Science 26 April 1991: Vol. 252. no. 5005, pp. 554 - 558 DOI: 10.1126/science.1850549

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Articles

Trk Receptor Expression and Inhibition in Neuroblastomas.

G. M. Brodeur, J. E. Minturn, R. Ho, A. M. Simpson, R. Iyer, C. R. Varela, J. E. Light, V. Kolla, and A. E. Evans (2009)
Clin. Cancer Res. 15, 3244-3250
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Mint2 with TrkA Is Involved in Regulation of Nerve Growth Factor-induced Neurite Outgrowth.

Y. Zhang, Y.-G. Wang, Q. Zhang, X.-J. Liu, X. Liu, L. Jiao, W. Zhu, Z.-H. Zhang, X.-L. Zhao, and C. He (2009)
J. Biol. Chem. 284, 12469-12479
 |  Abstract »  |  Full Text »  |  PDF »

p75 and TrkA Signaling Regulates Sympathetic Neuronal Firing Patterns via Differential Modulation of Voltage-Gated Currents.

J. A. Luther and S. J. Birren (2009)
J. Neurosci. 29, 5411-5424
 |  Abstract »  |  Full Text »  |  PDF »

Cardiovascular Actions of Neurotrophins.

A. Caporali and C. Emanueli (2009)
Physiol Rev 89, 279-308
 |  Abstract »  |  Full Text »  |  PDF »

Peroxisome Proliferator-activated Receptor {gamma} Up-regulates the Bcl-2 Anti-apoptotic Protein in Neurons and Induces Mitochondrial Stabilization and Protection against Oxidative Stress and Apoptosis.

K. Fuenzalida, R. Quintanilla, P. Ramos, D. Piderit, R. A. Fuentealba, G. Martinez, N. C. Inestrosa, and M. Bronfman (2007)
J. Biol. Chem. 282, 37006-37015
 |  Abstract »  |  Full Text »  |  PDF »

The effects of the sympathetic nerves on lumbar radicular pain: A BEHAVIOURAL AND IMMUNOHISTOCHEMICAL STUDY.

S. Mizuno, T. Takebayashi, T. Kirita, K. Tanimoto, N. Tohse, and T. Yamashita (2007)
J Bone Joint Surg Br 89-B, 1666-1672
 |  Abstract »  |  Full Text »  |  PDF »

The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain.

G. Ugolini, S. Marinelli, S. Covaceuszach, A. Cattaneo, and F. Pavone (2007)
PNAS 104, 2985-2990
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Nerve Growth Factor and Its Receptors NTRK1 and TNFRSF1B Is Regulated by Estrogen and Progesterone in the Uteri of Golden Hamsters.

Z. Shi, K. Y. Arai, W. Jin, Q. Weng, G. Watanabe, A. K. Suzuki, and K. Taya (2006)
Biol Reprod 74, 850-856
 |  Abstract »  |  Full Text »  |  PDF »

The Small GTPase Rab7 Controls the Endosomal Trafficking and Neuritogenic Signaling of the Nerve Growth Factor Receptor TrkA.

S. Saxena, C. Bucci, J. Weis, and A. Kruttgen (2005)
J. Neurosci. 25, 10930-10940
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR.

J. P. Aurikko, B. T. Ruotolo, J. G. Grossmann, M. C. Moncrieffe, E. Stephens, V.-M. Leppanen, C. V. Robinson, M. Saarma, R. A. Bradshaw, and T. L. Blundell (2005)
J. Biol. Chem. 280, 33453-33460
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Thimerosal on NGF Signal Transduction and Cell Death in Neuroblastoma Cells.

D. K. Parran, A. Barker, and M. Ehrich (2005)
Toxicol. Sci. 86, 132-140
 |  Abstract »  |  Full Text »  |  PDF »

Peroxisome Proliferator-activated Receptor {gamma} Is a Novel Target of the Nerve Growth Factor Signaling Pathway in PC12 Cells.

K. M. Fuenzalida, M. C. Aguilera, D. G. Piderit, P. C. Ramos, D. Contador, V. Quinones, A. Rigotti, F. C. Bronfman, and M. Bronfman (2005)
J. Biol. Chem. 280, 9604-9609
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of a Ligand-Receptor Complex on the Growth Cones as an Essential Step for the Uptake of Nerve Growth Factor at the Distal End of the Axon: A Single-Molecule Analysis.

