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Science 15 February 1991:
Vol. 251. no. 4995, pp. 804 - 807
DOI: 10.1126/science.1846707
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Articles

Science, Vol 251, Issue 4995, 804-807
Copyright © 1991 by American Association for the Advancement of Science

articles

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

AV Smrcka, Hepler JR, KO Brown, and PC Sternweis

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235.

The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C yields the second messengers inositol 1,4,5-trisphosphate (InsP3) and 1,2-diacylglycerol. This activity is regulated by a variety of hormones through G protein pathways. However, the specific G protein or proteins involved has not been identified. The alpha subunit of a newly discovered pertussis toxin-insensitive G protein (Gq) has recently been isolated and is now shown to stimulate the activity of polyphosphoinositide-specific phospholipase C (PI-PLC) from bovine brain. Both the maximal activity and the affinity of PI-PLC for calcium ion were affected. These results identify Gq as a G protein that regulates PI-PLC.


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   Abstract »    PDF »
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Pasteurella multocida Toxin Activates the Inositol Triphosphate Signaling Pathway in Xenopus Oocytes via Gqalpha -coupled Phospholipase C-beta 1.
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L. Birnbaumer, X. Zhu, M. Jiang, G. Boulay, M. Peyton, B. Vannier, D. Brown, D. Platano, H. Sadeghi, E. Stefani, et al. (1996)
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Gq-coupled Receptors Transmit the Signal for GLUT4 Translocation via an Insulin-independent Pathway.
K. Kishi, H. Hayashi, L. Wang, S. Kamohara, K. Tamaoka, T. Shimizu, F. Ushikubi, S. Narumiya, and Y. Ebina (1996)
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Gbeta gamma Transduces [Ca2+]i Oscillations and Galpha q a Sustained Response during Stimulation of Pancreatic Acinar Cells with [Ca2+]i-mobilizing Agonists.
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J. Biol. Chem. 270, 17741-17748
   Abstract »    Full Text »    PDF »
Identification of a Domain in the Angiotensin II Type 1 Receptor Determining G[IMAGE] Coupling by the Use of Receptor Chimeras.
C. Wang, S. Jayadev, and J. A. Escobedo (1995)
J. Biol. Chem. 270, 16677-16682
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Overexpression of Phospholipase C-[IMAGE]1 in Colorectal Carcinomas Is Associated with Overexpression of Factors That Bind Its Promoter.
S.-J. Lee, S. D. Lee, J.-G. Park, C.-M. Kim, S. H. Ryu, and P.-G. Suh (1995)
J. Biol. Chem. 270, 16378-16384
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G Protein Control of Drosophila Photoreceptor Phospholipase C.
J. L. R. Deer, J. B. Hurley, and S. L. Yarfitz (1995)
J. Biol. Chem. 270, 12623-12628
   Abstract »    Full Text »    PDF »
Prostaglandin F[IMAGE]Stimulates Formation of p21-GTP Complex and Mitogen-activated Protein Kinase in NIH-3T3 Cells via G[IMAGE]-protein-coupled Pathway.
T. Watanabe, I. Waga, Z.-i. Honda, K. Kurokawa, and T. Shimizu (1995)
J. Biol. Chem. 270, 8984-8990
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Mapping of G Protein Coupling Sites of the Angiotensin II Type 1 Receptor.
H. Shirai, K. Takahashi, T. Katada, and T. Inagami (1995)
Hypertension 25, 726-730
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Characterization of G(q) Family G Proteins G[IMAGE]alpha (G(14)alpha), G[IMAGE]alpha (G[IMAGE]alpha), and G(q)alpha Expressed in the Baculovirus-Insect Cell System.
F. Nakamura, M. Kato, K. Kameyama, T. Nukada, T. Haga, H. Kato, T. Takenawa, and U. Kikkawa (1995)
J. Biol. Chem. 270, 6246-6253
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Cloning and Identification of Amino Acid Residues of Human Phospholipase C[IMAGE]1 Essential for Catalysis.
H.-F. Cheng, M.-J. Jiang, C.-L. Chen, S.-M. Liu, L.-P. Wong, J. W. Lomasney, and K. King (1995)
J. Biol. Chem. 270, 5495-5505
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Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid beta-Protein Production in Human Neuronal NT2N Cells.
B. A. Wolf, A. M. Wertkin, Y. C. Jolly, R. P. Yasuda, B. B. Wolfe, R. J. Konrad, D. Manning, S. Ravi, J. R. Williamson, and V. M.-Y. Lee (1995)
J. Biol. Chem. 270, 4916-4922
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Guanine Nucleotide-Binding Proteins in Bipolar Affective Disorder: Effects of Long-term Lithium Treatment.
H. K. Manji, G. Chen, H. Shimon, J. K. Hsiao, W. Z. Potter, and R. H. Belmaker (1995)
Arch Gen Psychiatry 52, 135-144
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Coexpression of P2Y and P2U Receptors on Aortic Endothelial Cells : Comparison of Cell Localization and Signaling Pathways.
D. Communi, E. Raspe, S. Pirotton, and J.-M. Boeynaems (1995)
Circ. Res. 76, 191-198
   Abstract »    Full Text »
Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs.
G. Moore, T Ayabe, P. Visconti, R. Schultz, and G. Kopf (1994)
Development 120, 3313-3323
   Abstract »    PDF »
G protein-coupled signal transduction pathways for interleukin-8.
D Wu, G. LaRosa, and M. Simon (1993)
Science 261, 101-103
   Abstract »    PDF »
Regulation of Mammalian Adenylyl Cyclases by G-Protein {alpha} and {beta}{gamma} Subunits.
W.-J. Tang, J.A. Iniguez-Lluhi, S. Mumby, and A.G. Gilman (1992)
Cold Spring Harb Symp Quant Biol 57, 135-144
   Abstract »    PDF »
Detection of Coincident Signals by G Proteins and Adenylyl Cyclase.
H.R. Bourne, K.D. Lustig, Y.H. Wong, and B.R. Conklin (1992)
Cold Spring Harb Symp Quant Biol 57, 145-148
   Abstract »    PDF »
Diversity of G proteins in signal transduction.
M. Simon, M. Strathmann, and N Gautam (1991)
Science 252, 802-808
   Abstract »    PDF »
Phosphorylation and Regulation of G-protein-activated Phospholipase C-beta 3 by cGMP-dependent Protein Kinases.
C. Xia, Z. Bao, C. Yue, B. M. Sanborn, and M. Liu (2001)
J. Biol. Chem. 276, 19770-19777
   Abstract »    Full Text »    PDF »
Evidence for Selective Coupling of alpha 1-Adrenergic Receptors to Phospholipase C-beta 1 in Rat Neonatal Cardiomyocytes.
J. F. Arthur, S. J. Matkovich, C. J. Mitchell, T. J. Biden, and E. A. Woodcock (2001)
J. Biol. Chem. 276, 37341-37346
   Abstract »    Full Text »    PDF »


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