Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 March 1991:
Vol. 251. no. 4999, pp. 1330 - 1335
DOI: 10.1126/science.2003219
Prev | Table of Contents | Next

Articles

Science, Vol 251, Issue 4999, 1330-1335
Copyright © 1991 by American Association for the Advancement of Science

articles

Peptide processing and targeting in the neuronal secretory pathway

LJ Jung and RH Scheller

Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, CA 94305.

The abdominal ganglion of the marine mollusk Aplysia contains a pair of identified neuronal clusters, the bag cells, which control egg laying by means of a number of unique regulatory mechanisms. Each neuron in the bag cell clusters synthesizes several peptides derived from a single prohormone and packages them into separate vesicles. These vesicles are then differentially localized in specific neuronal processes, thus segregating peptides destined for autocrine and hormonal release sites. Therefore in this system, protein trafficking through the secretory pathway organizes multiple peptide neurochemical messengers to efficiently regulate simple behaviors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway: ROLE OF N- AND C-TERMINAL {alpha}-HELICAL DOMAINS.
M. Courel, M. S. Vasquez, V. Y. Hook, S. K. Mahata, and L. Taupenot (2008)
J. Biol. Chem. 283, 11807-11822
   Abstract »    Full Text »    PDF »
A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons.
D. M. Blitz, R. S. White, S. R. Saideman, A. Cook, A. E. Christie, F. Nadim, and M. P. Nusbaum (2008)
J. Exp. Biol. 211, 1000-1011
   Abstract »    Full Text »    PDF »
Leucine-rich repeat kinase 2 associates with lipid rafts.
T. Hatano, S.-i. Kubo, S. Imai, M. Maeda, K. Ishikawa, Y. Mizuno, and N. Hattori (2007)
Hum. Mol. Genet. 16, 678-690
   Abstract »    Full Text »    PDF »
Forced Moves or Good Tricks in Design Space? Landmarks in the Evolution of Neural Mechanisms for Action Selection.
T. J. Prescott (2007)
Adaptive Behavior 15, 9-31
   Abstract »    PDF »
Phytosulfokine-{alpha}, a Peptide Growth Factor Found in Higher Plants: Its Structure, Functions, Precursor and Receptors.
H. Yang, Y. Matsubayashi, H. Hanai, and Y. Sakagami (2000)
Plant Cell Physiol. 41, 825-830
   Abstract »    Full Text »    PDF »
Neurotrophin-3 Sorts to the Constitutive Secretory Pathway of Hippocampal Neurons and Is Diverted to the Regulated Secretory Pathway by Coexpression with Brain-Derived Neurotrophic Factor.
H. F. Farhadi, S. J. Mowla, K. Petrecca, S. J. Morris, N. G. Seidah, and R. A. Murphy (2000)
J. Neurosci. 20, 4059-4068
   Abstract »    Full Text »    PDF »
Proteinase inhibitor-inducing activity of the prohormone prosystemin resides exclusively in the C-terminal systemin domain.
J. E. Dombrowski, G. Pearce, and C. A. Ryan (1999)
PNAS 96, 12947-12952
   Abstract »    Full Text »    PDF »
Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons.
S. J. Mowla, S. Pareek, H. F. Farhadi, K. Petrecca, J. P. Fawcett, N. G. Seidah, S. J. Morris, W. S. Sossin, and R. A. Murphy (1999)
J. Neurosci. 19, 2069-2080
   Abstract »    Full Text »    PDF »
Functional Redundancy of FMRFamide-Related Peptides at the Drosophila Larval Neuromuscular Junction.
R. S. Hewes, E. C Snowdeal III, M. Saitoe, and P. H. Taghert (1998)
J. Neurosci. 18, 7138-7151
   Abstract »    Full Text »    PDF »
Assaying for peptides in individual Aplysia neurons with mass spectrometry.
D. T. Chiu and R. N. Zare (1998)
PNAS 95, 3338-3340
   Full Text »    PDF »
Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons.
T. Nakata, S. Terada, and N. Hirokawa (1998)
J. Cell Biol. 140, 659-674
   Abstract »    Full Text »    PDF »
Costorage and Corelease of Modulatory Peptide Cotransmitters with Partially Antagonistic Actions on the Accessory Radula Closer Muscle of Aplysia californica.
F. S. Vilim, D. A. Price, W. Lesser, I. Kupfermann, and K. R. Weiss (1996)
J. Neurosci. 16, 8092-8104
   Abstract »    Full Text »    PDF »
The Regulated Secretion and Vectorial Targeting of Neurotrophins in Neuroendocrine and Epithelial Cells.
J. V. Heymach Jr., A. Kruttgen, U. Suter, and E. M. Shooter (1996)
J. Biol. Chem. 271, 25430-25437
   Abstract »    Full Text »    PDF »
Structural Requirements for Targeting of Surfactant Protein B (SP-B) to Secretory Granules in Vitro and in Vivo.
S. Lin, H. T. Akinbi, J. S. Breslin, and T. E. Weaver (1996)
J. Biol. Chem. 271, 19689-19695
   Abstract »    Full Text »    PDF »
Differential Storage of Prolactin, Granins (Chromogranin B and Secretogranin II), and Constitutive Secretory Markers in Rat Pituitary GH(4)C(1) Cells.
S.-U. Gorr and S. U. Gorr (1996)
J. Biol. Chem. 271, 3575-3580
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)