Science 8 March 1991: Vol. 251. no. 4998, pp. 1231 - 1233 DOI: 10.1126/science.1848725

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Articles

PLC-{gamma}1 and Rac1 Coregulate EGF-Induced Cytoskeleton Remodeling and Cell Migration.

S. Li, Q. Wang, Y. Wang, X. Chen, and Z. Wang (2009)
Mol. Endocrinol. 23, 901-913
 |  Abstract »  |  Full Text »  |  PDF »

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells.

J. van Rheenen, X. Song, W. van Roosmalen, M. Cammer, X. Chen, V. DesMarais, S.-C. Yip, J. M. Backer, R. J. Eddy, and J. S. Condeelis (2007)
J. Cell Biol. 179, 1247-1259
 |  Abstract »  |  Full Text »  |  PDF »

Cytoskeletal Protein Transformation in HIV-1-Infected Macrophage Giant Cells.

I. Kadiu, M. Ricardo-Dukelow, P. Ciborowski, and H. E. Gendelman (2007)
J. Immunol. 178, 6404-6415
 |  Abstract »  |  Full Text »  |  PDF »

Cofilin takes the lead.

V. DesMarais, M. Ghosh, R. Eddy, and J. Condeelis (2005)
J. Cell Sci. 118, 19-26
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation.

G. Mouneimne, L. Soon, V. DesMarais, M. Sidani, X. Song, S.-C. Yip, M. Ghosh, R. Eddy, J. M. Backer, and J. Condeelis (2004)
J. Cell Biol. 166, 697-708
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase Activity of Phospholipase C-{gamma}1 Is Required for Nerve Growth Factor-regulated MAP Kinase Signaling Cascade in PC12 Cells.

R. Rong, J.-Y. Ahn, P. Chen, P.-G. Suh, and K. Ye (2003)
J. Biol. Chem. 278, 52497-52503
 |  Abstract »  |  Full Text »  |  PDF »

Villin Enhances Hepatocyte Growth Factor-induced Actin Cytoskeleton Remodeling in Epithelial Cells.

R. Athman, D. Louvard, and S. Robine (2003)
Mol. Biol. Cell 14, 4641-4653
 |  Abstract »  |  Full Text »  |  PDF »

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli.

J. Gartzke and K. Lange (2002)
Am J Physiol Cell Physiol 283, C1333-C1346
 |  Abstract »  |  Full Text »  |  PDF »

Molecular and structural analysis of the panallergen profilin B cell epitopes defined by monoclonal antibodies.

J. A. Asturias, N. Gomez-Bayon, M. C. Arilla, L. Sanchez-Pulido, A. Valencia, and A. Martinez (2002)
Int. Immunol. 14, 993-1001
 |  Abstract »  |  Full Text »  |  PDF »

Myosin II heavy chain isoforms are phosphorylated in an EGF-dependent manner: involvement of protein kinase C.

R. Straussman, L. Even, and S. Ravid (2002)
J. Cell Sci. 114, 3047-3057
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 4,5-Bisphosphate Modifies Tubulin Participation in Phospholipase Cbeta 1 Signaling.

J. S. Popova, A. K. Greene, J. Wang, and M. M. Rasenick (2002)
J. Neurosci. 22, 1668-1678
 |  Abstract »  |  Full Text »  |  PDF »

PLC-{gamma}1 Enzyme Activity Is Required for Insulin-Induced DNA Synthesis.

J. Eichhorn, A. G. Kayali, L. Resor, D. A. Austin, D. W. Rose, and N. J. G. Webster (2002)
Endocrinology 143, 655-664
 |  Abstract »  |  Full Text »  |  PDF »

Role of microvillar cell surfaces in the regulation of glucose uptake and organization of energy metabolism.

K. Lange (2002)
Am J Physiol Cell Physiol 282, C1-C26
 |  Abstract »  |  Full Text »  |  PDF »

Cytochalasin D reduces Ca2+ currents via cofilin-activated depolymerization of F-actin in guinea-pig cardiomyocytes.

U Rueckschloss and G Isenberg (2001)
J. Physiol. 537, 363-370
 |  Abstract »  |  Full Text »  |  PDF »

Four Tyrosine Residues in Phospholipase C-gamma 2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling.