T. Tani, Y. Miyamoto, K. E. Fujimori, T. Taguchi, T. Yanagida, Y. Sako, and Y. Harada (2005)
J. Neurosci. 25, 2181-2191
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activity of the Nerve Growth Factor (NGF) Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75NTR Interactions in the Presence of TrkA.

A. Colquhoun, G. M. Lawrance, I. L. Shamovsky, R. J. Riopelle, and G. M. Ross (2004)
J. Pharmacol. Exp. Ther. 310, 505-511
 |  Abstract »  |  Full Text »  |  PDF »

{beta}1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.

J. Gu, Y. Zhao, T. Isaji, Y. Shibukawa, H. Ihara, M. Takahashi, Y. Ikeda, E. Miyoshi, K. Honke, and N. Taniguchi (2004)
Glycobiology 14, 177-186
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophin and Neurotrophin Receptor Protein Expression in the Human Lung.

A. Ricci, L. Felici, S. Mariotta, F. Mannino, G. Schmid, C. Terzano, G. Cardillo, F. Amenta, and E. Bronzetti (2004)
Am. J. Respir. Cell Mol. Biol. 30, 12-19
 |  Abstract »  |  Full Text »  |  PDF »

The Neurotrophins Nerve Growth Factor, Brain-derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4 Are Survival and Activation Factors for Eosinophils in Patients with Allergic Bronchial Asthma.

C. Nassenstein, A. Braun, V. J. Erpenbeck, M. Lommatzsch, S. Schmidt, N. Krug, W. Luttmann, H. Renz, and J. C. Virchow Jr. (2003)
J. Exp. Med. 198, 455-467
 |  Abstract »  |  Full Text »  |  PDF »

Laser photocoagulation alters the pattern of staining for neurotrophin-4, GFAP, and CD68 in human retina.

S M S Ghazi-Nouri, A Assi, G A Limb, R A H Scott, K von Bussmann, I Humphrey, P J Luthert, and D G Charteris (2003)
Br J Ophthalmol 87, 488-492
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Regions of Internalin B Contribute to Its Ability to Turn on the Ras-Mitogen-activated Protein Kinase Pathway.

J. Copp, M. Marino, M. Banerjee, P. Ghosh, and P. van der Geer (2003)
J. Biol. Chem. 278, 7783-7789
 |  Abstract »  |  Full Text »  |  PDF »

Gangliosides Activate Trk Receptors by Inducing the Release of Neurotrophins.

S. J. Rabin, A. Bachis, and I. Mocchetti (2002)
J. Biol. Chem. 277, 49466-49472
 |  Abstract »  |  Full Text »  |  PDF »

Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes.

F. Iannone, C. De Bari, F. Dell'Accio, M. Covelli, V. Patella, G. Lo Bianco, and G. Lapadula (2002)
Rheumatology 41, 1413-1418
 |  Abstract »  |  Full Text »  |  PDF »

Damage-Induced Neuronal Endopeptidase (DINE/ECEL) Expression Is Regulated by Leukemia Inhibitory Factor and Deprivation of Nerve Growth Factor in Rat Sensory Ganglia after Nerve Injury.

R. Kato, S. Kiryu-Seo, and H. Kiyama (2002)
J. Neurosci. 22, 9410-9418
 |  Abstract »  |  Full Text »  |  PDF »

The Role of NGF Signaling in Human Limbal Epithelium Expanded by Amniotic Membrane Culture.

A. Touhami, M. Grueterich, and S. C. G. Tseng (2002)
Invest. Ophthalmol. Vis. Sci. 43, 987-994
 |  Abstract »  |  Full Text »  |  PDF »

p75-Nerve Growth Factor as an Antiapoptotic Complex: Independence versus Cooperativity in Protection from Enediyne Chemotherapeutic Agents.

C. Yan, Y. Liang, K. D. Nylander, J. Wong, R. M. Rudavsky, H. U. Saragovi, and N. F. Schor (2002)
Mol. Pharmacol. 61, 710-719
 |  Abstract »  |  Full Text »  |  PDF »

A Novel p75NTR Signaling Pathway Promotes Survival, Not Death, of Immunopurified Neocortical Subplate Neurons.

