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Science 3 May 1991:
Vol. 252. no. 5006, pp. 715 - 718
DOI: 10.1126/science.1827210
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Articles
Science, Vol 252, Issue 5006, 715-718
Copyright © 1991 by American Association for the Advancement of Science
Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein
S Khusmith,
Y Charoenvit,
S Kumar,
M Sedegah,
RL Beaudoin,
and
SL Hoffman
Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889.
The circumsporozoite (CS) protein has been the target for development of malaria sporozoite vaccines for a decade. However, immunization with subunit vaccines based on the CS protein has never given the complete protection found after immunization with irradiated sporozoites. BALB/c mice immunized with irradiated Plasmodium yoelii sporozoites produced antibodies and cytotoxic T cells against a 140-kilodalton protein, sporozoite surface protein 2 (SSP2). Mice immunized with P815 cells that had been transfected with either SSP2 or CS genes were partially protected, and those immunized with a mixture of SSP2 and CS transfectants were completely protected against malaria. These studies emphasize the importance of vaccine delivery systems in achieving protection and define a multi-antigen sporozoite vaccine.
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