Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 May 1991:
Vol. 252. no. 5006, pp. 706 - 709
DOI: 10.1126/science.2024123
Prev | Table of Contents | Next

Articles

Science, Vol 252, Issue 5006, 706-709
Copyright © 1991 by American Association for the Advancement of Science

articles

Identification of p53 gene mutations in bladder cancers and urine samples

D Sidransky, A Von Eschenbach, YC Tsai, P Jones, I Summerhayes, F Marshall, M Paul, P Green, Hamilton SR, P Frost, and al. et

Department of Oncology, Johns Hopkins University, Baltimore, MD 21231.

Although bladder cancers are very common, little is known about their molecular pathogenesis. In this study, invasive bladder cancers were evaluated for the presence of gene mutations in the p53 suppressor gene. Of 18 tumors evaluated, 11 (61 percent) were found to have genetic alterations of p53. The alterations included ten point mutations resulting in single amino acid substitutions, and one 24-base pair deletion. In all but one case, the mutations were associated with chromosome 17p allelic deletions, leaving the cells with only mutant forms of the p53 gene products. Through the use of the polymerase chain reaction and oligomer-specific hybridization, p53 mutations were identified in 1 to 7 percent of the cells within the urine sediment of each of three patients tested. The p53 mutations are the first genetic alterations demonstrated to occur in a high proportion of primary invasive bladder cancers. Detection of such mutations ex vivo has clinical implications for monitoring individuals whose tumor cells are shed extracorporeally.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
KRAS Mutations and Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer: Practical Application of Patient Selection.
A. Jimeno, W. A. Messersmith, F. R. Hirsch, W. A. Franklin, and S. G. Eckhardt (2009)
J. Clin. Oncol. 27, 1130-1136
   Abstract »    Full Text »    PDF »
Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer.
M. Brait, S. Begum, A. L. Carvalho, S. Dasgupta, A. L. Vettore, B. Czerniak, O. L. Caballero, W. H. Westra, D. Sidransky, and M. O. Hoque (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 2786-2794
   Abstract »    Full Text »    PDF »
p53 Gene and Protein Status: The Role of p53 Alterations in Predicting Outcome in Patients With Bladder Cancer.
B. George, R. H. Datar, L. Wu, J. Cai, N. Patten, S. J. Beil, S. Groshen, J. Stein, D. Skinner, P. A. Jones, et al. (2007)
J. Clin. Oncol. 25, 5352-5358
   Abstract »    Full Text »    PDF »
Detection of Aberrant Methylation of Four Genes in Plasma DNA for the Detection of Breast Cancer.
M. O. Hoque, Q. Feng, P. Toure, A. Dem, C. W. Critchlow, S. E. Hawes, T. Wood, C. Jeronimo, E. Rosenbaum, J. Stern, et al. (2006)
J. Clin. Oncol. 24, 4262-4269
   Abstract »    Full Text »    PDF »
Molecular Screening Testing for Colorectal Cancer.
B. Levin (2006)
Clin. Cancer Res. 12, 5014-5017
   Full Text »    PDF »
Phase I, Pharmacokinetic, and Pharmacodynamic Study of Intravenously Administered Ad5CMV-p53, an Adenoviral Vector Containing the Wild-Type p53 Gene, in Patients With Advanced Cancer.
A. W. Tolcher, D. Hao, J. de Bono, A. Miller, A. Patnaik, L. A. Hammond, L. Smetzer, J. Van Wart Hood, J. Merritt, E. K. Rowinsky, et al. (2006)
J. Clin. Oncol. 24, 2052-2058
   Abstract »    Full Text »    PDF »
Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?.
M. A. Knowles (2006)
Carcinogenesis 27, 361-373
   Abstract »    Full Text »    PDF »
Carcinogen exposure and gene promoter hypermethylation in bladder cancer.
C. J. Marsit, M. R. Karagas, H. Danaee, M. Liu, A. Andrew, A. Schned, H. H. Nelson, and K. T. Kelsey (2006)
Carcinogenesis 27, 112-116
   Abstract »    Full Text »    PDF »
Increased Expression of the Polycomb Group Gene, EZH2, in Transitional Cell Carcinoma of the Bladder.