M. F. DeFreitas, P. S. McQuillen, and C. J. Shatz (2001)
J. Neurosci. 21, 5121-5129
 |  Abstract »  |  Full Text »  |  PDF »

Nerve growth factor regulates TNF-{alpha} production in mouse macrophages via MAP kinase activation.

R. Barouch, G. Kazimirsky, E. Appel, and C. Brodie (2001)
J. Leukoc. Biol. 69, 1019-1026
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta} modulates programmed cell death in the retina of the developing chick embryo.

N. Dunker, N. Schuster, and K. Krieglstein (2001)
Development 128, 1933-1942
 |  Abstract »  |  Full Text »  |  PDF »

Sustained Signaling by Phospholipase C-{gamma} Mediates Nerve Growth Factor-Triggered Gene Expression.

D.-Y. Choi, J. J. Toledo-Aral, R. Segal, and S. Halegoua (2001)
Mol. Cell. Biol. 21, 2695-2705
 |  Abstract »  |  Full Text »

Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.

S. Mardy, Y. Miura, F. Endo, I. Matsuda, and Y. Indo (2001)
Hum. Mol. Genet. 10, 179-188
 |  Abstract »  |  Full Text »  |  PDF »

Taxane-Antibody Conjugates Afford Potent Cytotoxicity, Enhanced Solubility, and Tumor Target Selectivity.

V. Guillemard and H. U. Saragovi (2001)
Cancer Res. 61, 694-699
 |  Abstract »  |  Full Text »

Identification and Characterization of an Activating TrkA Deletion Mutation in Acute Myeloid Leukemia.

G. W. Reuther, Q. T. Lambert, M. A. Caligiuri, and C. J. Der (2000)
Mol. Cell. Biol. 20, 8655-8666
 |  Abstract »  |  Full Text »

Direct Effects of Nerve Growth Factor on Thecal Cells from Antral Ovarian Follicles.

G. A. Dissen, J. A. Parrott, M. K. Skinner, D. F. Hill, M. E. Costa, and S. R. Ojeda (2000)
Endocrinology 141, 4736-4750
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.

M. Bibel and Y.-A. Barde (2000)
Genes & Dev. 14, 2919-2937
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Colocalization of TrkB and Brain-Derived Neurotrophic Factor Proteins in Green-Red-Sensitive Cone Outer Segments.

A. Di Polo, L. Cheng, G. M. Bray, and A. J. Aguayo (2000)
Invest. Ophthalmol. Vis. Sci. 41, 4014-4021
 |  Abstract »  |  Full Text »

Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor.

W. J. Friedman (2000)
J. Neurosci. 20, 6340-6346
 |  Abstract »  |  Full Text »  |  PDF »

Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression After Temporary Focal Cerebral Ischemia Editorial Comment.

W.-R. Schabitz, C. Sommer, W. Zoder, M. Kiessling, M. Schwaninger, S. Schwab, and S. P. Finklestein (2000)
Stroke 31, 2212-2217
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin Receptor In Vitro and after Axotomy.

D. E. Syroid, P. J. Maycox, M. Soilu-Hanninen, S. Petratos, T. Bucci, P. Burrola, S. Murray, S. Cheema, K.-F. Lee, G. Lemke, et al. (2000)
J. Neurosci. 20, 5741-5747
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Expression of N-myc Messenger RNA in Neuroblastomas Found by Mass Screening.

T. Matsunaga, H. Shirasawa, T. Hishiki, H. Yoshida, K. Kouchi, Y. Ohtsuka, K. Kawamura, T. Etoh, and N. Ohnuma (2000)
Clin. Cancer Res. 6, 3199-3204
 |  Abstract »  |  Full Text »

Epithelial Rests of Malassez Express Immunoreactivity of TrkA and Its Distribution Is Regulated by Sensory Nerve Innervation.

T. Yamashiro, K. Fujiyama, T. Fukunaga, Y. Wang, and T. Takano–Yamamoto (2000)
J. Histochem. Cytochem. 48, 979-984
 |  Abstract »  |  Full Text »

Tissue Disposition and Pharmacokinetics of Recombinant Human Nerve Growth Factor after Acute and Chronic Subcutaneous Administration in Monkeys.