D. Watanabe, S. Hashimoto, M. Ishiai, M. Matsushita, Y. Baba, T. Kishimoto, T. Kurosaki, and S. Tsukada (2001)
J. Biol. Chem. 276, 38595-38601
 |  Abstract »  |  Full Text »  |  PDF »

Small Changes in the Regulation of One Arabidopsis Profilin Isovariant, PRF1, Alter Seedling Development.

E. C. McKinney, M. K. Kandasamy, and R. B. Meagher (2001)
PLANT CELL 13, 1179-1191
 |  Abstract »  |  Full Text »

Real Time Fluorescence Imaging of Plc{gamma} Translocation and Its Interaction with the Epidermal Growth Factor Receptor.

M. Matsuda, H. F. Paterson, R. Rodriguez, A. C. Fensome, M. V. Ellis, K. Swann, and M. Katan (2001)
J. Cell Biol. 153, 599-612
 |  Abstract »  |  Full Text »  |  PDF »

Chlamydomonas reinhardtii produces a profilin with unusual biochemical properties.

D. R. Kovar, P. Yang, W. S. Sale, B. K. Drobak, and C. J. Staiger (2001)
J. Cell Sci. 114, 4293-4305
 |  Abstract »  |  Full Text »  |  PDF »

Pleiotropic Contributions of Phospholipase C-gamma 1 (PLC-gamma 1) to T-Cell Antigen Receptor-Mediated Signaling: Reconstitution Studies of a PLC-gamma 1-Deficient Jurkat T-Cell Line.

B. J. Irvin, B. L. Williams, A. E. Nilson, H. O. Maynor, and R. T. Abraham (2000)
Mol. Cell. Biol. 20, 9149-9161
 |  Abstract »  |  Full Text »

Profilin II Is Alternatively Spliced, Resulting in Profilin Isoforms That Are Differentially Expressed and Have Distinct Biochemical Properties.

A. Lambrechts, A. Braun, V. Jonckheere, A. Aszodi, L. M. Lanier, J. Robbens, I. Van Colen, J. Vandekerckhove, R. Fässler, and C. Ampe (2000)
Mol. Cell. Biol. 20, 8209-8219
 |  Abstract »  |  Full Text »

Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C.

M. J. Rebecchi and S. N. Pentyala (2000)
Physiol Rev 80, 1291-1335
 |  Abstract »  |  Full Text »  |  PDF »

Activation of DNA Synthesis and AP-1 by Profilin, an Actin-Binding Protein, via Binding to a Cell Surface Receptor in Cultured Rat Mesangial Cells.

M. TAMURA, N. YANAGIHARA, H. TANAKA, A. OSAJIMA, T. HIRANO, K. HIGASHI, K. M. YAMADA, Y. NAKASHIMA, and H. HIRANO (2000)
J. Am. Soc. Nephrol. 11, 1620-1630
 |  Abstract »  |  Full Text »

Neutrophil-Induced Changes in the Biomechanical Properties of Endothelial Cells: Roles of ICAM-1 and Reactive Oxygen Species.

Q. Wang and C. M. Doerschuk (2000)
J. Immunol. 164, 6487-6494
 |  Abstract »  |  Full Text »  |  PDF »

Muscarinic Receptor Activation Promotes the Membrane Association of Tubulin for the Regulation of Gq-Mediated Phospholipase Cbeta 1 Signaling.

J. S. Popova and M. M. Rasenick (2000)
J. Neurosci. 20, 2774-2782
 |  Abstract »  |  Full Text »  |  PDF »

Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms.

A Di Nardo, R Gareus, D Kwiatkowski, and W Witke (2000)
J. Cell Sci. 113, 3795-3803
 |  Abstract »  |  PDF »

The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling.

R Hooshmand-Rad, L Hajkova, P Klint, R Karlsson, B Vanhaesebroeck, L Claesson-Welsh, and C. Heldin (2000)
J. Cell Sci. 113, 207-214
 |  Abstract »  |  PDF »

Functional Independence and Interdependence of the Src Homology Domains of Phospholipase C-gamma 1 in B-Cell Receptor Signal Transduction.

K. E. DeBell, B. A. Stoica, M.-C. Veri, A. Di Baldassarre, S. Miscia, L. J. Graham, B. L. Rellahan, M. Ishiai, T. Kurosaki, and E. Bonvini (1999)
Mol. Cell. Biol. 19, 7388-7398
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C-delta 1 Contains a Functional Nuclear Export Signal Sequence.

