Science 18 January 1991: Vol. 251. no. 4991, pp. 313 - 316 DOI: 10.1126/science.1846244

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Articles

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation.

L. F. Dodson, J. S. Boomer, C. M. Deppong, D. D. Shah, J. Sim, T. L. Bricker, J. H. Russell, and J. M. Green (2009)
Mol. Cell. Biol. 29, 3710-3721
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of T Lymphocyte Replicative Senescence via TNF-{alpha} Inhibition: Role of Caspase-3.

S. T. Parish, J. E. Wu, and R. B. Effros (2009)
J. Immunol. 182, 4237-4243
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message.

C. Nazarov-Stoica, J. Surls, C. Bona, S. Casares, and T.-D. Brumeanu (2009)
J. Immunol. 182, 102-110
 |  Abstract »  |  Full Text »  |  PDF »

Signals and Sequences That Control CD28 Localization to the Central Region of the Immunological Synapse.

M. Sanchez-Lockhart, B. Graf, and J. Miller (2008)
J. Immunol. 181, 7639-7648
 |  Abstract »  |  Full Text »  |  PDF »

Spontaneous Colitis Occurrence in Transgenic Mice with Altered B7-Mediated Costimulation.

G. Kim, O. Turovskaya, M. Levin, F. R. Byrne, J. S. Whoriskey, J. G. McCabe, and M. Kronenberg (2008)
J. Immunol. 181, 5278-5288
 |  Abstract »  |  Full Text »  |  PDF »

Elevating Calcium in Th2 Cells Activates Multiple Pathways to Induce IL-4 Transcription and mRNA Stabilization.

L. Guo, J. F. Urban, J. Zhu, and W. E. Paul (2008)
J. Immunol. 181, 3984-3993
 |  Abstract »  |  Full Text »  |  PDF »

Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells.

K. L. Edgtton, J. Y. Kausman, M. Li, K. O'Sullivan, C. Lo, P. Hutchinson, H. Yagita, S. R. Holdsworth, and A. R. Kitching (2008)
J. Am. Soc. Nephrol. 19, 515-526
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Export of NF90 to Stabilize IL-2 mRNA Is Mediated by AKT-Dependent Phosphorylation at Ser647 in Response to CD28 Costimulation.

Y. Pei, P. Zhu, Y. Dang, J. Wu, X. Yang, B. Wan, J. O. Liu, Q. Yi, and L. Yu (2008)
J. Immunol. 180, 222-229
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28 in fatal autoimmune disorder in scurfy mice.

N. Singh, P. R. Chandler, Y. Seki, B. Baban, M. Takezaki, D. J. Kahler, D. H. Munn, C. P. Larsen, A. L. Mellor, and M. Iwashima (2007)
Blood 110, 1199-1206
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role for I{kappa}BNS in T Cell Cytokine Regulation As Revealed by Targeted Gene Disruption.

M. Touma, V. Antonini, M. Kumar, S. L. Osborn, A. M. Bobenchik, D. B. Keskin, J. E. Connolly, M. J. Grusby, E. L. Reinherz, and L. K. Clayton (2007)
J. Immunol. 179, 1681-1692
 |  Abstract »  |  Full Text »  |  PDF »

TCR/CD28-Stimulated Actin Dynamics Are Required for NFAT1-Mediated Transcription of c-rel Leading to CD28 Response Element Activation.

J. C. Nolz, M. E. Fernandez-Zapico, and D. D. Billadeau (2007)
J. Immunol. 179, 1104-1112
 |  Abstract »  |  Full Text »  |  PDF »

Rapid transit in the immune cells: the role of mRNA turnover regulation.

K. S. A. Khabar (2007)
J. Leukoc. Biol. 81, 1335-1344
 |  Abstract »  |  Full Text »  |  PDF »

Paradoxical Effect of Reduced Costimulation in T Cell-Mediated Colitis.

G. Kim, M. Levin, S. P. Schoenberger, A. Sharpe, and M. Kronenberg (2007)
J. Immunol. 178, 5563-5570
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor Enhances In vivo Persistence and Antitumor Efficacy of Adoptively Transferred T Cells..

