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Science 3 May 1991:
Vol. 252. no. 5006, pp. 722 - 724
DOI: 10.1126/science.1850871
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Articles

Science, Vol 252, Issue 5006, 722-724
Copyright © 1991 by American Association for the Advancement of Science

articles

Transmission between pairs of hippocampal slice neurons: quantal levels, oscillations, and LTP

R Malinow

Department of Molecular and Cellular Physiology, Stanford University, CA 94305.

Long-term potentiation (LTP) of synaptic transmission after coincident pre- and postsynaptic activity is considered a cellular model of changes underlying learning and memory. In intact tissue, LTP has been observed only between populations of neurons, making analysis of mechanisms difficult. Transmission between individual pre- and postsynaptic hippocampal cells was studied, suggesting quantal amplitude distributions with little variability in quantal size. LTP between such pairs is manifested by large, persistent, and synapse-specific potentiation with a shift in amplitude distribution that suggests presynaptic changes. Oscillations in amplitude of transmission, apparently of presynaptic origin, are common and can be triggered by LTP.


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