Science 22 February 1991: Vol. 251. no. 4996, pp. 936 - 939 DOI: 10.1126/science.1840698

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Articles

Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.

H. Mizushima, X. Wang, S. Miyamoto, and E. Mekada (2009)
J. Cell Sci. 122, 4277-4286
 |  Abstract »  |  Full Text »  |  PDF »

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia.

H. P. Jia, D. C. Look, P. Tan, L. Shi, M. Hickey, L. Gakhar, M. C. Chappell, C. Wohlford-Lenane, and P. B. McCray Jr (2009)
Am J Physiol Lung Cell Mol Physiol 297, L84-L96
 |  Abstract »  |  Full Text »  |  PDF »

Muscle-Specific Overexpression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Increases Peripheral Glucose Disposal and Insulin Sensitivity.

Y. Fukatsu, T. Noguchi, T. Hosooka, T. Ogura, K. Kotani, T. Abe, T. Shibakusa, K. Inoue, M. Sakai, K. Tobimatsu, et al. (2009)
Endocrinology 150, 2683-2691
 |  Abstract »  |  Full Text »  |  PDF »

Insufficiency of Pro-heparin-binding Epidermal Growth Factor-like Growth Factor Shedding Enhances Hypoxic Cell Death in H9c2 Cardiomyoblasts via the Activation of Caspase-3 and c-Jun N-terminal Kinase.

T. Uetani, H. Nakayama, H. Okayama, T. Okura, J. Higaki, H. Inoue, and S. Higashiyama (2009)
J. Biol. Chem. 284, 12399-12409
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The Expression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor by Regulatory Macrophages.

J. P. Edwards, X. Zhang, and D. M. Mosser (2009)
J. Immunol. 182, 1929-1939
 |  Abstract »  |  Full Text »  |  PDF »

The epidermal growth factor receptor mediates allergic airway remodelling in the rat.

M. Tamaoka, M. Hassan, T. McGovern, D. Ramos-Barbon, T. Jo, Y. Yoshizawa, B. Tolloczko, Q. Hamid, and J. G. Martin (2008)
Eur. Respir. J. 32, 1213-1223
 |  Abstract »  |  Full Text »  |  PDF »

The Transactivated Epidermal Growth Factor Receptor Recruits Pyk2 to Regulate Src Kinase Activity.

D. Schauwienold, A. P. Sastre, N. Genzel, M. Schaefer, and H. P. Reusch (2008)
J. Biol. Chem. 283, 27748-27756
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition.

H. Yagi, F. Yotsumoto, and S. Miyamoto (2008)
Mol. Cancer Ther. 7, 3441-3451
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of proHB-EGF Carboxy-Terminal Fragment Nuclear Translocation: A New Molecular Target Therapy for Gastric Cancer.

T. Shimura, H. Kataoka, N. Ogasawara, E. Kubota, M. Sasaki, S. Tanida, and T. Joh (2008)
Clin. Cancer Res. 14, 3956-3965
 |  Abstract »  |  Full Text »  |  PDF »

Engineering insulin-like growth factor-1 for local delivery.

T. Tokunou, R. Miller, P. Patwari, M. E. Davis, V. F. M. Segers, A. J. Grodzinsky, and R. T. Lee (2008)
FASEB J 22, 1886-1893
 |  Abstract »  |  Full Text »  |  PDF »

HB-EGF but Not Amphiregulin or Their Receptors HER1 and HER4 Is Altered in Endometrium of Women With Unexplained Infertility.

L. Aghajanova, K. Bjuresten, S. Altmae, B.-M. Landgren, and A. Stavreus-Evers (2008)
Reproductive Sciences 15, 484-492
 |  Abstract »  |  PDF »

Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane.

M. Hieda, M. Isokane, M. Koizumi, C. Higashi, T. Tachibana, M. Shudou, T. Taguchi, Y. Hieda, and S. Higashiyama (2008)
J. Cell Biol. 180, 763-769
 |  Abstract »  |  Full Text »  |  PDF »

Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance.