C. M. Kowolik, M. S. Topp, S. Gonzalez, T. Pfeiffer, S. Olivares, N. Gonzalez, D. D. Smith, S. J. Forman, M. C. Jensen, and L. J.N. Cooper (2006)
Cancer Res. 66, 10995-11004
 |  Abstract »  |  Full Text »  |  PDF »

Subepithelial Myofibroblasts are Novel Nonprofessional APCs in the Human Colonic Mucosa.

J. I. Saada, I. V. Pinchuk, C. A. Barrera, P. A. Adegboyega, G. Suarez, R. C. Mifflin, J. F. Di Mari, V. E. Reyes, and D. W. Powell (2006)
J. Immunol. 177, 5968-5979
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.

A. Nirula, M. Ho, H. Phee, J. Roose, and A. Weiss (2006)
J. Exp. Med. 203, 1733-1744
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK plays a role in IL-4 synthesis in jacalin plus CD28-stimulated CD4+ T cells--II.

S. M. L. Tamma, K. W. Chung, T. Patel, S. P. Balan, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 1339-1347
 |  Abstract »  |  Full Text »  |  PDF »

Engagement of CD28 Outside of the Immunological Synapse Results in Up-Regulation of IL-2 mRNA Stability but Not IL-2 Transcription..

M. Sanchez-Lockhart and J. Miller (2006)
J. Immunol. 176, 4778-4784
 |  Abstract »  |  Full Text »  |  PDF »

The lectin jacalin plus costimulation with anti-CD28 antibody induces phosphorylation of p38 MAPK and IL-4 synthesis-I.

S. M. L. Tamma, S. P. Balan, K. W. Chung, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 876-880
 |  Abstract »  |  Full Text »  |  PDF »

LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation.

J. G. Wang, M. Collinge, V. Ramgolam, O. Ayalon, X. C. Fan, R. Pardi, and J. R. Bender (2006)
J. Immunol. 176, 2105-2113
 |  Abstract »  |  Full Text »  |  PDF »

Adaptive Tolerance and Clonal Anergy Are Distinct Biochemical States.

L. Chiodetti, S. Choi, D. L. Barber, and R. H. Schwartz (2006)
J. Immunol. 176, 2279-2291
 |  Abstract »  |  Full Text »  |  PDF »

Ligation of CD28 Stimulates the Formation of a Multimeric Signaling Complex Involving Grb-2-Associated Binder 2 (Gab2), Src Homology Phosphatase-2, and Phosphatidylinositol 3-Kinase: Evidence That Negative Regulation of CD28 Signaling Requires the Gab2 Pleckstrin Homology Domain.

R. V. Parry, G. C. Whittaker, M. Sims, C. E. Edmead, M. J. Welham, and S. G. Ward (2006)
J. Immunol. 176, 594-602
 |  Abstract »  |  Full Text »  |  PDF »

CD80 Cytoplasmic Domain Controls Localization of CD28, CTLA-4, and Protein Kinase C{theta} in the Immunological Synapse.

S.-Y. Tseng, M. Liu, and M. L. Dustin (2005)
J. Immunol. 175, 7829-7836
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of B7.1 Costimulatory Molecule Is Mediated by the IFN Regulatory Factor-7 through the Activation of JNK in Lipopolysaccharide-Stimulated Human Monocytic Cells.

W. Lim, K. Gee, S. Mishra, and A. Kumar (2005)
J. Immunol. 175, 5690-5700
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells.

J. Kim, A. C. Myers, L. Chen, D. M. Pardoll, Q.-A. Truong-Tran, A. P. Lane, J. F. McDyer, L. Fortuno, and R. P. Schleimer (2005)
Am. J. Respir. Cell Mol. Biol. 33, 280-289
 |  Abstract »  |  Full Text »  |  PDF »

Immune regulatory activity of CD34+ progenitor cells: evidence for a deletion-based mechanism mediated by TNF-{alpha}.

H. Gur, R. Krauthgamer, E. Bachar-Lustig, H. Katchman, R. Arbel-Goren, A. Berrebi, T. Klein, A. Nagler, A. Tabilio, M. F. Martelli, et al. (2005)
Blood 105, 2585-2593
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis C Virus Core Protein Induces an Anergic State Characterized by Decreased Interleukin-2 Production and Perturbation of Mitogen-Activated Protein Kinase Responses.

