Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 April 1991:
Vol. 252. no. 5004, pp. 431 - 434
DOI: 10.1126/science.2017680

Articles

Science, Vol 252, Issue 5004, 431-434
Copyright © 1991 by American Association for the Advancement of Science


articles

Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo

MA Rosenfeld, W Siegfried, K Yoshimura, K Yoneyama, M Fukayama, LE Stier, PK Paakko, P Gilardi, LD Stratford-Perricaudet, M Perricaudet, and al. et

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin (alpha 1AT) deficiency and cystic fibrosis. A replication-deficient adenoviral vector (Ad-alpha 1AT) containing an adenovirus major late promoter and a recombinant human alpha 1AT gene was used to infect epithelial cells of the cotton rat respiratory tract in vitro and in vivo. Freshly isolated tracheobronchial epithelial cells infected with Ad-alpha 1AT contained human alpha 1AT messenger RNA transcripts and synthesized and secreted human alpha 1AT. After in vivo intratracheal administration of Ad-alpha 1AT to these rats, human alpha 1AT messenger RNA was observed in the respiratory epithelium, human alpha 1AT was synthesized and secreted by lung tissue, and human alpha 1AT was detected in the epithelial lining fluid for at least 1 week.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa.
C. Tertilt, J. Joh, A. Krause, P. Chou, K. Schneeweiss, R. G. Crystal, and S. Worgall (2009)
Infect. Immun. 77, 3044-3055
   Abstract »    Full Text »    PDF »
Sustained Expression of {alpha}1-Antitrypsin after Transplantation of Manipulated Hematopoietic Stem Cells.
A. A. Wilson, L. W. Kwok, A.-H. Hovav, S. J. Ohle, F. F. Little, A. Fine, and D. N. Kotton (2008)
Am. J. Respir. Cell Mol. Biol. 39, 133-141
   Abstract »    Full Text »    PDF »
Protective Immunity to Pseudomonas aeruginosa Induced with a Capsid-Modified Adenovirus Expressing P. aeruginosa OprF.
S. Worgall, A. Krause, J. Qiu, J. Joh, N. R. Hackett, and R. G. Crystal (2007)
J. Virol. 81, 13801-13808
   Abstract »    Full Text »    PDF »
Neutralized Adenovirus-Immune Complexes Can Mediate Effective Gene Transfer via an Fc Receptor-Dependent Infection Pathway..
P. L. Leopold, R. L. Wendland, T. Vincent, and R. G. Crystal (2006)
J. Virol. 80, 10237-10247
   Abstract »    Full Text »    PDF »
Epitopes expressed in different adenovirus capsid proteins induce different levels of epitope-specific immunity..
A. Krause, J. H. Joh, N. R. Hackett, P. W. Roelvink, J. T. Bruder, T. J. Wickham, I. Kovesdi, R. G. Crystal, and S. Worgall (2006)
J. Virol. 80, 5523-5530
   Abstract »    Full Text »    PDF »
Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth..
T. Fushimi, T. P. O'Connor, and R. G. Crystal (2006)
Cancer Res. 66, 3513-3522
   Abstract »    Full Text »    PDF »
Gene Transfer of the Vascular Endothelial Growth Factor Receptor flt-1 Suppresses Pulmonary Metastasis Associated with Lung Growth.
M. Mae, T. P. O'Connor, and R. G. Crystal (2005)
Am. J. Respir. Cell Mol. Biol. 33, 629-635
   Abstract »    Full Text »    PDF »
Thrombopoietin Gene Transfer-Mediated Enhancement of Angiogenic Responses to Acute Ischemia.
H. Amano, N. R. Hackett, S. Rafii, and R. G. Crystal (2005)
Circ. Res. 97, 337-345
   Abstract »    Full Text »    PDF »
Gene Transfer-Mediated Pre-mRNA Segmental Trans-splicing As a Strategy to Deliver Intracellular Toxins for Cancer Therapy.
