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Science 5 April 1991:
Vol. 252. no. 5002, pp. 120 - 123
DOI: 10.1126/science.1672777
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Articles

Science, Vol 252, Issue 5002, 120-123
Copyright © 1991 by American Association for the Advancement of Science

articles

Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)

KJ Koller, DG Lowe, GL Bennett, N Minamino, K Kangawa, H Matsuo, and DV Goeddel

Department of Molecular Biology, Genentech, Inc., South San Francisco 94080.

The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ANPR-A guanylyl cyclase, neither hormone can significantly stimulate ANPR-B. A member of this hormone family, C-type natriuretic peptide (CNP), potently and selectively activated the human ANPR-B guanylyl cyclase. CNP does not increase guanosine 3',5'-monophosphate accumulation in cells expressing human ANPR-A. The affinity of CNP for ANPR-B is 50- or 500-fold higher than ANP or BNP, respectively. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.


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J.-Z. Sun, S.-J. Chen, G. Li, and Y.-F. Chen (2000)
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Coexistence of C-Type Natriuretic Peptide and Atrial Natriuretic Peptide Systems in the Bovine Cornea.
S. Z. Kim, H. S. Kim, K. S. Lee, S. J. Lee, K. H. Seul, G. Y. Koh, K. W. Cho, and S. H. Kim (2000)
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Depletion of Natriuretic Peptide C Receptors Eliminates Inhibitory Effects of C-Type Natriuretic Peptide on Evoked Neurotransmitter Efflux.
G. J. Trachte (2000)
J. Pharmacol. Exp. Ther. 294, 210-215
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Functional Deletion Mutation of the 5'-Flanking Region of Type A Human Natriuretic Peptide Receptor Gene and Its Association With Essential Hypertension and Left Ventricular Hypertrophy in the Japanese.
T. Nakayama, M. Soma, Y. Takahashi, D. Rehemudula, K. Kanmatsuse, and K. Furuya (2000)
Circ. Res. 86, 841-845
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Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo.
K. Morishige, H. Shimokawa, T. Yamawaki, K. Miyata, Y. Eto, T. Kandabashi, K. Yogo, T. Higo, K. Egashira, H. Ueno, et al. (2000)
J. Am. Coll. Cardiol. 35, 1040-1047
   Abstract »    Full Text »    PDF »
C-type natriuretic peptide inhibits ANP secretion and atrial dynamics in perfused atria: NPR-B-cGMP signaling.
S. J. Lee, S. Z. Kim, X. Cui, S. H. Kim, K. S. Lee, Y. J. Chung, and K. W. Cho (2000)
Am J Physiol Heart Circ Physiol 278, H208-H221
   Abstract »    Full Text »    PDF »
Modulation of endocardial natriuretic peptide receptors in right ventricular hypertrophy.
S. Z. Kim, K. W. Cho, and S. H. Kim (1999)
Am J Physiol Heart Circ Physiol 277, H2280-H2289
   Abstract »    Full Text »    PDF »
Hypertension Associated with Decreased Testosterone Levels in Natriuretic Peptide Receptor-A Gene-Knockout and Gene-Duplicated Mutant Mouse Models.
K. N. Pandey, P. M. Oliver, N. Maeda, and O. Smithies (1999)
Endocrinology 140, 5112-5119
   Abstract »    Full Text »
Further attenuation of endothelium-dependent relaxation imparted by natriuretic peptide receptor antagonism.
P. W. Wennberg, V. M. Miller, T. Rabelink, and J. C. Burnett Jr. (1999)
Am J Physiol Heart Circ Physiol 277, H1618-H1621
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Biological Effects of C-type Natriuretic Peptide in Human Myofibroblastic Hepatic Stellate Cells.
J. Tao, A. Mallat, C. Gallois, S. Belmadani, P.-F. Mery, J. T.-V. Nhieu, C. Pavoine, and S. Lotersztajn (1999)
J. Biol. Chem. 274, 23761-23769
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Hormonal Regulation of Natriuretic Peptide System during Induced Ovarian Follicular Development in the Rat.
J. Gutkowska, M. Jankowski, M. Ram Sairam, N. Fujio, A. M. Reis, S. Mukaddam-Daher, and J. Tremblay (1999)
Biol Reprod 61, 162-170
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Vasorelaxing effects of atrial and brain natriuretic peptides on coronary circulation in heart failure.
T. Matsumoto, A. Wada, T. Tsutamoto, T. Omura, H. Yokohama, M. Ohnishi, I. Nakae, M. Takahashi, and M. Kinoshita (1999)
Am J Physiol Heart Circ Physiol 276, H1935-H1942
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Atrial, B-type, and C-type natriuretic peptides cause mesenteric vasoconstriction in conscious dogs.
R. L. Woods and M. J. M. Jones (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R1443-R1452