S. Sundstrom, S. Ota, L. Y. Dimberg, M. G. Masucci, and A. Bergqvist (2005)
J. Virol. 79, 2230-2239
 |  Abstract »  |  Full Text »  |  PDF »

Induction of T-Cell Apoptosis in Rats by Genetically Engineered Glioma Cells Expressing Granulocyte-Macrophage Colony-Stimulating Factor and B7.1.

S.-H. Tseng, Y. Chen, C.-J. Chang, K.-F. Tai, S.-M. Lin, and L.-H. Hwang (2005)
Clin. Cancer Res. 11, 1639-1649
 |  Abstract »  |  Full Text »  |  PDF »

ROG Negatively Regulates T-Cell Activation but Is Dispensable for Th-Cell Differentiation.

B. Y. Kang, S.-C. Miaw, and I-C. Ho (2005)
Mol. Cell. Biol. 25, 554-562
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of TNF Receptor Type-2 (p75) as a Costimulator for IL-2 Induction and T Cell Survival: A Functional Link to CD28.

E. Y. Kim and H.-S. Teh (2004)
J. Immunol. 173, 4500-4509
 |  Abstract »  |  Full Text »  |  PDF »

Hyper-responsiveness to Stimulation of Human Immunodeficiency Virus-infected CD4+ T Cells Requires Nef and Tat Virus Gene Products and Results from Higher NFAT, NF-{kappa}B, and AP-1 Induction.

J.-F. Fortin, C. Barat, Y. Beausejour, B. Barbeau, and M. J. Tremblay (2004)
J. Biol. Chem. 279, 39520-39531
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function.

A. M. Thornton, E. E. Donovan, C. A. Piccirillo, and E. M. Shevach (2004)
J. Immunol. 172, 6519-6523
 |  Abstract »  |  Full Text »  |  PDF »

Immunomodulatory drug costimulates T cells via the B7-CD28 pathway.

R. LeBlanc, T. Hideshima, L. P. Catley, R. Shringarpure, R. Burger, N. Mitsiades, C. Mitsiades, P. Cheema, D. Chauhan, P. G. Richardson, et al. (2004)
Blood 103, 1787-1790
 |  Abstract »  |  Full Text »  |  PDF »

A mechanism underlying STAT4-mediated up-regulation of IFN-{gamma} induction inTCR-triggered T cells.

W.-R. Park, M. Nakahira, N. Sugimoto, Y. Bian, Y. Yashiro-Ohtani, X.-Y. Zhou, Y.-F. Yang, T. Hamaoka, and H. Fujiwara (2004)
Int. Immunol. 16, 295-302
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion.

W. N. D'Souza and L. Lefrancois (2003)
J. Immunol. 171, 5727-5735
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Functional Characterization of Voltage-dependent Calcium Channels in T Lymphocytes.

M. F. Kotturi, D. A. Carlow, J. C. Lee, H. J. Ziltener, and W. A. Jefferies (2003)
J. Biol. Chem. 278, 46949-46960
 |  Abstract »  |  Full Text »  |  PDF »

Structure/Function Analysis of the Murine CD95L Promoter Reveals the Identification of a Novel Transcriptional Repressor and Functional CD28 Response Element.

S. A. Crist, T. S. Griffith, and T. L. Ratliff (2003)
J. Biol. Chem. 278, 35950-35958
 |  Abstract »  |  Full Text »  |  PDF »

Incomplete Activation of CD4 T Cells by Antigen-Presenting Transitional Immature B Cells: Implications for Peripheral B and T Cell Responsiveness.

J. B. Chung, A. D. Wells, S. Adler, A. Jacob, L. A. Turka, and J. G. Monroe (2003)
J. Immunol. 171, 1758-1767
 |  Abstract »  |  Full Text »  |  PDF »

Thy-1 Signaling in the Context of Costimulation Provided by Dendritic Cells Provides Signal 1 for T Cell Proliferation and Cytotoxic Effector Molecule Expression, but Fails to Trigger Delivery of the Lethal Hit.

