Related Content
Search Google Scholar for:
|
|
Science 19 April 1991:
Vol. 252. no. 5004, pp. 424 - 427
DOI: 10.1126/science.1850169
|
|
Articles
Science, Vol 252, Issue 5004, 424-427
Copyright © 1991 by American Association for the Advancement of Science
A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice
AW Hugin,
MS Vacchio,
and
HC Morse 3rd
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
The development of an immunodeficiency syndrome of mice caused by a replication-defective murine leukemia virus (MuLV) is paradoxically associated with a rapid activation and proliferation of CD4+ T cells that are dependent on the presence of B cells. The responses of normal spleen cells to B cell lines that express the defective virus indicated that these lines express a cell surface determinant that shares "superantigenic" properties with some microbial antigens and Mls-like self antigens. This antigen elicited a potent proliferative response that was dependent on the presence of CD4+ T cells and was associated with selective expansion of cells bearing V beta 5. This response was markedly inhibited by a monoclonal antibody specific for the MuLV gag-encoded p30 antigen.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Retroelements and the human genome: New perspectives on an old relation.
- N. Bannert and R. Kurth (2004)
PNAS
101, 14572-14579
| Abstract »
| Full Text »
| PDF »
- Induction of Apoptosis by HIV-1-Infected Monocytic Cells.
- K. Sperber, P. Beuria, N. Singha, I. Gelman, P. Cortes, H. Chen, and T. Kraus (2003)
J. Immunol.
170, 1566-1578
| Abstract »
| Full Text »
| PDF »
- Superantigens: The Good, the Bad, and the Ugly.
- B. A. Torres, S. Kominsky, G. Q. Perrin, A. C. Hobeika, and H. M. Johnson (2001)
Experimental Biology and Medicine
226, 164-176
| Abstract »
| Full Text »
- Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process.
- R. J. Hayashi and O. Kanagawa (1999)
Int. Immunol.
11, 1581-1590
| Abstract »
| Full Text »
| PDF »
- Chronically HIV-1-Infected Monocytic Cells Induce Apoptosis in Cocultured T Cells.
- H. Chen, Y. K. Yip, I. George, M. Tyorkin, E. Salik, and K. Sperber (1998)
J. Immunol.
161, 4257-4267
| Abstract »
| Full Text »
| PDF »
- Staphylococcal Enterotoxin A Induces Survival of VH3-Expressing Human B Cells by Binding to the VH Region with Low Affinity.
- R. Domiati-Saad and P. E. Lipsky (1998)
J. Immunol.
161, 1257-1266
| Abstract »
| Full Text »
| PDF »
- CD28-B7 Costimulatory Blockade by CTLA4Ig Delays the Development of Retrovirus-Induced Murine AIDS.
- L. de Leval, S. Colombi, S. Debrus, M.-A. Demoitie, R. Greimers, P. Linsley, M. Moutschen, and J. Boniver (1998)
J. Virol.
72, 5285-5290
| Abstract »
| Full Text »
| PDF »
- Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis.
- H. Perron, J. A. Garson, F. Bedin, F. Beseme, G. Paranhos-Baccala, F. Komurian-Pradel, F. Mallet, P. W. Tuke, C. Voisset, J. L. Blond, et al. (1997)
PNAS
94, 7583-7588
| Abstract »
| Full Text »
| PDF »
- Endogenous Retroviral Sequences in the Pathogenesis of Systemic Autoimmune Disease.
- M. Walchner, C. Leib-Mosch, G. Messer, H. Germaier, G. Plewig, and P. Kind (1997)
Arch Dermatol
133, 767-771
| Abstract »
| PDF »
- Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS).
- O Kanagawa, B. Vaupel, S Gayama, G Koehler, and M Kopf (1993)
Science
262, 240-242
| Abstract »
| PDF »
- Superantigens and endogenous retroviruses: a confluence of puzzles.
- J. Coffin (1992)
Science
255, 411-413
| PDF »
- Selective depletion in HIV infection of T cells that bear specific T cell receptor V beta sequences.
- L Imberti, A Sottini, A Bettinardi, M Puoti, and D Primi (1991)
Science
254, 860-862
| Abstract »
| PDF »
|
|