J. D. Raman, N. P. Mongan, S. K. Tickoo, S. A. Boorjian, D. S. Scherr, and L. J. Gudas (2005)
Clin. Cancer Res. 11, 8570-8576
   Abstract »    Full Text »    PDF »
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
F. Diehl, M. Li, D. Dressman, Y. He, D. Shen, S. Szabo, L. A. Diaz Jr, S. N. Goodman, K. A. David, H. Juhl, et al. (2005)
PNAS 102, 16368-16373
   Abstract »    Full Text »    PDF »
Quantitative Methylation-Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distinguish Prostate Cancer Patients From Control Subjects.
M. O. Hoque, O. Topaloglu, S. Begum, R. Henrique, E. Rosenbaum, W. Van Criekinge, W. H. Westra, and D. Sidransky (2005)
J. Clin. Oncol. 23, 6569-6575
   Abstract »    Full Text »    PDF »
Molecular Evidence Supporting Field Effect in Urothelial Carcinogenesis.
T. D. Jones, M. Wang, J. N. Eble, G. T. MacLennan, A. Lopez-Beltran, S. Zhang, A. Cocco, and L. Cheng (2005)
Clin. Cancer Res. 11, 6512-6519
   Abstract »    Full Text »    PDF »
Molecular Genetic Evidence for a Common Clonal Origin of Urinary Bladder Small Cell Carcinoma and Coexisting Urothelial Carcinoma.
L. Cheng, T. D. Jones, R. P. McCarthy, J. N. Eble, M. Wang, G. T. MacLennan, A. Lopez-Beltran, X. J. Yang, M. O. Koch, S. Zhang, et al. (2005)
Am. J. Pathol. 166, 1533-1539
   Abstract »    Full Text »    PDF »
The T393C Polymorphism of the G{alpha}s Gene (GNAS1) Is a Novel Prognostic Marker in Bladder Cancer.
U. H. Frey, A. Eisenhardt, G. Lummen, H. Rubben, K.-H. Jockel, K. W. Schmid, and W. Siffert (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 871-877
   Abstract »    Full Text »    PDF »
Clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast.
B. Schlichtholz, M. Presler, and M. Matuszewski (2004)
Carcinogenesis 25, 2319-2323
   Abstract »    Full Text »    PDF »
Profiling the Evolution of Human Metastatic Bladder Cancer.
B. E. Nicholson, H. F. Frierson, M. R. Conaway, J. M. Seraj, M. A. Harding, G. M. Hampton, and D. Theodorescu (2004)
Cancer Res. 64, 7813-7821
   Abstract »    Full Text »    PDF »
p53 Heterozygosity Results in an Increased 2-Acetylaminofluorene-Induced Urinary Bladder but not Liver Tumor Response in DNA Repair-Deficient Xpa Mice.
E. M. Hoogervorst, C. Th. M. van Oostrom, R. B. Beems, J. van Benthem, S. Gielis, J. P. Vermeulen, P. W. Wester, J. G. Vos, A. de Vries, and H. van Steeg (2004)
Cancer Res. 64, 5118-5126
   Abstract »    Full Text »    PDF »
Quantitative Detection of Promoter Hypermethylation of Multiple Genes in the Tumor, Urine, and Serum DNA of Patients with Renal Cancer.
M. O. Hoque, S. Begum, O. Topaloglu, C. Jeronimo, E. Mambo, W. H. Westra, J. A. Califano, and D. Sidransky (2004)
Cancer Res. 64, 5511-5517
   Abstract »    Full Text »    PDF »
Induction of Centrosome Amplification and Chromosome Instability in Human Bladder Cancer Cells by p53 Mutation and Cyclin E Overexpression.
K. Kawamura, H. Izumi, Z. Ma, R. Ikeda, M. Moriyama, T. Tanaka, T. Nojima, L. S. Levin, K. Fujikawa-Yamamoto, K. Suzuki, et al. (2004)
Cancer Res. 64, 4800-4809
   Abstract »    Full Text »    PDF »
Molecular Diagnosis of Surgical Margins and Local Recurrence in Head and Neck Cancer Patients: A Prospective Study.
V. M. M. van Houten, C. R. Leemans, J. A. Kummer, J. Dijkstra, D. J. Kuik, M. W. M. van den Brekel, G. B. Snow, and R. H. Brakenhoff (2004)
Clin. Cancer Res. 10, 3614-3620
   Abstract »    Full Text »    PDF »
Real-Time Gap Ligase Chain Reaction: A Rapid Semiquantitative Assay for Detecting p53 Mutation at Low Levels in Surgical Margins and Lymph Nodes from Resected Lung and Head and Neck Tumors.
