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Science 1 February 1991:
Vol. 251. no. 4993, pp. 561 - 565
DOI: 10.1126/science.1899293
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Articles

Science, Vol 251, Issue 4993, 561-565
Copyright © 1991 by American Association for the Advancement of Science

articles

Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily

JA Ladias and SK Karathanasis

Department of Cardiology, Children's Hospital, Boston, MA.

Apolipoprotein AI (apoAI) is a lipid-binding protein that participates in the transport of cholesterol and other lipids in the plasma. A complementary DNA clone for a protein that bound to regulatory elements of the apoAI gene was isolated. This protein, designated apoAI regulatory protein-1 (ARP-1), is a novel member of the steroid hormone receptor superfamily. ARP-1 bound to DNA as a dimer, and its dimerization domain was localized to the COOH-terminal region. ARP-1 also bound to a thyroid hormone-responsive element and to regulatory regions of the apoB, apoCIII, insulin, and ovalbumin genes. In cotransfection experiments, ARP-1 downregulated the apoAI gene. The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis.


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Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age.
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In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries..
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Genes & Dev. 10, 2326-2334
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Control of Apolipoprotein AI Gene Expression through Synergistic Interactions between Hepatocyte Nuclear Factors 3and 4.
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J. Biol. Chem. 271, 13621-13628
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Binding Specificity and Modulation of the ApoA-I Promoter Activity by Homo- and Heterodimers of Nuclear Receptors.
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J. Biol. Chem. 271, 8402-8415
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Transcriptional Regulation of the Genes Involved in Lipoprotein Transport : The Role of Proximal Promoters and Long-range Regulatory Elements and Factors in Apolipoprotein Gene Regulation.
D. Kardassis, M. Laccotripe, I. Talianidis, and V. Zannis (1996)
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   Full Text »
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J. Biol. Chem. 270, 29916-29922
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J. Biol. Chem. 270, 28364-28373
   Abstract »    Full Text »    PDF »
Characterization of an Enhancer Element in the Human Apolipoprotein C-III Gene That Regulates Human Apolipoprotein A-I Gene Expression in the Intestinal Epithelium.
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J. Biol. Chem. 270, 7957-7962
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Development 121, 225-235
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Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons.
B Lutz, S Kuratani, A. Cooney, S Wawersik, S. Tsai, G Eichele, and M. Tsai (1994)
Development 120, 25-36
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Science 256, 107-110
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