Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 January 1991:
Vol. 251. no. 4991, pp. 283 - 287
DOI: 10.1126/science.1702904
Prev | Table of Contents | Next

Articles

Science, Vol 251, Issue 4991, 283-287
Copyright © 1991 by American Association for the Advancement of Science

articles

Chemistry and biology of the immunophilins and their immunosuppressive ligands

SL Schreiber

Harvard University, Cambridge, MA 02138.

Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B.
X. Hanoulle, A. Badillo, J.-M. Wieruszeski, D. Verdegem, I. Landrieu, R. Bartenschlager, F. Penin, and G. Lippens (2009)
J. Biol. Chem. 284, 13589-13601
   Abstract »    Full Text »    PDF »
A cyclophilin links redox and light signals to cysteine biosynthesis and stress responses in chloroplasts.
J. R. Dominguez-Solis, Z. He, A. Lima, J. Ting, B. B. Buchanan, and S. Luan (2008)
PNAS 105, 16386-16391
   Abstract »    Full Text »    PDF »
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation.
M. Wall, G. Poortinga, K. M. Hannan, R. B. Pearson, R. D. Hannan, and G. A. McArthur (2008)
Blood 112, 2305-2317
   Abstract »    Full Text »    PDF »
Cyclophilin and the Regulation of Symbiosis in Aiptasia pallida.
S. Perez and V. Weis (2008)
Biol. Bull. 215, 63-72
   Abstract »    Full Text »    PDF »
mTOR as a Target for Cancer Therapy.
P. J Houghton, J. B Easton, and R. T Kurmasheva (2008)
Am. Assoc. Cancer Res. Educ. Book 2008, 111-120
   Abstract »    Full Text »    PDF »
Structural and Functional Characterization of the Interaction between Cyclophilin B and a Heparin-derived Oligosaccharide.
X. Hanoulle, A. Melchior, N. Sibille, B. Parent, A. Denys, J.-M. Wieruszeski, D. Horvath, F. Allain, G. Lippens, and I. Landrieu (2007)
J. Biol. Chem. 282, 34148-34158
   Abstract »    Full Text »    PDF »
A chloroplast cyclophilin functions in the assembly and maintenance of photosystem II in Arabidopsis thaliana.
A. Fu, Z. He, H. S. Cho, A. Lima, B. B. Buchanan, and S. Luan (2007)
PNAS 104, 15947-15952
   Abstract »    Full Text »    PDF »
Cyclosporine Inhibits Mouse Cytomegalovirus Infection via a Cyclophilin-Dependent Pathway Specifically in Neural Stem/Progenitor Cells.
H. Kawasaki, E. S. Mocarski, I. Kosugi, and Y. Tsutsui (2007)
J. Virol. 81, 9013-9023
   Abstract »    Full Text »    PDF »
The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation.
B. Chambraud, H. Belabes, V. Fontaine-Lenoir, A. Fellous, and E. E. Baulieu (2007)
FASEB J 21, 2787-2797
   Abstract »    Full Text »    PDF »
The Heparin/Heparan Sulfate Sequence That Interacts with Cyclophilin B Contains a 3-O-Sulfated N-Unsubstituted Glucosamine Residue.
C. Vanpouille, A. Deligny, M. Delehedde, A. Denys, A. Melchior, X. Lienard, M. Lyon, J. Mazurier, D. G. Fernig, and F. Allain (2007)
J. Biol. Chem. 282, 24416-24429
   Abstract »    Full Text »    PDF »
A WD40 Domain Cyclophilin Interacts with Histone H3 and Functions in Gene Repression and Organogenesis in Arabidopsis.
H. Li, Z. He, G. Lu, S. C. Lee, J. Alonso, J. R. Ecker, and S. Luan (2007)
PLANT CELL 19, 2403-2416
   Abstract »    Full Text »    PDF »
Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis.
R. Pakula, A. Melchior, A. Denys, C. Vanpouille, J. Mazurier, and F. Allain (2007)
Glycobiology 17, 492-503
   Abstract »    Full Text »    PDF »
Sirolimus Causes Relaxation of Human Vascular Smooth Muscle: A Novel Action of Sirolimus Mediated via ATP-Sensitive Potassium Channels.
