Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 April 1991:
Vol. 252. no. 5004, pp. 443 - 446
DOI: 10.1126/science.2017683
Prev | Table of Contents | Next

Articles

Science, Vol 252, Issue 5004, 443-446
Copyright © 1991 by American Association for the Advancement of Science

articles

Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release

EA Finch, TJ Turner, and SM Goldin

Department of Neurobiology, Harvard Medical School, Boston, MA 02115.

Inositol 1,4,5-trisphosphate (IP3)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP3-induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP3-induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP3-induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP3-induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP3-induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inositol-1,4,5-trisphosphate receptor-mediated Ca2+ waves in pyramidal neuron dendrites propagate through hot spots and cold spots.
J. S. Fitzpatrick, A. M. Hagenston, D. N. Hertle, K. E. Gipson, L. Bertetto-D'Angelo, and M. F. Yeckel (2009)
J. Physiol. 587, 1439-1459
   Abstract »    Full Text »    PDF »
Structural Insights into Ca2+-dependent Regulation of Inositol 1,4,5-Trisphosphate Receptors by CaBP1.
C. Li, J. Chan, F. Haeseleer, K. Mikoshiba, K. Palczewski, M. Ikura, and J. B. Ames (2009)
J. Biol. Chem. 284, 2472-2481
   Abstract »    Full Text »    PDF »
Diverse Mechanisms Underlie Glycinergic Feedback Transmission onto Rod Bipolar Cells in Rat Retina.
A. E. Chavez and J. S. Diamond (2008)
J. Neurosci. 28, 7919-7928
   Abstract »    Full Text »    PDF »
Cytoplasmic calcium oscillations and store-operated calcium influx.
J. W. Putney and G. S. Bird (2008)
J. Physiol. 586, 3055-3059
   Abstract »    Full Text »    PDF »
Dendritic Excitability and Synaptic Plasticity.
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser (2008)
Physiol Rev 88, 769-840
   Abstract »    Full Text »    PDF »
Competition between Calcium-Activated K+ Channels Determines Cholinergic Action on Firing Properties of Basolateral Amygdala Projection Neurons.
J. M. Power and P. Sah (2008)
J. Neurosci. 28, 3209-3220
   Abstract »    Full Text »    PDF »
Order-Dependent Coincidence Detection in Cerebellar Purkinje Neurons at the Inositol Trisphosphate Receptor.
D. V. Sarkisov and S. S.-H. Wang (2008)
J. Neurosci. 28, 133-142
   Abstract »    Full Text »    PDF »
`Quantal' Ca2+ release at the cytoplasmic aspect of the Ins(1,4,5)P3R channel in smooth muscle.
J. G. McCarron, S. Chalmers, and T. C. Muir (2008)
J. Cell Sci. 121, 86-98
   Abstract »    Full Text »    PDF »
The Pathogenesis of Alzheimers Disease Is It a Lifelong "Calciumopathy"?.
G. E. Stutzmann (2007)
Neuroscientist 13, 546-559
   Abstract »    PDF »
Priming of intracellular calcium stores in rat CA1 pyramidal neurons.
M. Hong and W. N. Ross (2007)
J. Physiol. 584, 75-87
   Abstract »    Full Text »    PDF »
Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons.
J. M. Power and P. Sah (2007)
J. Physiol. 580, 835-857
   Abstract »    Full Text »    PDF »
Differential Regulation of Action Potential- and Metabotropic Glutamate Receptor-Induced Ca2+ Signals by Inositol 1,4,5-Trisphosphate in Dopaminergic Neurons.
G. Cui, B. E. Bernier, M. T. Harnett, and H. Morikawa (2007)
J. Neurosci. 27, 4776-4785
   Abstract »    Full Text »    PDF »
Inositol Trisphosphate Receptor Ca2+ Release Channels.
J. K. Foskett, C. White, K.-H. Cheung, and D.-O. D. Mak (2007)
Physiol Rev 87, 593-658
   Abstract »    Full Text »    PDF »
The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves.
E. Hernandez, M. F. Leite, M. T. Guerra, E. A. Kruglov, O. Bruna-Romero, M. A. Rodrigues, D. A. Gomes, F. J. Giordano, J. A. Dranoff, and M. H. Nathanson (2007)
J. Biol. Chem. 282, 10057-10067
   Abstract »    Full Text »    PDF »
Inositol trisphosphate receptor in higher plants: is it real?.
