Related Content
Search Google Scholar for:
|
|
Science 22 March 1991:
Vol. 251. no. 5000, pp. 1456 - 1464
DOI: 10.1126/science.2006420
|
|
Articles
Science, Vol 251, Issue 5000, 1456-1464
Copyright © 1991 by American Association for the Advancement of Science
The three-dimensional structure of canine parvovirus and its functional implications
J Tsao,
MS Chapman,
M Agbandje,
W Keller,
K Smith,
H Wu,
M Luo,
TJ Smith,
MG Rossmann,
RW Compans,
and
al. et
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907.
The three-dimensional atomic structure of a single-stranded DNA virus has been determined. Infectious virions of canine parvovirus contain 60 protein subunits that are predominantly VP-2. The central structural motif of VP-2 has the same topology (an eight-stranded antiparallel beta barrel) as has been found in many other icosahedral viruses but represents only about one-third of the capsid protein. There is a 22 angstrom (A) long protrusion on the threefold axes, a 15 A deep canyon circulating about each of the five cylindrical structures at the fivefold axes, and a 15 A deep depression at the twofold axes. By analogy with rhinoviruses, the canyon may be the site of receptor attachment. Residues related to the antigenic properties of the virus are found on the threefold protrusions. Some of the amino termini of VP-2 run to the exterior in full but not empty virions, which is consistent with the observation that some VP-2 polypeptides in full particles can be cleaved by trypsin. Eleven nucleotides are seen in each of 60 symmetry-related pockets on the interior surface of the capsid and together account for 13 percent of the genome.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Manipulation of the mechanical properties of a virus by protein engineering.
- C. Carrasco, M. Castellanos, P. J. de Pablo, and M. G. Mateu (2008)
PNAS
105, 4150-4155
| Abstract »
| Full Text »
| PDF »
- Surface-Exposed Adeno-Associated Virus Vp1-NLS Capsid Fusion Protein Rescues Infectivity of Noninfectious Wild-Type Vp2/Vp3 and Vp3-Only Capsids but Not That of Fivefold Pore Mutant Virions.
- J. C. Grieger, J. S. Johnson, B. Gurda-Whitaker, M. Agbandje-McKenna, and R. J. Samulski (2007)
J. Virol.
81, 7833-7843
| Abstract »
| Full Text »
| PDF »
- Asymmetric binding of transferrin receptor to parvovirus capsids.
- S. Hafenstein, L. M. Palermo, V. A. Kostyuchenko, C. Xiao, M. C. Morais, C. D. S. Nelson, V. D. Bowman, A. J. Battisti, P. R. Chipman, C. R. Parrish, et al. (2007)
PNAS
104, 6585-6589
| Abstract »
| Full Text »
| PDF »
- DNA-mediated anisotropic mechanical reinforcement of a virus.
- C. Carrasco, A. Carreira, I. A. T. Schaap, P. A. Serena, J. Gomez-Herrero, M. G. Mateu, and P. J. de Pablo (2006)
PNAS
103, 13706-13711
| Abstract »
| Full Text »
| PDF »
- Identification of novel murine parvovirus strains by epidemiological analysis of naturally infected mice.
- D. G. Besselsen, M. J. Romero, A. M. Wagner, K. S. Henderson, and R. S. Livingston (2006)
J. Gen. Virol.
87, 1543-1556
| Abstract »
| Full Text »
| PDF »
- Host-Selected Amino Acid Changes at the Sialic Acid Binding Pocket of the Parvovirus Capsid Modulate Cell Binding Affinity and Determine Virulence.
- A. Lopez-Bueno, M.-P. Rubio, N. Bryant, R. McKenna, M. Agbandje-McKenna, and J. M. Almendral (2006)
J. Virol.
80, 1563-1573
| Abstract »
| Full Text »
| PDF »
- Pushing the envelope: microinjection of Minute virus of mice into Xenopus oocytes causes damage to the nuclear envelope.
- S. Cohen and N. Pante (2005)
J. Gen. Virol.
86, 3243-3252
| Abstract »
| Full Text »
| PDF »
- Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice.
- M. Kontou, L. Govindasamy, H.-J. Nam, N. Bryant, A. L. Llamas-Saiz, C. Foces-Foces, E. Hernando, M.-P. Rubio, R. McKenna, J. M. Almendral, et al. (2005)
J. Virol.
79, 10931-10943
| Abstract »
| Full Text »
| PDF »
- Functional Relevance of Amino Acid Residues Involved in Interactions with Ordered Nucleic Acid in a Spherical Virus.
- J. Reguera, E. Grueso, A. Carreira, C. Sanchez-Martinez, J. M. Almendral, and M. G. Mateu (2005)
J. Biol. Chem.
280, 17969-17977
| Abstract »
| Full Text »
| PDF »
- Structure of Adeno-Associated Virus Type 4.