A. B. Singh, K. Sugimoto, P. Dhawan, and R. C. Harris (2007)
Am J Physiol Cell Physiol 293, C1660-C1668
 |  Abstract »  |  Full Text »  |  PDF »

Activation of a Nuclear Factor {kappa}B/Interleukin-1 Positive Feedback Loop by Amphiregulin in Human Breast Cancer Cells.

K. L. Streicher, N. E. Willmarth, J. Garcia, J. L. Boerner, T. G. Dewey, and S. P. Ethier (2007)
Mol. Cancer Res. 5, 847-861
 |  Abstract »  |  Full Text »  |  PDF »

Diphtheria Toxin Mutant CRM197 Possesses Weak EF2-ADP-ribosyl Activity that Potentiates its Anti-tumorigenic Activity.

T. Kageyama, M. Ohishi, S. Miyamoto, H. Mizushima, R. Iwamoto, and E. Mekada (2007)
J. Biochem. 142, 95-104
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl-terminal Fragment of Pro-HB-EGF Reverses Bcl6-mediated Gene Repression.

Y. Kinugasa, M. Hieda, M. Hori, and S. Higashiyama (2007)
J. Biol. Chem. 282, 14797-14806
 |  Abstract »  |  Full Text »  |  PDF »

Mitogenic Activity and Signaling Mechanism of 2-(14,15- Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite.

J. Chen, J.-K. Chen, J. R. Falck, S. Anjaiah, J. H. Capdevila, and R. C. Harris (2007)
Mol. Cell. Biol. 27, 3023-3034
 |  Abstract »  |  Full Text »  |  PDF »

Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells.

N. E. Willmarth and S. P. Ethier (2006)
J. Biol. Chem. 281, 37728-37737
 |  Abstract »  |  Full Text »  |  PDF »

A Diphtheria Toxin Receptor Deficient in Epidermal Growth Factor-Like Biological Activity.

N. Furukawa, M. Saito, T. Hakoshima, and K. Kohno (2006)
J. Biochem. 140, 831-841
 |  Abstract »  |  Full Text »  |  PDF »

Nardilysin Enhances Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor through Activation of Tumor Necrosis Factor-{alpha}-converting Enzyme.

E. Nishi, Y. Hiraoka, K. Yoshida, K. Okawa, and T. Kita (2006)
J. Biol. Chem. 281, 31164-31172
 |  Abstract »  |  Full Text »  |  PDF »

The N-terminal Domains of Neuregulin 1 Confer Signal Attenuation.

C. M. Warren, K. Kani, and R. Landgraf (2006)
J. Biol. Chem. 281, 27306-27316
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori Can Induce Heparin-Binding Epidermal Growth Factor Expression via Gastrin and Its Receptor..

J. H. Dickson, A. Grabowska, M. El-Zaatari, J. Atherton, and S. A. Watson (2006)
Cancer Res. 66, 7524-7531
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor Overexpression Results in Increased Tumor Cell Motility In vivo Coordinately with Enhanced Intravasation and Metastasis.

C. Xue, J. Wyckoff, F. Liang, M. Sidani, S. Violini, K.-L. Tsai, Z.-Y. Zhang, E. Sahai, J. Condeelis, and J. E. Segall (2006)
Cancer Res. 66, 192-197
 |  Abstract »  |  Full Text »  |  PDF »

Gene expression and immunolocalization of heparin-binding epidermal growth factor-like growth factor and human epidermal growth factor receptors in human corpus luteum.

Y. Akayama, S. Takekida, N. Ohara, H. Tateiwa, W. Chen, K. Nakabayashi, and T. Maruo (2005)
Hum. Reprod. 20, 2708-2714
 |  Abstract »  |  Full Text »  |  PDF »

HB-EGF promotes epithelial cell migration in eyelid development.

N. Mine, R. Iwamoto, and E. Mekada (2005)
Development 132, 4317-4326
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-Binding Epidermal Growth Factor-Like Growth Factor, Collateral Vessel Development, and Angiogenesis in Skeletal Muscle Ischemia.

