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Science 18 January 1991:
Vol. 251. no. 4991, pp. 288 - 292
DOI: 10.1126/science.1987644
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Articles

Science, Vol 251, Issue 4991, 288-292
Copyright © 1991 by American Association for the Advancement of Science

articles

CCAAT-enhancer binding protein: a component of a differentiation switch

RM Umek, AD Friedman, and SL McKnight

Howard Hughes Research Laboratories, Department of Embryology, Carnegic Institution of Washington, Baltimore, MD 21210.

The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase wherein proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.


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H. Homma, H. Kurachi, Y. Nishio, T. Takeda, T. Yamamoto, K. Adachi, K.-i. Morishige, M. Ohmichi, Y. Matsuzawa, and Y. Murata (2000)
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   Abstract »    Full Text »    PDF »
Activation of Peroxisome Proliferator-activated Receptor gamma  Bypasses the Function of the Retinoblastoma Protein in Adipocyte Differentiation.
J. B. Hansen, R. K. Petersen, B. M. Larsen, J. Bartkova, J. Alsner, and K. Kristiansen (1999)
J. Biol. Chem. 274, 2386-2393
   Abstract »    Full Text »    PDF »
A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.
I-C. Ho, J. H.-J. Kim, J. W. Rooney, B. M. Spiegelman, and L. H. Glimcher (1998)
PNAS 95, 15537-15541
   Abstract »    Full Text »    PDF »
Transcriptional Control of the pref-1 Gene in 3T3-L1 Adipocyte Differentiation. SEQUENCE REQUIREMENT FOR DIFFERENTIATION-DEPENDENT SUPPRESSION.
C. M. Smas, D. Kachinskas, C.-M. Liu, X. Xie, L. K. Dircks, and H. S. Sul (1998)
J. Biol. Chem. 273, 31751-31758
   Abstract »    Full Text »    PDF »
Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors.
J. Lekstrom-Himes and K. G. Xanthopoulos (1998)
J. Biol. Chem. 273, 28545-28548
   Abstract »    Full Text »    PDF »
Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPalpha Knockout Mice.
T. Kimura, V. M. Christoffels, S. Chowdhury, K. Iwase, H. Matsuzaki, M. Mori, W. H. Lamers, G. J. Darlington, and M. Takiguchi (1998)
J. Biol. Chem. 273, 27505-27510
   Abstract »    Full Text »    PDF »
WAT-free mice: diabetes without obesity.
S. L. McKnight (1998)
Genes & Dev. 12, 3145-3148
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Transcriptional Activation of Scavenger Receptor Expression in Human Smooth Muscle Cells Requires AP-1/c-Jun and C/EBPß : Both AP-1 Binding and JNK Activation Are Induced by Phorbol Esters and Oxidative Stress.
M. Mietus-Snyder, C. K. Glass, and R. E. Pitas (1998)
Arterioscler. Thromb. Vasc. Biol. 18, 1440-1449
   Abstract »    Full Text »    PDF »
Activating Transcription Factor-2 Regulates Phosphoenolpyruvate Carboxykinase Transcription through a Stress-inducible Mitogen-activated Protein Kinase Pathway.
J. Cheong, J. E. Coligan, and J. D. Shuman (1998)
J. Biol. Chem. 273, 22714-22718
   Abstract »    Full Text »    PDF »
Cutting Edge: A Conditionally Active Form of STAT6 Can Mimic Certain Effects of IL-4.
Y. Kamogawa, H. J. Lee, J. A. Johnston, M. McMahon, A. O'Garra, and N. Arai (1998)
J. Immunol. 161, 1074-1077
   Abstract »    Full Text »    PDF »
Gene-specific Transcriptional Activity of the Insulin cAMP-responsive Element Is Conferred by NF-Y in Combination with cAMP Response Element-binding Protein.
A. Eggers, G. Siemann, R. Blume, and W. Knepel (1998)
J. Biol. Chem. 273, 18499-18508
   Abstract »    Full Text »    PDF »
CCAAT/Enhancer Binding Protein alpha  Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors.
H. S. Radomska, C. S. Huettner, P. Zhang, T. Cheng, D. T. Scadden, and D. G. Tenen (1998)
Mol. Cell. Biol. 18, 4301-4314
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Understanding Adipocyte Differentiation.
F. M. GREGOIRE, C. M. SMAS, and H. S. SUL (1998)
Physiol Rev 78, 783-809
   Abstract »    Full Text »    PDF »
Human Translocation Liposarcoma-CCAAT/Enhancer Binding Protein (C/EBP) Homologous Protein (TLS-CHOP) Oncoprotein Prevents Adipocyte Differentiation by Directly Interfering with C/EBPbeta Function.
G. Adelmant, J. D. Gilbert, and S. O. Freytag (1998)
J. Biol. Chem. 273, 15574-15581
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C/EBPbeta , but not C/EBPalpha , is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.
T. N. Seagroves, S. Krnacik, B. Raught, J. Gay, B. Burgess-Beusse, G. J. Darlington, and J. M. Rosen (1998)
Genes & Dev. 12, 1917-1928
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Identification of Transcriptional Activation and Repression Domains in Human CCAAT/Enhancer-binding Protein epsilon.
E. A. Williamson, H. N. Xu, A. F. Gombart, W. Verbeek, A. M. Chumakov, A. D. Friedman, and H. P. Koeffler (1998)
J. Biol. Chem. 273, 14796-14804
   Abstract »    Full Text »    PDF »
Characterization of CCAAT/Enhancer-binding Protein alpha  as a Cyclic AMP-responsive Nuclear Regulator.
W. J. Roesler, E. A. Park, and P. J. McFie (1998)
J. Biol. Chem. 273, 14950-14957
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Effects of Age on the Posttranscriptional Regulation of CCAAT/Enhancer Binding Protein alpha  and CCAAT/Enhancer Binding Protein beta  Isoform Synthesis in Control and LPS-Treated Livers.
C.-C. Hsieh, W. Xiong, Q. Xie, J. P. Rabek, S. G. Scott, M. R. An, P. D. Reisner, D. T. Kuninger, and J. Papaconstantinou (1998)
Mol. Biol. Cell 9, 1479-1494
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Inhibition of CCAAT/Enhancer-binding Protein alpha  and beta  Translation by Upstream Open Reading Frames.
A. J. Lincoln, Y. Monczak, S. C. Williams, and P. F. Johnson (1998)
J. Biol. Chem. 273, 9552-9560
   Abstract »    Full Text »    PDF »
ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand.
J. B. Kim, H. M. Wright, M. Wright, and B. M. Spiegelman (1998)
PNAS 95, 4333-4337
   Abstract »    Full Text »    PDF »


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