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Science 1 March 1991:
Vol. 251. no. 4997, pp. 1039 - 1044
DOI: 10.1126/science.1998120
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Articles

Science, Vol 251, Issue 4997, 1039-1044
Copyright © 1991 by American Association for the Advancement of Science

articles

Molecular analysis of protein assembly in muscle development

HF Epstein and DA Fischman

Department of Neurology, Baylor College of Medicine, Houston, TX 77030.

The challenge presented by myofibril assembly in striated muscle is to understand the molecular mechanisms by which its protein components are arranged at each level of organization. Recent advances in the genetics and cell biology of muscle development have shown that in vivo assembly of the myofilaments requires a complex array of structural and associated proteins and that organization of whole sarcomeres occurs initially at the cell membrane. These studies have been complemented by in vitro analyses of the renaturation, polymerization, and three-dimensional structure of the purified proteins.


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