M. Yamaga, M. Fujii, H. Kamata, H. Hirata, and H. Yagisawa (1999)
J. Biol. Chem. 274, 28537-28541
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C-gamma 1 Is Required for Calcium-induced Keratinocyte Differentiation.

Z. Xie and D. D. Bikle (1999)
J. Biol. Chem. 274, 20421-20424
 |  Abstract »  |  Full Text »  |  PDF »

Physiological Requirement for Both SH2 Domains for Phospholipase C-gamma 1 Function and Interaction with Platelet-Derived Growth Factor Receptors.

Q.-s. Ji, A. Chattopadhyay, M. Vecchi, and G. Carpenter (1999)
Mol. Cell. Biol. 19, 4961-4970
 |  Abstract »  |  Full Text »  |  PDF »

Identification of profilin and src homology 3 domains as binding partners for Drosophila Enabled.

S. M. Ahern-Djamali, C. Bachmann, P. Hua, S. K. Reddy, A. S. Kastenmeier, U. Walter, and F. M. Hoffmann (1999)
PNAS 96, 4977-4982
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-gamma 1 Signaling Pathway.

J. M. Haugh, K. Schooler, A. Wells, H. S. Wiley, and D. A. Lauffenburger (1999)
J. Biol. Chem. 274, 8958-8965
 |  Abstract »  |  Full Text »  |  PDF »

Action of Phosphatidylinositol-specific Phospholipase Cgamma 1 on Soluble and Micellar Substrates. SEPARATING EFFECTS ON CATALYSIS FROM MODULATION OF THE SURFACE.

C. Zhou, D. Horstman, G. Carpenter, and M. F. Roberts (1999)
J. Biol. Chem. 274, 2786-2793
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Phospholipase C delta 4 (PLCdelta 4) Splice Variant as a Negative Regulator of PLC.

K. Nagano, K. Fukami, T. Minagawa, Y. Watanabe, C. Ozaki, and T. Takenawa (1999)
J. Biol. Chem. 274, 2872-2879
 |  Abstract »  |  Full Text »  |  PDF »

Profilin is predominantly associated with monomeric actin in Acanthamoeba.

D. Kaiser, V. Vinson, D. Murphy, and T. Pollard (1999)
J. Cell Sci. 112, 3779-3790
 |  Abstract »  |  PDF »

ARF1 Mediates Paxillin Recruitment to Focal Adhesions and Potentiates Rho-stimulated Stress Fiber Formation in Intact and Permeabilized Swiss 3T3 Fibroblasts.

J.C. Norman, D. Jones, S.T. Barry, M.R. Holt, S. Cockcroft, and D.R. Critchley (1998)
J. Cell Biol. 143, 1981-1995
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools.

P. Varnai and T. Balla (1998)
J. Cell Biol. 143, 501-510
 |  Abstract »  |  Full Text »  |  PDF »

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling.

P. A. JANMEY (1998)
Physiol Rev 78, 763-781
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II-induced Association of Phospholipase Cgamma 1 with the G-protein-coupled AT1 Receptor.

R. C. Venema, H. Ju, V. J. Venema, B. Schieffer, J. B. Harp, B. N. Ling, D. C. Eaton, and M. B. Marrero (1998)
J. Biol. Chem. 273, 7703-7708
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis.

M. G. Giansanti, S. Bonaccorsi, B. Williams, E. V. Williams, C. Santolamazza, M. L. Goldberg, and M. Gatti (1998)
Genes & Dev. 12, 396-410
 |  Abstract »  |  Full Text »

Effects of single amino acid substitutions in the actin-binding site on the biological activity of bovine profilin I.

K Schluter, M Schleicher, and B. Jockusch (1998)
J. Cell Sci. 111, 3261-3273
 |  Abstract »  |  PDF »

Gelsolin Modulates Phospholipase C Activity In Vivo through Phospholipid Binding.

H.-q. Sun, K.-m. Lin, and H. L. Yin (1997)
J. Cell Biol. 138, 811-820
 |  Abstract »  |  Full Text »  |  PDF »

Isolation and Molecular Cloning of Wortmannin-sensitive Bovine Type III Phosphatidylinositol 4-Kinases.