O. Krinke, Z. Novotna, O. Valentova, and J. Martinec (2007)
J. Exp. Bot. 58, 361-376
   Abstract »    Full Text »    PDF »
Modulation of calcium wave propagation in the dendrites and to the soma of rat hippocampal pyramidal neurons.
S. Watanabe, M. Hong, N. Lasser-Ross, and W. N. Ross (2006)
J. Physiol. 575, 455-468
   Abstract »    Full Text »    PDF »
Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quartal Ca2+release.
L. Ionescu, K.-H. Cheung, H. Vais, D.-O. D. Mak, C. White, and J. K. Foskett (2006)
J. Physiol. 573, 645-662
   Abstract »    Full Text »    PDF »
Kinetic, pharmacological and activity-dependent separation of two Ca2+ signalling pathways mediated by type 1 metabotropic glutamate receptors in rat Purkinje neurones.
M. Canepari and D. Ogden (2006)
J. Physiol. 573, 65-82
   Abstract »    Full Text »    PDF »
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice..
G. E. Stutzmann, I. Smith, A. Caccamo, S. Oddo, F. M. LaFerla, and I. Parker (2006)
J. Neurosci. 26, 5180-5189
   Abstract »    Full Text »    PDF »
Endogenously Bound Calmodulin Is Essential for the Function of the Inositol 1,4,5-Trisphosphate Receptor.
N. N. Kasri, K. Torok, A. Galione, C. Garnham, G. Callewaert, L. Missiaen, J. B. Parys, and H. De Smedt (2006)
J. Biol. Chem. 281, 8332-8338
   Abstract »    Full Text »    PDF »
Spatial segregation of neuronal calcium signals encodes different forms of LTP in rat hippocampus.
C. R. Raymond and S. J. Redman (2006)
J. Physiol. 570, 97-111
   Abstract »    Full Text »    PDF »
Calcium feedback mechanisms regulate oscillatory activity of a TRP-like Ca2+ conductance in C. elegans intestinal cells.
A. Y Estevez and K. Strange (2005)
J. Physiol. 567, 239-251
   Abstract »    Full Text »    PDF »
Spontaneously active and InsP3-activated ion channels in cell nuclei from rat cerebellar Purkinje and granule neurones.
S. M Marchenko, V. V Yarotskyy, T. N Kovalenko, P. G Kostyuk, and R. C Thomas (2005)
J. Physiol. 565, 897-910
   Abstract »    Full Text »    PDF »
Intracellular Calcium Regulation by Burst Discharge Determines Bidirectional Long-Term Synaptic Plasticity at the Cerebellum Input Stage.
D. Gall, F. Prestori, E. Sola, A. D'Errico, C. Roussel, L. Forti, P. Rossi, and E. D'Angelo (2005)
J. Neurosci. 25, 4813-4822
   Abstract »    Full Text »    PDF »
Ca2+-Calmodulin-dependent Facilitation and Ca2+ Inactivation of Ca2+ Release-activated Ca2+ Channels.
B. Moreau, S. Straube, R. J. Fisher, J. W. Putney Jr., and A. B. Parekh (2005)
J. Biol. Chem. 280, 8776-8783
   Abstract »    Full Text »    PDF »
Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials.
J. M. Power and P. Sah (2005)
J. Physiol. 562, 439-453
   Abstract »    Full Text »    PDF »
Dopamine Receptor-mediated Ca2+ Signaling in Striatal Medium Spiny Neurons.
T.-S. Tang and I. Bezprozvanny (2004)
J. Biol. Chem. 279, 42082-42094
   Abstract »    Full Text »    PDF »
Excitation of Cerebellar Interneurons by Group I Metabotropic Glutamate Receptors.
M. H. Karakossian and T. S. Otis (2004)
J Neurophysiol 92, 1558-1565
   Abstract »    Full Text »    PDF »
Simulation of calcium waves in ascidian eggs: insights into the origin of the pacemaker sites and the possible nature of the sperm factor.
