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Science 11 January 1991:
Vol. 251. no. 4990, pp. 195 - 198
DOI: 10.1126/science.1824801
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Articles

Science, Vol 251, Issue 4990, 195-198
Copyright © 1991 by American Association for the Advancement of Science

articles

Vaccination for disease

S Oehen, H Hengartner, and RM Zinkernagel

Laboratory for Experimental Pathology, University of Zurich, Switzerland.

Recombinant virus vaccines that express a limited number of epitopes are currently being developed to prevent disease by changing the relative balance between viral spread and the immune response. Some circumstances, however, were found in infections with a noncytopathic virus in which vaccination caused disease; sensitive parameters included the genetic background of the host, the time or dose of infection, and the constituents of the vaccine. Thus, immunopathologic damage by T cells may be an unwanted consequence of vaccination with the new types of peptide or recombinant vaccines that are being investigated for the human immunodeficiency viruses and other pathogens.


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