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Science 3 May 1991:
Vol. 252. no. 5006, pp. 718 - 721
DOI: 10.1126/science.2024124
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Articles

Science, Vol 252, Issue 5006, 718-721
Copyright © 1991 by American Association for the Advancement of Science

articles

Biohybrid artificial pancreas: long-term implantation studies in diabetic, pancreatectomized dogs

SJ Sullivan, T Maki, KM Borland, MD Mahoney, BA Solomon, TE Muller, AP Monaco, and WL Chick

BioHybrid Technologies, Inc., Shrewsbury, MA 01545.

Diabetic complications such as neuropathy, retinopathy, and renal and cardiovascular disease continue to pose major health risks for diabetic patients. Consequently, much effort has focused on approaches that could replace conventional insulin therapy and provide more precise regulation of blood glucose levels. The biohybrid perfused artificial pancreas was designed to incorporate islet tissue and a selectively permeable membrane that isolates this tissue from the immune system of the recipient. Biohybrid pancreas devices containing canine islet allografts were implanted in ten pancreatectomized dogs requiring 18 to 32 units of injected insulin daily. These implants resulted in good control of fasting glucose levels in six of these animals without further exogenous insulin for periods of up to 5 months.


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