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Science 10 May 1991: Vol. 252. no. 5007, pp. 802 - 808 DOI: 10.1126/science.1902986
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Articles
Science, Vol 252, Issue 5007, 802-808
Copyright © 1991 by American Association for the Advancement of Science
Diversity of G proteins in signal transduction
MI Simon,
MP Strathmann,
and
N Gautam
Division of Biology, California Institute of Technology, Pasadena 91125.
The heterotrimeric guanine nucleotide-binding proteins (G proteins) act as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors. The G proteins are present in all eukaryotic cells, and they control metabolic, humoral, neural, and developmental functions. More than a hundred different kinds of receptors and many different effectors have been described. The G proteins that coordinate receptor-effector activity are derived from a large gene family. At present, the family is known to contain at least sixteen different genes that encode the alpha subunit of the heterotrimer, four that encode beta subunits, and multiple genes encoding gamma subunits. Specific transient interactions between these components generate the pathways that modulate cellular responses to complex chemical signals.
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| Abstract »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
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| Abstract »
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| Abstract »
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22, 8379-8390
| Abstract »
| Full Text »
| PDF »
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- R. A. Lynch, L. Wagoner, S. Li, L. Sparks, J. Molkentin, and G. W. Dorn II (2002)
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10, 159-168
| Abstract »
| Full Text »
| PDF »
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- S. Hollinger and J. R. Hepler (2002)
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54, 527-559
| Abstract »
| Full Text »
| PDF »
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- J. L. Gu, S. Muller, V. Mancino, S. Offermanns, and M. I. Simon (2002)
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| Abstract »
| Full Text »
| PDF »
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277, 25707-25714
| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
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301, 1179-1189
| Abstract »
| Full Text »
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| Abstract »
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| Abstract »
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- G{{alpha}}16 Couples Chemoattractant Receptors to NF-{{kappa}}B Activation.
- M. Yang, H. Sang, A. Rahman, D. Wu, A. B. Malik, and R. D. Ye (2001)
J. Immunol.
166, 6885-6892
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- Oxytocin and its Receptor in the Process of Parturition.
- B. F. Mitchell and B. Schmid (2001)
Reproductive Sciences
8, 122-133
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- The G-Protein {beta}-Subunit GPB-2 in Caenorhabditis elegans Regulates the Go{{alpha}}-Gq{{alpha}} Signaling Network Through Interactions With the Regulator of G-Protein Signaling Proteins EGL-10 and EAT-16.
- A. M. van der Linden, F. Simmer, E. Cuppen, and R. H. A. Plasterk (2001)
Genetics
158, 221-235
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- The git5 G{beta} and git11 G{{gamma}} Form an Atypical G{beta}{{gamma}} Dimer Acting in the Fission Yeast Glucose/cAMP Pathway.
- S. Landry and C. S. Hoffman (2001)
Genetics
157, 1159-1168
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- Lymphocytes from spontaneously hypertensive rats exhibit enhanced adenylyl cyclase-Gi protein signaling.
- J. Marcil and M. B. Anand-Srivastava (2001)
Cardiovasc Res
49, 234-243
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- Signal Transduction Cascades Regulating Fungal Development and Virulence.
- K. B. Lengeler, R. C. Davidson, C. D'souza, T. Harashima, W.-C. Shen, P. Wang, X. Pan, M. Waugh, and J. Heitman (2000)
Microbiol. Mol. Biol. Rev.
64, 746-785
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- The Melanin-Concentrating Hormone Receptor Couples to Multiple G Proteins to Activate Diverse Intracellular Signaling Pathways.
- B. E. Hawes, E. Kil, B. Green, K. O'Neill, S. Fried, and M. P. Graziano (2000)
Endocrinology
141, 4524-4532
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- Calcium/Calmodulin-Dependent Protein Kinase II Regulates Caenorhabditis elegans Locomotion in Concert With a Go/Gq Signaling Network.
- M. Robatzek and J. H. Thomas (2000)
Genetics
156, 1069-1082
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- Volume overload cardiac hypertrophy exhibits decreased expression of Gsalpha and not of Gialpha in heart.
- F. Di Fusco, S. Hashim, and M. B. Anand-Srivastava (2000)
Am J Physiol Cell Physiol
279, C990-C998
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- Role of pertussis toxin-sensitive G protein in metabolic vasodilation of coronary microcirculation.
- T. Tanikawa, H. Kanatsuka, R. Koshida, M. Tanaka, A. Sugimura, T. Kumagai, M. Miura, T. Komaru, and K. Shirato (2000)
Am J Physiol Heart Circ Physiol
279, H1819-H1829
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- Cannabinoid CB1 Receptor-Mediated Inhibition of Prolactin Release and Signaling Mechanisms in GH4C1 Cells.
- B. Y. Ho, A. Stadnicka, P. L. Prather, A. R. Buckley, L. L. Current, Z. J. Bosnjak, and W.-M. Kwok (2000)
Endocrinology
141, 1675-1685
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- The Fission Yeast git5 Gene Encodes a G{beta} Subunit Required for Glucose-Triggered Adenylate Cyclase Activation.
- S. Landry, M. T. Pettit, E. Apolinario, and C. S. Hoffman (2000)
Genetics
154, 1463-1471
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- Trypsin Stimulates Integrin alpha 5beta 1-dependent Adhesion to Fibronectin and Proliferation of Human Gastric Carcinoma Cells through Activation of Proteinase-activated Receptor-2.
- S. Miyata, N. Koshikawa, H. Yasumitsu, and K. Miyazaki (2000)
J. Biol. Chem.
275, 4592-4598
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- Coupling of the Muscarinic m2 Receptor to G Protein-activated K+ Channels via Galpha z and a Receptor-Galpha z Fusion Protein. FUSION BETWEEN THE RECEPTOR AND Galpha z ELIMINATES CATALYTIC (COLLISION) COUPLING.
- D. Vorobiov, A. K. Bera, T. Keren-Raifman, R. Barzilai, and N. Dascal (2000)
J. Biol. Chem.
275, 4166-4170
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- Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein alpha Subunits in Go, G11, and G16.
- B. Yu, L. Gu, and M. I. Simon (2000)
J. Biol. Chem.
275, 71-76
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- The Molecular Basis for Distinct {beta}-Adrenergic Receptor Subtype Actions in Cardiomyocytes.
- S. F. Steinberg (1999)
Circ. Res.
85, 1101-1111
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- Physiological Regulation of G Protein-Linked Signaling.
- A. J. Morris and C. C. Malbon (1999)
Physiol Rev
79, 1373-1430
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- Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease.
- N. Dzimiri (1999)
Pharmacol. Rev.
51, 465-502
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- Regulation of Signal Transduction Pathways and Gene Expression by Mood Stabilizers and Antidepressants.
- G. Chen, K. A. Hasanat, J. M. Bebchuk, G. J. Moore, D. Glitz, and H. K. Manji (1999)
Psychosom Med
61, 599-617
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