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Science 22 February 1991:
Vol. 251. no. 4996, pp. 927 - 929
DOI: 10.1126/science.2000492
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Articles

Science, Vol 251, Issue 4996, 927-929
Copyright © 1991 by American Association for the Advancement of Science

articles

Chemical sensors based on controlled-release polymer systems

SM Barnard and DR Walt

Department of Chemistry, Tufts University, Medford, MA 02155.

A novel chemical sensor has been developed in which the polymer ethylene-vinyl acetate is used as a controlled-release system to deliver reagents to the sensing region of an optical fiber for a homogeneous competitive immunoassay based on fluorescence energy transfer. A competition reaction is used to enable continuous measurements of the solution antigen concentration. More generally, the technique allows irreversible indicating chemistries to be used in the construction of chemical sensors that can measure continuously for long periods. Although the sensor configuration has not been optimized in all respects, data are presented for a model system in which a fluorescein-labeled antibody and Texas Red-labeled immunoglobulin G (IgG) are used.


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