Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 February 1991:
Vol. 251. no. 4995, pp. 791 - 794
DOI: 10.1126/science.1990441
Prev | Table of Contents | Next

Articles

Science, Vol 251, Issue 4995, 791-794
Copyright © 1991 by American Association for the Advancement of Science

articles

Human immunodeficiency virus infection of human-PBL-SCID mice

DE Mosier, RJ Gulizia, SM Baird, DB Wilson, DH Spector, and SA Spector

Division of Immunology, Medical Biology Institute, La Jolla, CA 92037.

Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Potent Activity of a Nucleoside Reverse Transcriptase Inhibitor, 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine, against Human Immunodeficiency Virus Type 1 Infection in a Model Using Human Peripheral Blood Mononuclear Cell-Transplanted NOD/SCID Janus Kinase 3 Knockout Mice.
S. Hattori, K. Ide, H. Nakata, H. Harada, S. Suzu, N. Ashida, S. Kohgo, H. Hayakawa, H. Mitsuya, and S. Okada (2009)
Antimicrob. Agents Chemother. 53, 3887-3893
   Abstract »    Full Text »    PDF »
Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice.
D. M. Brainard, E. Seung, N. Frahm, A. Cariappa, C. C. Bailey, W. K. Hart, H.-S. Shin, S. F. Brooks, H. L. Knight, Q. Eichbaum, et al. (2009)
J. Virol. 83, 7305-7321
   Abstract »    Full Text »    PDF »
Humanized NOD/SCID/IL2R{gamma}null Mice Transplanted with Hematopoietic Stem Cells under Nonmyeloablative Conditions Show Prolonged Life Spans and Allow Detailed Analysis of Human Immunodeficiency Virus Type 1 Pathogenesis.
S. Watanabe, S. Ohta, M. Yajima, K. Terashima, M. Ito, H. Mugishima, S. Fujiwara, K. Shimizu, M. Honda, N. Shimizu, et al. (2007)
J. Virol. 81, 13259-13264
   Abstract »    Full Text »    PDF »
Multiple Restrictions of Human Immunodeficiency Virus Type 1 in Feline Cells.
C. Munk, J. Zielonka, H. Constabel, B.-P. Kloke, B. Rengstl, M. Battenberg, F. Bonci, M. Pistello, M. Lochelt, and K. Cichutek (2007)
J. Virol. 81, 7048-7060
   Abstract »    Full Text »    PDF »
Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives.
M. Stevens, M. Pollicita, C. Pannecouque, E. Verbeken, O. Tabarrini, V. Cecchetti, S. Aquaro, C. F. Perno, A. Fravolini, E. De Clercq, et al. (2007)
Antimicrob. Agents Chemother. 51, 1407-1413
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Pathobiology Studied in Humanized BALB/c-Rag2-/-{gamma}c-/- Mice.
S. Gorantla, H. Sneller, L. Walters, J. G. Sharp, S. J. Pirruccello, J. T. West, C. Wood, S. Dewhurst, H. E. Gendelman, and L. Poluektova (2007)
J. Virol. 81, 2700-2712
   Abstract »    Full Text »    PDF »
Hematopoietic stem cell-engrafted NOD/SCID/IL2R{gamma}null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses.
S. Watanabe, K. Terashima, S. Ohta, S. Horibata, M. Yajima, Y. Shiozawa, M. Z. Dewan, Z. Yu, M. Ito, T. Morio, et al. (2007)
Blood 109, 212-218
   Abstract »    Full Text »    PDF »
Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-{gamma}c-/- mice.
S. Baenziger, R. Tussiwand, E. Schlaepfer, L. Mazzucchelli, M. Heikenwalder, M. O. Kurrer, S. Behnke, J. Frey, A. Oxenius, H. Joller, et al. (2006)
PNAS 103, 15951-15956
   Abstract »    Full Text »    PDF »
Cocaine and {sigma}-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model.
M. D. Roth, K. M. Whittaker, R. Choi, D. P. Tashkin, and G. C. Baldwin (2005)
J. Leukoc. Biol. 78, 1198-1203
   Abstract »    Full Text »    PDF »