S. V. Harden, D. C. Thomas, N. Benoit, K. Minhas, W. H. Westra, J. A. Califano, W. Koch, and D. Sidransky (2004)
Clin. Cancer Res. 10, 2379-2385
   Abstract »    Full Text »    PDF »
p53 and RB: Simple Interesting Correlates or Tumor Markers of Critical Predictive Nature?.
C. Cordon-Cardo (2004)
J. Clin. Oncol. 22, 975-977
   Full Text »    PDF »
Combined Effects of p53, p21, and pRb Expression in the Progression of Bladder Transitional Cell Carcinoma.
S. J. Chatterjee, R. Datar, D. Youssefzadeh, B. George, P. J. Goebell, J. P. Stein, L. Young, S.-R. Shi, C. Gee, S. Groshen, et al. (2004)
J. Clin. Oncol. 22, 1007-1013
   Abstract »    Full Text »    PDF »
Detection of Bladder Cancer in Urine by a Tumor Suppressor Gene Hypermethylation Panel.
E. Dulaimi, R. G. Uzzo, R. E. Greenberg, T. Al-Saleem, and P. Cairns (2004)
Clin. Cancer Res. 10, 1887-1893
   Abstract »    Full Text »    PDF »
TSLC1 Gene Silencing in Cervical Cancer Cell Lines and Cervical Neoplasia.
R. D. M. Steenbergen, D. Kramer, B. J. M. Braakhuis, P. L. Stern, R. H. M. Verheijen, C. J. L. M. Meijer, and P. J. F. Snijders (2004)
J Natl Cancer Inst 96, 294-305
   Abstract »    Full Text »    PDF »
p53 Mutations in Bladder Cancer: Evidence for Exogenous versus Endogenous Risk Factors.
J. C. Schroeder, K. Conway, Y. Li, K. Mistry, D. A. Bell, and J. A. Taylor (2003)
Cancer Res. 63, 7530-7538
   Abstract »    Full Text »    PDF »
DNA Enrichment by Allele-Specific Hybridization (DEASH): A Novel Method for Haplotyping and for Detecting Low-Frequency Base Substitutional Variants and Recombinant DNA Molecules.
A. J. Jeffreys and C. A. May (2003)
Genome Res. 13, 2316-2324
   Abstract »    Full Text »    PDF »
High-Throughput Molecular Analysis of Urine Sediment for the Detection of Bladder Cancer by High-Density Single-Nucleotide Polymorphism Array.
M. O. Hoque, J. Lee, S. Begum, K. Yamashita, J. M. Engles, M. Schoenberg, W. H. Westra, and D. Sidransky (2003)
Cancer Res. 63, 5723-5726
   Abstract »    Full Text »    PDF »
Microsatellite Changes in Nipple Aspirate Fluid and Breast Tissue from Women with Breast Carcinoma or Its Precursors.
W. Zhu, W. Qin, H. Ehya, J. Lininger, and E. Sauter (2003)
Clin. Cancer Res. 9, 3029-3033
   Abstract »    Full Text »    PDF »
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations.
D. Dressman, H. Yan, G. Traverso, K. W. Kinzler, and B. Vogelstein (2003)
PNAS 100, 8817-8822
   Abstract »    Full Text »    PDF »
Efficient Therapeutic Gene Delivery after Systemic Administration of a Novel Polyethylenimine/DNA Vector in an Orthotopic Bladder Cancer Model.
P. Sweeney, T. Karashima, H. Ishikura, S. Wiehle, M. Yamashita, W. F. Benedict, R. J. Cristiano, and C. P. N. Dinney (2003)
Cancer Res. 63, 4017-4020
   Abstract »    Full Text »    PDF »
p53 Mutations and Survival in Stage I Non-Small-Cell Lung Cancer: Results of a Prospective Study.
S. A. Ahrendt, Y. Hu, M. Buta, M. P. McDermott, N. Benoit, S. C. Yang, L. Wu, and D. Sidransky (2003)
J Natl Cancer Inst 95, 961-970
   Abstract »    Full Text »    PDF »
A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up.