G. Dupont and R. Dumollard (2004)
J. Cell Sci. 117, 4313-4323
   Abstract »    Full Text »    PDF »
Growth Hormone Promotes Ca2+-Induced Ca2+ Release in Insulin-Secreting Cells by Ryanodine Receptor Tyrosine Phosphorylation.
Q. Zhang, M. Kohler, S.-N. Yang, F. Zhang, O. Larsson, and P.-O. Berggren (2004)
Mol. Endocrinol. 18, 1658-1669
   Abstract »    Full Text »    PDF »
The role of endothelial cell Ca2+ store release in the regulation of microvascular permeability in vivo.
C. A. Glass and D. O. Bates (2004)
Exp Physiol 89, 343-351
   Abstract »    Full Text »    PDF »
Substrates for Coincidence Detection and Calcium Signaling for Induction of Synaptic Potentiation in the Neonatal Visual Cortex.
L. A. Schrader, S. P. Perrett, L. Ye, and M. J. Friedlander (2004)
J Neurophysiol 91, 2747-2764
   Abstract »    Full Text »    PDF »
Small-Conductance Ca2+-Dependent K+ Channels Are the Target of Spike-Induced Ca2+ Release in a Feedback Regulation of Pyramidal Cell Excitability.
S.-I. Yamada, H. Takechi, I. Kanchiku, T. Kita, and N. Kato (2004)
J Neurophysiol 91, 2322-2329
   Abstract »    Full Text »    PDF »
Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2+-binding proteins.
S. L. Dargan, B. Schwaller, and I. Parker (2004)
J. Physiol. 556, 447-461
   Abstract »    Full Text »    PDF »
Origin and Mechanisms of Ca2+ Waves in Smooth Muscle as Revealed by Localized Photolysis of Caged Inositol 1,4,5-Trisphosphate.
J. G. McCarron, D. MacMillan, K. N. Bradley, S. Chalmers, and T. C. Muir (2004)
J. Biol. Chem. 279, 8417-8427
   Abstract »    Full Text »    PDF »
Three-dimensional Rearrangements within Inositol 1,4,5-Trisphosphate Receptor by Calcium.
K. Hamada, A. Terauchi, and K. Mikoshiba (2003)
J. Biol. Chem. 278, 52881-52889
   Abstract »    Full Text »    PDF »
Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals.
S. L Dargan and I. Parker (2003)
J. Physiol. 553, 775-788
   Abstract »    Full Text »    PDF »
Plasticity of Mitochondrial Calcium Signaling.
G. Csordas and G. Hajnoczky (2003)
J. Biol. Chem. 278, 42273-42282
   Abstract »    Full Text »    PDF »
A Reassessment of the Effects of Luminal [Ca2+] on Inositol 1,4,5-Trisphosphate-induced Ca2+ Release from Internal Stores.
R. Caroppo, M. Colella, A. Colasuonno, A. DeLuisi, L. Debellis, S. Curci, and A. M. Hofer (2003)
J. Biol. Chem. 278, 39503-39508
   Abstract »    Full Text »    PDF »
A Novel Ca2+-induced Ca2+ Release Mechanism in A7r5 Cells Regulated by Calmodulin-like Proteins.
N. N. Kasri, I. Sienaert, J. B. Parys, G. Callewaert, L. Missiaen, A. Jeromin, and H. De Smedt (2003)
J. Biol. Chem. 278, 27548-27555
   Abstract »    Full Text »    PDF »
Direct Interaction and Functional Coupling between Metabotropic Glutamate Receptor Subtype 1 and Voltage-sensitive Cav2.1 Ca2+ Channel.
J. Kitano, M. Nishida, Y. Itsukaichi, I. Minami, M. Ogawa, T. Hirano, Y. Mori, and S. Nakanishi (2003)
J. Biol. Chem. 278, 25101-25108
   Abstract »    Full Text »    PDF »
Synaptically activated Ca2+ waves in layer 2/3 and layer 5 rat neocortical pyramidal neurons.
M. E Larkum, S. Watanabe, T. Nakamura, N. Lasser-Ross, and W. N Ross (2003)
J. Physiol. 549, 471-488
   Abstract »    Full Text »    PDF »
Critical Regions for Activation Gating of the Inositol 1,4,5-Trisphosphate Receptor.