D. Chalothorn, S. M. Moore, H. Zhang, S. W. Sunnarborg, D. C. Lee, and J. E. Faber (2005)
Arterioscler Thromb Vasc Biol 25, 1884-1890
 |  Abstract »  |  Full Text »  |  PDF »

HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation.

M. Krampera, A. Pasini, A. Rigo, M. T. Scupoli, C. Tecchio, G. Malpeli, A. Scarpa, F. Dazzi, G. Pizzolo, and F. Vinante (2005)
Blood 106, 59-66
 |  Abstract »  |  Full Text »  |  PDF »

Comparative effects of heparin-binding epidermal growth factor-like growth factor on the growth of cultured human uterine leiomyoma cells and myometrial cells.

J. Wang, N. Ohara, S. Takekida, Q. Xu, and T. Maruo (2005)
Hum. Reprod. 20, 1456-1465
 |  Abstract »  |  Full Text »  |  PDF »

The Membrane-anchoring Domain of Epidermal Growth Factor Receptor Ligands Dictates Their Ability to Operate in Juxtacrine Mode.

J. Dong, L. K. Opresko, W. Chrisler, G. Orr, R. D. Quesenberry, D. A. Lauffenburger, and H. S. Wiley (2005)
Mol. Biol. Cell 16, 2984-2998
 |  Abstract »  |  Full Text »  |  PDF »

Intestinal adaptation after massive intestinal resection.

A R Weale, A G Edwards, M Bailey, and P A Lear (2005)
Postgrad. Med. J. 81, 178-184
 |  Abstract »  |  Full Text »  |  PDF »

In vitro differences between venous and arterial-derived smooth muscle cells: potential modulatory role of decorin.

A. P. Wong, N. Nili, and B. H. Strauss (2005)
Cardiovasc Res 65, 702-710
 |  Abstract »  |  Full Text »  |  PDF »

Transactivation of Epidermal Growth Factor Receptor Mediates Catecholamine-Induced Growth of Vascular Smooth Muscle.

H. Zhang, D. Chalothorn, L. F. Jackson, D. C. Lee, and J. E. Faber (2004)
Circ. Res. 95, 989-997
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of the Biological Activities of the Epidermal Growth Factor (EGF)-like Domain by the Heparin-binding Domain of Heparin-binding EGF-like Growth Factor.

R. Takazaki, Y. Shishido, R. Iwamoto, and E. Mekada (2004)
J. Biol. Chem. 279, 47335-47343
 |  Abstract »  |  Full Text »  |  PDF »

ADAM Binding Protein Eve-1 Is Required for Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands.

M. Tanaka, D. Nanba, S. Mori, F. Shiba, H. Ishiguro, K. Yoshino, N. Matsuura, and S. Higashiyama (2004)
J. Biol. Chem. 279, 41950-41959
 |  Abstract »  |  Full Text »  |  PDF »

Diphtheria Toxin-induced Autophagic Cardiomyocyte Death Plays a Pathogenic Role in Mouse Model of Heart Failure.

H. Akazawa, S. Komazaki, H. Shimomura, F. Terasaki, Y. Zou, H. Takano, T. Nagai, and I. Komuro (2004)
J. Biol. Chem. 279, 41095-41103
 |  Abstract »  |  Full Text »  |  PDF »

The role of perlecan in arterial injury and angiogenesis.

A. Segev, N. Nili, and B. H Strauss (2004)
Cardiovasc Res 63, 603-610
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy.

S. Miyamoto, M. Hirata, A. Yamazaki, T. Kageyama, H. Hasuwa, H. Mizushima, Y. Tanaka, H. Yagi, K. Sonoda, M. Kai, et al. (2004)
Cancer Res. 64, 5720-5727
 |  Abstract »  |  Full Text »  |  PDF »

Role of EGFR Transactivation in Preventing Apoptosis in Pseudomonas aeruginosa-Infected Human Corneal Epithelial Cells.

J. Zhang, H. Li, J. Wang, Z. Dong, S. Mian, and F.-S. X. Yu (2004)
Invest. Ophthalmol. Vis. Sci. 45, 2569-2576
 |  Abstract »  |  Full Text »  |  PDF »

HB-EGF Is a Potent Inducer of Tumor Growth and Angiogenesis.