B M Ryan, F Lefort, R McManus, J Daly, P W N Keeling, D G Weir, and D Kelleher (2003)
Mol. Pathol. 56, 172-179
   Abstract »    Full Text »    PDF »
A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up.
B M Ryan, F Lefort, R McManus, J Daly, P W N Keeling, D G Weir, and D Kelleher (2003)
Gut 52, 101-108
   Abstract »    Full Text »    PDF »
Tumor DNA in Plasma at Diagnosis of Breast Cancer Patients Is a Valuable Predictor of Disease-free Survival.
J. M. Silva, J. Silva, A. Sanchez, J. M. Garcia, G. Dominguez, M. Provencio, L. Sanfrutos, E. Jareno, A. Colas, P. Espana, et al. (2002)
Clin. Cancer Res. 8, 3761-3766
   Abstract »    Full Text »    PDF »
Multiple Head and Neck Tumors Frequently Originate from a Single Preneoplastic Lesion.
M. P. Tabor, R. H. Brakenhoff, H. J. Ruijter-Schippers, J. E. van der Wal, G. B. Snow, C. R. Leemans, and B. J. M. Braakhuis (2002)
Am. J. Pathol. 161, 1051-1060
   Abstract »    Full Text »    PDF »
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
M. Wei, H. Wanibuchi, K. Morimura, S. Iwai, K. Yoshida, G. Endo, D. Nakae, and S. Fukushima (2002)
Carcinogenesis 23, 1387-1397
   Abstract »    Full Text »    PDF »
Mutational Signature of the Proximate Bladder Carcinogen N-Hydroxy-4-acetylaminobiphenyl: Inconsistency with the p53 Mutational Spectrum in Bladder Cancer.
A. Besaratinia, S. E. Bates, and G. P. Pfeifer (2002)
Cancer Res. 62, 4331-4338
   Abstract »    Full Text »    PDF »
Diagnosis of Genito-Urinary Tract Cancer by Detection of Minichromosome Maintenance 5 Protein in Urine Sediments.
K. Stoeber, R. Swinn, A. T. Prevost, P. de Clive-Lowe, I. Halsall, S. M. Dilworth, J. Marr, W. H. Turner, N. Bullock, A. Doble, et al. (2002)
J Natl Cancer Inst 94, 1071-1079
   Abstract »    Full Text »    PDF »
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: Preliminary results of a prospective study.
S. A. Ahrendt, S. C. Yang, L. Wu, C. M. Roig, P. Russell, W. H. Westra, J. Jen, M. V. Brock, R. F. Heitmiller, and D. Sidransky (2002)
J. Thorac. Cardiovasc. Surg. 123, 466-474
   Abstract »    Full Text »    PDF »
Genetic Heterogeneity in Saliva from Patients with Oral Squamous Carcinomas: Implications in Molecular Diagnosis and Screening.
A. K. El-Naggar, L. Mao, G. Staerkel, M. M. Coombes, S. L. Tucker, M. A. Luna, G. L. Clayman, S. Lippman, and H. Goepfert (2001)
J. Mol. Diagn. 3, 164-170
   Abstract »    Full Text »    PDF »
Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-) knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Y. Mori, A. Koide, K. Fuwa, H. Wanibuchi, and S. Fukushima (2001)
Mutagenesis 16, 377-383
   Abstract »    Full Text »    PDF »
What we could do now: molecular pathology of bladder cancer.
M A Knowles (2001)
Mol. Pathol. 54, 215-221
   Abstract »    Full Text »    PDF »
Persistence of Genetically Altered Fields in Head and Neck Cancer Patients: Biological and Clinical Implications.
M. P. Tabor, R. H. Brakenhoff, V. M. M. van Houten, J. A. Kummer, M. H. J. Snel, P. J. F. Snijders, G. B. Snow, C. R. Leemans, and B. J. M. Braakhuis (2001)
Clin. Cancer Res. 7, 1523-1532
   Abstract »    Full Text »    PDF »
Filling the Void: Urinary Markers for Bladder Cancer Risk and Diagnosis.
A. F. Gazdar and B. Czerniak (2001)
J Natl Cancer Inst 93, 413-414
   Full Text »    PDF »
Cytogenetic Analysis of Multifocal Bladder Cancer Supports a Monoclonal Origin and Intraepithelial Spread of Tumor Cells.