K. Uchida, H. Miyauchi, T. Furuichi, T. Michikawa, and K. Mikoshiba (2003)
J. Biol. Chem. 278, 16551-16560
   Abstract »    Full Text »    PDF »
Ca2+ Signaling in Mouse Cortical Neurons Studied by Two-Photon Imaging and Photoreleased Inositol Triphosphate.
G. E. Stutzmann, F. M. LaFerla, and I. Parker (2003)
J. Neurosci. 23, 758-765
   Abstract »    Full Text »    PDF »
Modulation of Type 1 Inositol (1,4,5)-Trisphosphate Receptor Function by Protein Kinase A and Protein Phosphatase 1alpha.
T.-S. Tang, H. Tu, Z. Wang, and I. Bezprozvanny (2003)
J. Neurosci. 23, 403-415
   Abstract »    Full Text »    PDF »
Different Calcium Sources Are Narrowly Tuned to the Induction of Different Forms of LTP.
C. R. Raymond and S. J. Redman (2002)
J Neurophysiol 88, 249-255
   Abstract »    Full Text »    PDF »
Two-state Conformational Changes in Inositol 1,4,5-Trisphosphate Receptor Regulated by Calcium.
K. Hamada, T. Miyata, K. Mayanagi, J. Hirota, and K. Mikoshiba (2002)
J. Biol. Chem. 277, 21115-21118
   Abstract »    Full Text »    PDF »
Molecular Basis for Pacemaker Cells in Epithelia.
M. F. Leite, K. Hirata, T. Pusl, A. D. Burgstahler, K. Okazaki, J. M. Ortega, A. M. Goes, M. A. M. Prado, D. C. Spray, and M. H. Nathanson (2002)
J. Biol. Chem. 277, 16313-16323
   Abstract »    Full Text »    PDF »
Nuclear Calcium Signaling Evoked by Cholinergic Stimulation in Hippocampal CA1 Pyramidal Neurons.
J. M. Power and P. Sah (2002)
J. Neurosci. 22, 3454-3462
   Abstract »    Full Text »    PDF »
Baseline Cytosolic Ca2+ Oscillations Derived from a Non-endoplasmic Reticulum Ca2+ Store.
L. Missiaen, K. Van Acker, J. B. Parys, H. De Smedt, K. Van Baelen, A. F. Weidema, J. Vanoevelen, L. Raeymaekers, J. Renders, G. Callewaert, et al. (2001)
J. Biol. Chem. 276, 39161-39170
   Abstract »    Full Text »    PDF »
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic {beta}-Cell Function.
P. Gilon and J.-C. Henquin (2001)
Endocr. Rev. 22, 565-604
   Abstract »    Full Text »    PDF »
Serotonin Receptors Modulate GABAA Receptor Channels through Activation of Anchored Protein Kinase C in Prefrontal Cortical Neurons.
J. Feng, X. Cai, J. Zhao, and Z. Yan (2001)
J. Neurosci. 21, 6502-6511
   Abstract »    Full Text »    PDF »
Control of IP3-mediated Ca2+ puffs in Xenopus laevis oocytes by the Ca2+-binding protein parvalbumin.
L. M John, M. Mosquera-Caro, P. Camacho, and J. D Lechleiter (2001)
J. Physiol. 535, 3-16
   Abstract »    Full Text »    PDF »
Voltage-dependent Ca2+ release in rat megakaryocytes requires functional IP3 receptors.
M. J Mason and M. P Mahaut-Smith (2001)
J. Physiol. 533, 175-183
   Abstract »    Full Text »    PDF »
Control of InsP3-induced Ca2+ oscillations in permeabilized blowfly salivary gland cells: contribution of mitochondria.
B. Zimmermann (2000)
J. Physiol. 525, 707-719
   Abstract »    Full Text »    PDF »
Cytosolic Phosphorylation of Calnexin Controls Intracellular Ca2+ Oscillations via an Interaction with SERCA2b.
H. L. Roderick, J. D. Lechleiter, and P. Camacho (2000)
J. Cell Biol. 149, 1235-1248
   Abstract »    Full Text »    PDF »
Calmodulin Increases the Sensitivity of Type 3 Inositol-1,4,5-trisphosphate Receptors to Ca2+ Inhibition in Human Bronchial Mucosal Cells.
