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Science 1 February 1991:
Vol. 251. no. 4993, pp. 561 - 565
DOI: 10.1126/science.1899293
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Articles

Science, Vol 251, Issue 4993, 561-565
Copyright © 1991 by American Association for the Advancement of Science

articles

Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily

JA Ladias and SK Karathanasis

Department of Cardiology, Children's Hospital, Boston, MA.

Apolipoprotein AI (apoAI) is a lipid-binding protein that participates in the transport of cholesterol and other lipids in the plasma. A complementary DNA clone for a protein that bound to regulatory elements of the apoAI gene was isolated. This protein, designated apoAI regulatory protein-1 (ARP-1), is a novel member of the steroid hormone receptor superfamily. ARP-1 bound to DNA as a dimer, and its dimerization domain was localized to the COOH-terminal region. ARP-1 also bound to a thyroid hormone-responsive element and to regulatory regions of the apoB, apoCIII, insulin, and ovalbumin genes. In cotransfection experiments, ARP-1 downregulated the apoAI gene. The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis.


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Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization.
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Orphan Receptors Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) and Retinoid X Receptor (RXR) Activate and Bind the Rat Cholesterol 7alpha -Hydroxylase Gene (CYP7A).
D. Stroup, M. Crestani, and J. Y.L. Chiang (1997)
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   Abstract »    Full Text »    PDF »
Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age.
S. Y. Tsai and M.-J. Tsai (1997)
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Identification of a Retinoid/Chicken Ovalbumin Upstream Promoter Transcription Factor Response Element in the Human Retinoid X Receptor gamma 2 Gene Promoter.
P. M. Barger and D. P. Kelly (1997)
J. Biol. Chem. 272, 2722-2728
   Abstract »    Full Text »    PDF »
Characterization of the Human Cytochrome P4502D6 Promoter. A POTENTIAL ROLE FOR ANTAGONISTIC INTERACTIONS BETWEEN MEMBERS OF THE NUCLEAR RECEPTOR FAMILY.
W. Cairns, C. A.D. Smith, A. W. McLaren, and C. R. Wolf (1996)
J. Biol. Chem. 271, 25269-25276
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In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries..
M Gerard, J Y Chen, H Gronemeyer, P Chambon, D Duboule, and J Zakany (1996)
Genes & Dev. 10, 2326-2334
   Abstract »    PDF »
Control of Apolipoprotein AI Gene Expression through Synergistic Interactions between Hepatocyte Nuclear Factors 3and 4.
D. C. Harnish, S. Malik, E. Kilbourne, R. Costa, and S. K. Karathanasis (1996)
J. Biol. Chem. 271, 13621-13628
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Binding Specificity and Modulation of the ApoA-I Promoter Activity by Homo- and Heterodimers of Nuclear Receptors.
I. Tzameli and V. I. Zannis (1996)
J. Biol. Chem. 271, 8402-8415
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Genes Involved in Lipoprotein Transport : The Role of Proximal Promoters and Long-range Regulatory Elements and Factors in Apolipoprotein Gene Regulation.
D. Kardassis, M. Laccotripe, I. Talianidis, and V. Zannis (1996)
Hypertension 27, 980-1008
   Full Text »
Transcriptional Regulation of the Cholesteryl Ester Transfer Protein Gene by the Orphan Nuclear Hormone Receptor Apolipoprotein AI Regulatory Protein-1.
F.ço. Gaudet and G. S. Ginsburg (1995)
J. Biol. Chem. 270, 29916-29922
   Abstract »    Full Text »    PDF »
The Mouse Bone Morphogenetic Protein-4 Gene.
J. Q. Feng, D. Chen, A. J. Cooney, M.-J. Tsai, M. A. Harris, S. Y. Tsai, M. Feng, G. R. Mundy, and S. E. Harris (1995)
J. Biol. Chem. 270, 28364-28373
   Abstract »    Full Text »    PDF »
Characterization of an Enhancer Element in the Human Apolipoprotein C-III Gene That Regulates Human Apolipoprotein A-I Gene Expression in the Intestinal Epithelium.
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J. Biol. Chem. 270, 19979-19988
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J. Biol. Chem. 270, 16114-16121
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J. Biol. Chem. 270, 15066-15070
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J. S. Subauste and R. J. Koenig (1995)
J. Biol. Chem. 270, 7957-7962
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J. Biol. Chem. 270, 7004-7010
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S Kramer, S. West, and Y Hiromi (1995)
Development 121, 1361-1372
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The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination.
G Begemann, A. Michon, L vd Voorn, R Wepf, and M Mlodzik (1995)
Development 121, 225-235
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Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons.
B Lutz, S Kuratani, A. Cooney, S Wawersik, S. Tsai, G Eichele, and M. Tsai (1994)
Development 120, 25-36
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Y Hiromi, M Mlodzik, S. West, G. Rubin, and C. Goodman (1993)
Development 118, 1123-1135
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Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.
T. Wilson, R. Paulsen, K. Padgett, and J Milbrandt (1992)
Science 256, 107-110
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Placental Transforming Growth Factor-beta Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression.
P.-X. Li, J. Wong, A. Ayed, D. Ngo, A. M. Brade, C. Arrowsmith, R. C. Austin, and H. J. Klamut (2000)
J. Biol. Chem. 275, 20127-20135
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