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Science 15 March 1991:
Vol. 251. no. 4999, pp. 1355 - 1358
DOI: 10.1126/science.2003220

Articles

Science, Vol 251, Issue 4999, 1355-1358
Copyright © 1991 by American Association for the Advancement of Science


articles

Multiple representations of pain in human cerebral cortex

JD Talbot, S Marrett, AC Evans, E Meyer, MC Bushnell, and GH Duncan

Laboratoire de neurophysiologie comportementale, Faculte de medecine dentaire, Universite de Montreal, Quebec, Canada.

The representation of pain in the cerebral cortex is less well understood than that of any other sensory system. However, with the use of magnetic resonance imaging and positron emission tomography in humans, it has now been demonstrated that painful heat causes significant activation of the contralateral anterior cingulate, secondary somatosensory, and primary somatosensory cortices. This contrasts with the predominant activation of primary somatosensory cortex caused by vibrotactile stimuli in similar experiments. Furthermore, the unilateral cingulate activation indicates that this forebrain area, thought to regulate emotions, contains an unexpectedly specific representation of pain.


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