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Science 26 April 1991:
Vol. 252. no. 5005, pp. 579 - 582
DOI: 10.1126/science.2020855
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Articles

Science, Vol 252, Issue 5005, 579-582
Copyright © 1991 by American Association for the Advancement of Science

articles

Spatial control of gut-specific gene expression during Caenorhabditis elegans development

EJ Aamodt, MA Chung, and JD McGhee

Department of Medical Biochemistry, University of Calgary, Alberta, Canada.

The nematode Caenorhabditis elegans was transformed with constructs containing upstream deletions of the gut-specific ges-1 carboxylesterase gene. With particular deletions, ges-1 was expressed, not as normally in the gut, but rather in muscle cells of the pharynx (which belong to a sister lineage of the gut) or in body wall muscle and hypodermal cells (which belong to a cousin lineage of the gut). These observations suggest that gut-specific gene expression in C. elegans involves not only gut-specific activators but also multiple repressors that are present in particular nongut lineages.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The CRAL/TRIO and GOLD Domain Protein CGR-1 Promotes Induction of Vulval Cell Fates in Caenorhabditis elegans and Interacts Genetically With the Ras Signaling Pathway.
J. L. Goldstein, D. Glossip, S. Nayak, and K. Kornfeld (2006)
Genetics 172, 929-942
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Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates.
M. Belfiore, P. Pugnale, Z. Saudan, and A. Puoti (2004)
Development 131, 2935-2945
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DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF{beta} pathway to regulate C. elegans dauer development.
L. S. da Graca, K. K. Zimmerman, M. C. Mitchell, M. Kozhan-Gorodetska, K. Sekiewicz, Y. Morales, and G. I. Patterson,, (2004)
Development 131, 435-446
   Abstract »    Full Text »    PDF »
The Evolutionary Duplication and Probable Demise of an Endodermal GATA Factor in Caenorhabditis elegans.
T. Fukushige, B. Goszczynski, H. Tian, and J. D. McGhee (2003)
Genetics 165, 575-588
   Abstract »    Full Text »    PDF »
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System.
C. A. Wolkow, K. D. Kimura, M.-S. Lee, and G. Ruvkun (2000)
Science 290, 147-150
   Abstract »    Full Text »
Regulation of Metallothionein Gene Transcription. IDENTIFICATION OF UPSTREAM REGULATORY ELEMENTS AND TRANSCRIPTION FACTORS RESPONSIBLE FOR CELL-SPECIFIC EXPRESSION OF THE METALLOTHIONEIN GENES FROM CAENORHABDITIS ELEGANS.
L. H. Moilanen, T. Fukushige, and J. H. Freedman (1999)
J. Biol. Chem. 274, 29655-29665
   Abstract »    Full Text »    PDF »
pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx.
J. Kalb, K. Lau, B Goszczynski, T Fukushige, D Moons, P. Okkema, and J. McGhee (1998)
Development 125, 2171-2180
   Abstract »    PDF »
end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos.
J. Zhu, R. J. Hill, P. J. Heid, M. Fukuyama, A. Sugimoto, J. R. Priess, and J. H. Rothman (1997)
Genes & Dev. 11, 2883-2896
   Abstract »    Full Text »    PDF »
elt-2, a Second GATA Factor from the Nematode Caenorhabditis elegans.
M. G. Hawkins and J. D. McGhee (1995)
J. Biol. Chem. 270, 14666-14671
   Abstract »    Full Text »    PDF »
Establishment of gut fate in the E lineage of C. elegans: the roles of lineage-dependent mechanisms and cell interactions.
B Goldstein (1993)
Development 118, 1267-1277
   Abstract »    PDF »


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