science


articles

Diversity of G proteins in signal transduction

MI Simon, MP Strathmann, and N Gautam

Division of Biology, California Institute of Technology, Pasadena 91125.

The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors. The G proteins are present in all eukaryotic cells, and they control metabolic, humoral, neural, and developmental functions. More than a hundred different kinds of receptors and many different effectors have been described. The G proteins that coordinate receptor-effector activity are derived from a large gene family. At present, the family is known to contain at least sixteen different genes that encode the alpha subunit of the heterotrimer, four that encode beta subunits, and multiple genes encoding gamma subunits. Specific transient interactions between these components generate the pathways that modulate cellular responses to complex chemical signals.


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The Melanin-Concentrating Hormone Receptor Couples to Multiple G Proteins to Activate Diverse Intracellular Signaling Pathways.
B. E. Hawes, E. Kil, B. Green, K. O'Neill, S. Fried, and M. P. Graziano (2000)
Endocrinology 141, 4524-4532
   Abstract »    Full Text »    PDF »
Calcium/Calmodulin-Dependent Protein Kinase II Regulates Caenorhabditis elegans Locomotion in Concert With a Go/Gq Signaling Network.
M. Robatzek and J. H. Thomas (2000)
Genetics 156, 1069-1082
   Abstract »    Full Text »
Volume overload cardiac hypertrophy exhibits decreased expression of Gsalpha and not of Gialpha in heart.
F. Di Fusco, S. Hashim, and M. B. Anand-Srivastava (2000)
Am J Physiol Cell Physiol 279, C990-C998
   Abstract »    Full Text »    PDF »
Role of pertussis toxin-sensitive G protein in metabolic vasodilation of coronary microcirculation.
T. Tanikawa, H. Kanatsuka, R. Koshida, M. Tanaka, A. Sugimura, T. Kumagai, M. Miura, T. Komaru, and K. Shirato (2000)
Am J Physiol Heart Circ Physiol 279, H1819-H1829
   Abstract »    Full Text »    PDF »
Cannabinoid CB1 Receptor-Mediated Inhibition of Prolactin Release and Signaling Mechanisms in GH4C1 Cells.
B. Y. Ho, A. Stadnicka, P. L. Prather, A. R. Buckley, L. L. Current, Z. J. Bosnjak, and W.-M. Kwok (2000)
Endocrinology 141, 1675-1685
   Abstract »    Full Text »    PDF »
The Fission Yeast git5 Gene Encodes a G{beta} Subunit Required for Glucose-Triggered Adenylate Cyclase Activation.
S. Landry, M. T. Pettit, E. Apolinario, and C. S. Hoffman (2000)
Genetics 154, 1463-1471
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Trypsin Stimulates Integrin alpha 5beta 1-dependent Adhesion to Fibronectin and Proliferation of Human Gastric Carcinoma Cells through Activation of Proteinase-activated Receptor-2.
S. Miyata, N. Koshikawa, H. Yasumitsu, and K. Miyazaki (2000)
J. Biol. Chem. 275, 4592-4598
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Coupling of the Muscarinic m2 Receptor to G Protein-activated K+ Channels via Galpha z and a Receptor-Galpha z Fusion Protein. FUSION BETWEEN THE RECEPTOR AND Galpha z ELIMINATES CATALYTIC (COLLISION) COUPLING.
D. Vorobiov, A. K. Bera, T. Keren-Raifman, R. Barzilai, and N. Dascal (2000)
J. Biol. Chem. 275, 4166-4170
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Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein alpha Subunits in Go, G11, and G16.
B. Yu, L. Gu, and M. I. Simon (2000)
J. Biol. Chem. 275, 71-76
   Abstract »    Full Text »    PDF »
The Molecular Basis for Distinct {beta}-Adrenergic Receptor Subtype Actions in Cardiomyocytes.
S. F. Steinberg (1999)
Circ. Res. 85, 1101-1111
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Physiological Regulation of G Protein-Linked Signaling.
A. J. Morris and C. C. Malbon (1999)
Physiol Rev 79, 1373-1430
   Abstract »    Full Text »    PDF »
Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease.
N. Dzimiri (1999)
Pharmacol. Rev. 51, 465-502
   Abstract »    Full Text »    PDF »
Regulation of Signal Transduction Pathways and Gene Expression by Mood Stabilizers and Antidepressants.
G. Chen, K. A. Hasanat, J. M. Bebchuk, G. J. Moore, D. Glitz, and H. K. Manji (1999)
Psychosom Med 61, 599-617
   Abstract »    Full Text »    PDF »



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