L. Missiaen, H. DeSmedt, G. Bultynck, S. Vanlingen, P. Desmet, G. Callewaert, and J. B. Parys (2000)
Mol. Pharmacol. 57, 564-567
   Abstract »    Full Text »
Mapping of IP3-Mediated Ca2+ Signals in Single Human Neuroblastoma SH-SY5Y Cells: Cell Volume Shaping the Ca2+ Signal.
K. van Acker, B. Bautmans, G. Bultynck, K. Maes, A. F. Weidema, P. de Smet, J. B. Parys, H. de Smedt, L. Missiaen, and G. Callewaert (2000)
J Neurophysiol 83, 1052-1057
   Abstract »    Full Text »    PDF »
The role of Ca2+ feedback in shaping InsP3-evoked Ca2+ signals in mouse pancreatic acinar cells.
J F Kidd, K E Fogarty, R A Tuft, and P Thorn (1999)
J. Physiol. 520, 187-201
   Abstract »    Full Text »    PDF »
ATP Regulation of Type 1 Inositol 1,4,5-Trisphosphate Receptor Channel Gating by Allosteric Tuning of Ca2+ Activation.
D.-O. D. Mak, S. McBride, and J. K. Foskett (1999)
J. Biol. Chem. 274, 22231-22237
   Abstract »    Full Text »    PDF »
Relationship between Inositol 1,4,5-Trisphosphate Receptor Isoforms and Subcellular Ca2+ Signaling Patterns in Nonpigmented Ciliary Epithelia.
K. Hirata, M. H. Nathanson, A. D. Burgstahler, K. Okazaki, E. Mattei, and M. L. Sears (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2046-2053
   Abstract »    Full Text »    PDF »
Intracellular calcium oscillations induced by ATP in airway epithelial cells.
J. H. Evans and M. J. Sanderson (1999)
Am J Physiol Lung Cell Mol Physiol 277, L30-L41
   Abstract »    Full Text »    PDF »
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release.
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff (1999)
Physiol Rev 79, 1019-1088
   Abstract »    Full Text »    PDF »
Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation.
C. Arnoult, I. G. Kazam, P. E. Visconti, G. S. Kopf, M. Villaz, and H. M. Florman (1999)
PNAS 96, 6757-6762
   Abstract »    Full Text »    PDF »
Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes.
E. Boitier, R. Rea, and M. R. Duchen (1999)
J. Cell Biol. 145, 795-808
   Abstract »    Full Text »    PDF »
The Bell-shaped Ca2+ Dependence of the Inositol 1,4,5-Trisphosphate-induced Ca2+ Release Is Modulated by Ca2+/Calmodulin.
L. Missiaen, J. B. Parys, A. F. Weidema, H. Sipma, S. Vanlingen, P. De Smet, G. Callewaert, and H. De Smedt (1999)
J. Biol. Chem. 274, 13748-13751
   Abstract »    Full Text »    PDF »
Mitochondria Suppress Local Feedback Activation of Inositol 1,4,5-Trisphosphate Receptors by Ca2+.
G. Hajnoczky, R. Hager, and A. P. Thomas (1999)
J. Biol. Chem. 274, 14157-14162
   Abstract »    Full Text »    PDF »
Modulation of Inositol 1,4,5-Trisphosphate Binding to the Recombinant Ligand-binding Site of the Type-1 Inositol 1,4,5-Trisphosphate Receptor by Ca2+ and Calmodulin.
H. Sipma, P. De Smet, I. Sienaert, S. Vanlingen, L. Missiaen, J. B. Parys, and H. De Smedt (1999)
J. Biol. Chem. 274, 12157-12162
   Abstract »    Full Text »    PDF »
Elementary [Ca2+]i signals generated by electroporation functionally mimic those evoked by hormonal stimulation.
F. BOBANOVIC, M. D. BOOTMAN, M. J. BERRIDGE, N. A. PARKINSON, and P. LIPP (1999)
FASEB J 13, 365-376
   Abstract »    Full Text »
Ca2+-induced Ca2+ Release in Chromaffin Cells Seen from inside the ER with Targeted Aequorin.
