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Science 29 March 1991:
Vol. 251. no. 5001, pp. 1613 - 1615
DOI: 10.1126/science.1849316
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Articles

Science, Vol 251, Issue 5001, 1613-1615
Copyright © 1991 by American Association for the Advancement of Science

articles

Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells

TA Gilbertson, R Scobey, and M Wilson

Department of Zoology, University of California, Davis 95616.

The conduction of calcium ions through glutamate-gated channels is important in the induction of long-term potentiation and may trigger other cellular changes. In retinal bipolar cells, which lack the N-methyl-D-aspartate (NMDA) type of glutamate-gated channel, calcium permeability through non-NMDA channels was examined. Changes in extracellular calcium concentration unexpectedly affected the reversal potential for glutamate-induced currents in a manner consistent with these channels being highly permeable to calcium. External magnesium ions promote desensitization of these non-NMDA channels in a voltage-independent way. Thus, in addition to non-NMDA channels that conduct only sodium and potassium, there is a class that is also permeable to calcium.


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