- E. Padron, V. Bowman, N. Kaludov, L. Govindasamy, H. Levy, P. Nick, R. McKenna, N. Muzyczka, J. A. Chiorini, T. S. Baker, et al. (2005)
J. Virol.
79, 5047-5058
| Abstract »
| Full Text »
| PDF »
- Mutational Analysis of Narrow Pores at the Fivefold Symmetry Axes of Adeno-Associated Virus Type 2 Capsids Reveals a Dual Role in Genome Packaging and Activation of Phospholipase A2 Activity.
- S. Bleker, F. Sonntag, and J. A. Kleinschmidt (2005)
J. Virol.
79, 2528-2540
| Abstract »
| Full Text »
| PDF »
- Nuclear Export of the Nonenveloped Parvovirus Virion Is Directed by an Unordered Protein Signal Exposed on the Capsid Surface.
- B. Maroto, N. Valle, R. Saffrich, and J. M. Almendral (2004)
J. Virol.
78, 10685-10694
| Abstract »
| Full Text »
| PDF »
- The structure of human parvovirus B19.
- B. Kaufmann, A. A. Simpson, and M. G. Rossmann (2004)
PNAS
101, 11628-11633
| Abstract »
| Full Text »
| PDF »
- Epitope Mapping of the Major Capsid Protein of Type 2 Porcine Circovirus (PCV2) by Using Chimeric PCV1 and PCV2.
- P. Lekcharoensuk, I. Morozov, P. S. Paul, N. Thangthumniyom, W. Wajjawalku, and X. J. Meng (2004)
J. Virol.
78, 8135-8145
| Abstract »
| Full Text »
| PDF »
- Pathways of Cell Infection by Parvoviruses and Adeno-Associated Viruses.
- M. Vihinen-Ranta, S. Suikkanen, and C. R. Parrish (2004)
J. Virol.
78, 6709-6714
| Full Text »
| PDF »
- Parvovirus LuIII transducing vectors packaged by LuIII versus FPV capsid proteins: the VP1 N-terminal region is not a major determinant of human cell permissiveness.
- I. H. Maxwell and F. Maxwell (2004)
J. Gen. Virol.
85, 1251-1257
| Abstract »
| Full Text »
| PDF »
- Molecular architecture of the prolate head of bacteriophage T4.
- A. Fokine, P. R. Chipman, P. G. Leiman, V. V. Mesyanzhinov, V. B. Rao, and M. G. Rossmann (2004)
PNAS
101, 6003-6008
| Abstract »
| Full Text »
| PDF »
- Structure of Adeno-Associated Virus Serotype 5.
- R. W. Walters, M. Agbandje-McKenna, V. D. Bowman, T. O. Moninger, N. H. Olson, M. Seiler, J. A. Chiorini, T. S. Baker, and J. Zabner (2004)
J. Virol.
78, 3361-3371
| Abstract »
| Full Text »
| PDF »
- Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid.
- J. Reguera, A. Carreira, L. Riolobos, J. M. Almendral, and M. G. Mateu (2004)
PNAS
101, 2724-2729
| Abstract »
| Full Text »
| PDF »
- A parvovirus isolated from royal python (Python regius) is a member of the genus Dependovirus.
- S. L. Farkas, Z. Zadori, M. Benko, S. Essbauer, B. Harrach, and P. Tijssen (2004)
J. Gen. Virol.
85, 555-561
| Abstract »
| Full Text »
| PDF »
- Influence of flanking sequences on presentation efficiency of a CD8+ cytotoxic T-cell epitope delivered by parvovirus-like particles.
- P. Rueda, G. Moron, J. Sarraseca, C. Leclerc, and J. I. Casal (2004)
J. Gen. Virol.
85, 563-572
| Abstract »
| Full Text »
| PDF »
- In Vitro Disassembly of a Parvovirus Capsid and Effect on Capsid Stability of Heterologous Peptide Insertions in Surface Loops.
- A. Carreira, M. Menendez, J. Reguera, J. M. Almendral, and M. G. Mateu (2004)
J. Biol. Chem.
279, 6517-6525
| Abstract »
| Full Text »
| PDF »
- Parvovirus B19.
- N. S. Young and K. E. Brown (2004)
N. Engl. J. Med.
350, 586-597
| Full Text »
| PDF »
- Structures of Host Range-Controlling Regions of the Capsids of Canine and Feline Parvoviruses and Mutants.
- L. Govindasamy, K. Hueffer, C. R. Parrish, and M. Agbandje-McKenna (2003)
J. Virol.
77, 12211-12221
| Abstract »
| Full Text »
| PDF »
- Monoclonal Antibodies That Distinguish Antigenic Variants of Canine Parvovirus.
- M. Nakamura, K. Nakamura, T. Miyazawa, Y. Tohya, M. Mochizuki, and H. Akashi (2003)
Clin. Vaccine Immunol.
10, 1085-1089
| Abstract »
| Full Text »
| PDF »
- Exploitation of Microtubule Cytoskeleton and Dynein during Parvoviral Traffic toward the Nucleus.
- S. Suikkanen, T. Aaltonen, M. Nevalainen, O. Valilehto, L. Lindholm, M. Vuento, and M. Vihinen-Ranta (2003)
J. Virol.
77, 10270-10279
| Abstract »
| Full Text »
| PDF »
- Combinations of Two Capsid Regions Controlling Canine Host Range Determine Canine Transferrin Receptor Binding by Canine and Feline Parvoviruses.
