Science 15 February 1991: Vol. 251. no. 4995, pp. 802 - 804 DOI: 10.1126/science.1846706

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Articles

Epidermal growth factor and hepatocyte growth factor receptors collaborate to induce multiple biological responses in bovine mammary epithelial cells.

P. Accornero, E. Martignani, S. Miretti, L. Starvaggi Cucuzza, and M. Baratta (2009)
J Dairy Sci 92, 3667-3675
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Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.

H. Chang, M. Yoshimoto, K. Umeda, T. Iwasa, Y. Mizuno, S.-i. Fukada, H. Yamamoto, N. Motohashi, Y. Miyagoe-Suzuki, S. Takeda, et al. (2009)
FASEB J 23, 1907-1919
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Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer.

J. P. Eder, G. F. Vande Woude, S. A. Boerner, and P. M. LoRusso (2009)
Clin. Cancer Res. 15, 2207-2214
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Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor-Activating Mutations.

S. Yano, W. Wang, Q. Li, K. Matsumoto, H. Sakurama, T. Nakamura, H. Ogino, S. Kakiuchi, M. Hanibuchi, Y. Nishioka, et al. (2008)
Cancer Res. 68, 9479-9487
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Therapeutic angiogenesis using naked DNA expressing two isoforms of the hepatocyte growth factor in a porcine acute myocardial infarction model.

K. R. Cho, J.-S. Choi, W. Hahn, D. S. Kim, J. S. Park, D. S. Lee, and K.-B. Kim (2008)
Eur. J. Cardiothorac. Surg. 34, 857-863
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Hepatocyte Growth Factor and Sonic Hedgehog Expression in Cerebellar Neural Progenitor Cells Costimulate Medulloblastoma Initiation and Growth.

M. J. Binning, T. Niazi, C. A. Pedone, B. Lal, C. G. Eberhart, K. J. Kim, J. Laterra, and D. W. Fults (2008)
Cancer Res. 68, 7838-7845
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Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo.

Y. Zhang, P. J. Kaplan-Lefko, K. Rex, Y. Yang, J. Moriguchi, T. Osgood, B. Mattson, A. Coxon, M. Reese, T.-S. Kim, et al. (2008)
Cancer Res. 68, 6680-6687
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A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met.

C. Basilico, A. Arnesano, M. Galluzzo, P. M. Comoglio, and P. Michieli (2008)
J. Biol. Chem. 283, 21267-21277
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Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis.

L. P. Stabile, M. E. Rothstein, P. Keohavong, J. Jin, J. Yin, S. R. Land, S. Dacic, T. M. Luong, K. J. Kim, A. M. Dulak, et al. (2008)
Mol. Cancer Ther. 7, 1913-1922
 |  Abstract »  |  Full Text »  |  PDF »

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival.

H. Jin, R. Yang, Z. Zheng, M. Romero, J. Ross, H. Bou-Reslan, R. A.D. Carano, I. Kasman, E. Mai, J. Young, et al. (2008)
Cancer Res. 68, 4360-4368
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Induction of Efficient Differentiation and Survival of Porcine Neonatal Pancreatic Cell Clusters Using an EBV-based Plasmid Expressing HGF.

M. S. Kim, J.-W. Kim, C. Sun, S. T. Oh, K. H. Yoon, and S. K. Lee (2008)
J. Biochem. 143, 497-503
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Involvement of PI3K/Akt Signaling Pathway in Hepatocyte Growth Factor-Induced Migration of Uveal Melanoma Cells.

M. Ye, D. Hu, L. Tu, X. Zhou, F. Lu, B. Wen, W. Wu, Y. Lin, Z. Zhou, and J. Qu (2008)
Invest. Ophthalmol. Vis. Sci. 49, 497-504
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Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.

M. Esaki, G. Takemura, K.-i. Kosai, T. Takahashi, S. Miyata, L. Li, K. Goto, R. Maruyama, H. Okada, H. Kanamori, et al. (2008)
Am J Physiol Heart Circ Physiol 294, H1048-H1057
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Coupling of Grb2 to Gab1 Mediates Hepatocyte Growth Factor-induced High Intensity ERK Signal Required for Inhibition of HepG2 Hepatoma Cell Proliferation.