K. Nakayama, R. G. Pergolizzi, and R. G. Crystal (2005)
Cancer Res. 65, 254-263
   Abstract »    Full Text »    PDF »
Cytoplasmic Dynein Mediates Adenovirus Binding to Microtubules.
S. A. Kelkar, K. K. Pfister, R. G. Crystal, and P. L. Leopold (2004)
J. Virol. 78, 10122-10132
   Abstract »    Full Text »    PDF »
Effect of inhibition of multiple steps of angiogenesis in syngeneic murine pleural mesothelioma.
R. E. Merritt, R. E. Yamada, N. Wasif, R. G. Crystal, and R. J. Korst (2004)
Ann. Thorac. Surg. 78, 1042-1051
   Abstract »    Full Text »    PDF »
Cytokine-Mediated Downregulation of Coxsackievirus-Adenovirus Receptor in Endothelial Cells.
T. Vincent, R. F. Pettersson, R. G. Crystal, and P. L. Leopold (2004)
J. Virol. 78, 8047-8058
   Abstract »    Full Text »    PDF »
Modification to the Capsid of the Adenovirus Vector That Enhances Dendritic Cell Infection and Transgene-Specific Cellular Immune Responses.
S. Worgall, A. Busch, M. Rivara, D. Bonnyay, P. L. Leopold, R. Merritt, N. R. Hackett, P. W. Rovelink, J. T. Bruder, T. J. Wickham, et al. (2004)
J. Virol. 78, 2572-2580
   Abstract »    Full Text »    PDF »
Augmenting major histocompatibility complex class I expression by murine tumors in vivo enhances antitumor immunity induced by an active immunotherapy strategy.
R. E. Merritt, R. E. Yamada, R. G. Crystal, and R. J. Korst (2004)
J. Thorac. Cardiovasc. Surg. 127, 355-364
   Abstract »    Full Text »    PDF »
Association of Adenovirus with the Microtubule Organizing Center.
C. J. Bailey, R. G. Crystal, and P. L. Leopold (2003)
J. Virol. 77, 13275-13287
   Abstract »    Full Text »    PDF »
Cisplatin augments cytotoxic T-lymphocyte-mediated antitumor immunity in poorly immunogenic murine lung cancer.
R. E. Merritt, A. Mahtabifard, R. E. Yamada, R. G. Crystal, and R. J. Korst (2003)
J. Thorac. Cardiovasc. Surg. 126, 1609-1617
   Abstract »    Full Text »    PDF »
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency.
(2003)
Am. J. Respir. Crit. Care Med. 168, 818-900
   Full Text »    PDF »
Antitumor Effect by Interleukin-11 Receptor {alpha}-Locus Chemokine/CCL27, Introduced into Tumor Cells through a Recombinant Adenovirus Vector.
J.-Q. Gao, Y. Tsuda, K. Katayama, T. Nakayama, Y. Hatanaka, Y. Tani, H. Mizuguchi, T. Hayakawa, O. Yoshie, Y. Tsutsumi, et al. (2003)
Cancer Res. 63, 4420-4425
   Abstract »    Full Text »    PDF »
In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies.
A. Mahtabifard, R. E. Merritt, R. E. Yamada, R. G. Crystal, and R. J. Korst (2003)
J. Thorac. Cardiovasc. Surg. 126, 28-38
   Abstract »    Full Text »    PDF »
Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats.
G. J. Morton, K. D. Niswender, C. J. Rhodes, M. G. Myers Jr., J. E. Blevins, D. G. Baskin, and M. W. Schwartz (2003)
Endocrinology 144, 2016-2024
   Abstract »    Full Text »    PDF »
Up-regulation of CD14 in Liver Caused by Acute Ethanol Involves Oxidant-dependent AP-1 Pathway.
M. D. Wheeler and R. G. Thurman (2003)
J. Biol. Chem. 278, 8435-8441
   Abstract »    Full Text »    PDF »
Intratracheal adenovirus-mediated gene transfer is optimal in experimental lung transplantation.