C. B. Nguyen, L. Harris, E. Szönyi, S. A. Baughman, V. G. Hale, N. O. Dybdal, M. D. Sadick, and E. Escandón (2000)
Drug Metab. Dispos. 28, 598-607
 |  Abstract »  |  Full Text »

The Molecular Basis for Understanding Neurotrophins and Their Relevance to Neurologic Disease.

S. G. Kernie and L. F. Parada (2000)
Arch Neurol 57, 654-657
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Trk C Signaling Is Required for Retinal Progenitor Cell Proliferation.

I. Das, J. R. Sparrow, M. I. Lin, E. Shih, T. Mikawa, and B. L. Hempstead (2000)
J. Neurosci. 20, 2887-2895
 |  Abstract »  |  Full Text »  |  PDF »

Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action.

S. Maliartchouk, T. Debeir, N. Beglova, A. C. Cuello, K. Gehring, and H. U. Saragovi (2000)
J. Biol. Chem. 275, 9946-9956
 |  Abstract »  |  Full Text »  |  PDF »

Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways.

J. Sawada, A. Itakura, A. Tanaka, T. Furusaka, and H. Matsuda (2000)
Blood 95, 2052-2058
 |  Abstract »  |  Full Text »  |  PDF »

TrkA Amino Acids Controlling Specificity for Nerve Growth Factor.

L. O'Connell, J.-A. Hongo, L. G. Presta, and P. Tsoulfas (2000)
J. Biol. Chem. 275, 7870-7877
 |  Abstract »  |  Full Text »  |  PDF »

Pattern of Radiation-induced RET and NTRK1 Rearrangements in 191 Post-Chernobyl Papillary Thyroid Carcinomas: Biological, Phenotypic, and Clinical Implications.

H. M. Rabes, E. P. Demidchik, J. D. Sidorow, E. Lengfelder, C. Beimfohr, D. Hoelzel, and S. Klugbauer (2000)
Clin. Cancer Res. 6, 1093-1103
 |  Abstract »  |  Full Text »

BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain.

L. A. Mamounas, C. A. Altar, M. E. Blue, D. R. Kaplan, L. Tessarollo, and W. E. Lyons (2000)
J. Neurosci. 20, 771-782
 |  Abstract »  |  Full Text »  |  PDF »

Gab1 Mediates Neurite Outgrowth, DNA Synthesis, and Survival in PC12 Cells.

J. M. Korhonen, F. A. Said, A. J. Wong, and D. R. Kaplan (1999)
J. Biol. Chem. 274, 37307-37314
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor Signaling in Caveolae-like Domains at the Plasma Membrane.

C.-s. Huang, J. Zhou, A. K. Feng, C. C. Lynch, J. Klumperman, S. J. DeArmond, and W. C. Mobley (1999)
J. Biol. Chem. 274, 36707-36714
 |  Abstract »  |  Full Text »  |  PDF »

Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV.

E. Garaci, M. C. Caroleo, L. Aloe, S. Aquaro, M. Piacentini, N. Costa, A. Amendola, A. Micera, R. Calio, C.-F. Perno, et al. (1999)
PNAS 96, 14013-14018
 |  Abstract »  |  Full Text »  |  PDF »

Functional Blockade of Tyrosine Kinase A in the Rat Basal Forebrain by a Novel Antagonistic Anti-Receptor Monoclonal Antibody.

A. Cattaneo, S. Capsoni, E. Margotti, M. Righi, E. Kontsekova, P. Pavlik, P. Filipcik, and M. Novak (1999)
J. Neurosci. 19, 9687-9697
 |  Abstract »  |  Full Text »  |  PDF »

Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway.

I. E. Mazzoni, F. A. Said, R. Aloyz, F. D. Miller, and D. Kaplan (1999)
J. Neurosci. 19, 9716-9727
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphorylation Regulates Rapid Endocytosis in Adrenal Chromaffin Cells.

P. G. P. Nucifora and A. P. Fox (1999)
J. Neurosci. 19, 9739-9746
 |  Abstract »  |  Full Text »  |  PDF »

SH2-B, a Membrane-associated Adapter, Is Phosphorylated on Multiple Serines/Threonines in Response to Nerve Growth Factor by Kinases within the MEK/ERK Cascade.

L. Rui, J. Herrington, and C. Carter-Su (1999)
J. Biol. Chem. 274, 26485-26492
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Biology of Neuroblastoma.