A. Kondo, N. Hirayama, Y. Sugito, M. Shono, T. Tanaka, and N. Kitamura (2008)
J. Biol. Chem. 283, 1428-1436
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c-Met Receptor Tyrosine Kinase as a Therapeutic Target in Cancer.

R. Salgia (2008)
ASCO Educational Book 2008, 113-118
 |  Abstract »  |  Full Text »  |  PDF »

The hepatocyte growth factor system as a regulator of female and male gonadal function.

R. Zachow and M. Uzumcu (2007)
J. Endocrinol. 195, 359-371
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Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of N-nitrosodiethylamine Induced Hepatocarcinogenesis.

T. Takami, P. Kaposi-Novak, K. Uchida, L. E. Gomez-Quiroz, E. A. Conner, V. M. Factor, and S. S. Thorgeirsson (2007)
Cancer Res. 67, 9844-9851
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Identification of a Met-Binding Peptide from a Phage Display Library.

P. Zhao, T. Grabinski, C. Gao, R. S. Skinner, T. Giambernardi, Y. Su, E. Hudson, J. Resau, M. Gross, G. F. Vande Woude, et al. (2007)
Clin. Cancer Res. 13, 6049-6055
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Hepatocyte Growth Factor Receptor c-MET Is Associated with FAS and When Activated Enhances Drug-induced Apoptosis in Pediatric B Acute Lymphoblastic Leukemia with TEL-AML1 Translocation.

B. Accordi, S. Pillozzi, M. C. Dell'Orto, G. Cazzaniga, A. Arcangeli, G. t. Kronnie, and G. Basso (2007)
J. Biol. Chem. 282, 29384-29393
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A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.

W. D. Tolbert, J. Daugherty, C. Gao, Q. Xie, C. Miranti, E. Gherardi, G. Vande Woude, and H. E. Xu (2007)
PNAS 104, 14592-14597
 |  Abstract »  |  Full Text »  |  PDF »

Glutathione Peroxidase 3, Deleted or Methylated in Prostate Cancer, Suppresses Prostate Cancer Growth and Metastasis.

Y. P. Yu, G. Yu, G. Tseng, K. Cieply, J. Nelson, M. Defrances, R. Zarnegar, G. Michalopoulos, and J.-H. Luo (2007)
Cancer Res. 67, 8043-8050
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Hepatocyte Growth Factor Exerts Multiple Biological Functions on Bovine Mammary Epithelial Cells.

P. Accornero, E. Martignani, E. Macchi, and M. Baratta (2007)
J Dairy Sci 90, 4289-4296
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Pathways Involved in Cyclooxygenase-2 Induction by Hepatocyte Growth Factor in Non Small-Cell Lung Cancer.

J. M. Siegfried, C. T. Gubish, M. E. Rothstein, P. E. Q. de Oliveira, and L. P. Stabile (2007)
Mol. Pharmacol. 72, 769-779
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Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells.

R. Jagadeeswaran, S. Jagadeeswaran, V. P. Bindokas, and R. Salgia (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1488-L1494
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Activating Transcription Factor-1-mediated Hepatocyte Growth Factor-induced Down-regulation of Thrombospondin-1 Expression Leads to Thyroid Cancer Cell Invasion.

C. Ghoneim, M. Soula-Rothhut, C. Blanchevoye, L. Martiny, F. Antonicelli, and B. Rothhut (2007)
J. Biol. Chem. 282, 15490-15497
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Cross Talk between c-Met and Epidermal Growth Factor Receptor during Retinal Pigment Epithelial Wound Healing.

K.-P. Xu and F.-S. X. Yu (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2242-2248
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An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms.

H. Y. Zou, Q. Li, J. H. Lee, M. E. Arango, S. R. McDonnell, S. Yamazaki, T. B. Koudriakova, G. Alton, J. J. Cui, P.-P. Kung, et al. (2007)
Cancer Res. 67, 4408-4417
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c-Met is essential for wound healing in the skin.

J. Chmielowiec, M. Borowiak, M. Morkel, T. Stradal, B. Munz, S. Werner, J. Wehland, C. Birchmeier, and W. Birchmeier (2007)
J. Cell Biol. 177, 151-162
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Human skin pigmentation: melanocytes modulate skin color in response to stress.

