Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 March 1991:
Vol. 251. no. 4998, pp. 1243 - 1246
DOI: 10.1126/science.2006412
Prev | Table of Contents | Next

Articles

Science, Vol 251, Issue 4998, 1243-1246
Copyright © 1991 by American Association for the Advancement of Science

articles

Control of larval development by chemosensory neurons in Caenorhabditis elegans

CI Bargmann and HR Horvitz

Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Larval development of the nematode Caenorhabditis elegans is controlled by the activities of four classes of chemosensory neurons. The choice between normal development and development into a specialized larval form called a dauer larva is regulated by competing environmental stimuli: food and a dauer pheromone. When the neuron classes ADF, ASG, ASI, and ASJ are killed, animals develop as dauer larvae regardless of environmental conditions. These neurons might sense food or dauer pheromone, or both, to initiate the specialized differentiation of many cell types that occurs during dauer formation. Entry into and exit from the dauer stage are primarily controlled by different chemosensory neurons. The analysis of mutants defective in dauer formation indicates that the chemosensory neurons are active in the absence of sensory inputs and that dauer pheromone inhibits the ability of these neurons to generate a signal necessary for normal development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans.
R. Doonan, J. J. McElwee, F. Matthijssens, G. A. Walker, K. Houthoofd, P. Back, A. Matscheski, J. R. Vanfleteren, and D. Gems (2008)
Genes & Dev. 22, 3236-3241
   Abstract »    Full Text »    PDF »
Innate Immunity in Caenorhabditis elegans Is Regulated by Neurons Expressing NPR-1/GPCR.
K. L. Styer, V. Singh, E. Macosko, S. E. Steele, C. I. Bargmann, and A. Aballay (2008)
Science 322, 460-464
   Abstract »    Full Text »    PDF »
A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components.
R. A. Butcher, J. R. Ragains, E. Kim, and J. Clardy (2008)
PNAS 105, 14288-14292
   Abstract »    Full Text »    PDF »
C. elegans dauer formation and the molecular basis of plasticity.
N. Fielenbach and A. Antebi (2008)
Genes & Dev. 22, 2149-2165
   Abstract »    Full Text »    PDF »
Notch signalling is required for both dauer maintenance and recovery in C. elegans.
J. Ouellet, S. Li, and R. Roy (2008)
Development 135, 2583-2592
   Abstract »    Full Text »    PDF »
Neural Circuits Mediate Electrosensory Behavior in Caenorhabditis elegans.
C. V. Gabel, H. Gabel, D. Pavlichin, A. Kao, D. A. Clark, and A. D. T. Samuel (2007)
J. Neurosci. 27, 7586-7596
   Abstract »    Full Text »    PDF »
Embryo stability and vulnerability in an always changing world.
A. Hamdoun and D. Epel (2007)
PNAS 104, 1745-1750
   Abstract »    Full Text »    PDF »
Mos1 Mutagenesis Reveals a Diversity of Mechanisms Affecting Response of Caenorhabditis elegans to the Bacterial Pathogen Microbacterium nematophilum.
K. Yook and J. Hodgkin (2007)
Genetics 175, 681-697
   Abstract »    Full Text »    PDF »
Sulfated Signal from ASJ Sensory Neurons Modulates Stomatin-dependent Coordination in Caenorhabditis elegans.
B. T. Carroll, G. R. Dubyak, M. M. Sedensky, and P. G. Morgan (2006)
J. Biol. Chem. 281, 35989-35996
   Abstract »    Full Text »    PDF »
Endocrine signaling in Caenorhabditis elegans controls stress response and longevity..
R. Baumeister, E. Schaffitzel, and M. Hertweck (2006)
J. Endocrinol. 190, 191-202
   Abstract »    Full Text »    PDF »
The Molecular Identities of the Caenorhabditis elegans Intraflagellar Transport Genes dyf-6, daf-10 and osm-1.
L. R. Bell, S. Stone, J. Yochem, J. E. Shaw, and R. K. Herman (2006)
Genetics 173, 1275-1286
   Abstract »    Full Text »    PDF »
Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans.
A.-F. Ruaud and J.-L. Bessereau (2006)
Development 133, 2211-2222
   Abstract »    Full Text »    PDF »
Thioredoxin is related to life span regulation and oxidative stress response in Caenorhabditis elegans.
C. Jee, L. Vanoaica, J. Lee, B. J. Park, and J. Ahnn (2005)
Genes Cells 10, 1203-1210
   Abstract »    Full Text »    PDF »
