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Science 26 April 1991:
Vol. 252. no. 5005, pp. 569 - 572
DOI: 10.1126/science.1708527
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Articles

Science, Vol 252, Issue 5005, 569-572
Copyright © 1991 by American Association for the Advancement of Science

articles

Determination of primary motoneuron identity in developing zebrafish embryos

JS Eisen

Institute of Neuroscience, University of Oregon, Eugene 97403.

The developmental determination of primary motoneurons was investigated by transplanting identified motoneurons in embryonic zebrafish to new spinal cord positions. Some cells moved from the new positions in which they were placed back to their original positions, thus it was difficult to evaluate whether they were determined. Among cells that remained in their new positions, those transplanted about 1 hour before axogenesis developed axonal trajectories that were appropriate for their original soma positions, whereas those transplanted 2 to 3 hours before axogenesis developed morphologies appropriate for their new soma positions. These results suggest that motoneuronal identity is determined before axogenesis.


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