S. A. Kanaan, B. D. Kozower, T. Suda, N. Daddi, T. Tagawa, J. H. Ritter, T. Mohanakumar, and G. A. Patterson (2002)
J. Thorac. Cardiovasc. Surg. 124, 1130-1136
   Abstract »    Full Text »
Adenovirus Vector-mediated Overexpression of a Truncated Form of the p65 Nuclear Factor {kappa}B cDNA in Dendritic Cells Enhances Their Function Resulting in Immune-mediated Suppression of Preexisting Murine Tumors.
J. M. Lee, A. Mahtabifard, R. Yamada, R. G. Crystal, and R. J. Korst (2002)
Clin. Cancer Res. 8, 3561-3569
   Abstract »    Full Text »    PDF »
Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis.
H. Kuhn, U. Liebers, C. Gessner, A. Schumacher, C. Witt, J. Schauer, I. Kovesdi, and G. Wolff (2002)
Eur. Respir. J. 20, 703-709
   Abstract »    Full Text »    PDF »
Inhibition of HIV-1 Replication in Alveolar Macrophages by Adenovirus Gene Transfer Vectors.
J. Rice, R. Connor, S. Worgall, J. P. Moore, P. L. Leopold, R. J. Kaner, and R. G. Crystal (2002)
Am. J. Respir. Cell Mol. Biol. 27, 214-219
   Abstract »    Full Text »    PDF »
Tenascin-C Is Highly Expressed in Respiratory Distress Syndrome and Bronchopulmonary Dysplasia.
R. Kaarteenaho-Wiik, V. L. Kinnula, R. Herva, Y. Soini, R. Pollanen, and P. Paakko (2002)
J. Histochem. Cytochem. 50, 423-431
   Abstract »    Full Text »    PDF »
Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia.
N. Sato, P. L. Leopold, and R. G. Crystal (2001)
J Natl Cancer Inst 93, 1858-1864
   Abstract »    Full Text »    PDF »
Cu/Zn-Superoxide Dismutase Gene Attenuates Ischemia-Reperfusion Injury in the Rat Kidney.
M. Yin, M. D. Wheeler, H. D. Connor, Z. Zhong, H. Bunzendahl, A. Dikalova, R. J. Samulski, R. Schoonhoven, R. P. Mason, J. A. Swenberg, et al. (2001)
J. Am. Soc. Nephrol. 12, 2691-2700
   Abstract »    Full Text »    PDF »
Animal models of chronic obstructive pulmonary disease.
P A Dawkins and R A Stockley (2001)
Thorax 56, 972-977
   Full Text »    PDF »
Stromelysin Gene Transfer into Cultured Human Trabecular Cells and Rat Trabecular Meshwork In Vivo.
C. Kee, S. Sohn, and J.-M. Hwang (2001)
Invest. Ophthalmol. Vis. Sci. 42, 2856-2860
   Abstract »    Full Text »    PDF »
Distribution and mRNA Expression of Tenascin-C in Developing Human Lung.
R. Kaarteenaho-Wiik, V. Kinnula, R. Herva, P. Paakko, R. Pollanen, and Y. Soini (2001)
Am. J. Respir. Cell Mol. Biol. 25, 341-346
   Abstract »    Full Text »    PDF »
Gene Therapy in Cystic Fibrosis.
T. R. Flotte and B. L. Laube (2001)
Chest 120, 124S-131S
   Abstract »    Full Text »    PDF »
Adenoviral Augmentation of Elafin Protects the Lung Against Acute Injury Mediated by Activated Neutrophils and Bacterial Infection.
A. J. Simpson, W. A. H. Wallace, M. E. Marsden, J. R. W. Govan, D. J. Porteous, C. Haslett, and J.-M. Sallenave (2001)
J. Immunol. 167, 1778-1786
   Abstract »    Full Text »    PDF »
Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-{kappa}B activation and cytokine production.
M. D. Wheeler, S. Yamashina, M. Froh, I. Rusyn, and R. G. Thurman (2001)
J. Leukoc. Biol. 69, 622-630
   Abstract »    Full Text »
Adenovirus infection increases iNOS and peroxynitrite production in the lung.
