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Science 8 March 1991:
Vol. 251. no. 4998, pp. 1246 - 1249
DOI: 10.1126/science.1706535
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Articles

Science, Vol 251, Issue 4998, 1246-1249
Copyright © 1991 by American Association for the Advancement of Science

articles

Failure to elicit neuronal macroscopic mechanosensitive currents anticipated by single-channel studies

CE Morris and R Horn

Biology Department, University of Ottawa, Ontario, Canada.

Mechanosensitive channels can be observed in most cell types during single-channel recording and have been implicated in many cellular processes. Potassium-selective single-channel currents, both stretch-activated and stretch-inactivated, can be observed in growth cones and cell bodies of Lymnaea stagnalis neurons. Equivalent macroscopic mechanosensitive currents could not, however, be elicited while applying various mechanical stimuli. This discrepancy suggests that single-channel mechanosensitivity is an artifact of patch recording.


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Response.
C. E. MORRIS and R. HORN (1991)
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