P. P. Ongusaha, J. C. Kwak, A. J. Zwible, S. Macip, S. Higashiyama, N. Taniguchi, L. Fang, and S. W. Lee (2004)
Cancer Res. 64, 5283-5290
 |  Abstract »  |  Full Text »  |  PDF »

Phenotypic Variation Resulting From a Deficiency of Epidermal Growth Factor Receptor in Mice Is Caused by Extensive Genetic Heterogeneity That Can Be Genetically and Molecularly Partitioned.

K. E. Strunk, V. Amann, and D. W. Threadgill (2004)
Genetics 167, 1821-1832
 |  Abstract »  |  Full Text »  |  PDF »

Ectodomain Shedding of SHPS-1 and Its Role in Regulation of Cell Migration.

H. Ohnishi, H. Kobayashi, H. Okazawa, Y. Ohe, K. Tomizawa, R. Sato, and T. Matozaki (2004)
J. Biol. Chem. 279, 27878-27887
 |  Abstract »  |  Full Text »  |  PDF »

Selective Roles for Tumor Necrosis Factor {alpha}-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family: THE JUXTAMEMBRANE STALK DETERMINES CLEAVAGE EFFICIENCY.

C. L. Hinkle, S. W. Sunnarborg, D. Loiselle, C. E. Parker, M. Stevenson, W. E. Russell, and D. C. Lee (2004)
J. Biol. Chem. 279, 24179-24188
 |  Abstract »  |  Full Text »  |  PDF »

Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells.

A. B. Singh, T. Tsukada, R. Zent, and R. C. Harris (2004)
J. Cell Sci. 117, 1365-1379
 |  Abstract »  |  Full Text »  |  PDF »

Wound-Induced HB-EGF Ectodomain Shedding and EGFR Activation in Corneal Epithelial Cells.

K.-P. Xu, Y. Ding, J. Ling, Z. Dong, and F.-S. X. Yu (2004)
Invest. Ophthalmol. Vis. Sci. 45, 813-820
 |  Abstract »  |  Full Text »  |  PDF »

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.

U. Sahin, G. Weskamp, K. Kelly, H.-M. Zhou, S. Higashiyama, J. Peschon, D. Hartmann, P. Saftig, and C. P. Blobel (2004)
J. Cell Biol. 164, 769-779
 |  Abstract »  |  Full Text »  |  PDF »

Proliferative Effects of Heparin-Binding Epidermal Growth Factor-like Growth Factor on Pterygium Epithelial Cells and Fibroblasts.

T. M. Nolan, N. Di Girolamo, M. T. Coroneo, and D. Wakefield (2004)
Invest. Ophthalmol. Vis. Sci. 45, 110-113
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF.

D. Nanba, A. Mammoto, K. Hashimoto, and S. Higashiyama (2003)
J. Cell Biol. 163, 489-502
 |  Abstract »  |  Full Text »  |  PDF »

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

S. Yamazaki, R. Iwamoto, K. Saeki, M. Asakura, S. Takashima, A. Yamazaki, R. Kimura, H. Mizushima, H. Moribe, S. Higashiyama, et al. (2003)
J. Cell Biol. 163, 469-475
 |  Abstract »  |  Full Text »  |  PDF »

Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor.

E. IIVANAINEN, L. NELIMARKKA, V. ELENIUS, S.-M. HEIKKINEN, T. T. JUNTTILA, L. SIHOMBING, M. SUNDVALL, J. A. MAATTA, V. J. O. LAINE, S. YLA-HERTTUALA, et al. (2003)
FASEB J 17, 1609-1621
 |  Abstract »  |  Full Text »  |  PDF »

The Stress- and Inflammatory Cytokine-induced Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor Is Mediated by p38 MAPK, Distinct from the 12-O-Tetradecanoylphorbol-13-acetate- and Lysophosphatidic Acid-induced Signaling Cascades.