Z. K. Zsengeller, G. F. Ross, B. C. Trapnell, C. Szabo, and J. A. Whitsett (2001)
Am J Physiol Lung Cell Mol Physiol 280, L503-L511
   Abstract »    Full Text »    PDF »
Research Opportunities and Advances in Lung Disease.
R. G. Crystal (2001)
JAMA 285, 612-618
   Abstract »    Full Text »    PDF »
Adenovirus Serotype 7 Retention in a Late Endosomal Compartment prior to Cytosol Escape Is Modulated by Fiber Protein.
N. Miyazawa, R. G. Crystal, and P. L. Leopold (2001)
J. Virol. 75, 1387-1400
   Abstract »    Full Text »
Rapid Assessment of Adenovirus Serum Neutralizing Antibody Titer Based on Quantitative, Morphometric Evaluation of Capsid Binding and Intracellular Trafficking: Population Analysis of Adenovirus Capsid Association with Cells Is Predictive of Adenovirus Infectivity.
T. Vincent, B.-G. Harvey, S. M. Hogan, C. J. Bailey, R. G. Crystal, and P. L. Leopold (2001)
J. Virol. 75, 1516-1521
   Abstract »    Full Text »
Gene Therapy for Pulmonary Diseases.
J. West and D. M. Rodman (2001)
Chest 119, 613-617
   Abstract »    Full Text »    PDF »
Usefulness of Repeated Direct Intratumoral Gene Transfer Using Hemagglutinating Virus of Japan-Liposome Method for Cytosine Deaminase Suicide Gene Therapy.
H. Kanyama, N. Tomita, T. Yamano, T. Aihara, Y. Miyoshi, M. Ohue, M. Sekimoto, I. Sakita, Y. Tamaki, Y. Kaneda, et al. (2001)
Cancer Res. 61, 14-18
   Abstract »    Full Text »
Strategy for Systematic Assembly of Large RNA and DNA Genomes: Transmissible Gastroenteritis Virus Model.
B. Yount, K. M. Curtis, and R. S. Baric (2000)
J. Virol. 74, 10600-10611
   Abstract »    Full Text »
Tumor Regression Induced by Intratumor Administration of Adenovirus Vector Expressing CD40 Ligand and Naive Dendritic Cells.
T. Kikuchi, N. Miyazawa, M. A. S. Moore, and R. G. Crystal (2000)
Cancer Res. 60, 6391-6395
   Abstract »    Full Text »
Tenascin Expression and Distribution in Pleural Inflammatory and Fibrotic Diseases.
R. Kaarteenaho–Wiik, E. Lakari, Y. Soini, R. Pöllänen, V. L. Kinnula, and P. Pääkkö (2000)
J. Histochem. Cytochem. 48, 1257-1268
   Abstract »    Full Text »
Gene Transfer of a Soluble Receptor of VEGF Inhibits the Growth of Experimental Eyelid Malignant Melanoma.
S. Shiose, T. Sakamoto, H. Yoshikawa, Y. Hata, Y. Kawano, T. Ishibashi, H. Inomata, K. Takayama, and H. Ueno (2000)
Invest. Ophthalmol. Vis. Sci. 41, 2395-2403
   Abstract »    Full Text »
Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors.
T. Kikuchi, M. A. S. Moore, and R. G. Crystal (2000)
Blood 96, 91-99
   Abstract »    Full Text »    PDF »
Lung Overexpression of the Vascular Endothelial Growth Factor Gene Induces Pulmonary Edema.
R. J. Kaner, J. V. Ladetto, R. Singh, N. Fukuda, M. A. Matthay, and R. G. Crystal (2000)
Am. J. Respir. Cell Mol. Biol. 22, 657-664
   Abstract »    Full Text »
Gene Therapy for Lung Disease: Hype or Hope?.
S. M. Albelda, R. Wiewrodt, and J. B. Zuckerman (2000)
Ann Intern Med 132, 649-660
   Abstract »    Full Text »    PDF »
Tenascin mRNA Expression at the Foci of Recent Injury in Usual Interstitial Pneumonia.