S. M. M. Haeryfar, M. M. Al-alwan, J. S. Mader, G. Rowden, K. A. West, and D. W. Hoskin (2003)
J. Immunol. 171, 69-77
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the Costimulatory Molecule B7-H2 (Inducible Costimulator Ligand) by Human Airway Epithelial Cells.

S. Kurosawa, A. C. Myers, L. Chen, S. Wang, J. Ni, J. R. Plitt, N. M. Heller, B. S. Bochner, and R. P. Schleimer (2003)
Am. J. Respir. Cell Mol. Biol. 28, 563-573
 |  Abstract »  |  Full Text »  |  PDF »

SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production.

T. Ishii, K. Ohnuma, A. Murakami, N. Takasawa, T. Yamochi, S. Iwata, M. Uchiyama, N. H. Dang, H. Tanaka, and C. Morimoto (2003)
J. Immunol. 170, 3653-3661
 |  Abstract »  |  Full Text »  |  PDF »

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter.

S. Rao, S. Gerondakis, D. Woltring, and M. F. Shannon (2003)
J. Immunol. 170, 3724-3731
 |  Abstract »  |  Full Text »  |  PDF »

Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes.

A. Raghavan, R. L. Ogilvie, C. Reilly, M. L. Abelson, S. Raghavan, J. Vasdewani, M. Krathwohl, and P. R. Bohjanen (2002)
Nucleic Acids Res. 30, 5529-5538
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of IFN Regulatory Factor 4 Expression in Human T Cell Leukemia Virus-I-Transformed T Cells.

S. Sharma, N. Grandvaux, Y. Mamane, P. Genin, N. Azimi, T. Waldmann, and J. Hiscott (2002)
J. Immunol. 169, 3120-3130
 |  Abstract »  |  Full Text »  |  PDF »

CD28 plays a critical role in the segregation of PKCtheta within the immunologic synapse.

J. Huang, P.-F. Lo, T. Zal, N. R. J. Gascoigne, B. A. Smith, S. D. Levin, and H. M. Grey (2002)
PNAS 99, 9369-9373
 |  Abstract »  |  Full Text »  |  PDF »

Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway.

P. Ghosh, M. A. Buchholz, S. Yano, D. Taub, and D. L. Longo (2002)
Blood 99, 4517-4524
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation.

X.-Y. Zhou, Y. Yashiro-Ohtani, M. Nakahira, W. R. Park, R. Abe, T. Hamaoka, M. Naramura, H. Gu, and H. Fujiwara (2002)
J. Immunol. 168, 3847-3854
 |  Abstract »  |  Full Text »  |  PDF »

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?.

R. K. Burt, S. Slavin, W. H. Burns, and A. M. Marmont (2002)
Blood 99, 768-784
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms of IL-2 Gene Regulation Following Costimulation Through LFA-1.

C. Abraham and J. Miller (2001)
J. Immunol. 167, 5193-5201
 |  Abstract »  |  Full Text »  |  PDF »

Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor {alpha}-Chain Locus.

J.-H. Yeh, P. Lecine, J. A. Nunes, S. Spicuglia, P. Ferrier, D. Olive, and J. Imbert (2001)
Mol. Cell. Biol. 21, 4515-4527
 |  Abstract »  |  Full Text »  |  PDF »

A NF-{{kappa}}B/Sp1 Region Is Essential for Chromatin Remodeling and Correct Transcription of a Human Granulocyte- Macrophage Colony-Stimulating Factor Transgene.

D. Cakouros, P. N. Cockerill, A. G. Bert, R. Mital, D. C. Roberts, and M. F. Shannon (2001)
J. Immunol. 167, 302-310
 |  Abstract »  |  Full Text »  |  PDF »

A Transcription Function for the T Cell-specific Adapter (TSAd) Protein in T Cells: Critical Role of the TSAd Src Homology 2 Domain.

F. Marti, N. H. Post, E. Chan, and P. D. King (2001)
J. Exp. Med. 193, 1425-1430
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL.

J. S. Burr, N. D. L. Savage, G. E. Messah, S. L. Kimzey, A. S. Shaw, R. H. Arch, and J. M. Green (2001)
J. Immunol. 166, 5331-5335
 |  Abstract »  |  Full Text »  |  PDF »

B7-DC, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells.

