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Science 19 April 1991:
Vol. 252. no. 5004, pp. 443 - 446
DOI: 10.1126/science.2017683
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Articles

Science, Vol 252, Issue 5004, 443-446
Copyright © 1991 by American Association for the Advancement of Science

articles

Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release

EA Finch, TJ Turner, and SM Goldin

Department of Neurobiology, Harvard Medical School, Boston, MA 02115.

Inositol 1,4,5-trisphosphate (IP3)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP3-induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP3-induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP3-induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP3-induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP3-induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.


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   Abstract »    Full Text »    PDF »
A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes.
X.-P. Sun, N. Callamaras, J. S Marchant, and I. Parker (1998)
J. Physiol. 509, 67-80
   Abstract »    Full Text »    PDF »
Activation and co-ordination of InsP3-mediated elementary Ca2+ events during global Ca2+ signals in Xenopus oocytes.
N. Callamaras, J. S Marchant, X.-P. Sun, and I. Parker (1998)
J. Physiol. 509, 81-91
   Abstract »    Full Text »    PDF »
Functional Properties of the Type-3 InsP3 Receptor in 16HBE14o- Bronchial Mucosal Cells.
L. Missiaen, J. B. Parys, I. Sienaert, K. Maes, K. Kunzelmann, M. Takahashi, K. Tanzawa, and H. De Smedt (1998)
J. Biol. Chem. 273, 8983-8986
   Abstract »    Full Text »    PDF »
Intercellular Calcium Signaling via Gap Junction in Connexin-43-transfected Cells.
T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada (1998)
J. Biol. Chem. 273, 1519-1528
   Abstract »    Full Text »    PDF »
Allosteric regulation by cytoplasmic Ca2+ and IP3 of the gating of IP3 receptors in permeabilized guinea-pig vascular smooth muscle cells.
K. Hirose, S. Kadowaki, and M. Iino (1998)
J. Physiol. 506, 407-414
   Abstract »    Full Text »    PDF »
Modulation of calcium signals by intracellular pH in isolated rat pancreatic acinar cells.
T. Speake and A. C Elliott (1998)
J. Physiol. 506, 415-430
   Abstract »    Full Text »    PDF »
Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling.
E. J. Kaftan, B. E. Ehrlich, and J. Watras (1997)
J. Gen. Physiol. 110, 529-538
   Abstract »    Full Text »    PDF »
Dynamics of [Ca2+] in the Endoplasmic Reticulum and Cytoplasm of Intact HeLa Cells. A COMPARATIVE STUDY.
M. J. Barrero, M. Montero, and J. Alvarez (1997)
J. Biol. Chem. 272, 27694-27699
   Abstract »    Full Text »    PDF »
Molecular and Functional Evidence for Multiple Ca2+-binding Domains in the Type 1 Inositol 1,4,5-Trisphosphate Receptor.
I. Sienaert, L. Missiaen, H. De Smedt, J. B. Parys, H. Sipma, and R. Casteels (1997)
J. Biol. Chem. 272, 25899-25906
   Abstract »    Full Text »    PDF »


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