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Science 26 April 1991:
Vol. 252. no. 5005, pp. 533 - 536
DOI: 10.1126/science.1850548
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Articles

Science, Vol 252, Issue 5005, 533-536
Copyright © 1991 by American Association for the Advancement of Science

articles

The control of oxidant stress at fertilization

BM Shapiro

Department of Biochemistry, University of Washington, Seattle 98105.

Metazoan eggs alter their coats after fertilization to protect the early embryo. In sea urchins, this modification consists of a rapid, coordinated set of noncovalent macromolecular assembly steps that are stabilized by protein cross-linking. The sea urchin egg uses an oxidative cross-linking reaction that requires hydrogen peroxide and a secreted peroxidase and thus faces the challenge of oxidant stress at the beginning of its development. Protection from the deleterious effects of this oxidative mechanism is afforded by regulation of the production and utilization of oxidizing species. This regulation requires a specific protein kinase C-activated oxidase and ovothiol, an intracellular antioxidant.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)