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Science 5 April 1991: Vol. 252. no. 5002, pp. 120 - 123 DOI: 10.1126/science.1672777
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Articles
Science, Vol 252, Issue 5002, 120-123
Copyright © 1991 by American Association for the Advancement of Science
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)
KJ Koller,
DG Lowe,
GL Bennett,
N Minamino,
K Kangawa,
H Matsuo,
and
DV Goeddel
Department of Molecular Biology, Genentech, Inc., South San Francisco 94080.
The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ANPR-A guanylyl cyclase, neither hormone can significantly stimulate ANPR-B. A member of this hormone family, C-type natriuretic peptide (CNP), potently and selectively activated the human ANPR-B guanylyl cyclase. CNP does not increase guanosine 3',5'-monophosphate accumulation in cells expressing human ANPR-A. The affinity of CNP for ANPR-B is 50- or 500-fold higher than ANP or BNP, respectively. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.
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- The Guanylyl Cyclase-deficient Mouse Defines Differential Pathways of Natriuretic Peptide Signaling.
- M. J. Lopez, D. L. Garbers, and M. Kuhn (1997)
J. Biol. Chem.
272, 23064-23068
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- Neutral Endopeptidase Regulates C-Type Natriuretic Peptide Metabolism But Does Not Potentiate Its Bioactivity In Vivo.
- R. R. Brandt, M. T. Mattingly, A. L. Clavell, P. L. Barclay, and J. C. Burnett Jr (1997)
Hypertension
30, 184-190
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- Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells.
- H. G Hutchinson, P. T Trindade, D. B Cunanan, C.-F. Wu, and R. E Pratt (1997)
Cardiovasc Res
35, 158-167
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- The Cloning of a Caenorhabditis Elegans Guanylyl Cyclase and the Construction of a Ligand-sensitive Mammalian/Nematode Chimeric Receptor.
- E. J. Baude, V. K. Arora, S. Yu, D. L. Garbers, and B. J. Wedel (1997)
J. Biol. Chem.
272, 16035-16039
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- Atrial Natriuretic Peptide Induces Apoptosis in Neonatal Rat Cardiac Myocytes.
- C.-F. Wu, N. H. Bishopric, and R. E. Pratt (1997)
J. Biol. Chem.
272, 14860-14866
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- Atrial Natriuretic Peptide (ANP) Inhibits Its Own Secretion via ANPA Receptors: Altered Effect in Experimental Hypertension.
- H. Leskinen, O. Vuolteenaho, M. Toth, and H. Ruskoaho (1997)
Endocrinology
138, 1893-1902
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- Natriuretic Peptide Family as a Novel Antimigration Factor of Vascular Smooth Muscle Cells.
- M. Ikeda, M. Kohno, K. Yasunari, K. Yokokawa, T. Horio, M. Ueda, N. Morisaki, and J. Yoshikawa (1997)
Arterioscler Thromb Vasc Biol
17, 731-736
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- Thrombin Inhibits Atrial Natriuretic Peptide Receptor Activity in Cultured Bovine Endothelial Cells.
- D. W. Zlock, L. Cao, J. Wu, and D. G. Gardner (1997)
Hypertension
29, 83-90
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- Opposite Regulation of Gax Homeobox Expression by Angiotensin II and C-Type Natriuretic Peptide.
- J. Yamashita, H. Itoh, Y. Ogawa, N. Tamura, K. Takaya, T. Igaki, K. Doi, T.-H. Chun, M. Inoue, K. Masatsugu, et al. (1997)
Hypertension
29, 381-385
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- Expression of Guanylyl Cyclase-A/Atrial Natriuretic Peptide Receptor Blocks the Activation of Protein Kinase C in Vascular Smooth Muscle Cells: Role of cGMP and cGMP-Dependent Protein Kinase.