P. PAAKKO, R. KAARTEENAHO-WIIK, R. POLLANEN, and Y. SOINI (2000)
Am. J. Respir. Crit. Care Med. 161, 967-972
   Abstract »    Full Text »    PDF »
Prolonged Response to Antisense Cyclin D1 in a Human Squamous Cancer Xenograft Model.
E. R. Sauter, M. Herlyn, S.-C. Liu, S. Litwin, and J. A. Ridge (2000)
Clin. Cancer Res. 6, 654-660
   Abstract »    Full Text »
Enhanced Liver Uptake of Opsonized Red Blood Cells After In Vivo Transfer of Fcgamma RIIA cDNA to the Liver.
P. Bezdicek, S. Worgall, I. Kovesdi, M.-K. Kim, J.-G. Park, T. Vincent, P. L. Leopold, A. D. Schreiber, and R. G. Crystal (1999)
Blood 94, 3448-3455
   Abstract »    Full Text »    PDF »
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons.
N. Morral, W. O'Neal, K. Rice, M. Leland, J. Kaplan, P. A. Piedra, H. Zhou, R. J. Parks, R. Velji, E. Aguilar-Cordova, et al. (1999)
PNAS 96, 12816-12821
   Abstract »    Full Text »    PDF »
Antisense Cyclin D1 Induces Apoptosis and Tumor Shrinkage in Human Squamous Carcinomas.
E. R. Sauter, M. Nesbit, S. Litwin, A. J. P. Klein-Szanto, S. Cheffetz, and M. Herlyn (1999)
Cancer Res. 59, 4876-4881
   Abstract »    Full Text »    PDF »
Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model.
M.Y. Alexander, M.J. Brosnan, C. A Hamilton, P. Downie, A. M Devlin, F. Dowell, W. Martin, H. M Prentice, T. O'Brien, and A. F Dominiczak (1999)
Cardiovasc Res 43, 798-807
   Abstract »    Full Text »    PDF »
Variability of Human Systemic Humoral Immune Responses to Adenovirus Gene Transfer Vectors Administered to Different Organs.
B.-G. Harvey, N. R. Hackett, T. El-Sawy, T. K. Rosengart, E. A. Hirschowitz, M. D. Lieberman, M. L. Lesser, and R. G. Crystal (1999)
J. Virol. 73, 6729-6742
   Abstract »    Full Text »
Fiber Swap between Adenovirus Subgroups B and C Alters Intracellular Trafficking of Adenovirus Gene Transfer Vectors.
N. Miyazawa, P. L. Leopold, N. R. Hackett, B. Ferris, S. Worgall, E. Falck-Pedersen, and R. G. Crystal (1999)
J. Virol. 73, 6056-6065
   Abstract »    Full Text »
Engineering Viral Vectors to Subvert the Airway Defense Response.
D. C. Look and S. L. Brody (1999)
Am. J. Respir. Cell Mol. Biol. 20, 1103-1106
   Full Text »
E1-E4+ Adenoviral Gene Transfer Vectors Function as a "Pro-Life" Signal to Promote Survival of Primary Human Endothelial Cells.
R. Ramalingam, S. Rafii, S. Worgall, D. E. Brough, and R. G. Crystal (1999)
Blood 93, 2936-2944
   Abstract »    Full Text »    PDF »
Selective Expansion of Alveolar Macrophages In Vivo by Adenovirus-Mediated Transfer of the Murine Granulocyte-Macrophage Colony-Stimulating Factor cDNA.
S. Worgall, R. Singh, P. L. Leopold, R. J. Kaner, N. R. Hackett, N. Topf, M. A.S. Moore, and R. G. Crystal (1999)
Blood 93, 655-666
   Abstract »    Full Text »    PDF »
Adenovirus Vector-Mediated Perforin Expression Driven by a Glucocorticoid-Inducible Promoter Inhibits Tumor Growth In Vivo.