- K. Hueffer, L. Govindasamy, M. Agbandje-McKenna, and C. R. Parrish (2003)
J. Virol.
77, 10099-10105
| Abstract »
| Full Text »
| PDF »
- Characterization of Tissue Tropism Determinants of Adeno-Associated Virus Type 1.
- B. Hauck and W. Xiao (2003)
J. Virol.
77, 2768-2774
| Abstract »
| Full Text »
| PDF »
- The Natural Host Range Shift and Subsequent Evolution of Canine Parvovirus Resulted from Virus-Specific Binding to the Canine Transferrin Receptor.
- K. Hueffer, J. S. L. Parker, W. S. Weichert, R. E. Geisel, J.-Y. Sgro, and C. R. Parrish (2003)
J. Virol.
77, 1718-1726
| Abstract »
| Full Text »
| PDF »
- Marker Rescue of Adeno-Associated Virus (AAV) Capsid Mutants: a Novel Approach for Chimeric AAV Production.
- D. E. Bowles, J. E. Rabinowitz, and R. J. Samulski (2002)
J. Virol.
77, 423-432
| Abstract »
| Full Text »
| PDF »
- The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.
- Q. Xie, W. Bu, S. Bhatia, J. Hare, T. Somasundaram, A. Azzi, and M. S. Chapman (2002)
PNAS
99, 10405-10410
| Abstract »
| Full Text »
| PDF »
- Complementary Roles of Multiple Nuclear Targeting Signals in the Capsid Proteins of the Parvovirus Minute Virus of Mice during Assembly and Onset of Infection.
- E. Lombardo, J. C. Ramirez, J. Garcia, and J. M. Almendral (2002)
J. Virol.
76, 7049-7059
| Abstract »
| Full Text »
| PDF »
- Genome Replication and Postencapsidation Functions Mapping to the Nonstructural Gene Restrict the Host Range of a Murine Parvovirus in Human Cells.
- M.-P. Rubio, S. Guerra, and J. M. Almendral (2001)
J. Virol.
75, 11573-11582
| Abstract »
| Full Text »
- Identification of Aleutian Mink Disease Parvovirus Capsid Sequences Mediating Antibody-Dependent Enhancement of Infection, Virus Neutralization, and Immune Complex Formation.
- M. E. Bloom, S. M. Best, S. F. Hayes, R. D. Wells, J. B. Wolfinbarger, R. McKenna, and M. Agbandje-McKenna (2001)
J. Virol.
75, 11116-11127
| Abstract »
| Full Text »
| PDF »
- Phosphorylation Status of the Parvovirus Minute Virus of Mice Particle: Mapping and Biological Relevance of the Major Phosphorylation Sites.
- B. Maroto, J. C. Ramírez, and J. M. Almendral (2000)
J. Virol.
74, 10892-10902
| Abstract »
| Full Text »
- Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism.
- P. Wu, W. Xiao, T. Conlon, J. Hughes, M. Agbandje-McKenna, T. Ferkol, T. Flotte, and N. Muzyczka (2000)
J. Virol.
74, 8635-8647
| Abstract »
| Full Text »
- A Beta-Stranded Motif Drives Capsid Protein Oligomers of the Parvovirus Minute Virus of Mice into the Nucleus for Viral Assembly.
- E. Lombardo, J. C. Ramírez, M. Agbandje-McKenna, and J. M. Almendral (2000)
J. Virol.
74, 3804-3814
| Abstract »
| Full Text »
- Epitope Mapping of Human Anti-Adeno-Associated Virus Type 2 Neutralizing Antibodies: Implications for Gene Therapy and Virus Structure.
- M. Moskalenko, L. Chen, M. van Roey, B. A. Donahue, R. O. Snyder, J. G. Mcarthur, and S. D. Patel (2000)
J. Virol.
74, 1761-1766
| Abstract »
| Full Text »
- Repeat Transduction in the Mouse Lung by Using Adeno-Associated Virus Vectors with Different Serotypes.
- C. L. Halbert, E. A. Rutledge, J. M. Allen, D. W. Russell, and A. D. Miller (2000)
J. Virol.
74, 1524-1532
| Abstract »
| Full Text »
- Adding the Third Dimension to Virus Life Cycles: Three-Dimensional Reconstruction of Icosahedral Viruses from Cryo-Electron Micrographs.
- T. S. Baker, N. H. Olson, and S. D. Fuller (1999)
Microbiol. Mol. Biol. Rev.
63, 862-922
| Abstract »
| Full Text »
| PDF »
- Three-Dimensional Structure of Aleutian Mink Disease Parvovirus: Implications for Disease Pathogenicity.
- R. McKenna, N. H. Olson, P. R. Chipman, T. S. Baker, T. F. Booth, J. Christensen, B. Aasted, J. M. Fox, M. E. Bloom, J. B. Wolfinbarger, et al. (1999)
J. Virol.
73, 6882-6891
| Abstract »
| Full Text »
|
|