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Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells.
F. Liang, F. Schaufele, and D. G. Gardner (1999)
Endocrinology 140, 1695-1701
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Structure of the Type B Human Natriuretic Peptide Receptor Gene and Association of a Novel Microsatellite Polymorphism With Essential Hypertension.
D. Rehemudula, T. Nakayama, M. Soma, Y. Takahashi, J. Uwabo, M. Sato, Y. Izumi, K. Kanmatsuse, and Y. Ozawa (1999)
Circ. Res. 84, 605-610
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Intracellular Fragments of the Natriuretic Peptide Receptor-C (NPR-C) Attenuate Dopamine Efflux.
S. Kanwal, D. G. Lowe, and G. J. Trachte (1999)
Endocrinology 140, 1118-1124
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D. F. Sellitti and S. Q. Doi (1999)
Endocrinology 140, 1365-1374
   Abstract »    Full Text »
Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland.
S. G. Aller, I. D. Lombardo, S. Bhanot, and J. N. Forrest Jr. (1999)
Am J Physiol Cell Physiol 276, C442-C449
   Abstract »    Full Text »    PDF »
Functionally Active Catalytic Domain Is Essential for Guanylyl Cyclase-Linked Receptor Mediated Inhibition of Human Aldosterone Synthesis.
L. J. Olson, B. Y. Ho, L. W. Cashdollar, and J. G. Drewett (1998)
Mol. Pharmacol. 54, 761-769
   Abstract »    Full Text »
CNP causes receptor-mediated positive dromotropic effects in anesthetized dog hearts.
M. Hirose, Y. Furukawa, Y. Miyashita, F. Kurogouchi, K. Nakajima, M. Tsuboi, and S. Chiba (1998)
Am J Physiol Heart Circ Physiol 275, H717-H720
   Abstract »    Full Text »    PDF »
C-Type Natriuretic Peptide Increases Myocardial Contractility and Sinus Rate Mediated by Guanylyl Cyclase-Linked Natriuretic Peptide Receptors in Isolated, Blood-Perfused Dog Heart Preparations.
M. Hirose, Y. Furukawa, F. Kurogouchi, K. Nakajima, Y. Miyashita, and S. Chiba (1998)
J. Pharmacol. Exp. Ther. 286, 70-76
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Ligand-dependent regulation of NPR-A gene expression in inner medullary collecting duct cells.
L. Cao, S. C. Chen, T. Cheng, M. H. Humphreys, and D. G. Gardner (1998)
Am J Physiol Renal Physiol 275, F119-F125
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Natriuretic Peptide Regulation of Endochondral Ossification. EVIDENCE FOR POSSIBLE ROLES OF THE C-TYPE NATRIURETIC PEPTIDE/GUANYLYL CYCLASE-B PATHWAY.
A. Yasoda, Y. Ogawa, M. Suda, N. Tamura, K. Mori, Y. Sakuma, H. Chusho, K. Shiota, K. Tanaka, and K. Nakao (1998)
J. Biol. Chem. 273, 11695-11700
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Regulation of Endothelial Production of C-Type Natriuretic Peptide by Interaction between Endothelial Cells and Macrophages.
S.-i. Suga, H. Itoh, Y. Komatsu, H. Ishida, T. Igaki, J. Yamashita, K. Doi, T.-H. Chun, T. Yoshimasa, I. Tanaka, et al. (1998)
Endocrinology 139, 1920-1926
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Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.
M. Suda, Y. Ogawa, K. Tanaka, N. Tamura, A. Yasoda, T. Takigawa, M. Uehira, H. Nishimoto, H. Itoh, Y. Saito, et al. (1998)
PNAS 95, 2337-2342
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Low-Dose C-Type Natriuretic Peptide Does Not Affect Cardiac and Renal Function in Humans.
G. Barletta, C. Lazzeri, S. Vecchiarino, R. Del Bene, G. Messeri, A. Dello Sbarba, M. Mannelli, and G. La Villa (1998)
Hypertension 31, 802-808
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The Cloning and Expression of a New Guanylyl Cyclase Orphan Receptor.
S. Schulz, B. J. Wedel, A. Matthews, and D. L. Garbers (1998)
J. Biol. Chem. 273, 1032-1037
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Differential effects of rat pregnancy on uterine and lung atrial natriuretic factor receptors.
P. Vaillancourt, S. Omer, X.-F. Deng, S. Mulay, and D. R. Varma (1998)
Am J Physiol Endocrinol Metab 274, E52-E56
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Atrial Natriuretic Peptide Inhibits Evoked Catecholamine Release by Altering Sensitivity to Calcium.
S. Kanwal, B. J. Elmquist, and G. J. Trachte (1997)
J. Pharmacol. Exp. Ther. 283, 426-433
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Effect of endogenous natriuretic peptide system on ventricular and coronary function in failing heart.
K. Yamamoto, J. C. Burnett Jr., and M. M. Redfield (1997)
Am J Physiol Heart Circ Physiol 273, H2406-H2414