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
J. Halaschek-Wiener, J. S. Khattra, S. McKay, A. Pouzyrev, J. M. Stott, G. S. Yang, R. A. Holt, S. J.M. Jones, M. A. Marra, A. R. Brooks-Wilson, et al. (2005)
Genome Res. 15, 603-615
   Abstract »    Full Text »    PDF »
Inaugural Article: Biography of Cornelia I. Bargmann.
M. Marino (2005)
PNAS 102, 3181-3183
   Full Text »    PDF »
Inaugural Article: A circuit for navigation in Caenorhabditis elegans.
J. M. Gray, J. J. Hill, and C. I. Bargmann (2005)
PNAS 102, 3184-3191
   Abstract »    Full Text »    PDF »
Polymodal Sensory Function of the Caenorhabditis elegans OCR-2 Channel Arises from Distinct Intrinsic Determinants within the Protein and Is Selectively Conserved in Mammalian TRPV Proteins.
I. Sokolchik, T. Tanabe, P. F. Baldi, and J. Y. Sze (2005)
J. Neurosci. 25, 1015-1023
   Abstract »    Full Text »    PDF »
Activation of EGL-47, a G{alpha}o-Coupled Receptor, Inhibits Function of Hermaphrodite-Specific Motor Neurons to Regulate Caenorhabditis elegans Egg-Laying Behavior.
J. J. Moresco and M. R. Koelle (2004)
J. Neurosci. 24, 8522-8530
   Abstract »    Full Text »    PDF »
Apical sensory neurones mediate developmental retardation induced by conspecific environmental stimuli in freshwater pulmonate snails.
E. E. Voronezhskaya, M. Yu. Khabarova, and L. P. Nezlin (2004)
Development 131, 3671-3680
   Abstract »    Full Text »    PDF »
Mutations in Chemosensory Cilia Cause Resistance to Paraquat in Nematode Caenorhabditis elegans.
M. Fujii, Y. Matsumoto, N. Tanaka, K. Miki, T. Suzuki, N. Ishii, and D. Ayusawa (2004)
J. Biol. Chem. 279, 20277-20282
   Abstract »    Full Text »    PDF »
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.
H. Y. Mak and G. Ruvkun (2004)
Development 131, 1777-1786
   Abstract »    Full Text »    PDF »
Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.
S. Zhang, I. Sokolchik, G. Blanco, and J. Y. Sze (2004)
Development 131, 1629-1638
   Abstract »    Full Text »    PDF »
DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF{beta} pathway to regulate C. elegans dauer development.
L. S. da Graca, K. K. Zimmerman, M. C. Mitchell, M. Kozhan-Gorodetska, K. Sekiewicz, Y. Morales, and G. I. Patterson,, (2004)
Development 131, 435-446
   Abstract »    Full Text »    PDF »
Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein G{alpha}q and excitable cells in C. elegans.
N. Moghal, L. R. Garcia, L. A. Khan, K. Iwasaki, and P. W. Sternberg (2003)
Development 130, 4553-4566
   Abstract »    Full Text »    PDF »
Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans.
H. Thieringer, B. Moellers, G. Dodt, W.-H. Kunau, and M. Driscoll (2003)
J. Cell Sci. 116, 1797-1804
   Abstract »    Full Text »    PDF »
The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons.
O. Uchida, H. Nakano, M. Koga, and Y. Ohshima (2003)
Development 130, 1215-1224
   Abstract »    Full Text »    PDF »
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.
W. Li, S. G. Kennedy, and G. Ruvkun (2003)
Genes & Dev. 17, 844-858
   Abstract »    Full Text »    PDF »
A Caenorhabditis elegans Pheromone Antagonizes Volatile Anesthetic Action Through a Go-Coupled Pathway.
B. van Swinderen, L. B. Metz, L. D. Shebester, and C. M. Crowder (2002)
Genetics 161, 109-119
   Abstract »    Full Text »    PDF »
Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans.
E. L. Peckol, E. R. Troemel, and C. I. Bargmann (2001)
PNAS 98, 11032-11038
   Abstract »    Full Text »    PDF »
The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans.
T. R. Sarafi-Reinach, T. Melkman, O. Hobert, and P. Sengupta (2001)
Development 128, 3269-3281
   Abstract »    Full Text »    PDF »
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
S. B. Pierce, M. Costa, R. Wisotzkey, S. Devadhar, S. A. Homburger, A. R. Buchman, K. C. Ferguson, J. Heller, D. M. Platt, A. A. Pasquinelli, et al. (2001)
Genes & Dev. 15, 672-686
   Abstract »    Full Text »
Suppressors of Transforming Growth Factor-{beta} Pathway Mutants in the Caenorhabditis elegans Dauer Formation Pathway.
T. Inoue and J. H. Thomas (2000)
Genetics 156, 1035-1046