S.-Y. Tseng, M. Otsuji, K. Gorski, X. Huang, J. E. Slansky, S. I. Pai, A. Shalabi, T. Shin, D. M. Pardoll, and H. Tsuchiya (2001)
J. Exp. Med. 193, 839-846
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: In Vivo Identification of TCR Redistribution and Polarized IL-2 Production by Naive CD4 T Cells.

P. Reichert, R. L. Reinhardt, E. Ingulli, and M. K. Jenkins (2001)
J. Immunol. 166, 4278-4281
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-Independent Th2 Cell Differentiation by Stimulation of CD28: Regulation Via IL-4 Gene Expression and Mitogen-Activated Protein Kinase Activation.

A. Skapenko, P. E. Lipsky, H.-G. Kraetsch, J. R. Kalden, and H. Schulze-Koops (2001)
J. Immunol. 166, 4283-4292
 |  Abstract »  |  Full Text »  |  PDF »

CD86 expression correlates with amounts of HIV produced by macrophages in vitro.

X. Wang and D. E. Lewis (2001)
J. Leukoc. Biol. 69, 405-413
 |  Abstract »  |  Full Text »

Transcriptional Activation of the Interleukin-2 Promoter by Hepatitis C Virus Core Protein.

A. Bergqvist and C. M. Rice (2001)
J. Virol. 75, 772-781
 |  Abstract »  |  Full Text »

Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6.

F. Marti, A. Krause, N. H. Post, C. Lyddane, B. Dupont, M. Sadelain, and P. D. King (2001)
J. Immunol. 166, 197-206
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation of T Cells.

L. BUGEON and M. J. DALLMAN (2000)
Am. J. Respir. Crit. Care Med. 162, S164-168
 |  Abstract »  |  Full Text »  |  PDF »

The NF-{kappa}B Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes.

A. Khoshnan, C. Tindell, I. Laux, D. Bae, B. Bennett, and A. E. Nel (2000)
J. Immunol. 165, 1743-1754
 |  Abstract »  |  Full Text »  |  PDF »

CD81 and CD28 Costimulate T Cells Through Distinct Pathways.

D. A. Witherden, R. Boismenu, and W. L. Havran (2000)
J. Immunol. 165, 1902-1909
 |  Abstract »  |  Full Text »  |  PDF »

Autoantigen-Specific CD4+CD28low T Cell Subset Prevents Autoimmune Exocrinopathy in Murine Sjogren's Syndrome.

K. Saegusa, N. Ishimaru, K. Yanagi, N. Haneji, M. Nishino, M. Azuma, I. Saito, and Y. Hayashi (2000)
J. Immunol. 165, 2251-2257
 |  Abstract »  |  Full Text »  |  PDF »

Repression of IL-2 Promoter Activity by the Novel Basic Leucine Zipper p21SNFT Protein.

M. Iacobelli, W. Wachsman, and K. L. McGuire (2000)
J. Immunol. 165, 860-868
 |  Abstract »  |  Full Text »  |  PDF »

The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development.

J. D. Alvarez, D. H. Yasui, H. Niida, T. Joh, D. Y. Loh, and T. Kohwi-Shigematsu (2000)
Genes & Dev. 14, 521-535
 |  Abstract »  |  Full Text »

Mucosa-Specific Targets for Regulation of IFN-{gamma} Expression: Lamina Propria T Cells Use Different cis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-{gamma} Expression.

R. Gonsky, R. L. Deem, J. H. Bream, D. H. Lee, H. A. Young, and S. R. Targan (2000)
J. Immunol. 164, 1399-1407
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter.

C. Shang, J. Attema, D. Cakouros, P. N. Cockerill, and M. F. Shannon (1999)
Int. Immunol. 11, 1945-1956
 |  Abstract »  |  Full Text »  |  PDF »

Functional Disparity of Distinct CD28 Response Elements toward Mitogenic Responses.

A. Civil, I. Rensink, L. A. Aarden, and C. L. Verweij (1999)
J. Biol. Chem. 274, 34369-34374
 |  Abstract »  |  Full Text »  |  PDF »

Primary Human CD4+ T Cells Contain Heterogeneous I{kappa}B Kinase Complexes: Role in Activation of the IL-2 Promoter.