J. M. Maris and K. K. Matthay (1999)
J. Clin. Oncol. 17, 2264
 |  Abstract »  |  Full Text »  |  PDF »

Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation.

J. Kohn, R. S. Aloyz, J. G. Toma, M. Haak-Frendscho, and F. D. Miller (1999)
J. Neurosci. 19, 5393-5408
 |  Abstract »  |  Full Text »  |  PDF »

The Staurosporine-Like Compound L-753,000 (NB-506) Potentiates the Neurotrophic Effects of Neurotrophin-3 by Acting Selectively at the TrkA Receptor.

S. Pollack, L. Young, J. Bilsland, N. Wilkie, S. Ellis, F. Hefti, H. Broughton, and S. Harper (1999)
Mol. Pharmacol. 56, 185-195
 |  Abstract »  |  Full Text »

Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway.

M. Soilu-Hanninen, P. Ekert, T. Bucci, D. Syroid, P. F. Bartlett, and T. J. Kilpatrick (1999)
J. Neurosci. 19, 4828-4838
 |  Abstract »  |  Full Text »  |  PDF »

Brain-derived Neurotrophic Factor Promotes Survival and Chemoprotection of Human Neuroblastoma Cells.

D. S. Middlemas, B. K. Kihl, J. Zhou, and X. Zhu (1999)
J. Biol. Chem. 274, 16451-16460
 |  Abstract »  |  Full Text »  |  PDF »

The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells.

H. Yamashita, S. Avraham, S. Jiang, I. Dikic, and H. Avraham (1999)
J. Biol. Chem. 274, 15059-15065
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor.

B. A. Horger, C. A. Iyasere, M. T. Berhow, C. J. Messer, E. J. Nestler, and J. R. Taylor (1999)
J. Neurosci. 19, 4110-4122
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Mechanisms Mediating BDNF Modulation of Synaptic Plasticity in the Hippocampus.

W. A. Gottschalk, H. Jiang, N. Tartaglia, L. Feng, A. Figurov, and B. Lu (1999)
Learn. Mem. 6, 243-256
 |  Abstract »  |  Full Text »

Brain-derived Neurotrophic Factor Induces Phosphorylation of Fibroblast Growth Factor Receptor Substrate 2.

J. B. Easton, N. M. Moody, X. Zhu, and D. S. Middlemas (1999)
J. Biol. Chem. 274, 11321-11327
 |  Abstract »  |  Full Text »  |  PDF »

SH2-B Is Required for Nerve Growth Factor-induced Neuronal Differentiation.

L. Rui, J. Herrington, and C. Carter-Su (1999)
J. Biol. Chem. 274, 10590-10594
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Neurotrophins and their Receptors in Human Bone Marrow.

E. Labouyrie, P. Dubus, A. Groppi, F. X. Mahon, J. Ferrer, M. Parrens, J. Reiffers, A. de Mascarel, and J. P. Merlio (1999)
Am. J. Pathol. 154, 405-415
 |  Abstract »  |  Full Text »  |  PDF »

Caveolin Interacts with Trk A and p75NTR and Regulates Neurotrophin Signaling Pathways.

T. R. Bilderback, V.-R. Gazula, M. P. Lisanti, and R. T. Dobrowsky (1999)
J. Biol. Chem. 274, 257-263
 |  Abstract »  |  Full Text »  |  PDF »

A TrkA-selective, Fast Internalizing Nerve Growth Factor-Antibody Complex Induces Trophic but Not Neuritogenic Signals.

H. U. Saragovi, W. Zheng, S. Maliartchouk, G. M. DiGugliemo, Y. R. Mawal, A. Kamen, S. B. Woo, A. C. Cuello, T. Debeir, and K. E. Neet (1998)
J. Biol. Chem. 273, 34933-34940
 |  Abstract »  |  Full Text »  |  PDF »

P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors.

R. S. Aloyz, S. X. Bamji, C. D. Pozniak, J. G. Toma, J. Atwal, D. R. Kaplan, and F. D. Miller (1998)
J. Cell Biol. 143, 1691-1703
 |  Abstract »  |  Full Text »  |  PDF »

Dexamethasone Induces Hypertrophy of Developing Medial Septum Cholinergic Neurons: Potential Role of Nerve Growth Factor.

