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Science 15 March 1991: Vol. 251. no. 4999, pp. 1355 - 1358 DOI: 10.1126/science.2003220
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Articles
Science, Vol 251, Issue 4999, 1355-1358
Copyright © 1991 by American Association for the Advancement of Science
Multiple representations of pain in human cerebral cortex
JD Talbot,
S Marrett,
AC Evans,
E Meyer,
MC Bushnell,
and
GH Duncan
Laboratoire de neurophysiologie comportementale, Faculte de medecine dentaire, Universite de Montreal, Quebec, Canada.
The representation of pain in the cerebral cortex is less well understood than that of any other sensory system. However, with the use of magnetic resonance imaging and positron emission tomography in humans, it has now been demonstrated that painful heat causes significant activation of the contralateral anterior cingulate, secondary somatosensory, and primary somatosensory cortices. This contrasts with the predominant activation of primary somatosensory cortex caused by vibrotactile stimuli in similar experiments. Furthermore, the unilateral cingulate activation indicates that this forebrain area, thought to regulate emotions, contains an unexpectedly specific representation of pain.
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| Abstract »
| Full Text »
| PDF »
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- E. Geuze, H. G. M. Westenberg, A. Jochims, C. S. de Kloet, M. Bohus, E. Vermetten, and C. Schmahl (2007)
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96, 3409-3422
| Abstract »
| Full Text »
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J. Neurosci.
26, 12165-12173
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| Full Text »
| PDF »
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- L. Monconduit, A. Lopez-Avila, J.-L. Molat, M. Chalus, and L. Villanueva (2006)
J. Neurosci.
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| Abstract »
| Full Text »
| PDF »
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| PDF »
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| PDF »
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570, 169-183
| Abstract »
| Full Text »
| PDF »
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94, 1825-1836
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| Full Text »
| PDF »
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| Full Text »
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| Full Text »
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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J. Neurosci.
22, 8183-8192
| Abstract »
| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- C. Buchel, K. Bornhovd, M. Quante, V. Glauche, B. Bromm, and C. Weiller (2002)
J. Neurosci.
22, 970-976
| Abstract »
| Full Text »
| PDF »
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- N. Witting, R. C. Kupers, P. Svensson, L. Arendt-Nielsen; A. Gjedde, and T. S. Jensen (2001)
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57, 1817-1824
| Abstract »
| Full Text »
| PDF »
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63, 959-965
| Abstract »
| Full Text »
| PDF »
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- R. K. Fulbright, C. J. Troche, P. Skudlarski, J. C. Gore, and B. E. Wexler (2001)
Am. J. Roentgenol.
177, 1205-1210
| Abstract »
| Full Text »
| PDF »
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- B. H. Manning, N. M. Merin, I. D. Meng, and D. G. Amaral (2001)
J. Neurosci.
21, 8238-8246
| Abstract »
| Full Text »
| PDF »
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- L. Timmermann, M. Ploner, K. Haucke, F. Schmitz, R. Baltissen, and A. Schnitzler (2001)
J Neurophysiol
86, 1499-1503
| Abstract »
| Full Text »
| PDF »
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- N. P. L. G. Verhoeff and S. Kapur (2001)
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14, 332-340
| Abstract »
| PDF »
- Cortical Representation of the Sensory Dimension of Pain.
- R. K. Hofbauer, P. Rainville, G. H. Duncan, and M. C. Bushnell (2001)
J Neurophysiol
86, 402-411
| Abstract »
| Full Text »
| PDF »
- Hemispheric Lateralization of Somatosensory Processing.
- R. C. Coghill, I. Gilron, and M. J. Iadarola (2001)
J Neurophysiol
85, 2602-2612
| Abstract »
| Full Text »
| PDF »
- Potentiation of sensory responses in the anterior cingulate cortex following digit amputation in the anaesthetised rat.
- F. Wei and M. Zhuo (2001)
J. Physiol.
532, 823-833
| Abstract »
| Full Text »
| PDF »
- Cerebral cortical representation of reflexive and volitional swallowing in humans.
- M. K. Kern, S. Jaradeh, R. C. Arndorfer, and R. Shaker (2001)
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280, G354-G360
| Abstract »
| Full Text »
| PDF »
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- M. Liotti, S. Brannan, G. Egan, R. Shade, L. Madden, B. Abplanalp, R. Robillard, J. Lancaster, F. E. Zamarripa, P. T. Fox, et al. (2001)
PNAS
98, 2035-2040
| Abstract »
| Full Text »
| PDF »
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- N. Sawamoto, M. Honda, T. Okada, T. Hanakawa, M. Kanda, H. Fukuyama, J. Konishi, and H. Shibasaki (2000)
J. Neurosci.
20, 7438-7445
| Abstract »
| Full Text »
| PDF »
- Functional MR Imaging Analysis of Pain-related Brain Activation after Acute Mechanical Stimulation.