G.-E. Costin and V. J. Hearing (2007)
FASEB J 21, 976-994
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The Androgen Receptor Negatively Regulates the Expression of c-Met: Implications for a Novel Mechanism of Prostate Cancer Progression.

M. Verras, J. Lee, H. Xue, T.-H. Li, Y. Wang, and Z. Sun (2007)
Cancer Res. 67, 967-975
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Molecular Biology of Renal Cell Cancer and the Identification of Therapeutic Targets.

O. Iliopoulos (2006)
J. Clin. Oncol. 24, 5593-5600
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Malignant melanoma: genetics and therapeutics in the genomic era..

L. Chin, L. A. Garraway, and D. E. Fisher (2006)
Genes & Dev. 20, 2149-2182
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Direct Interaction of Focal Adhesion Kinase (FAK) with Met Is Required for FAK To Promote Hepatocyte Growth Factor-Induced Cell Invasion..

S.-Y. Chen and H.-C. Chen (2006)
Mol. Cell. Biol. 26, 5155-5167
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Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor-Induced Cell Motility of Human Synovial Sarcoma Cell Lines.

T. Watanabe, M. Tsuda, Y. Makino, S. Ichihara, H. Sawa, A. Minami, N. Mochizuki, K. Nagashima, and S. Tanaka (2006)
Mol. Cancer Res. 4, 499-510
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Mature Hepatocyte Growth Factor/Scatter Factor on the Surface of Human Granulocytes Is Released by a Mechanism Involving Activated Factor Xa..

T. Ohnishi, K. Kakimoto, K. Bandow, C. J. Lowenstein, Y. Daikuhara, and T. Matsuguchi (2006)
J. Immunol. 176, 6945-6953
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Involvement of the Ras-Ras-activated Rab5 Guanine Nucleotide Exchange Factor RIN2-Rab5 Pathway in the Hepatocyte Growth Factor-induced Endocytosis of E-cadherin.

T. Kimura, T. Sakisaka, T. Baba, T. Yamada, and Y. Takai (2006)
J. Biol. Chem. 281, 10598-10609
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Inactivation of von Hippel-Lindau Gene Induces Constitutive Phosphorylation of MET Protein in Clear Cell Renal Carcinoma..

N. Nakaigawa, M. Yao, M. Baba, S. Kato, T. Kishida, K. Hattori, Y. Nagashima, and Y. Kubota (2006)
Cancer Res. 66, 3699-3705
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Contact Inhibition of Hepatocyte Growth Regulated by Functional Association of the c-Met/Hepatocyte Growth Factor Receptor and LAR Protein-tyrosine Phosphatase.

M. Machide, A. Hashigasako, K. Matsumoto, and T. Nakamura (2006)
J. Biol. Chem. 281, 8765-8772
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Structural basis of hepatocyte growth factor/scatter factor and MET signalling..

E. Gherardi, S. Sandin, M. V. Petoukhov, J. Finch, M. E. Youles, L.-G. Ofverstedt, R. N. Miguel, T. L. Blundell, G. F. Vande Woude, U. Skoglund, et al. (2006)
PNAS 103, 4046-4051
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of Plasminogen Activator Inhibitor-1 in Cholestatic Liver Injury and Fibrosis.

I. Bergheim, L. Guo, M. A. Davis, I. Duveau, and G. E. Arteel (2006)
J. Pharmacol. Exp. Ther. 316, 592-600
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Hepatocyte Growth Factor/Scatter Factor and MET Are Involved in Arterial Repair and Atherogenesis.

H. McKinnon, E. Gherardi, M. Reidy, and D. Bowyer (2006)
Am. J. Pathol. 168, 340-348
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Inhibition of the Met Receptor in Mesothelioma.

T. Mukohara, G. Civiello, I. J. Davis, M. L. Taffaro, J. Christensen, D. E. Fisher, B. E. Johnson, and P. A. Janne (2005)
Clin. Cancer Res. 11, 8122-8130
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Up-Regulation of c-met Protooncogene Product Expression through Hypoxia-Inducible Factor-1{alpha} Is Involved in Trophoblast Invasion under Low-Oxygen Tension.