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Effect of Natriuretic Peptide Family on the Oxidized LDL–Induced Migration of Human Coronary Artery Smooth Muscle Cells.
M. Kohno, K. Yokokawa, K. Yasunari, H. Kano, M. Minami, M. Ueda, and J. Yoshikawa (1997)
Circ. Res. 81, 585-590
   Abstract »    Full Text »
Local Expression of C-Type Natriuretic Peptide Markedly Suppresses Neointimal Formation in Rat Injured Arteries Through an Autocrine/Paracrine Loop.
H. Ueno, A. Haruno, N. Morisaki, M. Furuya, K. Kangawa, A. Takeshita, and Y. Saito (1997)
Circulation 96, 2272-2279
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Gene expression of natriuretic peptide receptors in rats with DOCA-salt hypertension.
E. Nuglozeh, M. Mbikay, D. J. Stewart, and L. Legault (1997)
Am J Physiol Cell Physiol 273, C1427-C1434
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The Guanylyl Cyclase-deficient Mouse Defines Differential Pathways of Natriuretic Peptide Signaling.
M. J. Lopez, D. L. Garbers, and M. Kuhn (1997)
J. Biol. Chem. 272, 23064-23068
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Neutral Endopeptidase Regulates C-Type Natriuretic Peptide Metabolism But Does Not Potentiate Its Bioactivity In Vivo.
R. R. Brandt, M. T. Mattingly, A. L. Clavell, P. L. Barclay, and J. C. Burnett Jr (1997)
Hypertension 30, 184-190
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Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells.
H. G Hutchinson, P. T Trindade, D. B Cunanan, C.-F. Wu, and R. E Pratt (1997)
Cardiovasc Res 35, 158-167
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The Cloning of a Caenorhabditis Elegans Guanylyl Cyclase and the Construction of a Ligand-sensitive Mammalian/Nematode Chimeric Receptor.
E. J. Baude, V. K. Arora, S. Yu, D. L. Garbers, and B. J. Wedel (1997)
J. Biol. Chem. 272, 16035-16039
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Atrial Natriuretic Peptide Induces Apoptosis in Neonatal Rat Cardiac Myocytes.
C.-F. Wu, N. H. Bishopric, and R. E. Pratt (1997)
J. Biol. Chem. 272, 14860-14866
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Atrial Natriuretic Peptide (ANP) Inhibits Its Own Secretion via ANPA Receptors: Altered Effect in Experimental Hypertension.
H. Leskinen, O. Vuolteenaho, M. Toth, and H. Ruskoaho (1997)
Endocrinology 138, 1893-1902
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Natriuretic Peptide Family as a Novel Antimigration Factor of Vascular Smooth Muscle Cells.
M. Ikeda, M. Kohno, K. Yasunari, K. Yokokawa, T. Horio, M. Ueda, N. Morisaki, and J. Yoshikawa (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 731-736
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Thrombin Inhibits Atrial Natriuretic Peptide Receptor Activity in Cultured Bovine Endothelial Cells.
D. W. Zlock, L. Cao, J. Wu, and D. G. Gardner (1997)
Hypertension 29, 83-90
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Opposite Regulation of Gax Homeobox Expression by Angiotensin II and C-Type Natriuretic Peptide.
J. Yamashita, H. Itoh, Y. Ogawa, N. Tamura, K. Takaya, T. Igaki, K. Doi, T.-H. Chun, M. Inoue, K. Masatsugu, et al. (1997)
Hypertension 29, 381-385
   Abstract »    Full Text »    PDF »
Expression of Guanylyl Cyclase-A/Atrial Natriuretic Peptide Receptor Blocks the Activation of Protein Kinase C in Vascular Smooth Muscle Cells: Role of cGMP and cGMP-Dependent Protein Kinase.
R. Kumar, W. A. Cartledge, T. M. Lincoln, and K. N. Pandey (1997)
Hypertension 29, 414-421
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Differential Expression and Autoradiographic Localization of Atrial Natriuretic Peptide Receptor in Spontaneously Hypertensive and Normotensive Rat Testes: Diminution of Testosterone in Hypertension.
A. A. Kapasi, R. Kumar, J. R. Pauly, and K. N. Pandey (1996)
Hypertension 28, 847-853
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Cytoplasmic Domain of Natriuretic Peptide Receptor-C Inhibits Adenylyl Cyclase. INVOLVEMENT OF A PERTUSSIS TOXIN-SENSITIVE G PROTEIN.
MadhuB. Anand-Srivastava, PatriciaD. Sehl, and DavidG. Lowe (1996)
J. Biol. Chem. 271, 19324-19329
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Regulation of Endothelial Production of C-Type Natriuretic Peptide in Coculture With Vascular Smooth Muscle Cells : Role of the Vascular Natriuretic Peptide System in Vascular Growth Inhibition.
Y. Komatsu, H. Itoh, S.-i. Suga, Y. Ogawa, N. Hama, I. Kishimoto, O. Nakagawa, T. Igaki, K. Doi, T. Yoshimasa, et al. (1996)
Circ. Res. 78, 606-614