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Science 29 March 1991:
Vol. 251. no. 5001, pp. 1616 - 1618
DOI: 10.1126/science.2011743
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Articles

Science, Vol 251, Issue 5001, 1616-1618
Copyright © 1991 by American Association for the Advancement of Science

articles

Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor

RW Oppenheim, D Prevette, QW Yin, F Collins, and J MacDonald

Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.

During development of the nervous system, neurons in many regions are overproduced by proliferation, after which the excess cells are eliminated by cell death. The survival of only a proportion of neurons during normal development is thought to be regulated by the limited availability of neurotrophic agents. One such putative trophic agent is ciliary neurotrophic factor (CNTF), a polypeptide that promotes the survival of ciliary, sensory, and sympathetic neurons in vitro. In contrast to the results of in vitro studies, however, the daily treatment of chick embryos in vivo with purified human recombinant CNTF failed to rescue any of these cell populations from cell death, whereas CNTF did promote the in vivo survival of spinal motoneurons. Thus, CNTF may not act as a neurotrophic agent in vivo for those embryonic neurons (especially ciliary neurons) on which it acts in vitro. Rather, CNTF may be required for in vivo survival of motoneurons.


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Peripheral Neuropathies: Will Growth Factors Be Effective as Therapies?.
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Neurotrophic factors: two are better than one.
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Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses.
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CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death.
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Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
J. Conover, N. Ip, W. Poueymirou, B Bates, M. Goldfarb, T. DeChiara, and G. Yancopoulos (1993)
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The receptor for ciliary neurotrophic factor.
S Davis, T. Aldrich, D. Valenzuela, V. Wong, M. Furth, S. Squinto, and G. Yancopoulos (1991)
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