Potent Anti-R5 Human Immunodeficiency Virus Type 1 Effects of a CCR5 Antagonist, AK602/ONO4128/GW873140, in a Novel Human Peripheral Blood Mononuclear Cell Nonobese Diabetic-SCID, Interleukin-2 Receptor {gamma}-Chain-Knocked-Out AIDS Mouse Model.
H. Nakata, K. Maeda, T. Miyakawa, S. Shibayama, M. Matsuo, Y. Takaoka, M. Ito, Y. Koyanagi, and H. Mitsuya (2005)
J. Virol. 79, 2087-2096
   Abstract »    Full Text »    PDF »
Human Dendritic Cells Transduced with Herpes Simplex Virus Amplicons Encoding Human Immunodeficiency Virus Type 1 (HIV-1) gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Challenge.
S. Gorantla, K. Santos, V. Meyer, S. Dewhurst, W. J. Bowers, H. J. Federoff, H. E. Gendelman, and L. Poluektova (2005)
J. Virol. 79, 2124-2132
   Abstract »    Full Text »    PDF »
DNA Vaccines against Human Immunodeficiency Virus Type 1 in the Past Decade.
M. Giri, K. E. Ugen, and D. B. Weiner (2004)
Clin. Microbiol. Rev. 17, 370-389
   Abstract »    Full Text »    PDF »
Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: Implications for HIV-1 vaccine development.
Y. Nishimura, T. Igarashi, N. L. Haigwood, R. Sadjadpour, O. K. Donau, C. Buckler, R. J. Plishka, A. Buckler-White, and M. A. Martin (2003)
PNAS 100, 15131-15136
   Abstract »    Full Text »    PDF »
Induction of Protective Immune Responses against R5 Human Immunodeficiency Virus Type 1 (HIV-1) Infection in hu-PBL-SCID Mice by Intrasplenic Immunization with HIV-1-Pulsed Dendritic Cells: Possible Involvement of a Novel Factor of Human CD4+ T-Cell Origin.
A. Yoshida, R. Tanaka, T. Murakami, Y. Takahashi, Y. Koyanagi, M. Nakamura, M. Ito, N. Yamamoto, and Y. Tanaka (2003)
J. Virol. 77, 8719-8728
   Abstract »    Full Text »    PDF »
A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity.
K. Ichiyama, S. Yokoyama-Kumakura, Y. Tanaka, R. Tanaka, K. Hirose, K. Bannai, T. Edamatsu, M. Yanaka, Y. Niitani, N. Miyano-Kurosaki, et al. (2003)
PNAS 100, 4185-4190
   Abstract »    Full Text »    PDF »
NOD/SCID/gamma cnull mouse: an excellent recipient mouse model for engraftment of human cells.
M. Ito, H. Hiramatsu, K. Kobayashi, K. Suzue, M. Kawahata, K. Hioki, Y. Ueyama, Y. Koyanagi, K. Sugamura, K. Tsuji, et al. (2002)
Blood 100, 3175-3182
   Abstract »    Full Text »    PDF »
Immunological Characterization of Human Vaginal Xenografts in Immunocompromised Mice : Development of a Small Animal Model for the Study of Human Immunodeficiency Virus-1 Infection.
T. M. Kish, L. R. Budgeon, P. A. Welsh, and M. K. Howett (2001)
Am. J. Pathol. 159, 2331-2345
   Abstract »    Full Text »    PDF »
Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+ T Cells and Associated with a Proliferative Response to p24 Antigen.
J. C. L. B. de Quiros, W. L. Shupert, A. C. McNeil, J. C. Gea-Banacloche, M. Flanigan, A. Savage, L. Martino, E. E. Weiskopf, H. Imamichi, Y.-M. Zhang, et al. (2000)
J. Virol. 74, 2023-2028
   Abstract »    Full Text »    PDF »
cis Expression of the F12 Human Immunodeficiency Virus (HIV) Nef Allele Transforms the Highly Productive NL4-3 HIV Type 1 to a Replication-Defective Strain: Involvement of both Env gp41 and CD4 Intracytoplasmic Tails.
E. Olivetta, K. Pugliese, R. Bona, P. D'Aloja, F. Ferrantelli, A. C. Santarcangelo, G. Mattia, P. Verani, and M. Federico (2000)
J. Virol. 74, 483-492
   Abstract »    Full Text »    PDF »
Transfer of Human CD4+ T Lymphocytes Producing Beta Interferon in Hu-PBL-SCID Mice Controls Human Immunodeficiency Virus Infection.