- R. Kumar, W. A. Cartledge, T. M. Lincoln, and K. N. Pandey (1997)
Hypertension
29, 414-421
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- Differential Expression and Autoradiographic Localization of Atrial Natriuretic Peptide Receptor in Spontaneously Hypertensive and Normotensive Rat Testes: Diminution of Testosterone in Hypertension.
- A. A. Kapasi, R. Kumar, J. R. Pauly, and K. N. Pandey (1996)
Hypertension
28, 847-853
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- Cytoplasmic Domain of Natriuretic Peptide Receptor-C Inhibits Adenylyl Cyclase. INVOLVEMENT OF A PERTUSSIS TOXIN-SENSITIVE G PROTEIN.
- MadhuB. Anand-Srivastava, PatriciaD. Sehl, and DavidG. Lowe (1996)
J. Biol. Chem.
271, 19324-19329
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- Regulation of Endothelial Production of C-Type Natriuretic Peptide in Coculture With Vascular Smooth Muscle Cells : Role of the Vascular Natriuretic Peptide System in Vascular Growth Inhibition.
- Y. Komatsu, H. Itoh, S.-i. Suga, Y. Ogawa, N. Hama, I. Kishimoto, O. Nakagawa, T. Igaki, K. Doi, T. Yoshimasa, et al. (1996)
Circ. Res.
78, 606-614
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- Natriuretic Peptide Receptors in Human Artery and Vein and Rabbit Vein Graft.
- T. Ikeda, H. Itoh, Y. Komatsu, M. Hanyu, T. Yoshimasa, K. Matsuda, K. Nakao, and T. Ban (1996)
Hypertension
27, 833-837
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- Regional Expression of Natriuretic Peptide Receptors During the Formation of Arterial Neointima in the Rabbit.
- J. Brown and Q. Chen (1995)
Circ. Res.
77, 906-918
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- Gene Expression of Natriuretic Peptide Receptors in Myocardial Cells.
- X. Lin, J. Hanze, F. Heese, R. Sodmann, and R. E. Lang (1995)
Circ. Res.
77, 750-758
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- Localization of Atrial Natriuretic Factor Receptors in the Mesenteric Arterial Bed : Comparison With Angiotensin II and Endothelin Receptors.
- H. de Leon, M.-C. Bonhomme, G. Thibault, and R. Garcia (1995)
Circ. Res.
77, 64-72
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- Atrial Natriuretic Peptide Blocks Hemorrhagic Brain Edema After 4-Hour Delay in Rats.
- G. A. Rosenberg and E. Y. Estrada (1995)
Stroke
26, 874-877
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- Interaction of Atrial Natriuretic Peptide with Its Receptors in Bovine Lung Membranes.
- T. Abe, Y. Arakawa, A. K. Rajasekaran, T.-H. Yu, and O. Wada (1995)
J. Biol. Chem.
270, 7672-7678
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- Natriuretic Peptide Receptor-B (Guanylyl Cyclase-B) Mediates C-type Natriuretic Peptide Relaxation of Precontracted Rat Aorta.
- J. G. Drewett, B. M. Fendly, D. L. Garbers, and D. G. Lowe (1995)
J. Biol. Chem.
270, 4668-4674
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- Guanylyl Cyclases: Ligands and Functions.
- T.D. Chrisman, S. Schulz, and D.L. Garbers (1992)
Cold Spring Harb Symp Quant Biol
57, 155-161
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- Activation of Protein Kinase C Stimulates the Dephosphorylation of Natriuretic Peptide Receptor-B at a Single Serine Residue. A POSSIBLE MECHANISM OF HETEROLOGOUS DESENSITIZATION.
- L. R. Potter and T. Hunter (2000)
J. Biol. Chem.
275, 31099-31106
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- Guanylyl Cyclase-linked Natriuretic Peptide Receptors: Structure and Regulation.
- L. R. Potter and T. Hunter (2001)
J. Biol. Chem.
276, 6057-6060
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