S. Ghatta, R. R. Tunstall, S. Kareem, M. Rahman, and S. T. O'Rourke (2007)
J. Pharmacol. Exp. Ther. 320, 1204-1208
   Abstract »    Full Text »    PDF »
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS).
D. T. Teachey, D. A. Obzut, K. Axsom, J. K. Choi, K. C. Goldsmith, J. Hall, J. Hulitt, C. S. Manno, J. M. Maris, N. Rhodin, et al. (2006)
Blood 108, 1965-1971
   Abstract »    Full Text »    PDF »
Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells.
M. Gabillot-Carre, Y. Lepelletier, M. Humbert, P. de Sepuvelda, N. B. Hamouda, J. P. Zappulla, R. Liblau, A. Ribadeau-Dumas, F. Machavoine, S. Letard, et al. (2006)
Blood 108, 1065-1072
   Abstract »    Full Text »    PDF »
FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor..
T Yamaguchi, A Kurisaki, N Yamakawa, K Minakuchi, and H Sugino (2006)
J. Mol. Endocrinol. 36, 569-579
   Abstract »    Full Text »    PDF »
Establishment of a Cell Model Based on FKBP12 Dimerization for Screening of FK506-like Neurotrophic Small Molecular Compounds.
H. Xiao, L.-L. Wang, C.-L. Shu, M. Yu, S. Li, B.-F. Shen, and Y. Li (2006)
J Biomol Screen 11, 225-235
   Abstract »    PDF »
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL.
D. T. Teachey, D. A. Obzut, J. Cooperman, J. Fang, M. Carroll, J. K. Choi, P. J. Houghton, V. I. Brown, and S. A. Grupp (2006)
Blood 107, 1149-1155
   Abstract »    Full Text »    PDF »
Inhibition of Target of Rapamycin Signaling by Rapamycin in the Unicellular Green Alga Chlamydomonas reinhardtii.
J. L. Crespo, S. Diaz-Troya, and F. J. Florencio (2005)
Plant Physiology 139, 1736-1749
   Abstract »    Full Text »    PDF »
Bifurcated converging pathways for high Ca2+- and TGF{beta}-induced inhibition of growth of normal human keratinocytes.
M. Sakaguchi, H. Sonegawa, T. Nukui, Y. Sakaguchi, M. Miyazaki, M. Namba, and N.-h. Huh (2005)
PNAS 102, 13921-13926
   Abstract »    Full Text »    PDF »
Redox regulation in the chloroplast thylakoid lumen: a new frontier in photosynthesis research.
B. B. Buchanan and S. Luan (2005)
J. Exp. Bot. 56, 1439-1447
   Abstract »    Full Text »    PDF »
Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53.
D. Rosner, N. McCarthy, and M. Bennett (2005)
Cardiovasc Res 66, 601-610
   Abstract »    Full Text »    PDF »
Antileukemic activity of rapamycin in acute myeloid leukemia.
C. Recher, O. Beyne-Rauzy, C. Demur, G. Chicanne, C. Dos Santos, V. M.-D. Mas, D. Benzaquen, G. Laurent, F. Huguet, and B. Payrastre (2005)
Blood 105, 2527-2534
   Abstract »    Full Text »    PDF »
Interaction of FKBP12.6 with the Cardiac Ryanodine Receptor C-terminal Domain.
S. Zissimopoulos and F. A. Lai (2005)
J. Biol. Chem. 280, 5475-5485
   Abstract »    Full Text »    PDF »
Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells.
J. Fauconnier, A. Lacampagne, J.-M. Rauzier, P. Fontanaud, J.-M. Frapier, O. M. Sejersted, G. Vassort, and S. Richard (2005)
Am J Physiol Heart Circ Physiol 288, H778-H786
   Abstract »    Full Text »    PDF »
Mechanisms of desensitization of the adrenocorticotropin response to arginine vasopressin in ovine anterior pituitary cells.
A Hassan and D Mason (2005)
J. Endocrinol. 184, 29-40
   Abstract »    Full Text »    PDF »
Calcium Absorption Across Epithelia.
J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels (2005)
Physiol Rev 85, 373-422
   Abstract »    Full Text »    PDF »
Protein Expression Profiles in Pancreatic Adenocarcinoma Compared with Normal Pancreatic Tissue and Tissue Affected by Pancreatitis as Detected by Two-Dimensional Gel Electrophoresis and Mass Spectrometry.
