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Science 1 March 1991:
Vol. 251. no. 4997, pp. 1074 - 1076
DOI: 10.1126/science.1705362
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Articles

Science, Vol 251, Issue 4997, 1074-1076
Copyright © 1991 by American Association for the Advancement of Science

articles

Enhancement of HIV-1 cytocidal effects in CD4+ lymphocytes by the AIDS-associated mycoplasma

SC Lo, S Tsai, Benish JR, JW Shih, DJ Wear, and DM Wong

Department of Infections and Parasitic Diseases Pathology, Armed Forces Institute of Pathology, Washington, DC 20306.

Coinfection with Mycoplasma fermentans (incognitus strain) enhances the ability of human immunodeficiency virus type-1 (HIV-1) to induce cytopathic effects on human T lymphocytes in vitro. Syncytium formation of HIV-infected T cells was essentially eliminated in the presence of M. fermentans (incognitus strain), despite prominent cell death. However, replication and production of HIV-1 particles continued during the coinfection. Furthermore, the supernatant from cultures coinfected with HIV-1 and the mycoplasma contained a factor that inhibited the standard reverse transcriptase enzyme assay. The modification of the biological properties of HIV-1 by coinfection with mycoplasma may be involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS).


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