V. Vieillard, S. Jouveshomme, N. Leflour, E. Jean-Pierre, P. Debre, E. De Maeyer, and B. Autran (1999)
J. Virol. 73, 10281-10288
   Abstract »    Full Text »    PDF »
The Antiviral Activity of HIV-Specific CD8+ CTL Clones Is Limited by Elimination Due to Encounter with HIV-Infected Targets.
D. M. McKinney, D. A. Lewinsohn, S. R. Riddell, P. D. Greenberg, and D. E. Mosier (1999)
J. Immunol. 163, 861-867
   Abstract »    Full Text »    PDF »
Highly Potent RANTES Analogues either Prevent CCR5-Using Human Immunodeficiency Virus Type 1 Infection In Vivo or Rapidly Select for CXCR4-Using Variants.
D. E. Mosier, G. R. Picchio, R. J. Gulizia, R. Sabbe, P. Poignard, L. Picard, R. E. Offord, D. A. Thompson, and J. Wilken (1999)
J. Virol. 73, 3544-3550
   Abstract »    Full Text »    PDF »
HIV type-1 infection of the cotton rat (Sigmodon fulviventer and S. hispidus).
R. J. Langley, G. A. Prince, and H. S. Ginsberg (1998)
PNAS 95, 14355-14360
   Abstract »    Full Text »    PDF »
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands.
L. A. Dickinson, R. J. Gulizia, J. W. Trauger, E. E. Baird, D. E. Mosier, J. M. Gottesfeld, and P. B. Dervan (1998)
PNAS 95, 12890-12895
   Abstract »    Full Text »    PDF »
CD4-Immunoglobulin G2 Protects Hu-PBL-SCID Mice against Challenge by Primary Human Immunodeficiency Virus Type 1 Isolates.
M.-C. Gauduin, G. P. Allaway, W. C. Olson, R. Weir, P. J. Maddon, and R. A. Koup (1998)
J. Virol. 72, 3475-3478
   Abstract »    Full Text »    PDF »
The Cell Tropism of Human Immunodeficiency Virus Type 1 Determines the Kinetics of Plasma Viremia in SCID Mice Reconstituted with Human Peripheral Blood Leukocytes.
G. R. Picchio, R. J. Gulizia, K. Wehrly, B. Chesebro, and D. E. Mosier (1998)
J. Virol. 72, 2002-2009
   Abstract »    Full Text »    PDF »
HIV-1/Simian Immunodeficiency Virus Infection of Human and Nonhuman Primate Lymphocytes Results in the Migration of CD2+ T Cells into the Intestine of Engrafted SCID Mice.
H. H. Donze, J. E. Cummins Jr., R. S. Schwiebert, A. Kantele, Y. Han, P. N. Fultz, S. Jackson, and J. Mestecky (1998)
J. Immunol. 160, 2506-2513
   Abstract »    Full Text »    PDF »
Lymphoproliferative Disease in Human Peripheral Blood Mononuclear Cell-Injected SCID Mice. IV. Differential Activation of Human Th1 and Th2 Lymphocytes and Influence of the Atopic Status on Lymphoma Development.
V. Coppola, A. Veronesi, S. Indraccolo, F. Calderazzo, M. Mion, S. Minuzzo, G. Esposito, D. Mauro, B. Silvestri, P. Gallo, et al. (1998)
J. Immunol. 160, 2514-2522
   Abstract »    Full Text »    PDF »
TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus.
F. M. Uckun, L. M. Chelstrom, L. Tuel-Ahlgren, I. Dibirdik, J. D. Irvin, M.-C. Langlie, and D. E. Myers (1998)
Antimicrob. Agents Chemother. 42, 383-388
   Abstract »    Full Text »    PDF »
Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes.
G. Herbein, C. Van Lint, J. L. Lovett, and E. Verdin (1998)
J. Virol. 72, 660-670
   Abstract »    Full Text »    PDF »
Limits of the Human-PBL-SCID Mice Model: Severe Restriction of the Vbeta T-Cell Repertoire of Engrafted Human T Cells.
S. Garcia, G. Dadaglio, and M.-L. Gougeon (1997)
Blood 89, 329-336
   Abstract »    Full Text »    PDF »
Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates.
D. Mosier, R. Gulizia, P. MacIsaac, B. Torbett, and J. Levy (1993)
Science 260, 689-692
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)