J. Shen, M. D. Person, J. Zhu, J. L. Abbruzzese, and D. Li (2004)
Cancer Res. 64, 9018-9026
   Abstract »    Full Text »    PDF »
Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen.
G. Gopalan, Z. He, Y. Balmer, P. Romano, R. Gupta, A. Heroux, B. B. Buchanan, K. Swaminathan, and S. Luan (2004)
PNAS 101, 13945-13950
   Abstract »    Full Text »    PDF »
Mammalian Target of Rapamycin Inhibition.
J. P. Dutcher (2004)
Clin. Cancer Res. 10, 6382S-6387S
   Abstract »    Full Text »    PDF »
Introducing Immunophilins. From Organ Transplantation to Plant Biology.
P. Romano, Z. He, and S. Luan (2004)
Plant Physiology 134, 1241-1243
   Full Text »    PDF »
Immunophilins and Parvulins. Superfamily of Peptidyl Prolyl Isomerases in Arabidopsis.
Z. He, L. Li, and S. Luan (2004)
Plant Physiology 134, 1248-1267
   Abstract »    Full Text »    PDF »
Downregulation of Ca2+ and Mg2+ Transport Proteins in the Kidney Explains Tacrolimus (FK506)-Induced Hypercalciuria and Hypomagnesemia.
T. Nijenhuis, J. G.J. Hoenderop, and R. J.M. Bindels (2004)
J. Am. Soc. Nephrol. 15, 549-557
   Abstract »    Full Text »    PDF »
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling.
V. I. Brown, J. Fang, K. Alcorn, R. Barr, J. M. Kim, R. Wasserman, and S. A. Grupp (2003)
PNAS 100, 15113-15118
   Abstract »    Full Text »    PDF »
Artificially controlled aggregation of proteins and targeting in hematopoietic cells.
H. Rosen, Y. Gao, E. Johnsson, and I. Olsson (2003)
J. Leukoc. Biol. 74, 800-809
   Abstract »    Full Text »    PDF »
Pharmacodynamic Approach to Immunosuppressive Therapies Using Calcineurin Inhibitors and Mycophenolate Mofetil.
O. Millan, M. Brunet, J. M. Campistol, A. Faura, I. Rojo, E. Vidal, O. Jimenez, J. Vives, F. Oppenheimer, and J. Martorell (2003)
Clin. Chem. 49, 1891-1899
   Abstract »    Full Text »    PDF »
Protein Expression Profiling Identifies Macrophage Migration Inhibitory Factor and Cyclophilin A as Potential Molecular Targets in Non-Small Cell Lung Cancer.
M. J. Campa, M. Z. Wang, B. Howard, M. C. Fitzgerald, and E. F. Patz Jr. (2003)
Cancer Res. 63, 1652-1656
   Abstract »    Full Text »    PDF »
Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506.
P. I. Padilla, M.-j. Chang, G. Pacheco-Rodriguez, R. Adamik, J. Moss, and M. Vaughan (2003)
PNAS 100, 2322-2327
   Abstract »    Full Text »    PDF »
Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer.
A. Ryo, Y.-C. Liou, K. P. Lu, and G. Wulf (2003)
J. Cell Sci. 116, 773-783
   Abstract »    Full Text »    PDF »
LF 15-0195 Inhibits the Development of Rat Central Nervous System Autoimmunity by Inducing Long-Lasting Tolerance in Autoreactive CD4 T Cells.
V. Duplan, P. Dutartre, L. T. Mars, R. S. Liblau, P. Druet, and A. Saoudi (2003)
J. Immunol. 170, 2179-2185
   Abstract »    Full Text »    PDF »
Protein Kinase A Phosphorylation of the Cardiac Calcium Release Channel (Ryanodine Receptor) in Normal and Failing Hearts. ROLE OF PHOSPHATASES AND RESPONSE TO ISOPROTERENOL.
S. Reiken, M. Gaburjakova, S. Guatimosim, A. M. Gomez, J. D'Armiento, D. Burkhoff, J. Wang, G. Vassort, W. J. Lederer, and A. R. Marks (2003)
J. Biol. Chem. 278, 444-453
   Abstract »    Full Text »    PDF »
Effects of FK506 on [Ca2+]i Differ in Mouse and Rabbit Ventricular Myocytes.