M. Hayashi, M. Sakata, T. Takeda, M. Tahara, T. Yamamoto, Y. Okamoto, R. Minekawa, A. Isobe, M. Ohmichi, K. Tasaka, et al. (2005)
Endocrinology 146, 4682-4689
 |  Abstract »  |  Full Text »  |  PDF »

The Scatter Factor/Hepatocyte Growth Factor: c-Met Pathway in Human Embryonal Central Nervous System Tumor Malignancy.

Y. Li, B. Lal, S. Kwon, X. Fan, U. Saldanha, T. E. Reznik, E. B. Kuchner, C. Eberhart, J. Laterra, and R. Abounader (2005)
Cancer Res. 65, 9355-9362
 |  Abstract »  |  Full Text »  |  PDF »

Multifocal Renal Cancer: Genetic Basis and Its Medical Relevance.

D. P. Bottaro and W. M. Linehan (2005)
Clin. Cancer Res. 11, 7206-7208
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Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis.

R. Abounader and J. Laterra (2005)
Neuro-oncol 7, 436-451
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Hepatocyte Growth Factor Is Required for Alveologenesis in the Neonatal Rat.

S. Padela, J. Cabacungan, S. Shek, R. Belcastro, M. Yi, R. P. Jankov, and A. K. Tanswell (2005)
Am. J. Respir. Crit. Care Med. 172, 907-914
 |  Abstract »  |  Full Text »  |  PDF »

Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo.

S.-Z. Zhang, F.-Y. Pan, J.-F. Xu, J. Yuan, S.-Y. Guo, G. Dai, B. Xue, W.-G. Shen, C.-J. Wen, D.-H. Zhao, et al. (2005)
Mol. Cancer Ther. 4, 1577-1584
 |  Abstract »  |  Full Text »  |  PDF »

A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis.

M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia (2005)
J. Cell Sci. 118, 4343-4352
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Induces Redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a Up-regulation, Leading to Cell Cycle Arrest at G1 in HepG2 Hepatoma Cells.

J. Han, Y.-i. Tsukada, E. Hara, N. Kitamura, and T. Tanaka (2005)
J. Biol. Chem. 280, 31548-31556
 |  Abstract »  |  Full Text »  |  PDF »

Gene transfection of hepatocyte growth factor attenuates the progression of cardiac remodeling in the hypertrophied heart.

K. Iwata, Y. Sawa, S. Kitagawa-Sakakida, N. Kawaguchi, N. Matsuura, T. Nakamura, and H. Matsuda (2005)
J. Thorac. Cardiovasc. Surg. 130, 719-725
 |  Abstract »  |  Full Text »  |  PDF »

A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases.

A. Shrivastava, M.A. von Wronski, A.K. Sato, D.T. Dransfield, D. Sexton, N. Bogdan, R. Pillai, P. Nanjappan, B. Song, E. Marinelli, et al. (2005)
Protein Eng. Des. Sel. 18, 417-424
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors Expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas.

Y. Ren, B. Cao, S. Law, Y. Xie, P. Y. Lee, L. Cheung, Y. Chen, X. Huang, H. M. Chan, P. Zhao, et al. (2005)
Clin. Cancer Res. 11, 6190-6197
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance.

C. Dai, C.-G. Huh, S. S. Thorgeirsson, and Y. Liu (2005)
Am. J. Pathol. 167, 429-436
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Suppressor Activity and Epigenetic Inactivation of Hepatocyte Growth Factor Activator Inhibitor Type 2/SPINT2 in Papillary and Clear Cell Renal Cell Carcinoma.

M. R. Morris, D. Gentle, M. Abdulrahman, E. N. Maina, K. Gupta, R. E. Banks, M. S. Wiesener, T. Kishida, M. Yao, B. Teh, et al. (2005)
Cancer Res. 65, 4598-4606
 |  Abstract »  |  Full Text »  |  PDF »

Sema4D induces angiogenesis through Met recruitment by Plexin B1.

P. Conrotto, D. Valdembri, S. Corso, G. Serini, L. Tamagnone, P. M. Comoglio, F. Bussolino, and S. Giordano (2005)
Blood 105, 4321-4329
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Ameliorates the Progression of Experimental Autoimmune Myocarditis: A Potential Role for Induction of T Helper 2 Cytokines.