H. Takenobu, A. Yamazaki, M. Hirata, T. Umata, and E. Mekada (2003)
J. Biol. Chem. 278, 17255-17262
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.

R. Iwamoto, S. Yamazaki, M. Asakura, S. Takashima, H. Hasuwa, K. Miyado, S. Adachi, M. Kitakaze, K. Hashimoto, G. Raab, et al. (2003)
PNAS 100, 3221-3226
 |  Abstract »  |  Full Text »  |  PDF »

CXCR2 Regulates Respiratory Syncytial Virus-Induced Airway Hyperreactivity and Mucus Overproduction.

A. L. Miller, R. M. Strieter, A. D. Gruber, S. B. Ho, and N. W. Lukacs (2003)
J. Immunol. 170, 3348-3356
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Ultraviolet Irradiation and Heparin-Binding Epidermal Growth Factor-Like Growth Factor in the Pathogenesis of Pterygium.

T. M. Nolan, N. DiGirolamo, N. H. Sachdev, T. Hampartzoumian, M. T. Coroneo, and D. Wakefield (2003)
Am. J. Pathol. 162, 567-574
 |  Abstract »  |  Full Text »  |  PDF »

The Mitogenic Potential of Heparin-Binding Epidermal Growth Factor in the Human Endometrium Is Mediated by the Epidermal Growth Factor Receptor and Is Modulated by Tumor Necrosis Factor-{alpha}.

K. Chobotova, M.-E. Muchmore, J. Carver, H.-J Yoo, S. Manek, W. J. Gullick, D. H. Barlow, and H. J. Mardon (2002)
J. Clin. Endocrinol. Metab. 87, 5769-5777
 |  Abstract »  |  Full Text »  |  PDF »

Specific Molecular Interactions of Oversulfated Chondroitin Sulfate E with Various Heparin-binding Growth Factors. IMPLICATIONS AS A PHYSIOLOGICAL BINDING PARTNER IN THE BRAIN AND OTHER TISSUES.

S. S. Deepa, Y. Umehara, S. Higashiyama, N. Itoh, and K. Sugahara (2002)
J. Biol. Chem. 277, 43707-43716
 |  Abstract »  |  Full Text »  |  PDF »

Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors.

J. A. Fairley, J. Baillie, M. Bain, and J. H. Sinclair (2002)
J. Gen. Virol. 83, 2803-2810
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Cell Adhesion Molecules in Tumor Angiogenesis Induced by Cotransplantation of Cancer and Endothelial Cells to Nude Rats.

K. Tei, N. Kawakami-Kimura, O. Taguchi, K. Kumamoto, S. Higashiyama, N. Taniguchi, K.'i. Toda, R. Kawata, Y. Hisa, and R. Kannagi (2002)
Cancer Res. 62, 6289-6296
 |  Abstract »  |  Full Text »  |  PDF »

Microarray Analysis of Insulin and Insulin-like Growth Factor-1 (IGF-1) Receptor Signaling Reveals the Selective Up-regulation of the Mitogen Heparin-binding EGF-like Growth Factor by IGF-1.

C. Mulligan, J. Rochford, G. Denyer, R. Stephens, G. Yeo, T. Freeman, K. Siddle, and S. O'Rahilly (2002)
J. Biol. Chem. 277, 42480-42487
 |  Abstract »  |  Full Text »  |  PDF »

The soluble and membrane-anchored forms of heparin-binding epidermal growth factor-like growth factor appear to play opposing roles in the survival and apoptosis of human luteinized granulosa cells.

B. Pan, K. Sengoku, K. Goishi, N. Takuma, T. Yamashita, K. Wada, and M. Ishikawa (2002)
Mol. Hum. Reprod. 8, 734-741
 |  Abstract »  |  Full Text »  |  PDF »

Co-existence of heparin-binding epidermal growth factor-like growth factor and pinopodes in human endometrium at the time of implantation.

A. Stavreus-Evers, L. Aghajanova, H. Brismar, H. Eriksson, B.-M. Landgren, and O. Hovatta (2002)
Mol. Hum. Reprod. 8, 765-769
 |  Abstract »  |  Full Text »  |  PDF »

Microarray Analysis of Corneal Fibroblast Gene Expression after Interleukin-1 Treatment.