Z. Su, K. Sugishita, F. Li, M. Ritter, and W. H. Barry (2003)
J. Pharmacol. Exp. Ther. 304, 334-341
   Abstract »    Full Text »    PDF »
Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae.
J. L. Crespo and M. N. Hall (2002)
Microbiol. Mol. Biol. Rev. 66, 579-591
   Abstract »    Full Text »    PDF »
A Single-domain Cyclophilin from Leishmania donovani Reactivates Soluble Aggregates of Adenosine Kinase by Isomerase-independent Chaperone Function.
A. Chakraborty, I. Das, R. Datta, B. Sen, D. Bhattacharyya, C. Mandal, and A. K. Datta (2002)
J. Biol. Chem. 277, 47451-47460
   Abstract »    Full Text »    PDF »
A chloroplast FKBP interacts with and affects the accumulation of Rieske subunit of cytochrome bf complex.
R. Gupta, R. M. Mould, Z. He, and S. Luan (2002)
PNAS 99, 15806-15811
   Abstract »    Full Text »    PDF »
Identification and Characterization of Moca-cyp. A DROSOPHILA MELANOGASTER NUCLEAR CYCLOPHILIN.
L. Cavarec, T. Kamphausen, B. Dubourg, I. Callebaut, F. Lemeunier, D. Metivier, J. Feunteun, G. Fischer, and N. Modjtahedi (2002)
J. Biol. Chem. 277, 41171-41182
   Abstract »    Full Text »    PDF »
15-Deoxyspergualin Inhibits Akt Kinase Activation and Phosphatidylcholine Synthesis.
M. Kawada, T. Masuda, M. Ishizuka, and T. Takeuchi (2002)
J. Biol. Chem. 277, 27765-27771
   Abstract »    Full Text »    PDF »
Anti-Inflammatory Effects of a Cyclosporine Receptor-Binding Compound, D-43787.
A. Pahl, M. Zhang, K. Torok, H. Kuss, U. Friedrich, Z. Magyar, J. Szekely, K. Horvath, K. Brune, and I. Szelenyi (2002)
J. Pharmacol. Exp. Ther. 301, 738-746
   Abstract »    Full Text »    PDF »
The Structural Basis of Compstatin Activity Examined by Structure-Function-based Design of Peptide Analogs and NMR.
D. Morikis, M. Roy, A. Sahu, A. Troganis, P. A. Jennings, G. C. Tsokos, and J. D. Lambris (2002)
J. Biol. Chem. 277, 14942-14953
   Abstract »    Full Text »    PDF »
4E-binding Proteins, the Suppressors of Eukaryotic Initiation Factor 4E, Are Down-regulated in Cells with Acquired or Intrinsic Resistance to Rapamycin.
M. B. Dilling, G. S. Germain, L. Dudkin, A. L. Jayaraman, X. Zhang, F. C. Harwood, and P. J. Houghton (2002)
J. Biol. Chem. 277, 13907-13917
   Abstract »    Full Text »    PDF »
Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis by Activin.
Y.-G. Chen, H. M. Lui, S.-L. Lin, J. M. Lee, and S.-Y. Ying (2002)
Experimental Biology and Medicine 227, 75-87
   Abstract »    Full Text »    PDF »
Myocardial Disease in Failing Hearts: Defective Excitation-Contraction Coupling.
X.H.T. WEHRENS and A.R. MARKS (2002)
Cold Spring Harb Symp Quant Biol 67, 533-542
   Abstract »    PDF »
Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Cellular FKBP52 Protein in Transgene Expression.
K. Qing, J. Hansen, K. A. Weigel-Kelley, M. Tan, S. Zhou, and A. Srivastava (2001)
J. Virol. 75, 8968-8976
   Abstract »    Full Text »    PDF »
Bench to Bedside: The Development of Rapamycin and Its Application to Stent Restenosis.
S. O. Marx and A. R. Marks (2001)
Circulation 104, 852-855
   Full Text »    PDF »
Role for p27Kip1 in Vascular Smooth Muscle Cell Migration.
J. Sun, S. O. Marx, H.-J. Chen, M. Poon, A. R. Marks, and L. E. Rabbani (2001)
Circulation 103, 2967-2972
   Abstract »    Full Text »    PDF »
Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action.