B. Shi, S. J. Rabin, C. Brandoli, and I. Mocchetti (1998)
J. Neurosci. 18, 9326-9334
 |  Abstract »  |  Full Text »  |  PDF »

Activity-dependent Release of Brain-derived Neurotrophic Factor Underlies the Neuroprotective Effect of N-Methyl-D-aspartate.

A. M. Marini, S. J. Rabin, R. H. Lipsky, and I. Mocchetti (1998)
J. Biol. Chem. 273, 29394-29399
 |  Abstract »  |  Full Text »  |  PDF »

Lampetra fluviatilis Neurotrophin Homolog, Descendant of a Neurotrophin Ancestor, Discloses the Early Molecular Evolution of Neurotrophins in the Vertebrate Subphylum.

F. Hallbook, L.-G. Lundin, and K. Kullander (1998)
J. Neurosci. 18, 8700-8711
 |  Abstract »  |  Full Text »  |  PDF »

Glucosylceramide Synthase Inhibitor Inhibits the Action of Nerve Growth Factor in PC12 Cells.

T. Mutoh, A. Tokuda, J.-i. Inokuchi, and M. Kuriyama (1998)
J. Biol. Chem. 273, 26001-26007
 |  Abstract »  |  Full Text »  |  PDF »

Neuropeptides: Mediators of Inflammation and Tissue Repair?.

M. Schaffer, T. Beiter, H. D. Becker, and T. K. Hunt (1998)
Arch Surg 133, 1107-1116
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Solution Structure and Internal Motion of a Bioactive Peptide Derived from Nerve Growth Factor.

N. Beglova, L. LeSauteur, I. Ekiel, H. U. Saragovi, and K. Gehring (1998)
J. Biol. Chem. 273, 23652-23658
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Ras/MAP Kinase in the Regulation of Ca2+ Channels in Adult Bullfrog Sympathetic Neurons by Nerve Growth Factor.

S. Lei, W. F. Dryden, and P. A. Smith (1998)
J Neurophysiol 80, 1352-1361
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Phase-Specific Surface Expression of Nerve Growth Factor Receptors TrkA and p75NTR.

J. L. Urdiales, E. Becker, M. Andrieu, A. Thomas, J. Jullien, L. A. van Grunsven, S. Menut, G. I. Evan, D. Martin-Zanca, and B. B. Rudkin (1998)
J. Neurosci. 18, 6767-6775
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor Induces Process Formation in Meningeal Cells: Implications for Scar Formation in the Injured CNS.

J. Frisen, M. Risling, L. Korhonen, U. Zirrgiebel, C. B. Johansson, S. Cullheim, and D. Lindholm (1998)
J. Neurosci. 18, 5714-5722
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 Accelerates the Maturation of Early Sensory Neurons.

G. Middleton, L. G. P. Pinon, S. Wyatt, and A. M. Davies (1998)
J. Neurosci. 18, 3344-3350
 |  Abstract »  |  Full Text »  |  PDF »

Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines.

C. Missale, A. Codignola, S. Sigala, A. Finardi, M. Paez-Pereda, E. Sher, and P. Spano (1998)
PNAS 95, 5366-5371
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation.

J. Xing, J. M. Kornhauser, Z. Xia, E. A. Thiele, and M. E. Greenberg (1998)
Mol. Cell. Biol. 18, 1946-1955
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High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors.

R. Urfer, P. Tsoulfas, L. O'Connell, J.-A. Hongo, W. Zhao, and L. G. Presta (1998)
J. Biol. Chem. 273, 5829-5840
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The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death.

S. X. Bamji, M. Majdan, C. D. Pozniak, D. J. Belliveau, R. Aloyz, J. Kohn, C. G. Causing, and F. D. Miller (1998)
J. Cell Biol. 140, 911-923
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Role of Nerve Growth Factor in Cutaneous Wound Healing: Accelerating Effects in Normal and Healing-impaired Diabetic Mice.

H. Matsuda, H. Koyama, H. Sato, J. Sawada, A. Itakura, A. Tanaka, M. Matsumoto, K. Konno, H. Ushio, and K. Matsuda (1998)
J. Exp. Med. 187, 297-306
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Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis.