H. Futamatsu, J.-i. Suzuki, S. Mizuno, N. Koga, S. Adachi, H. Kosuge, Y. Maejima, K. Hirao, T. Nakamura, and M. Isobe (2005)
Circ. Res. 96, 823-830
 |  Abstract »  |  Full Text »  |  PDF »

The SPRY Domain-containing SOCS Box Protein 1 (SSB-1) Interacts with MET and Enhances the Hepatocyte Growth Factor-induced Erk-Elk-1-Serum Response Element Pathway.

D. Wang, Z. Li, E. M. Messing, and G. Wu (2005)
J. Biol. Chem. 280, 16393-16401
 |  Abstract »  |  Full Text »  |  PDF »

Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model.

K. Oh, Y. Iimuro, M. Takeuchi, Y. Kaneda, T. Iwasaki, N. Terada, T. Matsumoto, K. Nakanishi, and J. Fujimoto (2005)
Am J Physiol Gastrointest Liver Physiol 288, G729-G735
 |  Abstract »  |  Full Text »  |  PDF »

Des-{gamma}-carboxy Prothrombin Is a Potential Autologous Growth Factor for Hepatocellular Carcinoma.

M. Suzuki, H. Shiraha, T. Fujikawa, N. Takaoka, N. Ueda, Y. Nakanishi, K. Koike, A. Takaki, and Y. Shiratori (2005)
J. Biol. Chem. 280, 6409-6415
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection.

Y. Kashiwakura, K. Tamayose, K. Iwabuchi, Y. Hirai, T. Shimada, K. Matsumoto, T. Nakamura, M. Watanabe, K. Oshimi, and H. Daida (2005)
J. Virol. 79, 609-614
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate.

P. Biswas, A. Roy, R. Gong, A. Yango, E. Tolbert, J. Centracchio, and L. D. Dworkin (2005)
Am J Physiol Renal Physiol 288, F8-F15
 |  Abstract »  |  Full Text »  |  PDF »

Both Sp1 and Smad participate in mediating TGF-{beta}1-induced HGF receptor expression in renal epithelial cells.

X. Zhang, J. Yang, Y. Li, and Y. Liu (2005)
Am J Physiol Renal Physiol 288, F16-F26
 |  Abstract »  |  Full Text »  |  PDF »

Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats.

M. Ono, Y. Sawa, N. Fukushima, H. Suhara, T. Nakamura, C. Yokoyama, T. Tanabe, and H. Matsuda (2004)
Eur. J. Cardiothorac. Surg. 26, 1092-1097
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Suppresses Vascular Medial Hyperplasia and Matrix Accumulation in Advanced Pulmonary Hypertension of Rats.

M. Ono, Y. Sawa, S. Mizuno, N. Fukushima, H. Ichikawa, K. Bessho, T. Nakamura, and H. Matsuda (2004)
Circulation 110, 2896-2902
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Down-Regulation of Cdk2 Activity in Hepatocyte Growth Factor-Induced Cell Cycle Arrest at G1 in the Human Hepatocellular Carcinoma Cell Line HepG2.

Y.-i. Tsukada, T. Tanaka, K. Miyazawa, and N. Kitamura (2004)
J. Biochem. 136, 701-709
 |  Abstract »  |  Full Text »  |  PDF »

Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor {beta}-Chain in Met Binding and Signaling.

D. Kirchhofer, X. Yao, M. Peek, C. Eigenbrot, M. T. Lipari, K. L. Billeci, H. R. Maun, P. Moran, L. Santell, C. Wiesmann, et al. (2004)
J. Biol. Chem. 279, 39915-39924
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic Options for Variant Renal Cancer: A True Orphan Disease.

W. M. Stadler (2004)
Clin. Cancer Res. 10, 6393S-6396S
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Induces Proliferation of Lens Epithelial Cells through Activation of ERK1/2 and JNK/SAPK.

J. Choi, S. Y. Park, and C.-K. Joo (2004)
Invest. Ophthalmol. Vis. Sci. 45, 2696-2704
 |  Abstract »  |  Full Text »  |  PDF »

Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B.

J. R. Basile, A. Barac, T. Zhu, K.-L. Guan, and J. S. Gutkind (2004)
Cancer Res. 64, 5212-5224
 |  Abstract »  |  Full Text »  |  PDF »

Met provides essential signals for liver regeneration.