G. Zenke, U. Strittmatter, S. Fuchs, V. F. J. Quesniaux, V. Brinkmann, W. Schuler, M. Zurini, A. Enz, A. Billich, J.-J. Sanglier, et al. (2001)
J. Immunol. 166, 7165-7171
   Abstract »    Full Text »    PDF »
Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition.
L. Dudkin, M. B. Dilling, P. J. Cheshire, F. C. Harwood, M. Hollingshead, S. G. Arbuck, R. Travis, E. A. Sausville, and P. J. Houghton (2001)
Clin. Cancer Res. 7, 1758-1764
   Abstract »    Full Text »    PDF »
Cardiac Ryanodine Receptors and Accessory Proteins: Augmented Expression Does Not Necessarily Mean Big Function.
H. H. Valdivia (2001)
Circ. Res. 88, 134-136
   Full Text »    PDF »
The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner.
J. Trama, Q. Lu, R. G. Hawley, and S. N. Ho (2000)
J. Immunol. 165, 4884-4894
   Abstract »    Full Text »    PDF »
The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells.
G. Yue, R. S. Edinger, H.-F. Bao, J. P. Johnson, and D. C. Eaton (2000)
Am J Physiol Cell Physiol 279, C81-C88
   Abstract »    Full Text »    PDF »
Accumulation of rab4GTP in the Cytoplasm and Association with the Peptidyl-Prolyl Isomerase Pin1 during Mitosis.
L. Gerez, K. Mohrmann, M. van Raak, M. Jongeneelen, X. Z. Zhou, K. P. Lu, and P. van der Sluijs (2000)
Mol. Biol. Cell 11, 2201-2211
   Abstract »    Full Text »
Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.
G. Bultynck, P. De Smet, A F. Weidema, M. Ver Heyen, K. Maes, G. Callewaert, L. Missiaen, J. B Parys, and H. De Smedt (2000)
J. Physiol. 525, 681-693
   Abstract »    Full Text »    PDF »
Ligand-Binding Proteins: Their Potential for Application in Systems for Controlled Delivery and Uptake of Ligands.
F. A. De Wolf and G. M. Brett (2000)
Pharmacol. Rev. 52, 207-236
   Abstract »    Full Text »    PDF »
Multiple Components of the HSP90 Chaperone Complex Function in Regulation of Heat Shock Factor 1 In Vivo.
S. Bharadwaj, A. Ali, and N. Ovsenek (1999)
Mol. Cell. Biol. 19, 8033-8041
   Abstract »    Full Text »    PDF »
Cell Cycle Progression and Proliferation Despite 4BP-1 Dephosphorylation.
S. O. Marx and A. R. Marks (1999)
Mol. Cell. Biol. 19, 6041-6047
   Abstract »    Full Text »    PDF »
Cyclophilin B Binding to Platelets Supports Calcium-Dependent Adhesion to Collagen.
F. Allain, S. Durieux, A. Denys, M. Carpentier, and G. Spik (1999)
Blood 94, 976-983
   Abstract »    Full Text »    PDF »
Immunophilin FK506-Binding Protein 52 (Not FK506-Binding Protein 12) Mediates the Neurotrophic Action of FK506.
B. G. Gold, V. Densmore, W. Shou, M. M. Matzuk, and H. S. Gordon (1999)
J. Pharmacol. Exp. Ther. 289, 1202-1210
   Abstract »    Full Text »
Pharmacology of the Eosinophil.
M. A. Giembycz and M. A. Lindsay (1999)
Pharmacol. Rev. 51, 213-340
   Abstract »    Full Text »    PDF »
Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium.
S. Kanoh, M. Kondo, J. Tamaoki, H. Shirakawa, K. Aoshiba, S. Miyazaki, H. Kobayashi, N. Nagata, and A. Nagai (1999)
Am J Physiol Lung Cell Mol Physiol 276, L891-L899
   Abstract »    Full Text »    PDF »
Newer Immunosuppressive Drugs: A Review.
J. F. GUMMERT, T. IKONEN, and R. E. MORRIS (1999)
J. Am. Soc. Nephrol. 10, 1366-1380
   Abstract »    Full Text »
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
V. Baud, Z.-G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin (1999)
Genes & Dev. 13, 1297-1308
   Abstract »    Full Text »
The Transcription Factor CCAAT/Enhancer-binding Protein beta  Regulates Gluconeogenesis and Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription during Diabetes.