R. Simon, E. Eltze, K.-L. Schäfer, H. Bürger, A. Semjonow, L. Hertle, B. Dockhorn-Dworniczak, H.-J. Terpe, and W. Böcker (2001)
Cancer Res. 61, 355-362
   Abstract »    Full Text »
Lung Cancer Detection in the 21st Century: Potential Contributions and Challenges of Emerging Technologies.
P. M. Boiselle, A. Ernst, and D. D. Karp (2000)
Am. J. Roentgenol. 175, 1215-1221
   Full Text »    PDF »
Molecular Assays for the Diagnosis of Minimal Residual Head-and-Neck Cancer: Methods, Reliability, Pitfalls, and Solutions.
V. M. M. van Houten, M. P. Tabor, M. W. M. van den Brekel, F. Denkers, R. G. A. Wishaupt, J. A. Kummer, G. B. Snow, and R. H. Brakenhoff (2000)
Clin. Cancer Res. 6, 3803-3816
   Abstract »    Full Text »
Evaluation of Microsatellite Analysis in Urine Sediment for Diagnosis of Bladder Cancer.
A. Schneider, S. Borgnat, H. Lang, O. Régine, V. Lindner, M. Kassem, C. Saussine, P. Oudet, D. Jacqmin, and M. P. Gaub (2000)
Cancer Res. 60, 4617-4622
   Abstract »    Full Text »
Alcohol Consumption and Cigarette Smoking Increase the Frequency of p53 Mutations in Non-Small Cell Lung Cancer.
S. A. Ahrendt, J. T. Chow, S. C. Yang, L. Wu, M.-J. Zhang, J. Jen, and D. Sidransky (2000)
Cancer Res. 60, 3155-3159
   Abstract »    Full Text »
Detection by Denaturant Gradient Gel Electrophoresis of Tumor-specific Mutations in Biopsies and Relative Bronchoalveolar Lavage Fluid from Resectable Non-Small Cell Lung Cancer.
G. Ferretti, G. Curigliano, U. Pastorino, A. Cittadini, G. Flamini, M. G. Calabrò, Tommaso De Pas, L. Orlando, M. Mandalà, M. Colleoni, et al. (2000)
Clin. Cancer Res. 6, 2393-2400
   Abstract »    Full Text »
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers.
M. L. Gillison, W. M. Koch, R. B. Capone, M. Spafford, W. H. Westra, L. Wu, M. L. Zahurak, R. W. Daniel, M. Viglione, D. E. Symer, et al. (2000)
J Natl Cancer Inst 92, 709-720
   Abstract »    Full Text »    PDF »
Inhibitory effects of 1,3-diaminopropane, an ornithine decarboxylase inhibitor, on rat two-stage urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
E. I. Salim, H. Wanibuchi, K. Morimura, S. Kim, Y. Yano, S. Yamamoto, and S. Fukushima (2000)
Carcinogenesis 21, 195-203
   Abstract »    Full Text »    PDF »
Drug-induced Apoptosis in Lung Cancer Cells Is Not Mediated by the Fas/FasL (CD95/APO1) Signaling Pathway.
C. G. Ferreira, C. Tolis, S. W. Span, G. J. Peters, T. van Lopik, A. J. Kummer, H. M. Pinedo, and G. Giaccone (2000)
Clin. Cancer Res. 6, 203-212
   Abstract »    Full Text »
Digital PCR.
B. Vogelstein and K. W. Kinzler (1999)
PNAS 96, 9236-9241
   Abstract »    Full Text »    PDF »
Specific p53 Gene Mutations in Urinary Bladder Epithelium after the Chernobyl Accident.
S. Yamamoto, A. Romanenko, M. Wei, C. Masuda, W. Zaparin, W. Vinnichenko, A. Vozianov, C. C. R. Lee, K. Morimura, H. Wanibuchi, et al. (1999)
Cancer Res. 59, 3606-3609
   Abstract »    Full Text »    PDF »
Presence of Tumor DNA in Plasma of Breast Cancer Patients: Clinicopathological Correlations.
J. M. Silva, G. Dominguez, J. M. Garcia, R. Gonzalez, M. J. Villanueva, F. Navarro, M. Provencio, S. San Martin, P. Espana, and F. Bonilla (1999)
Cancer Res. 59, 3251-3256
   Abstract »    Full Text »    PDF »
Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array.