V. B. Mahajan, C. Wei, and P. J. McDonnell III (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2143-2151
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-Binding Epidermal Growth Factor-Like Growth Factor: Hypoxia-Inducible Expression In Vitro and Stimulation of Neurogenesis In Vitro and In Vivo.

K. Jin, X. O. Mao, Y. Sun, L. Xie, L. Jin, E. Nishi, M. Klagsbrun, and D. A. Greenberg (2002)
J. Neurosci. 22, 5365-5373
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling.

X. Yu, K. D. Sharma, T. Takahashi, R. Iwamoto, and E. Mekada (2002)
Mol. Biol. Cell 13, 2547-2557
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-Based Antidote for Diphtheria.

J.-H. Cha, J. S. Brooke, M. Y. Chang, and L. Eidels (2002)
Infect. Immun. 70, 2344-2350
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells.

J.-K. Chen, J. Capdevila, and R. C. Harris (2002)
PNAS 99, 6029-6034
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Mesangial Cell Hexokinase Activity and Expression by Heparin-binding Epidermal Growth Factor-like Growth Factor. EPIDERMAL GROWTH FACTORS AND PHORBOL ESTERS INCREASE GLUCOSE METABOLISM VIA A COMMON MECHANISM INVOLVING CLASSIC MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY ACTIVATION AND INDUCTION OF HEXOKINASE II EXPRESSION.

R. B. Robey, J. Ma, A. V. P. Santos, O. A. Noboa, P. E. Coy, and J. M. Bryson (2002)
J. Biol. Chem. 277, 14370-14378
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor-alpha Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability.

S. W. Sunnarborg, C. L. Hinkle, M. Stevenson, W. E. Russell, C. S. Raska, J. J. Peschon, B. J. Castner, M. J. Gerhart, R. J. Paxton, R. A. Black, et al. (2002)
J. Biol. Chem. 277, 12838-12845
 |  Abstract »  |  Full Text »  |  PDF »

The Expression of EGFR Family Ligands in Breast Carcinomas.

Z. Suo, B. Risberg, M. G. Karlsson, K. Villman, E. Skovlund, and J. M. Nesland (2002)
International Journal of Surgical Pathology 10, 91-99
 |  Abstract »  |  PDF »

Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture.

A. E. DeWitt, J. Y. Dong, H. S. Wiley, and D. A. Lauffenburger (2002)
J. Cell Sci. 114, 2301-2313
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Erk Mitogen-activated Protein Kinase Pathway Stimulates Neuroendocrine Differentiation in LNCaP Cells Independently of Cell Cycle Withdrawal and STAT3 Phosphorylation.

J. Kim, R. M. Adam, and M. R. Freeman (2002)
Cancer Res. 62, 1549-1554
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Syndecan-4 Expression in 3T3-F442A Mouse Adipocytes: Link between Syndecan-4 Induction and Cell Proliferation.

R. Landry, V. Rioux, and A. Bensadoun (2001)
Cell Growth Differ. 12, 497-504
 |  Abstract »  |  Full Text »  |  PDF »

Essential role for extracellular Ca2+ in JNK activation by mechanical stretch in bladder smooth muscle cells.

N. Kushida, Y. Kabuyama, O. Yamaguchi, and Y. Homma (2001)
Am J Physiol Cell Physiol 281, C1165-C1172
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-Binding EGF-Like Growth Factor Modulation by Antiprogestin and CG in the Baboon (Papio anubis).

R. E. Leach, R. Khalifa, D. R. Armant, A. Brudney, S. K. Das, S. K. Dey, and A. T. Fazleabas (2001)
J. Clin. Endocrinol. Metab. 86, 4520-4528
 |  Abstract »  |  Full Text »  |  PDF »

Mineralocorticoids upregulate arterial contraction to epidermal growth factor.

J. A. Florian, A. Dorrance, R. C. Webb, and S. W. Watts (2001)
Am J Physiol Regulatory Integrative Comp Physiol 281, R878-R886
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms.