T. Balla, G. J. Downing, H. Jaffe, S. Kim, A. Zolyomi, and K. J. Catt (1997)
J. Biol. Chem. 272, 18358-18366
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of the Human Phospholipase C-gamma 1 Promoter and Identification of a DR6-type Vitamin D-responsive Element.

Z. Xie and D. D. Bikle (1997)
J. Biol. Chem. 272, 6573-6577
 |  Abstract »  |  Full Text »  |  PDF »

Tubulin, Gq, and Phosphatidylinositol 4,5-Bisphosphate Interact to Regulate Phospholipase Cbeta 1 Signaling.

J. S. Popova, J. C. Garrison, S. G. Rhee, and M. M. Rasenick (1997)
J. Biol. Chem. 272, 6760-6765
 |  Abstract »  |  Full Text »  |  PDF »

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Produces Reversible Inhibition of Phospholipase C by Sequestering Phosphatidylinositol 4,5-Bisphosphate in Lateral Domains.

M. Glaser, S. Wanaski, C. A. Buser, V. Boguslavsky, W. Rashidzada, A. Morris, M. Rebecchi, S. F. Scarlata, L. W. Runnels, G. D. Prestwich, et al. (1996)
J. Biol. Chem. 271, 26187-26193
 |  Abstract »  |  Full Text »  |  PDF »

The Fcgamma RII Receptor Triggers pp125FAK Phosphorylation in Platelets.

B. Haimovich, C. Regan, L. DiFazio, E. Ginalis, P. Ji, U. Purohit, R. B. Rowley, J. Bolen, and R. Greco (1996)
J. Biol. Chem. 271, 16332-16337
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Phosphatidylinositol 4,5-Bisphosphate-binding Site in Chicken Skeletal Muscle alpha-Actinin.

K. Fukami, N. Sawada, T. Endo, and T. Takenawa (1996)
J. Biol. Chem. 271, 2646-2650
 |  Abstract »  |  Full Text »  |  PDF »

EJ-Ras Inhibits Phospholipase C{gamma}1 but Not Actin Polymerization Induced by Platelet-Derived Growth Factor-BB via Phosphatidylinositol 3-Kinase.

A. W. Heldman, D. E. Kandzari, R. W. Tucker, L. E. Crawford, E. R. Fearon, K. S. Koblan, and P. J. Goldschmidt-Clermont (1996)
Circ. Res. 78, 312-321
 |  Abstract »  |  Full Text »

The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis.

P Gonczy and S DiNardo (1996)
Development 122, 2437-2447
 |  Abstract »  |  PDF »

Calcium mobilization and influx during sperm exocytosis.

B Spungin and H Breitbart (1996)
J. Cell Sci. 109, 1947-1955
 |  Abstract »  |  PDF »

Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells.

M Rothkegel, O Mayboroda, M Rohde, C Wucherpfennig, R Valenta, and B. Jockusch (1996)
J. Cell Sci. 109, 83-90
 |  Abstract »  |  PDF »

Regulation of Profilin Localization in Saccharomyces cerevisiae by Phosphoinositide Metabolism.

D. B. Ostrander, J. A. Gorman, and G. M. Carman (1995)
J. Biol. Chem. 270, 27045-27050
 |  Abstract »  |  Full Text »  |  PDF »

Localization of a Binding Site for Phosphatidylinositol 4,5-Bisphosphate on Human Profilin.

R. H. Sohn, J. Chen, K. S. Koblan, P. F. Bray, and P. J. Goldschmidt-Clermont (1995)
J. Biol. Chem. 270, 21114-21120
 |  Abstract »  |  Full Text »  |  PDF »

Activation Induces Dephosphorylation of Cofilin and Its Translocation to Plasma Membranes in Neutrophil-like Differentiated HL-60 Cells.

K. Suzuki, T. Yamaguchi, T. Tanaka, T. Kawanishi, T. Nishimaki-Mogami, K. Yamamoto, T. Tsuji, T. Irimura, T. Hayakawa, and A. Takahashi (1995)
J. Biol. Chem. 270, 19551-19556
 |  Abstract »  |  Full Text »  |  PDF »

Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C-[IMAGE]1, and Other Phosphoproteins with Grb2 and the [IMAGE]-Chain of the TCR.

AndrE. Nel, S. Gupta, L. Lee, J. A. Ledbetter, and S. B. Kanner (1995)
J. Biol. Chem. 270, 18428-18436
 |  Abstract »  |  Full Text »  |  PDF »

Pleckstrin Inhibits Phosphoinositide Hydrolysis Initiated by G-protein-coupled and Growth Factor Receptors.