   Abstract »    Full Text »
Dauer Formation Induced by High Temperatures in Caenorhabditis elegans.
M. Ailion and J. H. Thomas (2000)
Genetics 156, 1047-1067
   Abstract »    Full Text »
egl-4 Acts Through a Transforming Growth Factor-{beta}/SMAD Pathway in Caenorhabditis elegans to Regulate Multiple Neuronal Circuits in Response to Sensory Cues.
S. A. Daniels, M. Ailion, J. H. Thomas, and P. Sengupta (2000)
Genetics 156, 123-141
   Abstract »    Full Text »
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.
A. Antebi, W.-H. Yeh, D. Tait, E. M. Hedgecock, and D. L. Riddle (2000)
Genes & Dev. 14, 1512-1527
   Abstract »    Full Text »
A Transmembrane Guanylyl Cyclase (DAF-11) and Hsp90 (DAF-21) Regulate a Common Set of Chemosensory Behaviors in Caenorhabditis elegans.
D. A. Birnby, E. M. Link, J. J. Vowels, H. Tian, P. L. Colacurcio, and J. H. Thomas (2000)
Genetics 155, 85-104
   Abstract »    Full Text »
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
S. Paradis, M. Ailion, A. Toker, J. H. Thomas, and G. Ruvkun (1999)
Genes & Dev. 13, 1438-1452
   Abstract »    Full Text »
Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans.
M Koga, M Take-uchi, T Tameishi, and Y Ohshima (1999)
Development 126, 5387-5398
   Abstract »    PDF »
The cat-1 Gene of Caenorhabditis elegans Encodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors.
J. S. Duerr, D. L. Frisby, J. Gaskin, A. Duke, K. Asermely, D. Huddleston, L. E. Eiden, and J. B. Rand (1999)
J. Neurosci. 19, 72-84
   Abstract »    Full Text »    PDF »
An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans.
M. Take-uchi, M. Kawakami, T. Ishihara, T. Amano, K. Kondo, and I. Katsura (1998)
PNAS 95, 11775-11780
   Abstract »    Full Text »    PDF »
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
S. Paradis and G. Ruvkun (1998)
Genes & Dev. 12, 2488-2498
   Abstract »    Full Text »
Control of Neural Development and Function in a Thermoregulatory Network by the LIM Homeobox Gene lin-11.
O. Hobert, T. D'Alberti, Y. Liu, and G. Ruvkun (1998)
J. Neurosci. 18, 2084-2096
   Abstract »    Full Text »    PDF »
unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors.
B. Prasad, B Ye, R Zackhary, K Schrader, G Seydoux, and R. Reed (1998)
Development 125, 1561-1568
   Abstract »    PDF »
Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans.
B. Harfe and A Fire (1998)
Development 125, 421-429
   Abstract »    PDF »
A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure.
C. Coburn, I Mori, Y Ohshima, and C. Bargmann (1998)
Development 125, 249-258
   Abstract »    PDF »
Analysis of osm-6, a Gene That Affects Sensory Cilium Structure and Sensory Neuron Function in Caenorhabditis elegans.
(1998)
Genetics 148, 187-200
The DAF-3 Smad protein antagonizes TGF-beta -related receptor signaling in the Caenorhabditis elegans dauer pathway.
G. I. Patterson, A. Koweek, A. Wong, Y. Liu, and G. Ruvkun (1997)
Genes & Dev. 11, 2679-2690
   Abstract »    Full Text »    PDF »
Molecular Cloning, Expression, and Localization of E1, an Onchocerca volvulus Antigen with Similarity to Brain Ankyrin.
K. D. Erttmann, D. W. Büttner, and M. Y. Gallin (1996)
J. Biol. Chem. 271, 1645-1650
   Abstract »    Full Text »    PDF »
The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates.
M Labouesse, E Hartwieg, and H. Horvitz (1996)
Development 122, 2579-2588
   Abstract »    PDF »
Olfactory Recognition and Discrimination in Caenorhabditis elegans.
J.H. Chou, E.R. Troemel, P. Sengupta, H.A. Colbert, L. Tong, D.M. Tobin, K. Roayaie, J.G. Crump, N.D. Dwyer, and C.I. Bargmann (1996)
Cold Spring Harb Symp Quant Biol 61, 157-164
   Abstract »    PDF »
The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye.
P. Svendsen and J. McGhee (1995)
Development 121, 1253-1262
   Abstract »    PDF »
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28..
P Arasu, B Wightman, and G Ruvkun (1991)
Genes & Dev. 5, 1825-1833
   Abstract »    PDF »
A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling.
K. Morita, M. Shimizu, H. Shibuya, and N. Ueno (2001)
PNAS 98, 6284-6288
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)