C. Arizmendi, S. Liu, C. Croniger, V. Poli, and J. E. Friedman (1999)
J. Biol. Chem. 274, 13033-13040
   Abstract »    Full Text »    PDF »
Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle.
R. Gallo, A. Padurean, T. Jayaraman, S. Marx, M. Roque, S. Adelman, J. Chesebro, J. Fallon, V. Fuster, A. Marks, et al. (1999)
Circulation 99, 2164-2170
   Abstract »    Full Text »    PDF »
Prevention of Cardiac Hypertrophy by Calcineurin Inhibition : Hope or Hype?.
E. N. Olson and J. D. Molkentin (1999)
Circ. Res. 84, 623-632
   Full Text »    PDF »
Borrowing to make ends meet.
J. Clardy (1999)
PNAS 96, 1826-1827
   Full Text »    PDF »
Immunophilins, Refsum disease, and lupus nephritis: The peroxisomal enzyme phytanoyl-COA alpha -hydroxylase is a new FKBP-associated protein.
B. Chambraud, C. Radanyi, J. H. Camonis, K. Rajkowski, M. Schumacher, and E.-E. Baulieu (1999)
PNAS 96, 2104-2109
   Abstract »    Full Text »    PDF »
Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells.
H. Hosoi, M. B. Dilling, T. Shikata, L. N. Liu, L. Shu, R. A. Ashmun, G. S. Germain, R. T. Abraham, and P. J. Houghton (1999)
Cancer Res. 59, 886-894
   Abstract »    Full Text »    PDF »
The Wheat Peptidyl Prolyl cis-trans-Isomerase FKBP77 Is Heat Induced and Developmentally Regulated.
I. Kurek, K. Aviezer, N. Erel, E. Herman, and A. Breiman (1999)
Plant Physiology 119, 693-704
   Abstract »    Full Text »
The Common Tetratricopeptide Repeat Acceptor Site for Steroid Receptor-associated Immunophilins and Hop Is Located in the Dimerization Domain of Hsp90.
A. Carrello, E. Ingley, R. F. Minchin, S. Tsai, and T. Ratajczak (1999)
J. Biol. Chem. 274, 2682-2689
   Abstract »    Full Text »    PDF »
FK-binding Protein Is Associated with the Ryanodine Receptor of Skeletal Muscle in Vertebrate Animals.
Y. Qi, E. M. Ogunbunmi, E. A. Freund, A. P. Timerman, and S. Fleischer (1998)
J. Biol. Chem. 273, 34813-34819
   Abstract »    Full Text »    PDF »
High-Molecular-Weight FK506-Binding Proteins Are Components of Heat-Shock Protein 90 Heterocomplexes in Wheat Germ Lysate.
R. K. Reddy, I. Kurek, A. M. Silverstein, M. Chinkers, A. Breiman, and P. Krishna (1998)
Plant Physiology 118, 1395-1401
   Abstract »    Full Text »
Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells.
H. Hosoi, M. B. Dilling, L. N. Liu, M. K. Danks, T. Shikata, A. Sekulic, R. T. Abraham, J. C. Lawrence Jr., and P. J. Houghton (1998)
Mol. Pharmacol. 54, 815-824
   Abstract »    Full Text »
PRIM: Proximity imaging of green fluorescent protein-tagged polypeptides.
D. A. De Angelis, G. Miesenbock, B. V. Zemelman, and J. E. Rothman (1998)
PNAS 95, 12312-12316
   Abstract »    Full Text »    PDF »
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity.
T. Clackson, W. Yang, L. W. Rozamus, M. Hatada, J. F. Amara, C. T. Rollins, L. F. Stevenson, S. R. Magari, S. A. Wood, N. L. Courage, et al. (1998)
PNAS 95, 10437-10442
   Abstract »    Full Text »    PDF »
Coupled Gating Between Individual Skeletal Muscle Ca2+ Release Channels (Ryanodine Receptors).
S. O. Marx, K. Ondrias, and A. R. Marks (1998)
Science 281, 818-821
   Abstract »    Full Text »
Isolation and Analysis of a T Cell Clone Variant Exhibiting Constitutively Phosphorylated Ser133 cAMP Response Element-Binding Protein.