M. T. Alonso, M. J. Barrero, P. Michelena, E. Carnicero, I. Cuchillo, A. G. Garcia, J. Garcia-Sancho, M. Montero, and J. Alvarez (1999)
J. Cell Biol. 144, 241-254
   Abstract »    Full Text »    PDF »
Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses following endothelin-1 stimulation.
C. Speed, C. Neylon, P. Little, and C. Mitchell (1999)
J. Cell Sci. 112, 669-679
   Abstract »    PDF »
Inositol 1,4,5-tris-phosphate activation of inositol tris-phosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.
D.-O. D. Mak, S. McBride, and J. K. Foskett (1998)
PNAS 95, 15821-15825
   Abstract »    Full Text »    PDF »
The Physiologic Concentration of Inositol 1,4,5-Trisphosphate in the Oocytes of Xenopus laevis.
V. Luzzi, C. E. Sims, J. S. Soughayer, and N. L. Allbritton (1998)
J. Biol. Chem. 273, 28657-28662
   Abstract »    Full Text »    PDF »
Ca2+ Homeostasis in the Agonist-sensitive Internal Store: Functional Interactions Between Mitochondria and the ER Measured In Situ in Intact Cells.
B. Landolfi, S. Curci, L. Debellis, T. Pozzan, and A. M. Hofer (1998)
J. Cell Biol. 142, 1235-1243
   Abstract »    Full Text »    PDF »
PKA induces Ca2+ release and enhances ciliary beat frequency in a Ca2+-dependent and -independent manner.
A. Braiman, O. Zagoory, and Z. Priel (1998)
Am J Physiol Cell Physiol 275, C790-C797
   Abstract »    Full Text »    PDF »
Carbachol-induced oscillations in membrane potential and [Ca2+]i in guinea-pig ileal smooth muscle cells.
M Kohda, S Komori, T Unno, and H Ohashi (1998)
J. Physiol. 511, 559-571
   Abstract »    Full Text »    PDF »
Differential Modulation of SERCA2 Isoforms by Calreticulin.
L. M. John, J. D. Lechleiter, and P. Camacho (1998)
J. Cell Biol. 142, 963-973
   Abstract »    Full Text »    PDF »
Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP.
T. M. Moore, P. M. Chetham, J. J. Kelly, and T. Stevens (1998)
Am J Physiol Lung Cell Mol Physiol 275, L203-L222
   Abstract »    Full Text »    PDF »
Relationship between Intracellular Calcium Store Depletion and Calcium Release-activated Calcium Current in a Mast Cell Line (RBL-1).
Y. Huang and J. W. Putney Jr. (1998)
J. Biol. Chem. 273, 19554-19559
   Abstract »    Full Text »    PDF »
Physiological Features of Visceral Smooth Muscle Cells, With Special Reference to Receptors and Ion Channels.
H. KURIYAMA, K. KITAMURA, T. ITOH, and R. INOUE (1998)
Physiol Rev 78, 811-920
   Abstract »    Full Text »    PDF »
Theoretical insights into the mechanism of spiral Ca2+ wave initiation in Xenopus oocytes.
G. Dupont (1998)
Am J Physiol Cell Physiol 275, C317-C322
   Abstract »    Full Text »    PDF »
Functional Coupling of Phosphatidylinositol 4,5-Bisphosphate to Inositol 1,4,5-Trisphosphate Receptor.
V. D. Lupu, E. Kaznacheyeva, U. M. Krishna, J. R. Falck, and I. Bezprozvanny (1998)
J. Biol. Chem. 273, 14067-14070
   Abstract »    Full Text »    PDF »
AMPA and NMDA Receptors Expressed by Differentiating Xenopus Spinal Neurons.
E. L. Gleason and N. C. Spitzer (1998)
J Neurophysiol 79, 2986-2998
   Abstract »    Full Text »    PDF »
A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes.
X.-P. Sun, N. Callamaras, J. S Marchant, and I. Parker (1998)
J. Physiol. 509, 67-80
   Abstract »    Full Text »    PDF »
Activation and co-ordination of InsP3-mediated elementary Ca2+ events during global Ca2+ signals in Xenopus oocytes.
N. Callamaras, J. S Marchant, X.-P. Sun, and I. Parker (1998)
J. Physiol. 509, 81-91
   Abstract »    Full Text »    PDF »
Functional Properties of the Type-3 InsP3 Receptor in 16HBE14o- Bronchial Mucosal Cells.