K. Narumi, A. Kojima, and R. G. Crystal (1998)
Am. J. Respir. Cell Mol. Biol. 19, 936-941
   Abstract »    Full Text »
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors.
S. Song, M. Morgan, T. Ellis, A. Poirier, K. Chesnut, J. Wang, M. Brantly, N. Muzyczka, B. J. Byrne, M. Atkinson, et al. (1998)
PNAS 95, 14384-14388
   Abstract »    Full Text »    PDF »
Intermittent, Repetitive Corticosteroid-Induced Upregulation of Platelet Levels After Adenovirus-Mediated Transfer to the Liver of a Chimeric Glucocorticoid-Responsive Promoter Controlling the Thrombopoietin cDNA.
K. Narumi, M. Suzuki, W. Song, M. A.S. Moore, and R. G. Crystal (1998)
Blood 92, 822-833
   Abstract »    Full Text »    PDF »
Genetics and respiratory disease bullet  2: Alpha1-antitrypsin deficiency, cirrhosis and emphysema.
R. Mahadeva and D. A Lomas (1998)
Thorax 53, 501-505
   Full Text »
Transfer of the Human Alpha1-Antitrypsin Gene into Pulmonary Macrophages In Vivo.
T. Ferkol, F. Mularo, J. Hilliard, S. Lodish, J. C. Perales, A. Ziady, and M. Konstan (1998)
Am. J. Respir. Cell Mol. Biol. 18, 591-601
   Abstract »    Full Text »
High-Efficiency Gene Transfer Into Ex Vivo Expanded Human Hematopoietic Progenitors and Precursor Cells by Adenovirus Vectors.
B. M. Frey, N. R. Hackett, J. M. Bergelson, R. Finberg, R. G. Crystal, M. A.S. Moore, and S. Rafii (1998)
Blood 91, 2781-2792
   Abstract »    Full Text »    PDF »
Cytotoxic T-Lymphocyte Target Proteins and Their Major Histocompatibility Complex Class I Restriction in Response to Adenovirus Vectors Delivered to Mouse Liver.
K. Jooss, H. C. J. Ertl, and J. M. Wilson (1998)
J. Virol. 72, 2945-2954
   Abstract »    Full Text »    PDF »
Pulmonary Cell Biology.
R. J. MASON and R. G. CRYSTAL (1998)
Am. J. Respir. Crit. Care Med. 157, S72-S81
   Full Text »    PDF »
A simplified system for generating recombinant adenoviruses.
T.-C. He, S. Zhou, L. T. da Costa, J. Yu, K. W. Kinzler, and B. Vogelstein (1998)
PNAS 95, 2509-2514
   Abstract »    Full Text »    PDF »
Adenovector-Mediated Expression of Human Thrombopoietin cDNA in Immune-Compromised Mice: Insights into the Pathophysiology of Osteomyelofibrosis.
B. M. Frey, S. Rafii, M. Teterson, D. Eaton, R. G. Crystal, and M. A.S. Moore (1998)
J. Immunol. 160, 691-699
   Abstract »    Full Text »    PDF »
Human Salivary Histatins: Promising Anti-Fungal Therapeutic Agents.
H. Tsai and L.A. Bobek (1998)
Critical Reviews in Oral Biology & Medicine 9, 480-497
   Abstract »    Full Text »    PDF »
In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector.
T. Hara, Y. Tan, and L. Huang (1997)
PNAS 94, 14547-14552
   Abstract »    Full Text »    PDF »
Dendritic Cells Genetically Modified with an Adenovirus Vector Encoding the cDNA for a Model Antigen Induce Protective and Therapeutic Antitumor Immunity.
W. Song, H.-L. Kong, H. Carpenter, H. Torii, R. Granstein, S. Rafii, M. A.S. Moore, and R. G. Crystal (1997)
J. Exp. Med. 186, 1247-1256
   Abstract »    Full Text »    PDF »
Liposome mediated gene transfer into the rat oesophagus.