A. Khoshnan, S. J. Kempiak, B. L. Bennett, D. Bae, W. Xu, A. M. Manning, C. H. June, and A. E. Nel (1999)
J. Immunol. 163, 5444-5452
 |  Abstract »  |  Full Text »  |  PDF »

Death by neglect as a deletional mechanism of peripheral tolerance.

P. Bertolino, M.-C. Trescol-Biemont, J. Thomas, B. F. de St Groth, M. Pihlgren, J. Marvel, and C. Rabourdin-Combe (1999)
Int. Immunol. 11, 1225-1238
 |  Abstract »  |  Full Text »  |  PDF »

TCR{alpha}{beta}-Independent CD28 Signaling and Costimulation Require Non-CD4-Associated Lck.

B. L. Leung, L. Haughn, A. Veillette, R. G. Hawley, R. Rottapel, and M. Julius (1999)
J. Immunol. 163, 1334-1341
 |  Abstract »  |  Full Text »  |  PDF »

CD28-Mediated Regulation of mRNA Stability Requires Sequences Within the Coding Region of the IL-2 mRNA.

J. A. Ragheb, M. Deen, and R. H. Schwartz (1999)
J. Immunol. 163, 120-129
 |  Abstract »  |  Full Text »  |  PDF »

SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity.

N. Fang and G. A. Koretzky (1999)
J. Biol. Chem. 274, 16206-16212
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Augments IL-2 Secretion of Activated Lamina Propria T Cells by Increasing mRNA Stability Without Enhancing IL-2 Gene Transactivation.

R. Gonsky, R. L. Deem, D. H. Lee, A. Chen, and S. R. Targan (1999)
J. Immunol. 162, 6621-6629
 |  Abstract »  |  Full Text »  |  PDF »

Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses.

R. Khattri, J. A. Auger, M. D. Griffin, A. H. Sharpe, and J. A. Bluestone (1999)
J. Immunol. 162, 5784-5791
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal.

C. Takahashi, R. S. Mittler, and A. T. Vella (1999)
J. Immunol. 162, 5037-5040
 |  Abstract »  |  Full Text »  |  PDF »

The Jun Kinase Cascade Is Responsible for Activating the CD28 Response Element of the IL-2 Promoter: Proof of Cross-Talk with the I{kappa}B Kinase Cascade.

S. J. Kempiak, T. S. Hiura, and A. E. Nel (1999)
J. Immunol. 162, 3176-3187
 |  Abstract »  |  Full Text »  |  PDF »

CD4-Mediated Inhibiton of IL-2 Production in Activated T Cells.

M. Bonnard, L. Haughn, and M. Julius (1999)
J. Immunol. 162, 1252-1260
 |  Abstract »  |  Full Text »  |  PDF »

The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-gamma Promoter in T Cells.

M. T. Sweetser, T. Hoey, Y.-L. Sun, W. M. Weaver, G. A. Price, and C. B. Wilson (1998)
J. Biol. Chem. 273, 34775-34783
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Nuclear Factor of Activated T Cells and AP-1 Are Insufficient for IL-2 Promoter Activation: Requirement for CD28 Up-Regulation of RE/AP.

V. S. Shapiro, M. N. Mollenauer, and A. Weiss (1998)
J. Immunol. 161, 6455-6458
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Jun and Rel Proteins in Up-regulation of Interleukin-4 Gene Activity by the T Cell Accessory Molecule CD28.

M. Li-Weber, M. Giasi, and P. H. Krammer (1998)
J. Biol. Chem. 273, 32460-32466
 |  Abstract »  |  Full Text »  |  PDF »

Mutational Analysis of CD28-Mediated Costimulation of Jun-N-Terminal Kinase and IL-2 Production.

C. Barz, T. Nagel, K. E. Truitt, and J. B. Imboden (1998)
J. Immunol. 161, 5366-5372
 |  Abstract »  |  Full Text »  |  PDF »

Ikappa B Kinases Serve as a Target of CD28 Signaling.

E. W. Harhaj and S.-C. Sun (1998)
J. Biol. Chem. 273, 25185-25190
 |  Abstract »  |  Full Text »  |  PDF »

A p56lck-independent Pathway of CD2 Signaling Involves Jun Kinase.