- C. Créac'h, P. Henry, J. M. Caillé, and M. Allard (2000)
AJNR Am. J. Neuroradiol.
21, 1402-1406
| Abstract »
| Full Text »
- Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications V. Central nervous system processing of somatic and visceral sensory signals.
- U. Ladabaum, S. Minoshima, and C. Owyang (2000)
Am J Physiol Gastrointest Liver Physiol
279, G1-G6
| Abstract »
| Full Text »
| PDF »
- Cortical Responses to Thermal Pain Depend on Stimulus Size: A Functional MRI Study.
- A. V. Apkarian, P. A. Gelnar, B. R. Krauss, and N. M. Szeverenyi (2000)
J Neurophysiol
83, 3113-3122
| Abstract »
| Full Text »
| PDF »
- Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus, in the human thalamus.
- A. Blomqvist, E.-T. Zhang, and A. D. Craig (2000)
Brain
123, 601-619
| Abstract »
| Full Text »
| PDF »
- Selective sparing of pain pathways in a patient with adult cerebral adrenoleukodystrophy.
- A. Romaniello, A. Aversa, G. Cruccu, M. Leandri, and M. Manfredi (2000)
Neurology
54, 528
| Full Text »
| PDF »
- Central Processing of Rectal Pain: A Functional MR Imaging Study.
- M. V. Baciu, B. L. Bonaz, E. Papillon, R. A. Bost, J.-F. Le Bas, J. Fournet, and C. M. Segebarth (1999)
AJNR Am. J. Neuroradiol.
20, 1920-1924
| Abstract »
| Full Text »
- Loss of Synaptic Depression in Mammalian Anterior Cingulate Cortex after Amputation.
- F. Wei, P. Li, and M. Zhuo (1999)
J. Neurosci.
19, 9346-9354
| Abstract »
| Full Text »
| PDF »
- Ventromedial Thalamic Neurons Convey Nociceptive Signals from the Whole Body Surface to the Dorsolateral Neocortex.
- L. Monconduit, L. Bourgeais, J.-F. Bernard, D. Le Bars, and L. Villanueva (1999)
J. Neurosci.
19, 9063-9072
| Abstract »
| Full Text »
| PDF »
- Pain Intensity Processing Within the Human Brain: A Bilateral, Distributed Mechanism.
- R. C. Coghill, C. N. Sang, J. Ma. Maisog, and M. J. Iadarola (1999)
J Neurophysiol
82, 1934-1943
| Abstract »
| Full Text »
| PDF »
- Haemodynamic brain responses to acute pain in humans: Sensory and attentional networks.
- R. Peyron, L. Garcia-Larrea, M.-C. Gregoire, N. Costes, P. Convers, F. Lavenne, F. Mauguiere, D. Michel, and B. Laurent (1999)
Brain
122, 1765-1780
| Abstract »
| Full Text »
| PDF »
- Brain processing of capsaicin-induced secondary hyperalgesia: A functional MRI study.
- R. Baron, Y. Baron, E. Disbrow, and T. P. L. Roberts (1999)
Neurology
53, 548
| Abstract »
| Full Text »
- Pain perception: Is there a role for primary somatosensory cortex?.
- M. C. Bushnell, G. H. Duncan, R. K. Hofbauer, B. Ha, J.-I. Chen, and B. Carrier (1999)
PNAS
96, 7705-7709
| Abstract »
| Full Text »
| PDF »
- Dissociating Pain from Its Anticipation in the Human Brain.
- A. Ploghaus, I. Tracey, J. S. Gati, S. Clare, R. S. Menon, P. M. Matthews, and J. N. P. Rawlins (1999)
Science
284, 1979-1981
| Abstract »
| Full Text »
- Differentiating Cortical Areas Related to Pain Perception From Stimulus Identification: Temporal Analysis of fMRI Activity.
- A. V. Apkarian, A. Darbar, B. R. Krauss, P. A. Gelnar, and N. M. Szeverenyi (1999)
J Neurophysiol
81, 2956-2963
| Abstract »
| Full Text »
| PDF »
- Parallel Activation of Primary and Secondary Somatosensory Cortices in Human Pain Processing.
- M. Ploner, F. Schmitz, H.-J. Freund, and A. Schnitzler (1999)
J Neurophysiol
81, 3100-3104
| Abstract »
| Full Text »
| PDF »
- Relation between neuropsychological and neuroimaging findings in patients with late whiplash syndrome.