L. Missiaen, J. B. Parys, I. Sienaert, K. Maes, K. Kunzelmann, M. Takahashi, K. Tanzawa, and H. De Smedt (1998)
J. Biol. Chem. 273, 8983-8986
   Abstract »    Full Text »    PDF »
Intercellular Calcium Signaling via Gap Junction in Connexin-43-transfected Cells.
T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada (1998)
J. Biol. Chem. 273, 1519-1528
   Abstract »    Full Text »    PDF »
Allosteric regulation by cytoplasmic Ca2+ and IP3 of the gating of IP3 receptors in permeabilized guinea-pig vascular smooth muscle cells.
K. Hirose, S. Kadowaki, and M. Iino (1998)
J. Physiol. 506, 407-414
   Abstract »    Full Text »    PDF »
Modulation of calcium signals by intracellular pH in isolated rat pancreatic acinar cells.
T. Speake and A. C Elliott (1998)
J. Physiol. 506, 415-430
   Abstract »    Full Text »    PDF »
Dynamics of [Ca2+] in the Endoplasmic Reticulum and Cytoplasm of Intact HeLa Cells. A COMPARATIVE STUDY.
M. J. Barrero, M. Montero, and J. Alvarez (1997)
J. Biol. Chem. 272, 27694-27699
   Abstract »    Full Text »    PDF »
Molecular and Functional Evidence for Multiple Ca2+-binding Domains in the Type 1 Inositol 1,4,5-Trisphosphate Receptor.
I. Sienaert, L. Missiaen, H. De Smedt, J. B. Parys, H. Sipma, and R. Casteels (1997)
J. Biol. Chem. 272, 25899-25906
   Abstract »    Full Text »    PDF »
Effects of Adenophostin-A and Inositol-1,4,5-trisphosphate on Cl- Currents in Xenopus laevis Oocytes.
H. C. Hartzell, K. Machaca, and Y. Hirayama (1997)
Mol. Pharmacol. 51, 683-692
   Abstract »    Full Text »
Inositol 1,4,5-Trisphosphate and Calcium Regulate the Calcium Channel Function of the Hepatic Inositol 1,4,5-Trisphosphate Receptor.
J.-F. Dufour, I. M. Arias, and T. J. Turner (1997)
J. Biol. Chem. 272, 2675-2681
   Abstract »    Full Text »    PDF »
Dynamics of calcium regulation in Paramecium and possible morphogenetic implication.
M Prajer, A Fleury, and M Laurent (1997)
J. Cell Sci. 110, 529-535
   Abstract »    PDF »
The Effects of Inositol 1,4,5-Trisphosphate (InsP3) Analogues on the Transient Kinetics of Ca2+ Release from Cerebellar Microsomes. InsP3 ANALOGUES ACT AS PARTIAL AGONISTS.
M. Mezna and F. Michelangeli (1996)
J. Biol. Chem. 271, 31818-31823
   Abstract »    Full Text »    PDF »
Inositol 1,4,5-Trisphosphate-dependent Oscillations of Luminal [Ca2+] in Permeabilized HSY Cells.
A. Tanimura and R. J. Turner (1996)
J. Biol. Chem. 271, 30904-30908
   Abstract »    Full Text »    PDF »
Characterization of a Cytosolic and a Luminal Ca2+ Binding Site in the Type I Inositol 1,4,5-Trisphosphate Receptor.
I. Sienaert, H. De Smedt, J. B. Parys, L. Missiaen, S. Vanlingen, H. Sipma, and R. Casteels (1996)
J. Biol. Chem. 271, 27005-27012
   Abstract »    Full Text »    PDF »
Reversible Desensitization of Inositol Trisphosphate-induced Calcium Release Provides a Mechanism for Repetitive Calcium Spikes.
E. Oancea and T. Meyer (1996)
J. Biol. Chem. 271, 17253-17260
   Abstract »    Full Text »    PDF »
Threshold for Inositol 1,4,5-Trisphosphate Action.
L. Missiaen, H. De Smedt, J. B. Parys, I. Sienaert, S. Vanlingen, and R. Casteels (1996)
J. Biol. Chem. 271, 12287-12293
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)