L. Tessarollo, P. Tsoulfas, M. J. Donovan, M. E. Palko, J. Blair-Flynn, B. L. Hempstead, and L. F. Parada (1997)
PNAS 94, 14776-14781
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Nerve Growth Factor Modulates Synaptic Transmission between Sympathetic Neurons and Cardiac Myocytes.

S. T. Lockhart, G. G. Turrigiano, and S. J. Birren (1997)
J. Neurosci. 17, 9573-9582
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Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice.

D. J. Liebl, L. Tessarollo, M. E. Palko, and L. F. Parada (1997)
J. Neurosci. 17, 9113-9121
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A Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic Neurons In Vivo.

A. M. Fagan, M. Garber, M. Barbacid, I. Silos-Santiago, and D. M. Holtzman (1997)
J. Neurosci. 17, 7644-7654
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Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands.

S. Maliartchouk and H. U. Saragovi (1997)
J. Neurosci. 17, 6031-6037
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Rapid Retrograde Tyrosine Phosphorylation of trkA and Other Proteins in Rat Sympathetic Neurons in Compartmented Cultures.

D. L. Senger and R. B. Campenot (1997)
J. Cell Biol. 138, 411-421
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Nerve Growth Factor Accelerates Seizure Development, Enhances Mossy Fiber Sprouting, and Attenuates Seizure-Induced Decreases in Neuronal Density in the Kindling Model of Epilepsy.

B. Adams, M. Sazgar, P. Osehobo, C. E. E. M. Van der Zee, J. Diamond, M. Fahnestock, and R. J. Racine (1997)
J. Neurosci. 17, 5288-5296
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Differential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding to the p75 Neurotrophin Receptor.

M. Ryden, B. Hempstead, and C. F. Ibanez (1997)
J. Biol. Chem. 272, 16322-16328
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A Novel Drosophila Receptor Tyrosine Kinase Expressed Specifically in the Nervous System. UNIQUE STRUCTURAL FEATURES AND IMPLICATION IN DEVELOPMENTAL SIGNALING.

I. Oishi, S. Sugiyama, Z.-J. Liu, H. Yamamura, Y. Nishida, and Y. Minami (1997)
J. Biol. Chem. 272, 11916-11923
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Association of p75NTR with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae.

T. R. Bilderback, R. J. Grigsby, and R. T. Dobrowsky (1997)
J. Biol. Chem. 272, 10922-10927
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Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor.

M. E. Cunningham, R. M. Stephens, D. R. Kaplan, and L. A. Greene (1997)
J. Biol. Chem. 272, 10957-10967
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Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway.

L. L. Dugan, D. J. Creedon, E. M. Johnson Jr., and D. M. Holtzman (1997)
PNAS 94, 4086-4091
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Signal Transduction Mediated by the Truncated trkB Receptor Isoforms, trkB.T1 and trkB.T2.

G. T. Baxter, M. J. Radeke, R. C. Kuo, V. Makrides, B. Hinkle, R. Hoang, A. Medina-Selby, D. Coit, P. Valenzuela, and S. C. Feinstein (1997)
J. Neurosci. 17, 2683-2690
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Overexpression of N-Acetylglucosaminyltransferase III Disrupts the Tyrosine Phosphorylation of Trk with Resultant Signaling Dysfunction in PC12 Cells Treated with Nerve Growth Factor.

Y. Ihara, Y. Sakamoto, M. Mihara, K. Shimizu, and N. Taniguchi (1997)
J. Biol. Chem. 272, 9629-9634
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NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis.

D. J. Belliveau, I. Krivko, J. Kohn, C. Lachance, C. Pozniak, D. Rusakov, D. Kaplan, and F. D. Miller (1997)
J. Cell Biol. 136, 375-388
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Nerve Growth Factor Induces Apoptosis in Human Medulloblastoma Cell Lines that Express TrkA Receptors.

Y. Muragaki, T. T. Chou, D. R. Kaplan, J. Q. Trojanowski, and V. M.-Y. Lee (1997)
J. Neurosci. 17, 530-542
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Inhibition of Endogenous Ganglioside Synthesis Does Not Block Neurite Formation by Retinoic Acid-treated Neuroblastoma Cells.

R. Li and S. Ladisch (1997)
J. Biol. Chem. 272, 1349-1354
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