- B. P Radanov, I. Bicik, J. Dvorak, J. Antinnes, G. K von Schulthess, and A. Buck (1999)
J. Neurol. Neurosurg. Psychiatry
66, 485-489
| Abstract »
| Full Text »
- Response of Anterior Parietal Cortex to Different Modes of Same-Site Skin Stimulation.
- M. Tommerdahl, K. A. Delemos, O. V. Favorov, C. B. Metz, C. J. Vierck Jr., and B. L. Whitsel (1998)
J Neurophysiol
80, 3272-3283
| Abstract »
| Full Text »
| PDF »
- Temporal and Intensity Coding of Pain in Human Cortex.
- C. A. Porro, V. Cettolo, M. P. Francescato, and P. Baraldi (1998)
J Neurophysiol
80, 3312-3320
| Abstract »
| Full Text »
| PDF »
- Stimulation of Human Thalamus for Pain Relief: Possible Modulatory Circuits Revealed by Positron Emission Tomography.
- G. H. Duncan, R. C. Kupers, S. Marchand, J.-G. Villemure, J. M. Gybels, and M. C. Bushnell (1998)
J Neurophysiol
80, 3326-3330
| Abstract »
| Full Text »
| PDF »
- Functional MRI of Galvanic Vestibular Stimulation.
- E. Lobel, J. F. Kleine, D. L. Bihan, A. Leroy-Willig, and A. Berthoz (1998)
J Neurophysiol
80, 2699-2709
| Abstract »
| Full Text »
| PDF »
- Painful Stimuli Evoke Potentials Recorded From the Parasylvian Cortex in Humans.
- F. A. Lenz, M. Rios, D. Chau, G. L. Krauss, T. A. Zirh, and R. P. Lesser (1998)
J Neurophysiol
80, 2077-2088
| Abstract »
| Full Text »
| PDF »
- Functional MRI Study of Thalamic and Cortical Activations Evoked by Cutaneous Heat, Cold, and Tactile Stimuli.
- K. D. Davis, C. L. Kwan, A. P. Crawley, and D. J. Mikulis (1998)
J Neurophysiol
80, 1533-1546
| Abstract »
| Full Text »
| PDF »
- Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease.
- R. Soufer, J. D. Bremner, J. A. Arrighi, I. Cohen, B. L. Zaret, M. M. Burg, and P. Goldman-Rakic (1998)
PNAS
95, 6454-6459
| Abstract »
| Full Text »
| PDF »
- Painful Stimuli Evoke Potentials Recorded Over the Human Anterior Cingulate Gyrus.
- F. A. Lenz, M. Rios, A. Zirh, D. Chau, G. Krauss, and R. P. Lesser (1998)
J Neurophysiol
79, 2231-2234
| Abstract »
| Full Text »
| PDF »
- Shape and roughness activate different somatosensory areas in the human brain.
- P. E. Roland, B. O'Sullivan, and R. Kawashima (1998)
PNAS
95, 3295-3300
| Abstract »
| Full Text »
| PDF »
- Reduced cortical responses to noxious heat in patients with rheumatoid arthritis.
- A K P Jones and S W G Derbyshire (1997)
Ann Rheum Dis
56, 601-607
| Abstract »
| Full Text »
- Cerebral Processing of Acute Skin and Muscle Pain in Humans.
- P. Svensson, S. Minoshima, A. Beydoun, T. J. Morrow, and K. L. Casey (1997)
J Neurophysiol
78, 450-460
| Abstract »
| Full Text »
| PDF »
- Functional MRI of Pain- and Attention-Related Activations in the Human Cingulate Cortex.
- K. D. Davis, S. J. Taylor, A. P. Crawley, M. L. Wood, and D. J. Mikulis (1997)
J Neurophysiol
77, 3370-3380
| Abstract »
| Full Text »
| PDF »
- Morphology and Distribution of Spinothalamic Lamina I Neurons in the Monkey.
- E.-T. Zhang and A. D. Craig (1997)
J. Neurosci.
17, 3274-3284
| Abstract »
| Full Text »
| PDF »
- The thermal grill illusion: unmasking the burn of cold pain.
- A. Craig and M. Bushnell (1994)
Science
265, 252-255
| Abstract »
| PDF »
- Parietal Pseudothalamic Pain Syndrome: Clinical Features and Anatomic Correlates.
- J. D. Schmahmann and D. Leifer (1992)
Arch Neurol
49, 1032-1037
| Abstract »
| PDF »
- Distributed neural network underlying musical sight-reading and keyboard performance.
- J Sergent, E Zuck, S Terriah, and B MacDonald (1992)
Science
257, 106-109
| Abstract »
| PDF »
|
|