B. C. Berk (2001)
Physiol Rev 81, 999-1030
 |  Abstract »  |  Full Text »  |  PDF »

cDNA Array Analysis of Altered Gene Expression in Human Endothelial Cells in Response to Chlamydia pneumoniae Infection.

B. K. Coombes and J. B. Mahony (2001)
Infect. Immun. 69, 1420-1427
 |  Abstract »  |  Full Text »  |  PDF »

Vanadium Stimulates Human Bronchial Epithelial Cells to Produce Heparin-Binding Epidermal Growth Factor-Like Growth Factor . A Mitogen for Lung Fibroblasts.

L. Zhang, A. B. Rice, K. Adler, P. Sannes, L. Martin, W. Gladwell, J.-S. Koo, T. E. Gray, and J. C. Bonner (2001)
Am. J. Respir. Cell Mol. Biol. 24, 123-131
 |  Abstract »  |  Full Text »

The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.

J. C. Tsai, L. Liu, J. Guan, and W. C. Aird (2000)
Am J Physiol Cell Physiol 279, C1414-C1424
 |  Abstract »  |  Full Text »  |  PDF »

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing.

S. Tokumaru, S. Higashiyama, T. Endo, T. Nakagawa, J.-i. Miyagawa, K. Yamamori, Y. Hanakawa, H. Ohmoto, K. Yoshino, Y. Shirakata, et al. (2000)
J. Cell Biol. 151, 209-220
 |  Abstract »  |  Full Text »  |  PDF »

Dysregulation of EGF Family of Growth Factors and COX-2 in the Uterus during the Preattachment and Attachment Reactions of the Blastocyst with the Luminal Epithelium Correlates with Implantation Failure in LIF- Deficient Mice.

H. Song, H. Lim, S. K. Das, B. C. Paria, and S. K. Dey (2000)
Mol. Endocrinol. 14, 1147-1161
 |  Abstract »  |  Full Text »

Antisense Inhibition of Epidermal Growth Factor Receptor Decreases Expression of Human Surfactant Protein A.

J. M. Klein, T. A. McCarthy, J. M. Dagle, and J. M. Snyder (2000)
Am. J. Respir. Cell Mol. Biol. 22, 676-684
 |  Abstract »  |  Full Text »

Localization of CD9, an Enhancer Protein for Proheparin-Binding Epidermal Growth Factor-Like Growth Factor, in Human Atherosclerotic Plaques : Possible Involvement of Juxtacrine Growth Mechanism on Smooth Muscle Cell Proliferation.

M. Nishida, J.-i. Miyagawa, S. Yamashita, S. Higashiyama, A. Nakata, N. Ouchi, R. Tamura, K. Yamamori, S. Kihara, N. Taniguchi, et al. (2000)
Arterioscler Thromb Vasc Biol 20, 1236-1243
 |  Abstract »  |  Full Text »  |  PDF »

Cell Surface Monkey CD9 Antigen Is a Coreceptor That Increases Diphtheria Toxin Sensitivity and Diphtheria Toxin Receptor Affinity.

J.-H. Cha, J. S. Brooke, K. N. Ivey, and L. Eidels (2000)
J. Biol. Chem. 275, 6901-6907
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-Binding EGF-Like Growth Factor Is Up-Regulated in the Obstructed Kidney in a Cell- and Region-Specific Manner and Acts to Inhibit Apoptosis.

H. T. Nguyen, S. H. Bride, A.-B. Badawy, R. M. Adam, J. Lin, A. Orsola, P. D. Guthrie, M. R. Freeman, and C. A. Peters (2000)
Am. J. Pathol. 156, 889-898
 |  Abstract »  |  Full Text »  |  PDF »

Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes.

Y. Shirakata, T. Komurasaki, H. Toyoda, Y. Hanakawa, K. Yamasaki, S. Tokumaru, K. Sayama, and K. Hashimoto (2000)
J. Biol. Chem. 275, 5748-5753
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor-like Ligands Differentially Up-Regulate Matrix Metalloproteinase 9 in Head and Neck Squamous Carcinoma Cells.