R. Sunder-Plassmann and E. L. Reinherz (1998)
J. Biol. Chem. 273, 24249-24257
 |  Abstract »  |  Full Text »  |  PDF »

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter.

M. Faris, K. M. Latinis, S. J. Kempiak, G. A. Koretzky, and A. Nel (1998)
Mol. Cell. Biol. 18, 5414-5424
 |  Abstract »  |  Full Text »

Human Endothelial Cells Effectively Costimulate Cytokine Production by, But Not Differentiation of, Naive CD4+ T Cells.

W. Ma and J. S. Pober (1998)
J. Immunol. 161, 2158-2167
 |  Abstract »  |  Full Text »  |  PDF »

A CD28-Associated Signaling Pathway Leading to Cytokine Gene Transcription and T Cell Proliferation Without TCR Engagement.

R. Siefken, S. Klein-He{beta}ling, E. Serfling, R. Kurrle, and R. Schwinzer (1998)
J. Immunol. 161, 1645-1651
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of CD28/CD3-Mediated Costimulation of Naive and Memory Human T Lymphocytes by Intracellular Incorporation of Polyclonal Antibodies Specific for the Activator Protein-1 Transcriptional Complex.

D. G. Woodside and B. W. McIntyre (1998)
J. Immunol. 161, 649-658
 |  Abstract »  |  Full Text »  |  PDF »

V7 (CD101) Ligation Inhibits TCR/CD3-Induced IL-2 Production by Blocking Ca2+ Flux and Nuclear Factor of Activated T Cell Nuclear Translocation.

L. R. B. Soares, L. Tsavaler, A. Rivas, and E. G. Engleman (1998)
J. Immunol. 161, 209-217
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-kappa B.

K. Kalli, C. Huntoon, M. Bell, and D. J. McKean (1998)
Mol. Cell. Biol. 18, 3140-3148
 |  Abstract »  |  Full Text »

Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter.

E. Parra, K. McGuire, G. Hedlund, and M. Dohlsten (1998)
J. Immunol. 160, 5374-5381
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Repression of the IL-2 Gene in Th Cells by ZEB.

D. H. Yasui, T. Genetta, T. Kadesch, T. M. Williams, S. L. Swain, L. V. Tsui, and B. T. Huber (1998)
J. Immunol. 160, 4433-4440
 |  Abstract »  |  Full Text »  |  PDF »

Role of Transcriptional Repressor ICER in Cyclic AMP-mediated Attenuation of Cytokine Gene Expression in Human Thymocytes.

J. Bodor and J. F. Habener (1998)
J. Biol. Chem. 273, 9544-9551
 |  Abstract »  |  Full Text »  |  PDF »

Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation.

L. A. Zuckerman, L. Pullen, and J. Miller (1998)
J. Immunol. 160, 3259-3268
 |  Abstract »  |  Full Text »  |  PDF »

The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.

C. Tsatsanis, C. Patriotis, S. E. Bear, and P. N. Tsichlis (1998)
PNAS 95, 3827-3832
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2.

W. G. Butscher, C. Powers, M. Olive, C. Vinson, and K. Gardner (1998)
J. Biol. Chem. 273, 552-560
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Induction of the CD28-Responsive Complex in Granulocyte Colony-Stimulating Factor Mobilized CD4 T Cells.

J. Tanaka, M. Mielcarek, and B. Torok-Storb (1998)
Blood 91, 347-352
 |  Abstract »  |  Full Text »  |  PDF »

The Ca2+/Calmodulin-dependent Kinase Type IV Is Involved in the CD5-mediated Signaling Pathway in Human T Lymphocytes.

S. I. Gringhuis, L. F. M. H. de Leij, G. A. Wayman, H. Tokumitsu, and E. Vellenga (1997)
J. Biol. Chem. 272, 31809-31820
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-7 Upregulates the Interleukin-2-Gene Expression in Activated Human T Lymphocytes at the Transcriptional Level by Enhancing the DNA Binding Activities of Both Nuclear Factor of Activated T Cells and Activator Protein-1.

S. I. Gringhuis, L. F.M.H. de Leij, E. W. Verschuren, P. Borger, and E. Vellenga (1997)
Blood 90, 2690-2700
 |  Abstract »  |  Full Text »  |  PDF »

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