S. M. Belkowski, C. S. Rubin, and M. B. Prystowsky (1998)
J. Immunol. 161, 659-665
   Abstract »    Full Text »    PDF »
Second Family of Histone Deacetylases.
L. Aravind, E. V. Koonin;, M. Dangl, A. Lusser, G. Brosch, A. Loidl, H. Haas, and P. Loidl; (1998)
Science 280, 1167a-1167
   Full Text »
Isolation and identification of a C39 demethylated metabolite of rapamycin from pig liver microsomes and evaluation of its immunosuppressive activity.
M. J. M. Nickmilder, D. Latinne, J.-P. De Houx, R. K. Verbeeck, and G. J. J. Lhoest (1998)
Clin. Chem. 44, 532-538
   Abstract »    Full Text »    PDF »
The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.
M. Shen, P. T. Stukenberg, M. W. Kirschner, and K. P. Lu (1998)
Genes & Dev. 12, 706-720
   Abstract »    Full Text »
Identification of Tropoelastin as a Ligand for the 65-kD FK506-binding Protein, FKBP65, in the Secretory Pathway.
E. C. Davis, T. J. Broekelmann, Y. Ozawa, and R. P. Mecham (1998)
J. Cell Biol. 140, 295-303
   Abstract »    Full Text »    PDF »
cFKBP/SMAP; a novel molecule involved in the regulation of smooth muscle differentiation.
K Fukuda, Y Tanigawa, G Fujii, S Yasugi, and S Hirohashi (1998)
Development 125, 3535-3542
   Abstract »    PDF »
Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism.
M. B. Yaffe, M. Schutkowski, M. Shen, X. Z. Zhou, P. T. Stukenberg, J. Rahfeld, J. Xu, J. Kuang, M. W. Kirschner, G. Fischer, et al. (1997)
Science 278, 1957-1960
   Abstract »    Full Text »
A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets.
J. Huang and S. L. Schreiber (1997)
PNAS 94, 13396-13401
   Abstract »    Full Text »    PDF »
Characterization of Saccharomyces cerevisiae dna2 Mutants Suggests a Role for the Helicase Late in S Phase.
D. F. Fiorentino and G. R. Crabtree (1997)
Mol. Biol. Cell 8, 2519-2537
   Abstract »    Full Text »
FKBP12 Binds the Inositol 1,4,5-Trisphosphate Receptor at Leucine-Proline (1400-1401) and Anchors Calcineurin to this FK506-like Domain.
A. M. Cameron, F. C. Nucifora Jr., E. T. Fung, D. J. Livingston, R. A. Aldape, C. A. Ross, and S. H. Snyder (1997)
J. Biol. Chem. 272, 27582-27588
   Abstract »    Full Text »    PDF »
Regulation of eIF-4E BP1 Phosphorylation by mTOR.
K. Hara, K. Yonezawa, M. T. Kozlowski, T. Sugimoto, K. Andrabi, Q.-P. Weng, M. Kasuga, I. Nishimoto, and J. Avruch (1997)
J. Biol. Chem. 272, 26457-26463
   Abstract »    Full Text »    PDF »
Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence.
A. A. Bukovsky, A. Weimann, M. A. Accola, and H. G. Gottlinger (1997)
PNAS 94, 10943-10948
   Abstract »    Full Text »    PDF »
Neuroprotective Actions of FK506 in Experimental Stroke: In Vivo Evidence against an Antiexcitotoxic Mechanism.
S. P. Butcher, D. C. Henshall, Y. Teramura, K. Iwasaki, and J. Sharkey (1997)
J. Neurosci. 17, 6939-6946
   Abstract »    Full Text »    PDF »
Rapamycin Inhibits {alpha}1-Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes : Evidence for Involvement of p70 S6 Kinase.
M. O. Boluyt, J.-S. Zheng, A. Younes, X. Long, L. O'Neill, H. Silverman, E. G. Lakatta, and M. T. Crow (1997)
Circ. Res. 81, 176-186
   Abstract »    Full Text »
Comparative Dose-Dependence Study of FK506 and Cyclosporin A on the Rate of Axonal Regeneration in the Rat Sciatic Nerve.
M.-S. Wang, M. Zeleny-Pooley, and B. G. Gold (1997)
J. Pharmacol. Exp. Ther. 282, 1084-1093
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)