M. Borowiak, A. N. Garratt, T. Wustefeld, M. Strehle, C. Trautwein, and C. Birchmeier (2004)
PNAS 101, 10608-10613
 |  Abstract »  |  Full Text »  |  PDF »

Bi-directional Regulation of Ser-985 Phosphorylation of c-Met via Protein Kinase C and Protein Phosphatase 2A Involves c-Met Activation and Cellular Responsiveness to Hepatocyte Growth Factor.

A. Hashigasako, M. Machide, T. Nakamura, K. Matsumoto, and T. Nakamura (2004)
J. Biol. Chem. 279, 26445-26452
 |  Abstract »  |  Full Text »  |  PDF »

Identification of C-Met Oncogene as a Broadly Expressed Tumor-Associated Antigen Recognized by Cytotoxic T-Lymphocytes.

K. Schag, S. M. Schmidt, M. R. Muller, T. Weinschenk, S. Appel, M. M. Weck, F. Grunebach, S. Stevanovic, H.-G. Rammensee, and P. Brossart (2004)
Clin. Cancer Res. 10, 3658-3666
 |  Abstract »  |  Full Text »  |  PDF »

The Function of Neurotrophic Factor Receptors Expressed by the Developing Adductor Motor Pool In Vivo.

T. W. Gould and R. W. Oppenheim (2004)
J. Neurosci. 24, 4668-4682
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte growth factor inhibits the formation of the basement membrane of alveolar epithelial cells in vitro.

A. Furuyama and K. Mochitate (2004)
Am J Physiol Lung Cell Mol Physiol 286, L939-L946
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor/Met System Promotes Endometrial and Endometriotic Stromal Cell Invasion via Autocrine and Paracrine Pathways.

S. Yoshida, T. Harada, M. Mitsunari, T. Iwabe, Y. Sakamoto, S. Tsukihara, Y. Iba, S. Horie, and N. Terakawa (2004)
J. Clin. Endocrinol. Metab. 89, 823-832
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Src Phosphorylates Grb2-associated Binder 1 upon Hepatocyte Growth Factor Stimulation.

P.-C. Chan, Y.-L. Chen, C.-H. Cheng, K.-C. Yu, L. A. Cary, K.-H. Shu, W. L. Ho, and H.-C. Chen (2003)
J. Biol. Chem. 278, 44075-44082
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A Selective Small Molecule Inhibitor of c-Met Kinase Inhibits c-Met-Dependent Phenotypes in Vitro and Exhibits Cytoreductive Antitumor Activity in Vivo.

J. G. Christensen, R. Schreck, J. Burrows, P. Kuruganti, E. Chan, P. Le, J. Chen, X. Wang, L. Ruslim, R. Blake, et al. (2003)
Cancer Res. 63, 7345-7355
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Suppression of Met Expression: A Possible Cancer Treatment: Commentary re: S. J. Kim et al., Reduced c-Met Expression by an Adenovirus Expressing a c-Met Ribozyme Inhibits Tumorigenic Growth and Lymph Node Metastases of PC3-LN4 Prostate Tumor Cells in an Orthotopic Nude Mouse Model. Clin. Cancer Res., 14: 5161-5170, 2003..

N. Shinomiya and G. F. Vande Woude (2003)
Clin. Cancer Res. 9, 5085-5090
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Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.

N. Schiering, S. Knapp, M. Marconi, M. M. Flocco, J. Cui, R. Perego, L. Rusconi, and C. Cristiani (2003)
PNAS 100, 12654-12659
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Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.

E. Gherardi, M. E. Youles, R. N. Miguel, T. L. Blundell, L. Iamele, J. Gough, A. Bandyopadhyay, G. Hartmann, and P. J. G. Butler (2003)
PNAS 100, 12039-12044
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The N-terminal Domain of Hepatocyte Growth Factor Inhibits the Angiogenic Behavior of Endothelial Cells Independently from Binding to the c-met Receptor.

T. Merkulova-Rainon, P. England, S. Ding, C. Demerens, and G. Tobelem (2003)
J. Biol. Chem. 278, 37400-37408
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Immunohistochemical Localization of Hepatocyte Growth Factor Activator (HGFA) in Developing Mouse Liver Tissues: Heterogeneous Distribution of HGFA Protein.

