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Science 4 January 1991:
Vol. 251. no. 4989, pp. 78 - 81
DOI: 10.1126/science.1824727
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Articles

Science, Vol 251, Issue 4989, 78-81
Copyright © 1991 by American Association for the Advancement of Science

articles

Glycosylphosphatidylinositol: a candidate system for interleukin-2 signal transduction

DD Eardley and ME Koshland

Department of Biological Sciences, University of California, Santa Barbara 93106.

The mechanism of interleukin-2 (IL-2) signal transduction was analyzed by use of an inducible B lymphoma. Like normal antigen-activated B lymphocytes, the lymphoma cells respond to IL-2 by proliferating and differentiating into antibody-secreting cells; both responses are blocked by a second interleukin, IL-4. Analyses of the signaling pathway showed that IL-2 stimulated the rapid hydrolysis of an inositol-containing glycolipid to yield two possible second messengers, a myristylated diacylglycerol and an inositol phosphate-glycan. The myristylated diacylglycerol response exhibited the same IL-2 dose dependence as the growth and differentiative responses, and the generation of both hydrolysis products was inhibited by IL-4. These correlations implicate the glycosyl-phosphatidylinositol system in the intracellular relay of the IL-2 signal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Erythropoietin Induces Glycosylphosphatidylinositol Hydrolysis. POSSIBLE INVOLVEMENT OF PHOSPHOLIPASE C-gamma 2.
C. Boudot, E. Petitfrere, Z. Kadri, S. Chretien, P. Mayeux, B. Haye, and C. Billat (1999)
J. Biol. Chem. 274, 33966-33972
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Antagonistic Roles for Phospholipase D Activities in B Cell Signaling: While the Antigen Receptors Transduce Mitogenic Signals Via a Novel Phospholipase D Activity, Phosphatidylcholine-Phospholipase D Mediates Antiproliferative Signals.
J. J. Gilbert, T. R. Pettitt, S. D. Seatter, S. D. Reid, M. J. O. Wakelam, and M. M. Harnett (1998)
J. Immunol. 161, 6575-6584
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Dual Role of Ceramide in the Control of Apoptosis Following IL-2 Withdrawal.
I. Flores, C. Martinez-A, Y. A. Hannun, and I. Merida (1998)
J. Immunol. 160, 3528-3533
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A Point Mutation in Interleukin-2 That Alters Ligand Internalization.
D. Z. Chang, Z. Wu, and T. L. Ciardelli (1996)
J. Biol. Chem. 271, 13349-13355
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Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced alpha-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation.
I. Flores, T. Casaseca, C. Martinez-A, H. Kanoh, and I. Merida (1996)
J. Biol. Chem. 271, 10334-10340
   Abstract »    Full Text »    PDF »
Potocytosis: sequestration and transport of small molecules by caveolae.
R. Anderson, B. Kamen, K. Rothberg, and S. Lacey (1992)
Science 255, 410-411
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Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association.
M Hatakeyama, T Kono, N Kobayashi, A Kawahara, S. Levin, R. Perlmutter, and T Taniguchi (1991)
Science 252, 1523-1528
   Abstract »    PDF »
Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D.
B. Scallon, W. Fung, T. Tsang, S Li, H Kado-Fong, K. Huang, and J. Kochan (1991)
Science 252, 446-448
   Abstract »    PDF »


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