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Science 15 February 1991:
Vol. 251. no. 4995, pp. 788 - 791
DOI: 10.1126/science.1990440

Articles

Science, Vol 251, Issue 4995, 788-791
Copyright © 1991 by American Association for the Advancement of Science


articles

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis

MI Cybulsky and MA Gimbrone Jr

Department of Pathology, Brigham and Women's Hospital, Boston, MA.

An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the amino-terminal sequence of each being highly homologous to human VCAM-1. In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions. This lesion-localized expression suggests a potential endothelium-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis and may provide a molecular marker for early atherosclerosis.


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Human mast cell progenitors use alpha 4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.
J. A. Boyce, E. A. Mellor, B. Perkins, Y.-C. Lim, and F. W. Luscinskas (2002)
Blood 99, 2890-2896
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Plasma tumour necrosis factor-{alpha} and early carotid atherosclerosis in healthy middle-aged men.
T. Skoog, W. Dichtl, S. Boquist, C. Skoglund-Andersson, F. Karpe, R. Tang, M.G. Bond, U. de Faire, J. Nilsson, P. Eriksson, et al. (2002)
Eur. Heart J. 23, 376-383
   Abstract »    Full Text »    PDF »
Coronary Artery Disease and Periodontal Disease: Is There a Link?.
S. Abou-Raya, A. Naeem, H. A.-E. Kheir, and S. El Beltagy (2002)
Angiology 53, 141-148
   Abstract »    PDF »
Leukocyte Recruitment Into Developing Atherosclerotic Lesions: The Complex Interaction Between Multiple Molecules Keeps Getting More Complex.
M. E. Rosenfeld (2002)
Arterioscler. Thromb. Vasc. Biol. 22, 361-363
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The effect of 17{beta}-estradiol on MCP-1 serum levels in postmenopausal women.
S. Stork, K. Baumann, C. von Schacky, and P. Angerer (2002)
Cardiovasc Res 53, 642-649
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Inflammation and cholesterol.
J. Nilsson, M.P.S. Ares, M. Lindholm, G.N. Fredriksonl, and S. Jovinge (2002)
Eur. Heart J. Suppl. 4, A18-A25
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Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit.
M. S Conte, G. A VanMeter, L. M Akst, T. Clemons, M. Kashgarian, and J. R Bender (2002)
Cardiovasc Res 53, 502-511
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Local Overexpression of Monocyte Chemoattractant Protein-1 at Vessel Wall Induces Infiltration of Macrophages and Formation of Atherosclerotic Lesion: Synergism With Hypercholesterolemia.
M. Namiki, S. Kawashima, T. Yamashita, M. Ozaki, T. Hirase, T. Ishida, N. Inoue, K.-i. Hirata, A. Matsukawa, R. Morishita, et al. (2002)
Arterioscler. Thromb. Vasc. Biol. 22, 115-120
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Thrombin Stimulation of the Vascular Cell Adhesion Molecule-1 Promoter in Endothelial Cells Is Mediated by Tandem Nuclear Factor-kappa B and GATA Motifs.
T. Minami and W. C. Aird (2001)
J. Biol. Chem. 276, 47632-47641
   Abstract »    Full Text »    PDF »
Immune Mechanisms in Atherosclerosis.
G. K. Hansson (2001)
Arterioscler. Thromb. Vasc. Biol. 21, 1876-1890
   Abstract »    Full Text »    PDF »
Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells.
C. G. Kevil, R. P. Patel, and D. C. Bullard (2001)
Am J Physiol Cell Physiol 281, C1442-C1447
   Abstract »    Full Text »    PDF »



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