S. A. Ahrendt, S. Halachmi, J. T. Chow, L. Wu, N. Halachmi, S. C. Yang, S. Wehage, J. Jen, and D. Sidransky (1999)
PNAS 96, 7382-7387
   Abstract »    Full Text »    PDF »
Detection of Mutations of p53 Tumor Suppressor Gene in Pancreatic Juice and Its Application to Diagnosis of Patients with Pancreatic Cancer: Comparison with K-ras Mutation.
Y. Yamaguchi, H. Watanabe, S. Yrdiran, K. Ohtsubo, Y. Motoo, T. Okai, and N. Sawabu (1999)
Clin. Cancer Res. 5, 1147-1153
   Abstract »    Full Text »    PDF »
LOH and mutational analysis of p53 alleles in mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.
K. Morimura, S. Yamamoto, T. Murai, S. Mori, T.-X. Chen, H. Wanibuchi, and S. Fukushima (1999)
Carcinogenesis 20, 715-718
   Abstract »    Full Text »    PDF »
Detection of K-ras Mutations of Bronchoalveolar Lavage Fluid Cells Aids the Diagnosis of Lung Cancer in Small Pulmonary Lesions.
F. Oshita, I. Nomura, K. Yamada, Y. Kato, G. Tanaka, and K. Noda (1999)
Clin. Cancer Res. 5, 617-620
   Abstract »    Full Text »    PDF »
Urinary Bladder Transitional Cell Carcinogenesis Is Associated with Down-Regulation of NF1 Tumor Suppressor Gene in Vivo and in Vitro.
V. Aaltonen, P. J. Bostrom, K.-O. Soderstrom, O. Hirvonen, J. Tuukkanen, M. Nurmi, M. Laato, and J. Peltonen (1999)
Am. J. Pathol. 154, 755-765
   Abstract »    Full Text »    PDF »
Relationship between Schistosomiasis and Bladder Cancer.
M. H. Mostafa, S. A. Sheweita, and P. J. O'Connor (1999)
Clin. Microbiol. Rev. 12, 97-111
   Abstract »    Full Text »    PDF »
Detection of H-ras Mutations in Urine Sediments by a Mutant-enriched PCR Technique.
J. R. Conejo, T. Parra, M. Cantero, A. Jimenez, V. Granizo, V. Gabriel de Arriba, and F. Carballo (1998)
Clin. Chem. 44, 1570-1572
   Full Text »    PDF »
Review : p53 in the pathogenesis, diagnosis, and treatment of cancer.
E. Perz and J. G. Kuhn (1998)
Journal of Oncology Pharmacy Practice 4, 75-102
   Abstract »    PDF »
Science, medicine, and the future: Molecular assessment of cancer.
C. Caldas (1998)
BMJ 316, 1360-1363
   Full Text »
Rearranged Ig Heavy Chain DNA Is Detectable in Cell-Free Blood Samples of Patients With B-Cell Neoplasia.
N. Frickhofen, E. Muller, M. Sandherr, T. Binder, M. Bangerter, C. Wiest, M. Enz, and H. Heimpel (1997)
Blood 90, 4953-4960
   Abstract »    Full Text »    PDF »
Nucleic Acid-Based Methods for the Detection of Cancer.
D. Sidransky (1997)
Science 278, 1054-1058
   Abstract »    Full Text »
p53 Protein and Proliferating Cell Nuclear Antigen (PCNA) Expression in Small Round Cell Tumors of Bone and Adjacent Soft Tissue: A Study of 60 Cases.
K. Devaney, S. L. Abbondanzo, K. M. Shekitka, R. B. Wolov, and D. E. Sweet (1995)
International Journal of Surgical Pathology 2, 259-267
   Abstract »    PDF »
Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck.
J. A. Brennan, J. O. Boyle, W. M. Koch, S. N. Goodman, R. H. Hruban, Y. J. Eby, M. J. Couch, A. A. Forastiere, and D. Sidransky (1995)
N. Engl. J. Med. 332, 712-717
   Abstract »    Full Text »    PDF »
Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck.
J. A. Brennan, L. Mao, R. H. Hruban, J. O. Boyle, Y. J. Eby, W. M. Koch, S. N. Goodman, and D. Sidransky (1995)
N. Engl. J. Med. 332, 429-435
   Abstract »    Full Text »    PDF »
Identification of the von Hippel-Lindau (VHL) Gene: Its Role in Renal Cancer.