C. S. Abrams, H. Wu, W. Zhao, E. Belmonte, D. White, and L. F. Brass (1995)
J. Biol. Chem. 270, 14485-14492
 |  Abstract »  |  Full Text »  |  PDF »

Association of Polyomavirus Middle Tumor Antigen with Phospholipase C-[IMAGE]1.

W. Su, W. Liu, B. S. Schaffhausen, and T. M. Roberts (1995)
J. Biol. Chem. 270, 12331-12334
 |  Abstract »  |  Full Text »  |  PDF »

Association of p72[IMAGE] with the src Homology-2 (SH2) Domains of PLC[IMAGE]1 in B Lymphocytes.

A. L. Sillman and J. G. Monroe (1995)
J. Biol. Chem. 270, 11806-11811
 |  Abstract »  |  Full Text »  |  PDF »

The Actin-binding Properties of the Physarum Actin-Fragmin Complex.

J. Gettemans, Y. De Ville, E. Waelkens, and J. Vandekerckhove (1995)
J. Biol. Chem. 270, 2644-2651
 |  Abstract »  |  Full Text »  |  PDF »

A role for phospholipase C activity but not ryanodine receptors in the initiation and propagation of intercellular calcium waves.

M Hansen, S Boitano, E. Dirksen, and M. Sanderson (1995)
J. Cell Sci. 108, 2583-2590
 |  Abstract »  |  PDF »

Sperm exocytosis reconstructed in a cell-free system: evidence for the involvement of phospholipase C and actin filaments in membrane fusion.

B Spungin, I Margalit, and H Breitbart (1995)
J. Cell Sci. 108, 2525-2535
 |  Abstract »  |  PDF »

Profilin mutations disrupt multiple actin-dependent processes during Drosophila development.

E. Verheyen and L Cooley (1994)
Development 120, 717-728
 |  Abstract »  |  PDF »

Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability.

C. Flanagan, E. Schnieders, A. Emerick, R Kunisawa, A Admon, and J Thorner (1993)
Science 262, 1444-1448
 |  Abstract »  |  PDF »

On the crawling of animal cells.

T. Stossel (1993)
Science 260, 1086-1094
 |  Abstract »  |  PDF »

Identification and characterization of a cDNA encoding mouse CAP: a homolog of the yeast adenylyl cyclase associated protein.

A. Vojtek and J. Cooper (1993)
J. Cell Sci. 105, 777-785
 |  Abstract »  |  PDF »

Regulation of development and differentiation by the extracellular matrix.

J. Adams and F. Watt (1993)
Development 117, 1183-1198
 |  PDF »

Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes.

A Shariff and E. Luna (1992)
Science 256, 245-247
 |  Abstract »  |  PDF »

Role of SH2-containing Proteins in Cellular Signaling by Receptor Tyrosine Kinases.

J. Schlessinger, M. Mohammadi, B. Margolis, and A. Ullrich (1992)
Cold Spring Harb Symp Quant Biol 57, 67-74
 |  Abstract »  |  PDF »

Growth factors and cancer.

S. Aaronson (1991)
Science 254, 1146-1153
 |  Abstract »  |  PDF »

New clue found to growth factor action.

M Hoffman (1991)
Science 251, 1181
 |  PDF »

Aging Fibroblasts Present Reduced Epidermal Growth Factor (EGF) Responsiveness Due to Preferential Loss of EGF Receptors.

H. Shiraha, K. Gupta, K. Drabik, and A. Wells (2000)
J. Biol. Chem. 275, 19343-19351
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C-gamma Mediates the Hydrolysis of Phosphatidylinositol, but Not of Phosphatidylinositol 4,5-Bisphoshate, in Carbamylcholine-stimulated Islets of Langerhans.

C. J. Mitchell, M. M. Kelly, M. Blewitt, J. R. Wilson, and T. J. Biden (2001)
J. Biol. Chem. 276, 19072-19077
 |  Abstract »  |  Full Text »  |  PDF »

Profilin I is essential for cell survival and cell division in early mouse development.

W. Witke, J. D. Sutherland, A. Sharpe, M. Arai, and D. J. Kwiatkowski (2001)
PNAS 98, 3832-3836
 |  Abstract »  |  Full Text »  |  PDF »

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