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Science 15 February 1991:
Vol. 251. no. 4995, pp. 761 - 766
DOI: 10.1126/science.1846704

Articles

Science, Vol 251, Issue 4995, 761-766
Copyright © 1991 by American Association for the Advancement of Science


articles

The myoD gene family: nodal point during specification of the muscle cell lineage

H Weintraub, R Davis, S Tapscott, M Thayer, M Krause, R Benezra, TK Blackwell, D Turner, R Rupp, S Hollenberg, and al. et

Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.


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S. M. Hughes, M. M.-Y. Chi, O. H. Lowry, and K. Gundersen (1999)
J. Cell Biol. 145, 633-642
   Abstract »    Full Text »    PDF »
Myogenic Basic Helix-Loop-Helix Proteins and Sp1 Interact as Components of a Multiprotein Transcriptional Complex Required for Activity of the Human Cardiac alpha -Actin Promoter.
E. Biesiada, Y. Hamamori, L. Kedes, and V. Sartorelli (1999)
Mol. Cell. Biol. 19, 2577-2584
   Abstract »    Full Text »    PDF »
Reduced Differentiation Potential of Primary MyoD-/- Myogenic Cells Derived from Adult Skeletal Muscle.
L. A. Sabourin, A. Girgis-Gabardo, P. Seale, A. Asakura, and M. A. Rudnicki (1999)
J. Cell Biol. 144, 631-643
   Abstract »    Full Text »    PDF »



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