W. M. Linehan, M. I. Lerman, and B. Zbar (1995)
JAMA 273, 564-570
   Abstract »    PDF »
Cell cycle control and cancer.
L. Hartwell and M. Kastan (1994)
Science 266, 1821-1828
   Abstract »    PDF »
Accumulation of Nuclear p53 and Tumor Progression in Bladder Cancer.
D. Esrig, D. Elmajian, S. Groshen, J. A. Freeman, J. P. Stein, S.-C. Chen, P. W. Nichols, D. G. Skinner, P. A. Jones, and R. J. Cote (1994)
N. Engl. J. Med. 331, 1259-1264
   Abstract »    Full Text »
Hubert Humphrey's Bladder Cancer.
R. J. Homer, W.J. Braund, R. H. Hruban, P. van der Riet, and D. Sidransky (1994)
N. Engl. J. Med. 331, 880-881
   Full Text »
Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells..
C A Reznikoff, C Belair, E Savelieva, Y Zhai, K Pfeifer, T Yeager, K J Thompson, S DeVries, C Bindley, and M A Newton (1994)
Genes & Dev. 8, 2227-2240
   Abstract »    PDF »
p53 Gene Mutations as Markers of Tumor Spread in Synchronous Oral Cancers.
W. M. Koch, J. O. Boyle, L. Mao, J. Hakim, R. H. Hruban, and D. Sidransky (1994)
Arch Otolaryngol Head Neck Surg 120, 943-947
   Abstract »    PDF »
Geographic variation of p53 mutational profile in nonmalignant human liver.
F Aguilar, C. Harris, T Sun, M Hollstein, and P Cerutti (1994)
Science 264, 1317-1319
   Abstract »    PDF »
Molecular Biology and the Early Detection of Carcinoma of the Bladder -- The Case of Hubert H. Humphrey.
R. H. Hruban, P. van der Riet, Y. S. Erozan, and D. Sidransky (1994)
N. Engl. J. Med. 330, 1276-1278
   Full Text »
Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells.
Y Matsumura, D Hanbury, J Smith, and D Tarin (1994)
BMJ 308, 619-624
   Abstract »    Full Text »
Poster Session.
(1993)
Toxicol Pathol 21, 623-646
   PDF »
Molecular Screening: Prospects for a New Approach.
D. Sidransky, J. Boyle, and W. Koch (1993)
Arch Otolaryngol Head Neck Surg 119, 1187-1190
   Abstract »    PDF »
Retrieval of p53 Protein in Paraffin-Embedded Head and Neck Tumor Tissues.
Z. P. Pavelic, L. G. Portugal, M. J. Gootee, P. J. Stambrook, C. Smith, R. E. Mugge, L. Pavelic, K. Wilson, C. R. Buncher, Y.-Q. Li, et al. (1993)
Arch Otolaryngol Head Neck Surg 119, 1206-1209
   Abstract »    PDF »
Sensitive two-stage PCR of p53 genomic DNA exons 5-9..
W C Kusser, D B Levin, and B W Glickman (1993)
Genome Res. 2, 250-252
   Abstract »    PDF »
Oncogenic forms of p53 inhibit p53-regulated gene expression.
S. Kern, J. Pietenpol, S Thiagalingam, A Seymour, K. Kinzler, and B Vogelstein (1992)
Science 256, 827-830
   Abstract »    PDF »
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
D Sidransky, T Tokino, Hamilton SR, K. Kinzler, B Levin, P Frost, and B Vogelstein (1992)
Science 256, 102-105
   Abstract »    PDF »
Tumor suppressor genes.
R. Weinberg (1991)
Science 254, 1138-1146
   Abstract »    PDF »
DEFECTS IN AN ANTIONCOGENE ARE LINKED TO BLADDER CANCER.
(1991)
Journal Watch (General) 1991, 6
   Full Text »
Regulation of Transformation and the Cell Cycle by p53.
G.P. Zambetti, R.S. Quartin, J. Martinez, I. Georgoff, J. Momand, D. Dittmer, C.A. Finlay, and A.J. Levine (1991)
Cold Spring Harb Symp Quant Biol 56, 219-225
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)