P. O-charoenrat, H. Modjtahedi, P. Rhys-Evans, W. J. Court, G. M. Box, and S. A. Eccles (2000)
Cancer Res. 60, 1121-1128
 |  Abstract »  |  Full Text »

Trafficking and Proteolytic Release of Epidermal Growth Factor Receptor Ligands Are Modulated by Their Membrane-anchoring Domains.

J. Dong and H. S. Wiley (2000)
J. Biol. Chem. 275, 557-564
 |  Abstract »  |  Full Text »  |  PDF »

Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites.

X Yu, S Miyamoto, and E Mekada (2000)
J. Cell Sci. 113, 2139-2147
 |  Abstract »  |  PDF »

Acceleration of trophoblast differentiation by heparin-binding EGF-like growth factor is dependent on the stage-specific activation of calcium influx by ErbB receptors in developing mouse blastocysts.

J Wang, L Mayernik, J. Schultz, and D. Armant (2000)
Development 127, 33-44
 |  Abstract »  |  PDF »

Granulocyte-Macrophage Colony-Stimulating Factor Induces Expression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor/Diphtheria Toxin Receptor and Sensitivity to Diphtheria Toxin in Human Neutrophils.

F. Vinante, M. Marchi, A. Rigo, P. Scapini, G. Pizzolo, and M. A. Cassatella (1999)
Blood 94, 3169-3177
 |  Abstract »  |  Full Text »  |  PDF »

The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading.

Z.'e. Gechtman, J. L. Alonso, G. Raab, D. E. Ingber, and M. Klagsbrun (1999)
J. Biol. Chem. 274, 28828-28835
 |  Abstract »  |  Full Text »  |  PDF »

Ribozyme-mediated Down-Regulation of ErbB-4 in Estrogen Receptor-positive Breast Cancer Cells Inhibits Proliferation Both in Vitro and in Vivo.

C. K. Tang, X.-Z. W. Concepcion, M. Milan, X. Gong, E. Montgomery, and M. E. Lippman (1999)
Cancer Res. 59, 5315-5322
 |  Abstract »  |  Full Text »  |  PDF »

Contact-dependent Growth Inhibition and Apoptosis of Epidermal Growth Factor (EGF) Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor.

R. Iwamoto, K. Handa, and E. Mekada (1999)
J. Biol. Chem. 274, 25906-25912
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Roles for Heparin-Binding Epidermal Growth Factor-Like Growth Factor Are Suggested by Its Cell-Specific Expression during the Human Endometrial Cycle and Early Placentation.

R. E. Leach, R. Khalifa, N. D. Ramirez, S. K. Das, J. Wang, S. K. Dey, R. Romero, and D. R. Armant (1999)
J. Clin. Endocrinol. Metab. 84, 3355-3363
 |  Abstract »  |  Full Text »

Isolation of Mouse Stromal Cells Associated with a Human Tumor Using Differential Diphtheria Toxin Sensitivity.

J. L. Arbiser, G. Raab, R. M. Rohan, S. Paul, K. Hirschi, E. Flynn, E. R. Price, D. E. Fisher, C. Cohen, and M. Klagsbrun (1999)
Am. J. Pathol. 155, 723-729
 |  Abstract »  |  Full Text »  |  PDF »

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats.

A. B. Rice, C. R. Moomaw, D. L. Morgan, and J. C. Bonner (1999)
Am. J. Pathol. 155, 213-221
 |  Abstract »  |  Full Text »  |  PDF »

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.

J. Dong, L. K. Opresko, P. J. Dempsey, D. A. Lauffenburger, R. J. Coffey, and H. S. Wiley (1999)
PNAS 96, 6235-6240
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-alpha Deficiency Reduces Pulmonary Fibrosis in Transgenic Mice.

D. K. Madtes, A. L. Elston, R. C. Hackman, A. R. Dunn, and J. G. Clark (1999)
Am. J. Respir. Cell Mol. Biol. 20, 924-934
 |  Abstract »  |  Full Text »

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