R M Schmid, H Weidenbach, G F Draenert, S Liptay, H Luhrs, and G Adler (1997)
Gut 41, 549-556
   Abstract »    Full Text »    PDF »
Optimal techniques for arterial gene transfer.
L. J Feldman and G. Steg (1997)
Cardiovasc Res 35, 391-404
   Abstract »    Full Text »    PDF »
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands.
C. Delporte, B. C. O'Connell, X. He, H. E. Lancaster, A. C. O'Connell, P. Agre, and B. J. Baum (1997)
PNAS 94, 3268-3273
   Abstract »    Full Text »    PDF »
Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery.
I. van der Woude, A. Wagenaar, A. A. P. Meekel, M. B. A. ter Beest, M. H. J. Ruiters, J. B. F. N. Engberts, and D. Hoekstra (1997)
PNAS 94, 1160-1165
   Abstract »    Full Text »    PDF »
Adenovirus-mediated Expression of Aquaporin-5 in Epithelial Cells.
C. Delporte, B. C. O'Connell, X. He, I. S. Ambudkar, P. Agre, and B. J. Baum (1996)
J. Biol. Chem. 271, 22070-22075
   Abstract »    Full Text »    PDF »
Keratinocyte Gene Transfer and Gene Therapy.
J.A. Garlick and E.S. Fenjves (1996)
Critical Reviews in Oral Biology & Medicine 7, 204-221
   Abstract »    Full Text »    PDF »
CARDIAC GENE TRANSFER BY INTRACORONARY INFUSION OF ADENOVIRUS VECTOR--MEDIATED REPORTER GENE IN THE TRANSPLANTED MOUSE HEART.
J. Lee, H. Laks, D. C. Drinkwater, A. Blitz, L. Lam, Y. Shiraishi, P. Chang, T. A. Drake, and A. Ardehali (1996)
J. Thorac. Cardiovasc. Surg. 111, 246-252
   Abstract »    Full Text »
VEGF165 Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo.
J. Muhlhauser, M. J. Merrill, R. Pili, H. Maeda, M. Bacic, B. Bewig, A. Passaniti, N. A. Edwards, R. G. Crystal, and M. C. Capogrossi (1995)
Circ. Res. 77, 1077-1086
   Abstract »    Full Text »
Transfer of Genes to Humans: Early Lessons and Obstacles to Success.
R. G. Crystal (1995)
Science 270, 404-410
   Abstract »    PDF »
In Vivo Adenovirus-Mediated Gene Transfer Via the Pulmonary Artery of Rats.
S. K. Schachtner, J. J. Rome, R. F. Hoyt Jr, K. D. Newman, R. Virmani, and D. A. Dichek (1995)
Circ. Res. 76, 701-709
   Abstract »    Full Text »
Gene Therapy.
F. Levine and T. Friedmann (1993)
Arch Pediatr Adolesc Med 147, 1167-1174
   Abstract »    PDF »
The basic science of gene therapy.
R. Mulligan (1993)
Science 260, 926-932
   Abstract »    PDF »
Identifying strategies for immune intervention.
A Lanzavecchia (1993)
Science 260, 937-944
   Abstract »    PDF »
Recent Advances in Pulmonary Medicine- First of Two Parts.
S. E. Weinberger (1993)
N. Engl. J. Med. 328, 1389-1397
   Full Text »
An adenovirus vector for gene transfer into neurons and glia in the brain.
G Le Gal La Salle, J. Robert, S Berrard, V Ridoux, L. Stratford-Perricaudet, M Perricaudet, and J Mallet (1993)
Science 259, 988-990
   Abstract »
Human Gene Therapy: A Role for the Primary Care Physician.
C. J. Schmeichel and J. M. Loeb (1992)
Arch Fam Med 1, 113-120
   Abstract »    PDF »
POSSIBLE BREAKTHROUGH IN GENE THERAPY FOR LUNG DISEASE.
(1991)
Journal Watch (General) 1991, 6
   Full Text »
New vector delivers genes to lung cells.
M Hoffman (1991)
Science 252, 374
   PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)