I. Iida, K. Johkura, R. Teng, S. Kubota, L. Cui, X. Zhao, N. Ogiwara, Y. Okouchi, K. Asanuma, J. Nakayama, et al. (2003)
J. Histochem. Cytochem. 51, 1139-1149
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Angiogenesis: Basic Mechanisms and Clinical Applications.

V. Chhokar and A. L. Tucker (2003)
Seminars in Cardiothoracic and Vascular Anesthesia 7, 253-280
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Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase.

M.-H. Wang, D. Wang, and Y.-Q. Chen (2003)
Carcinogenesis 24, 1291-1300
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Erythropoietin Receptors Associate with a Ubiquitin Ligase, p33RUL, and Require Its Activity for Erythropoietin-induced Proliferation.

A. D. Friedman, D. Nimbalkar, and F. W. Quelle (2003)
J. Biol. Chem. 278, 26851-26861
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HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro.

S. Ding, T. Merkulova-Rainon, Z. C. Han, and G. Tobelem (2003)
Blood 101, 4816-4822
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p38 MAPK Is Involved in Activin A- and Hepatocyte Growth Factor-mediated Expression of Pro-endocrine Gene Neurogenin 3 in AR42J-B13 Cells.

T. Ogihara, H. Watada, R. Kanno, F. Ikeda, T. Nomiyama, Y. Tanaka, A. Nakao, M. S. German, I. Kojima, and R. Kawamori (2003)
J. Biol. Chem. 278, 21693-21700
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Counteractive effects of HGF on PDGF-induced mesangial cell proliferation in a rat model of glomerulonephritis.

K. Bessho, S. Mizuno, K. Matsumoto, and T. Nakamura (2003)
Am J Physiol Renal Physiol 284, F1171-F1180
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Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.

X. Zhang and Y. Liu (2003)
Am J Physiol Renal Physiol 284, F1216-F1225
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Clinical, Cellular, and Molecular Aspects of Cancer Invasion.

M. Mareel and A. Leroy (2003)
Physiol Rev 83, 337-376
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Hepatocyte Growth Factor Production by Neutrophils Infiltrating Bronchioloalveolar Subtype Pulmonary Adenocarcinoma: Role in Tumor Progression and Death.

M. Wislez, N. Rabbe, J. Marchal, B. Milleron, B. Crestani, C. Mayaud, M. Antoine, P. Soler, and J. Cadranel (2003)
Cancer Res. 63, 1405-1412
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Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.

A. Forgie, S. Wyatt, P. H. Correll, and A. M. Davies (2003)
Development 130, 995-1002
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Hepatocyte Growth Factor Induces GATA-4 Phosphorylation and Cell Survival in Cardiac Muscle Cells.

K. Kitta, R. M. Day, Y. Kim, I. Torregroza, T. Evans, and Y. J. Suzuki (2003)
J. Biol. Chem. 278, 4705-4712
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Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial Infarction.

H. Jin, R. Yang, W. Li, A. K. Ogasawara, R. Schwall, D. A. Eberhard, Z. Zheng, D. Kahn, and N. F. Paoni (2003)
J. Pharmacol. Exp. Ther. 304, 654-660
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Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.

X. Zhang, Y. Li, C. Dai, J. Yang, P. Mundel, and Y. Liu (2003)
Am J Physiol Renal Physiol 284, F82-F94
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Synergistic Effect of Focal Adhesion Kinase Overexpression and Hepatocyte Growth Factor Stimulation on Cell Transformation.

P.-C. Chan, C.-C. Liang, K.-C. Yu, M.-C. Chang, W. L. Ho, B.-H. Chen, and H.-C. Chen (2002)
J. Biol. Chem. 277, 50373-50379
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Hepatocyte Growth Factor Inhibits Anoikis by Induction of Activator Protein 1-dependent Cyclooxygenase-2. IMPLICATION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA PROGRESSION.

Q. Zeng, L. K. McCauley, and C.-Y. Wang (2002)
J. Biol. Chem. 277, 50137-50142
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Autocrine Activation of the Hepatocyte Growth Factor Receptor/Met Tyrosine Kinase Induces Tumor Cell Motility by Regulating Pseudopodial Protrusion.

J. Vadnais, G. Nault, Z. Daher, M. Amraei, Y. Dodier, I. R. Nabi, and J. Noel (2002)
J. Biol. Chem. 277, 48342-48350
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